Abstract:
BACKGROUND:Skip metastasis to mediastinal lymph nodes is a well-known phenomenon in non-small cell lung cancer (NSCLC). Little is reported in the literature about its clinical importance. It is still under discussion whether any prognostic differences exist between resected NSCLC with either skip metastases or continuous mediastinal lymph node metastases (N2). PATIENTS AND METHODS:We analyzed retrospectively the data of 45 patients with a pN2-stage, who underwent resection for NSCLC. Seventeen of these patients (37.8%), showing no metastatic involvement of hilar (N1) lymph nodes, were compared to the remaining 28 patients with infiltration of hilar nodes (N1) as well as N2 nodes. RESULTS:Multivariate analysis showed no statistically significant difference between the skip metastasis and the continuous N2 group regarding sex, age, histology, T- or M-status. The frequency of skip metastasis was higher in patients with a primary tumor in the upper lobe (n = 12, 71%) compared to the lower lobe (n = 5, 29%). This difference was not statistically significant. In patients with a non-continuous lymph node spread, 29 out of 119 resected mediastinal lymph nodes were infiltrated (1.7 per patient, range: 1-10). Compared to 83 metastatic involved lymph nodes out of 198 resected mediastinal nodes (three per patient, range: 1-10) in patients with involvement of N1 and N2 nodes (P = 0.034, Mann-Whitney test). The 5-year survival rate of pN2 patients with skip metastasis was 41% compared to 14% in patients with involvement of N1 and N2 nodes (P = 0.019). CONCLUSIONS:pN2 patients with mediastinal lymph node skip metastasis have a more favorable prognosis compared to pN2 patients with continuous infiltration of the regional lymph nodes. Patients with a continuous lymph node involvement show an increased number of infiltrated mediastinal lymph nodes per patient compared to patients with a non-continuous spread. Skip metastasis is an independent prognostic factor of survival. The presence of skip metastasis seems to be a unique subgroup of pN2 disease in NSCLC.
journal_name
J Surg Oncoljournal_title
Journal of surgical oncologyauthors
Prenzel KL,Mönig SP,Sinning JM,Baldus SE,Gutschow CA,Grass G,Schneider PM,Hölscher AHdoi
10.1002/jso.10219subject
Has Abstractpub_date
2003-04-01 00:00:00pages
256-60issue
4eissn
0022-4790issn
1096-9098journal_volume
82pub_type
杂志文章abstract::We have operated upon six patients with cervical esophageal carcinoma and reconstructed these with free jejunal graft. The pathology of all six patients was squamous cell carcinoma, and no patient had apparent distant metastasis. The procedure was a two team approach. While the surgical oncology team resected the esop...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930420307
更新日期:1989-11-01 00:00:00
abstract::We studied the effect of tumor size on monoclonal antibody (mAb) in a murine hepatic model. Intrasplenic injection of HT-29 LMM metastatic human colon cancer cell line reproducibility results in hepatic metastases formation in congenitally athymic mice. HT-29-15, a murine mAb of the IgG1 class reactive with the HT-29 ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930490409
更新日期:1992-04-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Brain metastasis is a rare but dismal event in sarcomas. However, the pattern of occurrence and the prognostic factors associated with post-brain metastasis survival (PBMS) are not yet well-characterized. METHODS:Sarcoma patients treated at one institute within 10-year period were retrospectiv...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.22011
更新日期:2011-12-01 00:00:00
abstract::We studied survival and prognostic factors in all cases of hepatocellular carcinoma seen at a Midwestern teaching hospital from 1947 through 1986. Of the 70 cases, 56 were diagnosed during life and 14 at autopsy. There were 47 males and 23 females with age at diagnosis ranging from 14 to 88. Median survival for the 56...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930450409
更新日期:1990-12-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Two staged tissue expander-implant with acellular dermal matrix (TE/I + ADM) and deep inferior epigastric perforator (DIEP) flap are the most common implant and autologous methods of reconstruction in the U.S. Implant-based techniques are disproportionally more popular, partially due to its pr...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.24692
更新日期:2017-09-01 00:00:00
abstract::Fifty-four patients with advanced upper gastrointestinal cancer were assessed for their nutritional status prior to any form of therapy. Anthropometric parameters--weight loss, arm muscle circumference, skin-fold thickness--and biochemical parameters--serum albumin and delayed cutaneous hypersensitivity reactions to p...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930290417
更新日期:1985-08-01 00:00:00
abstract::About one third of leiomyosarcomas of the gastrointestinal tract do develop metastasis; and nearly 90% of the metastasis are intra-abdominal. It is said that leiomyosarcoma rarely involves regional nodes, although two series reported 8% of leiomyosarcomas of the stomach and 7% of the small intestines had nodal metasta...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930150403
更新日期:1980-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Stage II colon cancer is primarily a surgical disease. Only a still not well-defined subset of patients may benefit from postoperative adjuvant chemotherapy. The relationship between adjuvant chemotherapy and survival after relapse is furthermore still not definitely explored in this group of ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.25798
更新日期:2019-12-11 00:00:00
abstract:BACKGROUND:The benefit derived from lymph node dissection (LND) in patients with pancreatic neuroendocrine tumors (pNETs) based on clinicopathological characteristics remains unclear. METHODS:Patients undergoing surgery for pNET between 1997 and 2016 were identified using a multi-institutional dataset. The therapeutic...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,多中心研究
doi:10.1002/jso.25689
更新日期:2019-12-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Remifentanil infusion is used as an intraoperative anesthetic for thyroidectomy, but has been associated with acute opioid tolerance and hyperalgesia. A national shortage of remifentanil provided an opportunity to study postoperative pain in patients undergoing thyroidectomy. METHODS:Retrospe...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.25746
更新日期:2019-12-01 00:00:00
abstract::The latissimus dorsi (LD) muscle has been previously described to repair diaphragmatic defects, but as a "reverse" flap, relying on secondary blood supply from the perforating lumbar vessels rather than primary inflow from the dominant thoracodorsal artery. We report resection of a retroperitoneal synovial sarcoma, wi...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.20317
更新日期:2006-09-01 00:00:00
abstract::The aim of the present study was to demonstrate the practicality of intraoperative fine needle aspiration (FNA) cytology of pancreatic lesions in 43 patients. The indication for performing this procedure was to determine the nature of pancreatic masses. Conclusive cytologic diagnoses were reached in 41 patients who re...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930460407
更新日期:1991-04-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Only a few surgeons with much experience of laparoscopic surgery perform laparoscopy-assisted total gastrectomy (LATG), because of its technical difficulty and concern about subsequent complications. The aim of this study was to evaluate the technical feasibility and safety of LATG as compared ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.21345
更新日期:2009-10-01 00:00:00
abstract:INTRODUCTION:Breast conservative surgery (BCS) and sentinel lymph node biopsy (SLNB) after neoadjuvant treatment (NAT) is safe and effective for selected patients. This aim of this study is to evaluate the impact of anatomic site of response on outcomes and to assess the real population who may benefit from nonsurgical...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.26236
更新日期:2021-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Accurately assessing breast volume (BV) relative to the volume of breast tissue to be removed could help objectively determine the optimal surgical candidates for breast conserving surgery. The objective of this study was to determine the optimal mammography-based method of BV estimation. MET...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.25076
更新日期:2018-06-01 00:00:00
abstract::Giant cell tumor of bone is a challenging surgical problem due to its mostly aggressive growth with tendency to recur locally, to develop in rare instances pulmonary metastases without histologic evidence of malignant changes, and due to its potential to dedifferentiate into a frankly malignant tumor in a limited numb...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930570408
更新日期:1994-12-01 00:00:00
abstract::A case of extramammary Paget's disease is reported. The distinguishing features of the case are: (1) localization of the primary lesion to the scrotum, (2) development of metastases in the absence of a recognizable underlying carcinoma, and (3) response of the systemic disease to a combination of radiation therapy and...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930380111
更新日期:1988-05-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:The therapeutic role of systematic lymph node dissection (LND) remains unclear in advanced epithelial ovarian cancer (EOC), especially during interval debulking surgery (IDS) performed after neoadjuvant chemotherapy (NAC). We analyzed the therapeutic and prognostic roles of systematic LND in ad...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.24669
更新日期:2017-09-01 00:00:00
abstract:BACKGROUND:We sought to define the management of mixed hepatocellular carcinoma-intrahepatic cholangiocarcinoma (HCC-ICC) as well as characterize short- and long-term outcomes of patients with mixed HCC-ICC. METHODS:Patients diagnosed with HCC-ICC, HCC, or ICC between 2004 and 2015 were identified from the National Ca...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.25331
更新日期:2019-03-01 00:00:00
abstract::Six patients with advanced local-regional breast cancer were reviewed. Five out of the six patients previously had had radiation therapy as part of the initial therapy. All patients had preoperative cycles of combination chemotherapy, either CMF or CAF. The two stage III patients had greater than 75% reduction in meas...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930220415
更新日期:1983-04-01 00:00:00
abstract:BACKGROUND:The purpose of this study was to determine whether LAPTM4B over-expression is associated with the prognosis and chemotherapy resistance in patients with stages III and IV epithelial ovarian carcinoma, i.e., patients with peritoneal metastasis or lymph node metastasis of epithelial ovarian carcinoma. METHODS...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.21912
更新日期:2011-07-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:The aim of this study was to investigate the potential role of indocyanine green (ICG) fluorescence imaging after intraoperative intravenous (IV) injection for the "ex vivo" detection of metastatic lymph nodes (mLNs) of colorectal cancer origin. METHODS:Fresh-fixed LNs in cassettes and/or par...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.24318
更新日期:2016-09-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:The number of patients diagnosed with head and neck squamous cell carcinoma (HNSCC) at an advanced age has increased. The aim of this study is to evaluate the age at which disease-specific survival (DSS) significantly decreases in HNSCC. METHODS:We performed a retrospective study of 5469 pati...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.25895
更新日期:2020-06-01 00:00:00
abstract:BACKGROUND:This retrospective study was conducted to compare the treatment and quality of life (QOL) results between radical surgery and definitive chemoradiotherapy (CRT) for stage II-III carcinoma of the esophagus. METHODS:Between 2000 and 2009, 128 consecutive patients were selected for this study in which 72 were ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.21361
更新日期:2009-11-01 00:00:00
abstract:BACKGROUND:Cytoreductive surgery (CRS) and hyperthermic intra-peritoneal chemotherapy (HIPEC) treatment of colorectal peritoneal metastases (PM) is an established treatment alternative. The study aim was, first, to investigate the outcome of high-volume disease defined by the peritoneal cancer index (PCI) 20; second, t...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.23610
更新日期:2014-08-01 00:00:00
abstract::Two hundred fifty-one patients with colorectal carcinoma were studied following complete primary resection to determine patterns of failure. Seventy-two patients (29%) subsequently developed failures: Local failure (LF) occurred as the only failure in 49% of the failure group and as some component in 81%; distant meta...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930220118
更新日期:1983-01-01 00:00:00
abstract:PURPOSE:The epidemiology and clinicopathology of aneurysmal bone cysts (ABCs) secondary to giant cell tumors of bone (GCTBs) have been well documented in the previous literature. However, reports on whether secondary ABCs could affect the postoperative recurrence of GCTBs are rare. This study analyzed the effects of se...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.25588
更新日期:2019-09-01 00:00:00
abstract::Lymph node involvement in colorectal cancer, one of the most important prognostic factors, can be sometimes underestimated. In this study the authors report the results of two different techniques of specimen preparation and examination. In 240 patients (Group I), histologic examination was performed using a conventio...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930510305
更新日期:1992-11-01 00:00:00
abstract:BACKGROUND:The most effective treatment for patients with esophageal small cell carcinoma has not yet been established because of the overall extremely poor prognosis regardless of the mode of treatment. The role of esophagectomy has been controversial in the management of patients with this disease. METHODS:The clini...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/(sici)1096-9098(199702)64:2<130::aid-jso8>
更新日期:1997-02-01 00:00:00
abstract::The use of preoperative imaging has become routine for many reconstructive microsurgeons to help localize perforators for planning of microvascular free flaps. However, with advancements in imaging technology, perforator mapping represents only one potential benefit as virtual planning and medical modeling, and flap t...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.25194
更新日期:2018-10-01 00:00:00