Abstract:
:Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasm arising in the stomach. These tumors were previously classified as smooth muscle tumors, but in recent years it has become clear that they are clinically, pathologically, and molecularly distinct from other tumors and are much more common than previously appreciated. Historically, patients with primary localized or advanced GIST have been managed surgically, as there was no proven role of other treatment modalities such as radiation or chemotherapy. However, the field of GIST was revolutionized with the 1998 discovery that the vast majority of these tumors have oncogenic gain-of-function mutations of the KIT receptor tyrosine kinase. Follow-up studies have confirmed that KIT is both a useful diagnostic marker and an excellent therapeutic target. Imatinib, an inhibitor of KIT kinase activity, is now the standard front-line therapy for patients with advanced GIST. In this review, we discuss pathological and molecular features of gastric GISTs and review the historic and current roles of surgery in the treatment of patients with primary or metastatic GIST. The importance of a multi-disciplinary approach using both surgery and imatinib therapy is emphasized.
journal_name
J Surg Oncoljournal_title
Journal of surgical oncologyauthors
Heinrich MC,Corless CLdoi
10.1002/jso.20230subject
Has Abstractpub_date
2005-06-01 00:00:00pages
195-207; discussion 207issue
3eissn
0022-4790issn
1096-9098journal_volume
90pub_type
杂志文章,评审abstract:BACKGROUND:Local recurrence (LR) of sacral chordoma is a difficult problem and the mortality risk associated with LR remains poorly described. The purpose of this study was to evaluate the risk of mortality in patients with LR and determine if patient age is associated with mortality. METHODS:A total of 218 patients (...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.25774
更新日期:2019-11-22 00:00:00
abstract::In a test of electromagnetic induction hyperthermia to deep viscera of a live dog model, we found that heating was not uniform to any depth, but was quite variable. In general, there was a thermal gradient between peripheral and central portions of the transposed spleen of about 1 degree C. Though heat generation with...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930290204
更新日期:1985-06-01 00:00:00
abstract::Over the last decade, the use of neoadjuvant chemo-radiation has been an integral part of the care of patients with locally advanced rectal cancer. However, emerging data are beginning to challenge the current treatment paradigm of neoadjuvant chemo-radiation followed by radical resection and subsequent adjuvant chemo...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.24267
更新日期:2016-09-01 00:00:00
abstract::The sentinel node (SN) is defined as the first draining node from the primary lesion and it has proven to be a good indicator of the metastatic status of regional lymph nodes in solid tumors. In the past 5 years, the validity of SN concept for gastric cancer has been demonstrated by a number of single institutional st...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.20220
更新日期:2005-06-01 00:00:00
abstract:PURPOSE:The aims of the study were to estimate the frequency of epiphora and to identify factors associated with epiphora after orbital-sparing maxillectomy via modified Weber-Ferguson incision with lower blepharoplasty (OSOSM-MWFILB). METHODS:We performed a retrospective cohort study enrolling a sample derived from t...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.26408
更新日期:2021-02-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:To describe the use of the mastoid skull post of a surgical image guidance system for image guided surgery and intraoperative navigation of the nasopharynx. This adaptation overcomes the limitations of a headset frame or head clamp and can be applied to open and closed surgery of the nasal cav...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.21005
更新日期:2008-05-01 00:00:00
abstract::A consecutive series of 73 patients treated with intraarterial infusion of 5-fluorouracil (5-FU) for liver metastases from colorectal primary was studied retrospectively using multivariate analysis in order to find determinants of survival. Nontreatment factors had a great impact on variation in survival with liver tu...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930310406
更新日期:1986-04-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:The most common cause of failure in large segment bone allografts used for oncologic reconstruction is allograft fracture. Reinforcement with pressurized intramedullary cement may improve the mechanical properties of allografts. METHODS:We reviewed the prospectively collected records of 45 pa...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.10316
更新日期:2003-12-01 00:00:00
abstract::We retrospectively reviewed 16 patients in whom primary retroperitoneal liposarcoma was diagnosed and treated. These patients were classified according to the first definitive surgical procedure employed: complete excision with or without radiotherapy; partial excision followed by radiotherapy; only biopsy of tumor fo...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930470110
更新日期:1991-05-01 00:00:00
abstract:BACKGROUND:Adrenal venous sampling (AVS) is the definitive evaluation for primary aldosteronism (PA). Pre-AVS cross-sectional imaging does not reduce the need for AVS. The goal of this study was to examine whether performing AVS prior to imaging could decrease the use of imaging in the evaluation of PA at a high volume...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.23963
更新日期:2015-08-01 00:00:00
abstract::The aim of the present study was to demonstrate the practicality of intraoperative fine needle aspiration (FNA) cytology of pancreatic lesions in 43 patients. The indication for performing this procedure was to determine the nature of pancreatic masses. Conclusive cytologic diagnoses were reached in 41 patients who re...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930460407
更新日期:1991-04-01 00:00:00
abstract::A 29-year-old female was diagnosed with a symptomatic, extra-abdominal desmoid tumor during the first trimester of pregnancy. Computerized tomography (CT) and transabdominal ultrasound (US) noted a mass within the left rectus sheath measuring up to 15 cm in greatest diameter, with mild compression of the uterus. Preop...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.20189
更新日期:2005-02-01 00:00:00
abstract:BACKGROUND:The aim of this study was to analyze the potential utilization of external jugular vein (EJV) cutdown approach for totally implantable venous access device (TIVAD) placement. METHODS:This is a prospective, non-randomized, observational, uni-institutional study. All patients (n = 451) were first subjected to...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.21341
更新日期:2009-09-01 00:00:00
abstract:BACKGROUND:The object of the current study was to review the outcomes of hepatic resection for hepatocellular carcinoma (HCC) ≥ 10 cm. METHODS:Between 1995 and 2007, fifty-three patients with HCC ≥ 10 cm underwent hepatic resection, and clinical data were compared to those of patients with non-surgical treatment (n = ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.21931
更新日期:2011-09-01 00:00:00
abstract:PURPOSE:We assessed which classification of lymph node metastasis better predicted outcomes in patients with colorectal carcinoma. METHODS:We identified 318 patients (176 men) with stage III colon cancer who underwent curative resection. The number of LNs dissected, LNR, and disease-free survival time, were analyzed. ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.21273
更新日期:2009-09-01 00:00:00
abstract:BACKGROUND:Since the majority of patients with early gastric cancer show long-term survival after surgery, a special attention must be directed to preserving gastric function in these patients. Little is known about the protocol of surgical treatment appropriate for early gastric cancer patients. This study was designe...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/(sici)1096-9098(199701)64:1<42::aid-jso9>3
更新日期:1997-01-01 00:00:00
abstract::Giant cell tumor of bone is a challenging surgical problem due to its mostly aggressive growth with tendency to recur locally, to develop in rare instances pulmonary metastases without histologic evidence of malignant changes, and due to its potential to dedifferentiate into a frankly malignant tumor in a limited numb...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930570408
更新日期:1994-12-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Tumor markers are a clinical tool frequently used in oncology in association with other clinical and radiologic information. For gastrointestinal cancer, carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA 19-9) tumor markers have found selected clinical application. The use of th...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.20107
更新日期:2004-09-15 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Lymph node involvement is common in thyroid cancer, but the system of staging does not consider the histological features of lymph node metastases. We conducted a meta-analysis to investigate the prognostic role of extranodal extension (ENE) in thyroid cancer patients. METHODS:We ran PubMed a...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,meta分析,评审
doi:10.1002/jso.24070
更新日期:2015-12-01 00:00:00
abstract::Ossifying skeletal muscle angiomas are relatively rare occurrences. The preoperative diagnosis is exceedingly difficult, although ossification may be reflected radiologically as a "Swiss cheese" appearance. Two patients are described whose skeletal muscle angiomas contained osseous tissue. The osseus tissue varied fro...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930250110
更新日期:1984-01-01 00:00:00
abstract::A study was conducted to assess the suppression of segmental pancreatic allograft rejection by cyclosporine (CSA) alone in baboons and dogs, and subtotal marrow irradiation (TL1) alone and TL 1 in combination with CSA in baboons. Total pancreatectomy in the dog and primate provided a reliable diabetic model, induced a...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930380217
更新日期:1988-06-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Tumor angiogenesis is receiving increased attention as a prognostic factor and also as a possible target for new anticancer agents. We investigated whether extent of vascular endothelial growth factor (VEGF) mRNA expression correlated with degree of neovascularization, and whether this express...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/(sici)1096-9098(199712)66:4<257::aid-jso7>
更新日期:1997-12-01 00:00:00
abstract::Serum copper levels (SCL) have been done in 106 patients of squamous cell carcinoma of the cervix and in 15 cases of local recurrences. The mean SCL has been significantly elevated in them in comparison to controls (P less than 0.001). The SCL falls to near normal range following successful therapy. There is a trend t...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930220313
更新日期:1983-03-01 00:00:00
abstract:INTRODUCTION:Alpha-fetoprotein (AFP) has a valuable role in postoperative surveillance for hepatocellular carcinoma (HCC) recurrence. The utility of pretreatment or baseline AFP remains controversial. The present study hypothesized that elevated baseline AFP levels are associated with worse overall survival in HCC pati...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.24742
更新日期:2017-12-01 00:00:00
abstract::Cancer patients undergoing surgery often present with unusual and challenging problems. Their age and the fact that they are often chronically ill place them at increased surgical risk. In many instances the need for surgical intervention is crucial to the extent that risk-assessment becomes an academic issue, especia...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.2930440312
更新日期:1990-07-01 00:00:00
abstract:INTRODUCTION:The ACS-NSQIP surgical risk calculator is an open-access on-line tool that estimates the risk of adverse post-operative outcomes for a wide range of surgical procedures. Wide surgical resection of soft tissue sarcoma (STS) often requires complex reconstructive procedures that can be associated with relativ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.24357
更新日期:2016-10-01 00:00:00
abstract::Reconstructive procedures following chest wall resection pose a special surgical challenge. With modern surgical technique, a wide range of reconstructive options are at the surgeon's disposal and, hence it is imperative that the appropriate procedure be selected in a given patient. A total of 64 patients underwent re...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930550311
更新日期:1994-03-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:There have been few reports on the objective assessment of quality of life (QOL) in patients with gastric cancer following palliative operations. The benefit of a palliative operation for survival and QOL of patients with gastric cancer is not clear. METHODS:Survival and hospital-free surviva...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/(sici)1096-9098(199809)69:1<41::aid-jso8>3
更新日期:1998-09-01 00:00:00
abstract::The clinical experience is reviewed in 597 Norwegian testicular cancer patients (age range: 15-45 years) treated from 1979 to 1986. During this period, computer tomography, determination of serum AFP/HCG, and cisplatin-based chemotherapy represented the modern diagnostic and therapeutic modalities. Before orchiectomy ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.2930390110
更新日期:1988-09-01 00:00:00
abstract::Three cases of metastatic cancer to inguinal lymph nodes from unknown primaries are presented. All three patients had exhaustive workups which produced no primary lesions. There were two cases of metastatic squamous cell carcinoma and one of melanoma. A review of the literature shows that it is unusual to have metasta...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930170107
更新日期:1981-01-01 00:00:00