Abstract:
BACKGROUND:Cytoreductive surgery (CRS) and hyperthermic intra-peritoneal chemotherapy (HIPEC) treatment of colorectal peritoneal metastases (PM) is an established treatment alternative. The study aim was, first, to investigate the outcome of high-volume disease defined by the peritoneal cancer index (PCI) 20; second, to report the long-term disease-free survival of patients with >5 years observation. METHODS:Consecutive patients with colorectal PM from a prospective HIPEC database between 2004 and 2010 were included, 67 patients. Clinicopathological and outcome parameters were compared between low PCI (n = 40) and high PCI (n = 27). A subgroup analysis on patients with >5 years observation was performed (n = 32). Disease-free survival after 5 years defined cure. RESULTS:Median overall survival (OS) was 28 months, low PCI-group 33 months versus high PCI-group 17 months (P = 0.03). Median OS of patients with complete CRS (n = 56) was 30 months, low PCI-group 37 months versus high PCI-group 27 months (P = 0.2), with 5-year survival of 31% and 21%, respectively. No difference in morbidity/mortality. The cure rate was 22% in the subgroup (7/32) and 28% in those with complete CRS (7/25). Two patients in the cured group had PCI 29 and 34. DISCUSSION:Treatment of high-volume disease may result in long-term survival and even cure. The key is to reach a complete CRS. The overall cure rate is 22%.
journal_name
J Surg Oncoljournal_title
Journal of surgical oncologyauthors
Cashin PH,Dranichnikov F,Mahteme Hdoi
10.1002/jso.23610subject
Has Abstractpub_date
2014-08-01 00:00:00pages
203-6issue
2eissn
0022-4790issn
1096-9098journal_volume
110pub_type
杂志文章abstract:BACKGROUND AND OBJECTIVES:The optimal extent of lymphadenectomy in patients with esophageal cancer is controversial. This study aimed to examine the therapeutic value of lymph node (LN) dissection for each LN station in patients with esophageal squamous cell carcinoma (ESCC) who receive neoadjuvant chemotherapy. METHO...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.23965
更新日期:2015-07-01 00:00:00
abstract:PURPOSE:Little is known about long-term radiographic findings after treatment with accelerated partial breast irradiation (APBI). METHODS:Univariate and multivariate analysis of factors leading to formation and resolution of seroma were performed in patients treated with lumpectomy and APBI. RESULTS:Post-treatment im...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.24646
更新日期:2017-08-01 00:00:00
abstract:BACKGROUND:Rapid genetic counseling and testing (RGCT) in newly diagnosed high-risk breast cancer (BC) patients may influence surgical treatment decisions. To successfully integrate RGCT in practice, knowledge of professionals', and patients' attitudes toward RGCT is essential. METHODS:Between 2008 and 2010, we perfor...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.24763
更新日期:2017-12-01 00:00:00
abstract:BACKGROUND:The use of neoadjuvant chemotherapy (NACT) for the treatment of locally advanced cervical cancer (LACC) remains controversial. In current clinical practice, platinum-based chemotherapy is the major option for patients with LACC. However, serious adverse events have been reported after platinum-based chemothe...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.22052
更新日期:2012-02-01 00:00:00
abstract::We retrospectively studied the relationship between nutritional status as indicated by the presence or absence of the cutaneous delayed hypersensitivity response and treatment-related morbidity, disease recurrence, and survival at 2 years in 67 consecutive patients with head and neck carcinoma. Serial nutritional asse...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930550110
更新日期:1994-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Stages II and III rectal tumors are known as locally advanced rectal cancer (LARC) because they are characterized by a high incidence of local and distant relapses and a low probability of long-term survival. Adjuvant treatments have been advocated to ameliorate overall survival (OS), local re...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/1096-9098(200005)74:1<2::aid-jso2>3.0.co;2
更新日期:2000-05-01 00:00:00
abstract::Little information is available regarding acute upper gastrointestinal bleeding as a presenting sign of gastric carcinoma. Of 427 patients with gastric cancer, 36 (8.4%) underwent early endoscopy due to hematemesis. The hemorrhage was self-limited in 16 patients (44.4%), most of whom underwent elective surgery. Twenty...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930360212
更新日期:1987-10-01 00:00:00
abstract::Anastomotic complications are responsible for significant morbidity and mortality following esophagectomy for cancer. Conflicting reports exist regarding the superiority of hand-sewn versus stapled techniques. This systematic review identified eight randomized clinical trials examining this issue. None of the studies ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.21510
更新日期:2010-05-01 00:00:00
abstract:BACKGROUND:Subtotal stomach preserving pancreaticoduodenectomy (SSPPD) is compared retrospectively with pylorus preserving pancreaticoduodenectomy (PPPD). METHODS:During 2002-2005, 21 patients (13 female, 8 male) underwent SSPPD. The mean age was 64.3 (range 33-80). PPPD was performed for 12 patients after 1999. Days ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.20608
更新日期:2007-02-01 00:00:00
abstract::A case report is presented giving the first detailed description of a benign common duct stricture occurring in a patient receiving hepatic artery infusion of FUDR for metastatic colon cancer. It is postulated that the stricture results from a combination of drug toxicity, and hypoxemia of the duct, with the lesion oc...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930310113
更新日期:1986-01-01 00:00:00
abstract:OBJECTIVES:To document radical cystectomy (RC) outcomes in patients over 80 years old across Quebec during the years 2000-2009 and to examine potentially related factors. METHODS:Within Quebec health insurance medical services database, we identified patients over 80 years who underwent RC. The outcomes analyzed were ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.23887
更新日期:2015-06-01 00:00:00
abstract:INTRODUCTION:Breast conservative surgery (BCS) and sentinel lymph node biopsy (SLNB) after neoadjuvant treatment (NAT) is safe and effective for selected patients. This aim of this study is to evaluate the impact of anatomic site of response on outcomes and to assess the real population who may benefit from nonsurgical...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.26236
更新日期:2021-01-01 00:00:00
abstract:BACKGROUND:One of the reasons for the poor prognosis of pancreatic carcinoma is the difficulty of obtaining an early diagnosis of pancreatic carcinoma. One possibility is the application of radioimmunoscintigraphy using radiolabeled monoclonal antibodies (Mabs). METHODS:We labeled chimeric (human/mouse) Fab fragments ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.10311
更新日期:2003-11-01 00:00:00
abstract::Preoperative radiological findings of nodal status in 74 patients, using endoscopic ultrasonography (EUS), computed tomography (CT), ultrasonography (US), and magnetic resonance imaging (MRI), were compared to histopathology reports following transthoracic total esophagectomy with radical lymphadenectomy (TTE), involv...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/(SICI)1096-9098(199603)61:3<214::AID-JSO10
更新日期:1996-03-01 00:00:00
abstract:BACKGROUND:Receptor-binding cancer antigen expressed on SiSO cells (RCAS1) has been reported to act as a ligand for a receptor present on normal peripheral lymphocytes and to induce apoptotic cell death. We aimed to elucidate the significance of RCAS1 expression in human esophageal squamous cell carcinomas (ESCC). MET...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.20249
更新日期:2005-05-01 00:00:00
abstract::A large number of adrenal tumors are now identified either incidentally or associated with a metastatic workup for cancer. While the vast majority of these lesions are benign, those that prove to be primary or secondary cancers are traditionally treated with surgical resection. A wide variety of alternative, less inva...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.23191
更新日期:2012-10-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:There have been few reports on the objective assessment of quality of life (QOL) in patients with gastric cancer following palliative operations. The benefit of a palliative operation for survival and QOL of patients with gastric cancer is not clear. METHODS:Survival and hospital-free surviva...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/(sici)1096-9098(199809)69:1<41::aid-jso8>3
更新日期:1998-09-01 00:00:00
abstract:BACKGROUND:Immunoreactivity for p53 tumor suppressor gene product is commonly found in human malignancies and some premalignant lesions, but its role in cancer development and its value as a marker of tumor biologic behavior is still unclear. OBJECTIVES:This study was undertaken to assess p53 immunoexpression in esoph...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/(sici)1096-9098(199705)65:1<3::aid-jso2>3.
更新日期:1997-05-01 00:00:00
abstract::This paper presents an apparent case of danazol-induced primary hepatocellular carcinoma in a 49-year-old patient, following two years of continuous therapy with this inhibitor of pituitary gonadotrophin. Discontinuation of the drug failed to cause regression of the tumour. ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930280209
更新日期:1985-02-01 00:00:00
abstract:PURPOSE:To describe venous thromboembolism (VTE) rates in patients with pancreatic cancer (PC) during neoadjuvant therapy. METHODS:Factors associated with VTE were evaluated using multivariable logistic regression modeling in patients with resectable and BLR PC treated with neoadjuvant therapy between 2009 and 2014. ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.24361
更新日期:2016-10-01 00:00:00
abstract::The cases of 42 patients with malignant ascites treated with a peritoneal venous shunt over a 5-year period are reviewed to establish the incidence of surgical and postsurgical complications. Although the yield of malignant cells found in the peripheral blood was increased after shunting, no new hematogenous metastase...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930330109
更新日期:1986-09-01 00:00:00
abstract::The results of treatment with intracavitary bleomycin are reported in twenty patients with a malignant pleural effusion and five patients with malignant ascites. The control rate was 17/20 (85%) patients with malignant pleural effusions and 3/5 (60%) patients with malignant ascites. Toxicities were minimal with fever ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930160312
更新日期:1981-01-01 00:00:00
abstract::Surgery is a mainstay of primary breast cancer therapy. Alterations in surgical technique have reduced normal tissue injury, yet pain and functional compromise continue to occur following treatment. A tenuous evidence base bolstered by considerable expert opinion suggests that early intervention with conventional reha...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.20782
更新日期:2007-04-01 00:00:00
abstract::The use of preoperative imaging has become routine for many reconstructive microsurgeons to help localize perforators for planning of microvascular free flaps. However, with advancements in imaging technology, perforator mapping represents only one potential benefit as virtual planning and medical modeling, and flap t...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.25194
更新日期:2018-10-01 00:00:00
abstract::Intrapancreatic extension of pancreatic duct cell carcinoma in 19 resectable cases was evaluated by both hematoxylin and eosin (H&E) staining and quick immunostaining using antibodies against cancer-associated antigens--e.g., CA19-9, DUPAN 2, and CEA--on the intraoperative frozen-section biopsy during the course of la...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930400105
更新日期:1989-01-01 00:00:00
abstract::A study was carried out to determine the interrelationship between the inhalation of nitrogen dioxide (0.4 +/- 0.50 ppm), lung metastases development from circulating cancer cells, and death rate from such metastases. C57 BL/6J mice were used in these experiments. Animals were divided into control and NO2-exposed grou...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930280115
更新日期:1985-01-01 00:00:00
abstract::The last two decades have seen great improvements in the management of patients with germ-cell tumors of the ovary. The initial treatment approach includes conservative surgery and cisplatin-based chemotherapy in most cases. At completion of chemotherapy, the role of second-look surgery remains questionable. We retros...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/(SICI)1096-9098(199605)62:1<40::AID-JSO9>3
更新日期:1996-05-01 00:00:00
abstract::This review evaluates the use of robotic-assisted laparoscopic surgery in the treatment of gynecologic malignancies and objectively evaluates the use of these systems in performing radical hysterectomies and surgical staging of gynecologic malignancies. The review focuses on surgical length, blood loss, complications,...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.22080
更新日期:2012-04-01 00:00:00
abstract::Mice with intravesical urothelial tumors (MBT-2) were challenged with E coli inoculated intravesically. Adherence of bacteria measured at 15 min or persistent infection at 24 h was significantly greater in the tumor-bearing bladders than in normal non-tumor-bearing mice. The tumor-bearing portion of the bladder contai...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930230405
更新日期:1983-08-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:We assessed the optimal extent of lymph node dissection and the effect of splenectomy in patients with proximal gastric cancer. METHOD:Recurrence and survival rates were compared between 881 patients with proximal gastric cancer who underwent modified radical lymphadenectomy and 3,098 patient...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.21137
更新日期:2008-12-01 00:00:00