Abstract:
BACKGROUND AND OBJECTIVES:This study aimed to evaluate treatment outcomes of acral melanoma (AM) based on the excision margin. METHODS:A retrospective cohort study was conducted for patients with primary AM, analyzing recurrence rates, local and in-transit recurrence-free survival (LITRFS), disease-free survival (DFS), and melanoma-specific survival (MSS). RESULTS:Data from 129 patients of AM were analyzed. In 53 patients with thin AM (thickness ≤1 mm), neither recurrence nor mortality occurred regardless of whether the excision margin was >1 cm or not. Seventy-six patients had thick AM (thickness >1 mm), including 36 treated with a <2 cm excision margin and 40 with a 2 cm margin. Multivariate analyses revealed that a 2 cm margin was associated with a reduced rate of local recurrence (HR, 0.120; P-value = 0.023) and LITR (HR, 0.187; P-value = 0.013) compared with a <2 cm margin. DFS and MSS did not differ between the two groups. CONCLUSIONS:Thin AM were successfully treated with a 1 cm excision margin. For thick AM, a 2 cm excision margin provided improved local control, compared with a <2 cm margin; however, this benefit did not translate into a survival gain. J. Surg. Oncol. 2016;114:933-939. © 2016 Wiley Periodicals, Inc.
journal_name
J Surg Oncoljournal_title
Journal of surgical oncologyauthors
Lee KT,Kim EJ,Lee DY,Kim JH,Jang KT,Mun GHdoi
10.1002/jso.24442subject
Has Abstractpub_date
2016-12-01 00:00:00pages
933-939issue
8eissn
0022-4790issn
1096-9098journal_volume
114pub_type
杂志文章abstract:BACKGROUND AND OBJECTIVES:Stage III malignant melanoma is a heterogeneous disease where those cases deemed marginally resectable or irresecatble are frequently incurable by surgery alone. Targeted therapy takes advantage of the high incidence of BRAF mutations in melanomas, most notably the V600E mutation. These agents...
journal_title:Journal of surgical oncology
pub_type: 临床试验,杂志文章
doi:10.1002/jso.24744
更新日期:2017-12-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:D2-40 staining has been reported to be useful for both identifying lymphatic vessel invasion (LVI) and counting lymphatic vessel density (LVD) in various cancers. The aim of this study was to clarify the prognostic significance of D2-40 staining in patients with esophageal squamous cell carcin...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.22079
更新日期:2012-03-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Due to their rare incidence soft tissue sarcomas (STS) are often resected without clear margins. The aim of this study was to investigate the impact of re-excision of STS on survival. METHODS:Out of 752 patients with STS (406 men and 346 women, average age 51 years), 310 patients were referre...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.21639
更新日期:2010-11-01 00:00:00
abstract:BACKGROUND:Positron emission tomography/computed tomography (PET/CT) scanning is commonly used for the preoperative staging of patients with at least intermediate thickness (>1 mm) melanomas. Its role in staging at initial diagnosis for clinically asymptomatic patients is not yet established. METHODS:We examined recor...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.23549
更新日期:2014-06-01 00:00:00
abstract:OBJECTIVES:To investigate predictors of occult nipple-areolar complex (NAC) involvement in patients with carcinoma in situ (CIS) and to validate an online probability calculator (CancerMath; www.lifemath.net/cancer/breastcancer/nipplecalc/index.php). METHODS:Mastectomized patients with CIS (n = 104) were retrospective...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.24768
更新日期:2017-12-01 00:00:00
abstract:BACKGROUND:Immunoreactivity for p53 tumor suppressor gene product is commonly found in human malignancies and some premalignant lesions, but its role in cancer development and its value as a marker of tumor biologic behavior is still unclear. OBJECTIVES:This study was undertaken to assess p53 immunoexpression in esoph...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/(sici)1096-9098(199705)65:1<3::aid-jso2>3.
更新日期:1997-05-01 00:00:00
abstract:BACKGROUND:Skip metastasis to mediastinal lymph nodes is a well-known phenomenon in non-small cell lung cancer (NSCLC). Little is reported in the literature about its clinical importance. It is still under discussion whether any prognostic differences exist between resected NSCLC with either skip metastases or continuo...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.10219
更新日期:2003-04-01 00:00:00
abstract::Patients with primary squamous cell epitheliomas of the oral cavity, pharynx, and larynx were stratified according to stage and site and randomized to receive either intratumoral immunotherapy with Corynebacterium parvum followed 2 weeks later by surgery and postoperative C parvum for 2 years or surgery alone. There w...
journal_title:Journal of surgical oncology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/jso.2930280215
更新日期:1985-02-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Desmoplastic melanoma (DM) is a rare variant of cutaneous melanoma. Our goal was to study the surgical management of DM, identify prognostic factors, and impact of treatment options. METHODS:Patients with DM (n = 1,735) were identified from the Surveillance, Epidemiology, and End Results data...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.21778
更新日期:2011-02-01 00:00:00
abstract::Development of a carcinoma in the pancreas of a young man who had five years previously undergone intensive radiotherapy and subsequent chemotherapy for treatment of a lymphoma suggests that induction of the second neoplasm occurred as the result of the therapy of the first. While definite proof of causality is lackin...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930080603
更新日期:1976-01-01 00:00:00
abstract::Correlations between levels of tissue polypeptide antigen (TPA) in serum and histologic stage or progression of cancer were studied in 94 patients with gastric cancer. Levels of TPA in serum from patients with cancerous invasion into the vein of the stomach wall (v-invasion) were elevated in parallel to the progressio...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930410214
更新日期:1989-06-01 00:00:00
abstract:BACKGROUND:Use of hospice services among patients with pancreatic cancer following pancreatic resection remains unknown. METHODS:Patients with pancreatic cancer who underwent resection were identified in the Medicare Standard Analytic Files. Outcomes included overall hospice use, early hospice enrollment (≥4 weeks bef...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.25623
更新日期:2019-09-01 00:00:00
abstract:BACKGROUND:Signet ring cell cancer (SRCC) patients have a poor oncologic outcome. The aim of this study was to determine whether the potential drawbacks of hyperthermic intraperitoneal chemotherapy (HIPEC) outweigh the benefits in patients with peritoneally metastasized SRCC. METHODS:Patients with peritoneal carcinoma...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,多中心研究
doi:10.1002/jso.23784
更新日期:2015-02-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Large scale data on the treatment of pathologic proximal femur fractures (PPFFs) are lacking. The purpose of this study was to evaluate trends in patient demographics, complication rates, and relative utilization rates of various techniques associated with PPFFs. METHODS:The American College ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,多中心研究
doi:10.1002/jso.25669
更新日期:2019-11-01 00:00:00
abstract::Mice with intravesical urothelial tumors (MBT-2) were challenged with E coli inoculated intravesically. Adherence of bacteria measured at 15 min or persistent infection at 24 h was significantly greater in the tumor-bearing bladders than in normal non-tumor-bearing mice. The tumor-bearing portion of the bladder contai...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930230405
更新日期:1983-08-01 00:00:00
abstract::A massive lymphatic leak developed following radical retroperitoneal lymph node dissection for recurrent extragonadal seminoma. Chylous ascites persisted for over 3 months, with an average daily external drainage of 1.5 liters, and was successfully treated with a peritoneovenous shunt. ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930360315
更新日期:1987-11-01 00:00:00
abstract:BACKGROUND:At present, the majority of outcome studies of survival of hepatocellular carcinoma (HCC) post-liver resection (post-LR) present actuarial survival data, which often results in overestimation of survival. We sought to evaluate the actual 10-year survival post-LR for HCC and identify variables that are associ...
journal_title:Journal of surgical oncology
pub_type: 临床试验,杂志文章
doi:10.1002/jso.26259
更新日期:2021-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:This study aims to investigate the surgical outcomes observed in robotic transperitoneal aortic lymphadenectomy (AL) in gynecological cancer patients. METHODS:Retrospective data were collected and analyzed on 71 patients undergoing robotic surgical procedures for gynecological cancers, includi...
journal_title:Journal of surgical oncology
pub_type: 临床试验,杂志文章
doi:10.1002/jso.25335
更新日期:2019-03-01 00:00:00
abstract::Eighty-nine breast cancer patients were studied for the end result of therapy. During surgery, the anaesthesia administered was either halothane (61 cases) or ether (28 cases) mixture with nitrogen and oxygen. The holstead method for mastectomy was used for all cases. The results showed that the type of anaesthesia in...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930110312
更新日期:1979-01-01 00:00:00
abstract:BACKGROUND:Amongst various options of vascularized lymph node transfers, the submental flap has the lowest risk for iatrogenic lymphedema. The aim of this study was to gain insight into distribution, number, and size of lymph nodes along the mandible using computed tomography angiography (CTA). METHODS:A total of 52 C...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.26117
更新日期:2020-07-15 00:00:00
abstract:PURPOSE:Imatinib mesylate (IM) demonstrates substantial efficacy in most patients with metastatic gastrointestinal stromal tumors (GISTs). However, progression of GIST eventually develops and emerges as a challenge. To assess the role of surgery in the multidisciplinary management of GISTs, we studied the surgical outc...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.21630
更新日期:2010-11-01 00:00:00
abstract::Cryotechnology is currently used for both treatment and diagnosis of breast disease. Due to the natural analgesic effect of cold, cryoablation is potentially more patient-friendly than other technologies which raise tissue temperature. Freezing produces a predictable volume of necrosis and is easily observed and contr...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.20201
更新日期:2005-04-01 00:00:00
abstract:INTRODUCTION:Patients with Stage IV melanoma have limited therapeutic options with few long-term survivors. Our goal was to study the impact of metastasectomy on survival in these patients. METHODS:Patients with Stage IV melanoma were identified from the Surveillance, Epidemiology, and End Results (SEER) database (198...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.21903
更新日期:2011-08-01 00:00:00
abstract::Intraperitoneal (IP) cisplatin administered at the time of intraabdominal malignancies such as gastric cancer may prevent or delay intraabdominal recurrence. Perioperative IP cisplatin raises concerns regarding systemic toxicity and retardation of wound healing. Systemic cisplatin toxicity may be reduced by administer...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930520415
更新日期:1993-04-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Only a few surgeons with much experience of laparoscopic surgery perform laparoscopy-assisted total gastrectomy (LATG), because of its technical difficulty and concern about subsequent complications. The aim of this study was to evaluate the technical feasibility and safety of LATG as compared ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.21345
更新日期:2009-10-01 00:00:00
abstract:BACKGROUND:Rapid genetic counseling and testing (RGCT) in newly diagnosed high-risk breast cancer (BC) patients may influence surgical treatment decisions. To successfully integrate RGCT in practice, knowledge of professionals', and patients' attitudes toward RGCT is essential. METHODS:Between 2008 and 2010, we perfor...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.24763
更新日期:2017-12-01 00:00:00
abstract::Diffuse malignant peritoneal mesothelioma (DMPM) has been traditionally regarded as a rapidly lethal disease. Recently, several independent prospective trials have reported improved survival with an intensive loco-regional treatment strategy including cytoreductive surgery (CRS) along with peri-operative intra-periton...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.21055
更新日期:2008-09-15 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Resection of primary retroperitoneal sarcomas (RPS) has a high incidence of recurrence. This study aims to identify patterns of recurrence and its impact on overall survival. METHODS:Adult patients with primary retroperitoneal soft tissue sarcomas who underwent resection in 2000-2016 at eight...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,多中心研究
doi:10.1002/jso.25606
更新日期:2019-09-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:ERCP prior to pancreaticoduodenectomy is unnecessary in select patients. When performed, it should be in conjunction with endoscopic ultrasound (EUS) to increase diagnostic sensitivity and allow for metal stent placement. The aim of this study was to determine differences in endoscopic practic...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.24191
更新日期:2016-05-01 00:00:00
abstract::A case of bilateral seminoma of the testis is presented that occurred after a lag period of six years following right orchiectomy, even with correct cobalt therapy. The question of early detection of seminoma in the other testis is posed. A common consensus for repeat biopsies to detect new tumor growth should be dete...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930240204
更新日期:1983-10-01 00:00:00