Does age influence disease-specific survival in patients with squamous cell carcinomas of the head and neck?

Abstract:

BACKGROUND AND OBJECTIVES:The number of patients diagnosed with head and neck squamous cell carcinoma (HNSCC) at an advanced age has increased. The aim of this study is to evaluate the age at which disease-specific survival (DSS) significantly decreases in HNSCC. METHODS:We performed a retrospective study of 5469 patients with HNSCC treated at our center (1985-2016). External validation with 2082 oral squamous cell carcinomas from a collaborative institution from another continent was performed. RESULTS:We observed an orderly decrease in overall survival as age at diagnosis increased. There were no differences in DSS based on age for patients <80 years old (P = .623), while older patients had a significant decrease in DSS. These results were validated in the independent dataset. In a multivariable analysis performed in the test set, compared to patients <80 years old, patients between 80 to 85 had a 1.50 times higher risk of disease-specific death (95% confidence interval [CI]: 1.19-1.89; P = .001), and patients >85 had a 2.19 times higher risk (95% CI: 1.68-2.87; P < .001). CONCLUSIONS:DSS started to significantly decrease in HNSCC at 80 years old. These findings, validated in an independent cohort, indicate that chronological age on its own should not withhold curative treatment in the majority of patients with HNSCC.

journal_name

J Surg Oncol

authors

Lop J,Valero C,García J,Quer M,Ganly I,Shah JP,Patel SG,León X

doi

10.1002/jso.25895

subject

Has Abstract

pub_date

2020-06-01 00:00:00

pages

1058-1066

issue

7

eissn

0022-4790

issn

1096-9098

journal_volume

121

pub_type

杂志文章
  • Secondary angiosarcoma: A fatal complication of chronic lymphedema.

    abstract::Secondary Angiosarcoma (Stewart-Treves Syndrome) is a rare malignant cutaneous lesion, which arises in chronic lymphedema of the extremity, often observed after breast cancer treatment. We reviewed the history and the oncological outcome of two patients with this disease. Multimodal therapy including hyperthermic isol...

    journal_title:Journal of surgical oncology

    pub_type:

    doi:10.1002/jso.25598

    authors: Farzaliyev F,Hamacher R,Steinau Professor HU,Bertram S,Podleska LE

    更新日期:2020-01-01 00:00:00

  • Cervical lymph node metastasis in patients with submucosal carcinoma of the thoracic esophagus.

    abstract:BACKGROUND AND OBJECTIVES:The effect of esophagectomy with three-field lymph node dissection for submucosal carcinoma of the thoracic esophagus remains controversial. The aim of this study was to evaluate the effect of esophagectomy with three-field lymph node dissection for submucosal carcinoma of the thoracic esophag...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/1096-9098(200009)75:1<37::aid-jso7>3.0.co;

    authors: Igaki H,Kato H,Tachimori Y,Nakanishi Y

    更新日期:2000-09-01 00:00:00

  • Predictors of postoperative morbidity after laparoscopic versus open radical hysterectomy plus external beam radiotherapy: a propensity-matched comparison.

    abstract:BACKGROUND:Identification of peri-operative variables predicting postoperative morbidity may improve postoperative patients' care. We aimed to identify patients' characteristics and operative factors predictive of early (≤ 30-day) and late (≤ 6-month) morbidity in cervical cancer patients undergoing surgery plus extern...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.23747

    authors: Bogani G,Cromi A,Serati M,Di Naro E,Uccella S,Donadello N,Ghezzi F

    更新日期:2014-12-01 00:00:00

  • Brachytherapy in lung cancer.

    abstract::Brachytherapy, the direct application of a radioactive isotope into the tumor bed, delivers a high dose to the tumor as compared to the surrounding normal tissue. Interstitial brachytherapy, the placement of the isotope into a tumor bed where no lumen exists, has been described but is utilized infrequently in clinical...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章,评审

    doi:10.1002/(sici)1096-9098(199801)67:1<60::aid-jso13>

    authors: Gaspar LE

    更新日期:1998-01-01 00:00:00

  • Enhancement of metastasis development by BCG immunotherapy.

    abstract::When BALB/c mice bearing growing transplants of a syngeneic colon carcinoma--Colon Tumor 26 (CT 26)--were treated with Bacillus Calmette-Guerin (BCG), no effect on tumor growth rate or survival time was observed compared to untreated controls. However, after excision of primary tumor transplants, enhanced development ...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930150307

    authors: Colmerauer ME,Koziol JA,Pilch YH

    更新日期:1980-01-01 00:00:00

  • Prognostic significance of mRNA-encoding estrogen receptor and epithelial growth factor receptor in breast carcinoma progression into lymph nodes: 1. Estrogen receptor encoding mRNA.

    abstract::The main objective of this study was to differentiate between lymph nodes infiltrated by estrogen receptor-positive (ER+) and estrogen receptor-negative (ER-) breast carcinoma. Lymph nodes were obtained from 40 postmenopausal cancer patients, 10 from each disease stage. Six patients from each group had estrogen recept...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930400107

    authors: Hakim AA

    更新日期:1989-01-01 00:00:00

  • Patterns of failure following surgery alone for colorectal carcinoma.

    abstract::Two hundred fifty-one patients with colorectal carcinoma were studied following complete primary resection to determine patterns of failure. Seventy-two patients (29%) subsequently developed failures: Local failure (LF) occurred as the only failure in 49% of the failure group and as some component in 81%; distant meta...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930220118

    authors: Chung CK,Stryker JA,Demuth WE Jr

    更新日期:1983-01-01 00:00:00

  • Surgical management of ovarian carcinoma metastatic to the breast and axilla: A role for metastasectomy?

    abstract::As patients with ovarian cancer are living longer, surgeons will be faced with the management of metastatic lesions amenable to resection more frequently. We present two patients with ovarian cancer metastatic to the breast who underwent resection for their metastases, but their outcomes differed significantly. After ...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.24055

    authors: Rossfeld KK,Carson WE 3rd

    更新日期:2015-11-01 00:00:00

  • The role and value of surgery in metastatic renal adenocarcinoma: a retrospective clinical study of 106 nephrectomized cases.

    abstract::The results of treatment of 106 consecutive nephrectomized cases with metastatic renal adenocarcinoma were analyzed. Over 50% of the patients were dead at 1 year and more than 80% at 2 years from the first metastases. The corresponding 5-year survival rate was 7.3%. Fourteen patients demonstrated a response to radioth...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930260213

    authors: Appelqvist P

    更新日期:1984-06-01 00:00:00

  • Prognosis of T4 gastric carcinoma patients: an appraisal of aggressive surgical treatment.

    abstract:BACKGROUND AND OBJECTIVES:Despite precipitous drop in the incidence of gastric carcinoma in Japan, it is still one of the leading causes of death associated with malignant disease. Once the contiguous organs are involved the prognosis becomes dismal. Prognostic factors governing the survival of patients with T4 gastric...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.1046

    authors: Dhar DK,Kubota H,Tachibana M,Kinugasa S,Masunaga R,Shibakita M,Kohno H,Nagasue N

    更新日期:2001-04-01 00:00:00

  • Malignant pheochromocytoma and paraganglioma: a population level analysis of long-term survival over two decades.

    abstract:BACKGROUND AND OBJECTIVES:Pheochromocytoma (PHEO) and paraganglioma (PGL) are rare tumors. Aims of this study were to describe and to compare demographic, clinical, pathologic, and survival characteristics of malignant PHEO and PGL. METHODS:Patients were identified in SEER, 1988-2009. Analyses included chi-square, ANO...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.23297

    authors: Goffredo P,Sosa JA,Roman SA

    更新日期:2013-05-01 00:00:00

  • Actual 10-year survivors and 10-year recurrence free survivors after primary liver resection for hepatocellular carcinoma in the 21st century: A single institution contemporary experience.

    abstract:BACKGROUND:At present, the majority of outcome studies of survival of hepatocellular carcinoma (HCC) post-liver resection (post-LR) present actuarial survival data, which often results in overestimation of survival. We sought to evaluate the actual 10-year survival post-LR for HCC and identify variables that are associ...

    journal_title:Journal of surgical oncology

    pub_type: 临床试验,杂志文章

    doi:10.1002/jso.26259

    authors: Linn YL,Chee MY,Koh YX,Teo JY,Cheow PC,Chow PKH,Chan CY,Chung AYF,Ooi LLPJ,Goh BKP

    更新日期:2021-01-01 00:00:00

  • Outcome according to residual disease (surgeon's report vs pre-chemotherapy imaging) in patients with bevacizumab-treated ovarian cancer: Analysis of the ROSiA study.

    abstract:BACKGROUND AND OBJECTIVES:The single-arm ROSiA study evaluated frontline bevacizumab for advanced ovarian cancer. We explored how discordant surgically and radiologically assessed postoperative residual disease affects outcomes. METHODS:After debulking surgery, 1021 patients received 4 to 8 cycles of carboplatin-pacli...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.25647

    authors: Korach J,Colombo N,Mendiola C,Selle F,Dolado I,Donica M,Oza AM

    更新日期:2019-09-01 00:00:00

  • Biodistribution of monoclonal antibody A7 and its F(ab')2 fragment in athymic nude mice bearing human pancreatic carcinoma.

    abstract::Xenografts of a human pancreatic carcinoma cell line, HPC-YS, which reacted with the monoclonal antibody (MAb) A7, were used to investigate the in vivo localization of radioiodinated MAb A7 after intraperitoneal injection. MAb A7 localized to the tumor 4 days and 8 days after injection with a tissue/blood ratio of 1.4...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930500309

    authors: Otsuji E,Yamaguchi T,Yamaoka N,Yamaguchi N,Imanishi J,Takahashi T

    更新日期:1992-07-01 00:00:00

  • Expression of B7-H4 in blood of patients with gastric cancer predicts tumor progression and prognosis.

    abstract:BACKGROUND AND OBJECTIVES:B7-H4 is a novel molecular B7 ligand that plays an important role as a negative regulator of the T cell-mediated immune response. However, the clinical significance of B7-H4 expression in gastric cancer remains uncertain. Here, we assessed B7-H4 expression in blood of patients with gastric can...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.21722

    authors: Arigami T,Uenosono Y,Hirata M,Hagihara T,Yanagita S,Ishigami S,Natsugoe S

    更新日期:2010-12-01 00:00:00

  • Outcomes in operative management of pancreatic cancer.

    abstract::Pancreatic cancer is a highly lethal malignancy that often presents at an advanced stage. Surgical resection can prolong survival and offers the only potential for cure. However, pancreatectomy is associated with significant morbidity and mortality. This article reviews perioperative outcomes, post-resection long-term...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章,评审

    doi:10.1002/jso.23744

    authors: Bliss LA,Witkowski ER,Yang CJ,Tseng JF

    更新日期:2014-10-01 00:00:00

  • Mutational status of KIT and PDGFRA and expression of PDGFRA are not associated with prognosis after curative resection of primary gastrointestinal stromal tumors (GISTs).

    abstract:BACKGROUND:The aim of this study was to investigate if immunohistochemical expression and mutational status of KIT and PDGFRA in GISTs are associated with the clinical course and disease-free survival after curative resection of the primary tumor without adjuvant systemic therapy. METHODS:Paraffin-embedded tumor secti...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.21905

    authors: Kern A,Görgens H,Dittert DD,Krüger S,Richter KK,Schackert HK,Saeger HD,Baretton G,Pistorius S

    更新日期:2011-07-01 00:00:00

  • Temporal trends in liver-directed therapy of patients with intrahepatic cholangiocarcinoma in the United States: a population-based analysis.

    abstract:BACKGROUND AND OBJECTIVES:Data on outcomes after liver-directed therapy for intrahepatic cholangiocarcinoma (ICC) are limited due to the rarity of the disease. We sought to define overall utilization and temporal trends of liver-directed therapy for ICC. METHODS:We identified 5,388 patients with ICC using the Surveill...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.23605

    authors: Amini N,Ejaz A,Spolverato G,Kim Y,Herman JM,Pawlik TM

    更新日期:2014-08-01 00:00:00

  • Can risk groups accurately predict non-sentinel lymph node metastasis in sentinel lymph node-positive endometrial cancer patients? A Turkish Gynecologic Oncology Group Study (TRSGO-SLN-004).

    abstract:BACKGROUND AND OBJECTIVES:The purpose of this study was to find out the risk factors associated with non-sentinel lymph node metastasis and determine the incidence of non-sentinel lymph node metastasis according to risk groups in sentinel lymph node (SLN)-positive endometrial cancer patients. METHODS:Patients who unde...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.26310

    authors: Altin D,Taskin S,Tokgozoglu N,Vatansever D,Guler AH,Gungor M,Tasci T,Turan H,Kahramanoglu I,Yalcin I,Celik C,Kose F,Ortac F,Arvas M,Ayhan A,Taskiran C

    更新日期:2020-12-01 00:00:00

  • Postradiation slipped capital femoral epiphyses (SCFE).

    abstract::This study details the case reports of two children who developed slipped capital femoral epiphyses (SCFE) after receiving external irradiation. The clinical and diagnostic features of postradiation SCFE are reviewed and discussed. Guidelines for the management of children who receive pelvic irradiation are presented....

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930360110

    authors: Sabio H,Sussman M,Levien M

    更新日期:1987-09-01 00:00:00

  • Utility of CEA and CA 19-9 tumor markers in diagnosis and prognostic assessment of mucinous epithelial cancers of the appendix.

    abstract:BACKGROUND AND OBJECTIVES:Tumor markers are a clinical tool frequently used in oncology in association with other clinical and radiologic information. For gastrointestinal cancer, carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA 19-9) tumor markers have found selected clinical application. The use of th...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.20107

    authors: Carmignani CP,Hampton R,Sugarbaker CE,Chang D,Sugarbaker PH

    更新日期:2004-09-15 00:00:00

  • Patient rated outcomes and survivorship following cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy (CS + HIPEC).

    abstract:BACKGROUND:Cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy (CS + HIPEC) is a treatment combining cytoreductive surgery with hyperthermic chemotherapy directly into the peritoneal cavity. Recipients may gain extended life when compared with best supportive care; yet results often are achieved with s...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.23089

    authors: Duckworth KE,McQuellon RP,Russell GB,Cashwell CS,Shen P,Stewart JH 4th,Levine EA

    更新日期:2012-09-15 00:00:00

  • Prognostic value of different metastatic sites for patients with FIGO stage IVB endometrial cancer after surgery: A SEER database analysis.

    abstract:OBJECTIVE:This study aimed to investigate the association between different metastatic sites and survival in endometrial cancer (EC) patients with International Federation of Gynecology and Obstetrics (FIGO) stage IVB disease. METHODS:FIGO stage IVB patients with EC were selected from the surveillance, epidemiology, a...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.26102

    authors: Li H,Zhang R,Chen C,Wu C,Lin H,Li J,Lin Z

    更新日期:2020-10-01 00:00:00

  • Neoplasms in skin and subcutis over the breast, simulating breast neoplasms: case reports and literature review.

    abstract::Twenty cases of neoplasms in skin and subcutaneous tissue over the breast were reviewed. There were 17 women, from 15 to 70 years of age, and three men, from 25 to 66 years of age. Among the benign skin neoplasms, superficial leiomyoma, granular cell tumor, and eccrine acrospiroma were misdiagnosed clinically as prima...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930310312

    authors: Ilie B

    更新日期:1986-03-01 00:00:00

  • Young patients with synchronous colorectal liver metastases.

    abstract:BACKGROUND:An increasing proportion of patients are presenting with colorectal cancer at an early age. A proportion of these occur with genetic syndromes; however the majority present as sporadic. The purpose of this study is to investigate the prognosis and treatment of young patients with sporadic metastatic colorect...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.24181

    authors: Smith JD,Lowery MA,Fell D,Gallagher DJ,Nash GM,Kemeny NE

    更新日期:2016-04-01 00:00:00

  • Tumor spread and outcome of treatment in primary esophageal small cell carcinoma.

    abstract:BACKGROUND:The most effective treatment for patients with esophageal small cell carcinoma has not yet been established because of the overall extremely poor prognosis regardless of the mode of treatment. The role of esophagectomy has been controversial in the management of patients with this disease. METHODS:The clini...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/(sici)1096-9098(199702)64:2<130::aid-jso8>

    authors: Nishimaki T,Suzuki T,Nakagawa S,Watanabe K,Aizawa K,Hatakeyama K

    更新日期:1997-02-01 00:00:00

  • Comparative value of aspiration cytology in the diagnostic evaluation of breast masses.

    abstract::For 38 consecutive patients presenting with breast masses we compared accuracy of diagnosis, before biopsy, of the techniques of clinical examination, bilateral xeromammography, and aspiration cytology with a 10-cc syringe and a 22-gauge needle. Of the 38 patients, nine had carcinoma and 29 had benign breast disease. ...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930120409

    authors: Frazier TG,Rowland CH,Woolery CL

    更新日期:1979-12-01 00:00:00

  • Survival rates of breast carcinoma patients after surgery and anaesthetic.

    abstract::Eighty-nine breast cancer patients were studied for the end result of therapy. During surgery, the anaesthesia administered was either halothane (61 cases) or ether (28 cases) mixture with nitrogen and oxygen. The holstead method for mastectomy was used for all cases. The results showed that the type of anaesthesia in...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930110312

    authors: Alsabti E

    更新日期:1979-01-01 00:00:00

  • Prostate cancer stem cells and their potential roles in metastasis.

    abstract::Most solid tumors have now been reported to contain stem cell-like cells called cancer stem cells (CSCs). These cells are endowed with high tumorigenic capacity and may be the cells that drive tumor formation, maintain tumor homeostasis, and mediate tumor metastasis. Since these self-renewing cancer cells may be the s...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章,评审

    doi:10.1002/jso.21806

    authors: Li H,Tang DG

    更新日期:2011-05-01 00:00:00

  • Aberrations of the K-ras, p53, and APC genes in extrahepatic bile duct cancer.

    abstract:BACKGROUND AND OBJECTIVES:The genetic alterations involved in extrahepatic bile duct (EHBD) cancer are poorly understood. Our aim was to identify aberrations of the K-ras, p53, and APC genes in EHBD cancer. METHODS:We investigated aberrations of these genes in 52 EHBD cancers using polymerase chain reaction (PCR) sing...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/(sici)1096-9098(200003)73:3<158::aid-jso9>

    authors: Suto T,Habano W,Sugai T,Uesugi N,Funato O,Kanno S,Saito K,Nakamura Si

    更新日期:2000-03-01 00:00:00