Abstract:
INTRODUCTION:Alpha-fetoprotein (AFP) has a valuable role in postoperative surveillance for hepatocellular carcinoma (HCC) recurrence. The utility of pretreatment or baseline AFP remains controversial. The present study hypothesized that elevated baseline AFP levels are associated with worse overall survival in HCC patients. METHODS:Adult HCC patients were identified using the National Cancer Database (2004-2013). Patients were stratified according to baseline AFP measurements into the following groups: Negative (<20), Borderline (20-199), Elevated (200-1999), and Highly Elevated (>2000). The primary outcome was overall survival (OS), which was analyzed by log-rank test and graphed using Kaplan-Meier method. Multivariate regression modeling was used to determine hazard ratios (HR) for OS. RESULTS:Of 41 107 patients identified, 15 809 (33.6%) were Negative. Median overall survival was highest in the Negative group, followed by Borderline, Elevated, and Highly Elevated (28.7 vs 18.9 vs 8.8 vs 3.2 months; P < 0.001). On multivariate analysis, overall survival hazard ratios for the Borderline, Elevated, and Highly Elevated groups were 1.18 (P = 0.267), 1.94 (P < 0.001), and 1.77 (P = 0.007), respectively (reference Negative). CONCLUSION:Baseline AFP independently predicted overall survival in HCC patients regardless of treatment plan. A baseline AFP value is a simple and effective method to assist in expected survival for HCC patients.
journal_name
J Surg Oncoljournal_title
Journal of surgical oncologyauthors
Silva JP,Gorman RA,Berger NG,Tsai S,Christians KK,Clarke CN,Mogal H,Gamblin TCdoi
10.1002/jso.24742subject
Has Abstractpub_date
2017-12-01 00:00:00pages
831-840issue
7eissn
0022-4790issn
1096-9098journal_volume
116pub_type
杂志文章abstract:BACKGROUND:A tracheobronchial injury is an uncommon complication of an esophagectomy. Differences in outcomes may exist for patients with injuries detected intraoperatively and postoperatively. METHODS:A retrospective review was performed for patients who underwent an esophagectomy for cancer at Jackson Memorial Hospi...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.23577
更新日期:2014-06-01 00:00:00
abstract:OBJECTIVES:To develop and validate a nomogram to estimate the pretest probability of malignancy in Chinese patients with solid solitary pulmonary nodule (SPN). MATERIALS AND METHODS:A primary cohort of 1798 patients with pathologically confirmed solid SPNs after surgery was retrospectively studied at five institutions...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,多中心研究
doi:10.1002/jso.24704
更新日期:2017-11-01 00:00:00
abstract:BACKGROUND:Subtotal stomach preserving pancreaticoduodenectomy (SSPPD) is compared retrospectively with pylorus preserving pancreaticoduodenectomy (PPPD). METHODS:During 2002-2005, 21 patients (13 female, 8 male) underwent SSPPD. The mean age was 64.3 (range 33-80). PPPD was performed for 12 patients after 1999. Days ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.20608
更新日期:2007-02-01 00:00:00
abstract::A retrospective review is presented of 20 evaluable patients who underwent surgical resection or biopsy for limited stage thyroid carcinoma at two institutions between 1963 and 1983. The majority had external radiotherapy to the whole neck and upper mediastinum and the total dose given varied from 3,800 to 6,000 rads....
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930300205
更新日期:1985-10-01 00:00:00
abstract::We studied survival and prognostic factors in all cases of hepatocellular carcinoma seen at a Midwestern teaching hospital from 1947 through 1986. Of the 70 cases, 56 were diagnosed during life and 14 at autopsy. There were 47 males and 23 females with age at diagnosis ranging from 14 to 88. Median survival for the 56...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930450409
更新日期:1990-12-01 00:00:00
abstract::Of 134 patients with thymoma, 79 (59%) also had myasthenia gravis (MG). The thymoma with MG differed from that in the absence of MG in the following aspects: The ratio of lymphocytes to epithelial cells in the tumor was larger, the polygonal cell type was more prominent (i.e., in 83% of the MG patients this cell type ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930380305
更新日期:1988-07-01 00:00:00
abstract::Esophageal small cell carcinoma is a highly aggressive disease, and no effective treatment has yet been reported. We present here two cases of esophageal small cell carcinoma preoperatively treated with a combination of hyperthermia, irradiation, and an intravenous infusion of cis-diammine-dichloroplatinum (CDDP). The...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930590115
更新日期:1995-05-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:The psychosocial impact of local-regional thyroid cancer recurrence is not known. The aim of this study was to explore thyroid cancer patients' experiences relating to diagnosis and treatment of local-regional disease recurrence. METHODS:We conducted 15 semi-structured interviews with survivor...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.23345
更新日期:2013-07-01 00:00:00
abstract::Side-effects to levamisole given as adjuvant to surgery in a consecutive series of 203 neoplastic patients are reported: Thirty-four patients (16.7%) suffered gastric adverse reactions; 8 (3.9%) allergic; 6 (2.9%) intestinal; 6 (2.9% neurologic; 4 (1.9%) severe hyperthermia (more than 40.5 degrees C); 3 (1.4%) flu-lik...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930160310
更新日期:1981-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:ERCP prior to pancreaticoduodenectomy is unnecessary in select patients. When performed, it should be in conjunction with endoscopic ultrasound (EUS) to increase diagnostic sensitivity and allow for metal stent placement. The aim of this study was to determine differences in endoscopic practic...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.24191
更新日期:2016-05-01 00:00:00
abstract::Bile salts appear to be important promoters of colon carcinogenesis. This study was designed to assess the importance of the fecal stream in cholic acid-induced colon tumor promotion. Male Sprague-Dawley rats underwent transverse colostomy after induction with dimethylhydrazine (DMH) and the excluded distal colon was ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930360408
更新日期:1987-12-01 00:00:00
abstract::A case of symptomatic granular cell tumor of the esophagus is described. Another 32 cases collected from the English literature are analyzed. The reported cases have occurred mostly in women of less than 50 years of age presenting with dysphagia. Excision of the lesion is curative. ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930330409
更新日期:1986-12-01 00:00:00
abstract::Intraoperative radiation therapy (IORT) was delivered to remnant rat liver after partial hepatectomy to determine the chronic effects of treatment on survival, blood chemistry, liver weight, and histology. Survival at one year was 100%. Remnant liver weight was markedly increased in all animals. Liver function appeare...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930500205
更新日期:1992-06-01 00:00:00
abstract::The records of 130 patients with soft tissue and bone sarcomas were retrospectively analyzed to identify the subgroups of patients that would benefit from tomographic studies for pulmonary metastasis. Sixty-six of 96 patients with a normal conventional chest roentgenogram (CXR) had tomography to diagnose pulmonary met...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930380414
更新日期:1988-08-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Stages II and III rectal tumors are known as locally advanced rectal cancer (LARC) because they are characterized by a high incidence of local and distant relapses and a low probability of long-term survival. Adjuvant treatments have been advocated to ameliorate overall survival (OS), local re...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/1096-9098(200005)74:1<2::aid-jso2>3.0.co;2
更新日期:2000-05-01 00:00:00
abstract::Non-GIST soft tissue sarcomas are a heterogeneous grouping of mesenchymal tumors that comprise less than 1% of adult malignancies. Treatment continues to be based on cytotoxic chemotherapy regimens. However, characterization of the molecular pathway deregulations that drive these tumors has led to the emergence of mor...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.23802
更新日期:2015-04-01 00:00:00
abstract::A malignant tumor of the submandibular gland was found to consist predominately of spindle cell elements that initially suggested a primary sarcoma. Further examination revealed that the spindled malignant cells were derived from a high-grade mucoepidermoid carcinoma. ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930310116
更新日期:1986-01-01 00:00:00
abstract:BACKGROUND:Interleukin-6 (IL-6) is closely associated with tumor progression. Whether it can predict postoperative prognosis of patients with T2 gallbladder cancer (GBC) remains controversial. METHODS:We retrospectively collected the medical records of 125 patients with T2 GBC. Then, we analyzed the association betwee...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.25085
更新日期:2018-06-01 00:00:00
abstract:BACKGROUND:Angiosarcoma is an aggressive vascular neoplasm with a high propensity for local recurrence. Electrochemotherapy is an emerging skin-directed therapy, exerting prominent cytotoxic activity, and antivascular effects. Its efficacy in angiosarcoma has not been investigated. METHODS:This multicenter retrospecti...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.24287
更新日期:2016-08-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Tumor markers are a clinical tool frequently used in oncology in association with other clinical and radiologic information. For gastrointestinal cancer, carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA 19-9) tumor markers have found selected clinical application. The use of th...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.20107
更新日期:2004-09-15 00:00:00
abstract:BACKGROUND AND OBJECTIVES:To clarify optimal treatment guidelines for residual or local recurrence after endoscopic resection (ER). METHODS:Eighty-six patients underwent gastrectomy due to incomplete ER and local recurrence after ER. The pathological findings of ER and gastrectomy specimens were analyzed. RESULTS:The...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1002/jso.21074
更新日期:2008-07-01 00:00:00
abstract:BACKGROUND:Esophageal cancer is increasingly recognized in younger patients. We compared clinicopathological characteristics, treatment, and survival of patients aged ≤50 years with patients aged >50 years diagnosed with esophageal cancer in the Netherlands. METHODS:From the nationwide Netherlands Cancer Registry we i...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.23533
更新日期:2014-05-01 00:00:00
abstract::Supernatant fluids from three human cultured cell lines, K562, NALM-1, and Daudi, all isolated from patients with lymphoreticular malignancies, were tested for suppressive activity toward normal lymphocytes in vitro. It was found that the K562 line elaborated material which effectively suppressed the response of norma...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930230106
更新日期:1983-05-01 00:00:00
abstract::Breakdown of membrane phospholipids is a causative event leading to irreversible cell injury after ischemia and reperfusion insults, which might be one mechanism leading to liver tumor cell death after repeated arterial ischemia as well. After 2 hr of hepatic dearterialization followed by 30 min of reperfusion tumor p...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/(SICI)1096-9098(199604)61:4<284::AID-JSO11
更新日期:1996-04-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:This study aimed to evaluate treatment outcomes of acral melanoma (AM) based on the excision margin. METHODS:A retrospective cohort study was conducted for patients with primary AM, analyzing recurrence rates, local and in-transit recurrence-free survival (LITRFS), disease-free survival (DFS)...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.24442
更新日期:2016-12-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Accurately assessing breast volume (BV) relative to the volume of breast tissue to be removed could help objectively determine the optimal surgical candidates for breast conserving surgery. The objective of this study was to determine the optimal mammography-based method of BV estimation. MET...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.25076
更新日期:2018-06-01 00:00:00
abstract::A 65-year-old man presented with supraclavicular, mediastinal, and retroperitoneal lymphadenopathy clinically thought to be due to malignant lymphoma. Biopsy of a supraclavicular lymph node revealed metastatic adenocarcinoma positive for prostatic-specific antigen. This site of the primary tumor was confirmed by needl...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930350210
更新日期:1987-06-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Pemetrexed is an appealing agent to use for cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (HIPEC). However, the optimal method of pemetrexed delivery still remains undefined. Using a murine model, we compared the use of open and closed abdomen techniques on the absorptio...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.24960
更新日期:2018-05-01 00:00:00
abstract:INTRODUCTION:Breast conservative surgery (BCS) and sentinel lymph node biopsy (SLNB) after neoadjuvant treatment (NAT) is safe and effective for selected patients. This aim of this study is to evaluate the impact of anatomic site of response on outcomes and to assess the real population who may benefit from nonsurgical...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.26236
更新日期:2021-01-01 00:00:00
abstract::Maximum diameter, tumour volume, and inflammatory response of host tissue in 282 surgical specimens with primary carcinoma of the bronchus were measured. Cell type, pT- and pN-stage, maximum diameter and volume of the primaries, and inflammatory response of host tissue were analyzed in respect to survival of the patie...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930360203
更新日期:1987-10-01 00:00:00