Abstract:
:The last two decades have seen great improvements in the management of patients with germ-cell tumors of the ovary. The initial treatment approach includes conservative surgery and cisplatin-based chemotherapy in most cases. At completion of chemotherapy, the role of second-look surgery remains questionable. We retrospectively analyzed the long-term outcome (median follow-up, 8 years) of 40 patients who received various chemotherapy regimens after primary surgery and focused on the role of second-look surgery. A second-look laparotomy was performed at completion of chemotherapy in 22 patients. Histological findings were no tumor in 13; mature teratoma in 5; immature teratoma in 1; active disease in 3. Six of the latter nine patients had persistent radiologic abnormalities after chemotherapy. All three patients with active disease had elevated serum tumor markers. Five out of the six patients with residual teratoma lesions had a teratoma component in the primary tumor. According to histological findings at second-look surgery, the number of patients without long-term evidence of disease is 12, 5, 1 and 0, respectively. Eighteen patients were not subjected to second-look surgery. One of them had clearly progressive disease and the other 17 experienced a clinical complete response at completion of chemotherapy. All patients but one are alive without evidence of disease. We conclude that second-look surgery is not necessary in patients with elevated serum tumor marker levels and in those patients with neither radiologic abnormality nor teratoma element in the primary tumor. However, we recommend a second-look procedure for the small subset of patients with a teratoma component in the primary tumor and persistent radiologic abnormalities along with normal serum tumor markers at the end of chemotherapy.
journal_name
J Surg Oncoljournal_title
Journal of surgical oncologyauthors
Culine S,Lhomme C,Michel G,Leclere J,Duvillard P,Droz JPdoi
10.1002/(SICI)1096-9098(199605)62:1<40::AID-JSO9>3subject
Has Abstractpub_date
1996-05-01 00:00:00pages
40-5issue
1eissn
0022-4790issn
1096-9098pii
10.1002/(SICI)1096-9098(199605)62:1<40::AID-JSO9>3journal_volume
62pub_type
杂志文章abstract:BACKGROUND:The role of postmastectomy radiation therapy (PMRT) after neoadjuvant chemotherapy (NAC) and mastectomy is unclear, especially in patients that have post-treatment tumor negative axillary nodes (ypN0). METHODS:The National Cancer Data Base was used to identify women that had PMRT after NAC and mastectomy fo...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.24551
更新日期:2017-05-01 00:00:00
abstract::In order to determine whether current programs for the management of metastatic breast cancer have led to improved patient survival, we determined the median survival times for five-year intervals of 849 patients admitted to the City of Hope National Medical Center with metastatic breast cancer from 1955 to 1980. Surv...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930480304
更新日期:1991-11-01 00:00:00
abstract:INTRODUCTION:The number of incidentally discovered adrenal lesions is increasing due to the widespread use of abdominal imaging. Although most incidentalomas are benign, larger suspicious lesions will require adrenalectomy. The aim of this study is to determine the risk of malignancy in patients undergoing surgery for ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.21553
更新日期:2010-10-01 00:00:00
abstract:BACKGROUND:Recurrent pleomorphic adenoma (PA) of the parotid gland is a challenging surgical issue with controversy regarding management and long term outcome. METHODS:All patients who were operated for recurrent PA of the parotid gland between the years 1991 and 2013 were reviewed. Patient demographics, clinicopathol...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.24392
更新日期:2016-11-01 00:00:00
abstract:BACKGROUND:Some cases of mass-forming intrahepatic cholangiocarcinoma (ICC) are diagnosed as hepatocellular carcinoma (HCC) based on preoperative imaging and clinical findings. We investigated the backgrounds of such cases. METHODS:Sixty-seven patients with mass-forming ICC underwent surgery from 1980 to 2002. Twenty-...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.20091
更新日期:2004-08-01 00:00:00
abstract:BACKGROUND:CD40 and CD154 are associated with lymphocyte signaling pathways and they are also expressed in some malignant neoplasms, but the significance in pancreatic cancer is unknown. METHODS:Eighty pancreatic cancer specimens were stained immunohistochemically, and the results were correlated with the patients' cl...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.21812
更新日期:2011-03-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:In this study, we identified matrix metalloproteinase (MMP)-2 and 9 expression in exophytic papilloma (EP), inverted papilloma (IP) with dysplasia, IP with carcinoma, and invasive squamous cell carcinoma (SCC). We also compared the presence of MMP-2 and 9 with human papilloma virus (HPV) infec...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.20386
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND:An increasing proportion of patients are presenting with colorectal cancer at an early age. A proportion of these occur with genetic syndromes; however the majority present as sporadic. The purpose of this study is to investigate the prognosis and treatment of young patients with sporadic metastatic colorect...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.24181
更新日期:2016-04-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:This study aimed to analyze the association between health-related quality of life and treatment modality among esophageal squamous cell carcinoma (ESCC) survivors. METHODS:Patients completed the EORTC QLQ-C30 and EORTC QLQ-OES18 at baseline and follow-up. A time to deterioration model analys...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.26264
更新日期:2021-01-01 00:00:00
abstract::Maximum diameter, tumour volume, and inflammatory response of host tissue in 282 surgical specimens with primary carcinoma of the bronchus were measured. Cell type, pT- and pN-stage, maximum diameter and volume of the primaries, and inflammatory response of host tissue were analyzed in respect to survival of the patie...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930360203
更新日期:1987-10-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:We performed a retrospective analysis to assess the influence of different prognostic factors, including the International Prognostic Index (IPI), that can predict the outcome in patients with primary large bowel lymphoma (Stage IE) treated with combined therapy (surgery followed by chemothera...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.10103
更新日期:2002-06-01 00:00:00
abstract:BACKGROUND:CD109, a TGF-β co-receptor, is reported to be preferentially expressed during the early stages of tumorigenesis in several carcinoma types. Myxofibrosarcoma is one of the most common soft-tissue sarcomas found in elderly patients. This study aimed to elucidate the impact of CD109 expression in myxofibrosarco...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.23934
更新日期:2015-06-01 00:00:00
abstract::To define more precisely the prognostic index for patients with primary carcinoma of the gallbladder in Taiwan, we retrospectively reviewed the data of 74 patients with gallbladder carcinoma treated over a period of 15 years, from 1979 to 1993. Of these patients, 75% had Nevin stage V gallbladder cancer. The most comm...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/(SICI)1096-9098(199601)61:1<49::AID-JSO11>
更新日期:1996-01-01 00:00:00
abstract::The circumferential resection of the trachea with end-to-end anastomosis is a well-established clinical procedure. Still, some problems remain to be solved, such as the choice of optimal suture material. Dogs are primarily used for experimental work in this field, but are difficult to obtain. This operation was perfor...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930370114
更新日期:1988-01-01 00:00:00
abstract::For extremity soft tissue sarcomas, limb salvage is now standard of care. The extent of surgical margins is balanced with functionality of the resected limb. Although negative margins are the goal, the necessary width is unclear. Additional considerations for margin adequacy include presence of anatomic barriers such ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.24112
更新日期:2016-03-01 00:00:00
abstract::Ten patients with advanced ovarian carcinoma were treated with hexamethylmelamine and melphalan after failing first-line combination chemotherapy. In eight patients residual disease was evident only at second-look laparotomy. Surgical debulking was accomplished in four patients but only two patients had residual disea...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930210305
更新日期:1982-11-01 00:00:00
abstract:BACKGROUND:The aim of this study is to investigate clinical significance of miR-155 expression in breast cancer. METHODS:TaqMan real-time RT-PCR was performed to detect miR-155 expression in breast cancer tissues. The correlation of miR-155 expression with clinicopathological factors and prognosis of breast cancer pat...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.22153
更新日期:2012-09-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Total pelvic exenteration are performed in patients with locally advanced or recurrent pelvic malignances. Many patients have prolong hospital length of stay (LOS), but risk factors are not clearly identified. METHODS:From 2002 through 2012, 100 consecutive patients undergoing pelvic exentera...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.24878
更新日期:2018-03-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:The objectives of this study were to investigate the role of growth factors and matrix metalloproteinases in the brain metastasis. METHODS:Tumors from 40 patients with brain metastasis (30 lung cancer, 10 breast cancer) were studied to investigate the expression-patterns of EGFR, MT1-MMP, MMP...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.21296
更新日期:2009-07-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:To determine the prognostic significance of the colposcopic tumor size in the management of cervical cancer. METHODS:Clinicopathological analysis was performed in 751 consecutive patients with stage IB squamous cervical cancer who were surgically treated in a single institute. The colposcopic...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/1096-9098(200102)76:2<133::aid-jso1024>3.0
更新日期:2001-02-01 00:00:00
abstract:BACKGROUND:Peritonectomy combined with perioperative intraperitoneal chemotherapy is a successful treatment option for patients with peritoneal dissemination of appendiceal and colorectal malignancy. Despite its efficacy, recurrences remain a common problem. METHODS:Patients with peritoneal dissemination from appendic...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.21084
更新日期:2008-09-15 00:00:00
abstract::A patient with a feminizing malignant Leydig cell tumor is presented. Hormonal assays revealed increased production of prolactin, estradiol, and total estrogens. Eleven years after the onset of his disease he remains clinically well. ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930270203
更新日期:1984-10-01 00:00:00
abstract::Perineural invasion is associated with tumor spreading and an unfavorable prognosis in a variety of cancers. Recently, neural cell adhesion molecule (NCAM) has been reported to be affinitive to neural tissues, which suggests some relationship between NCAM and perineural invasion. This study was designed to elucidate t...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930530205
更新日期:1993-06-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Soft tissue sarcomas (STS) are mesenchymal malignancies. Treatment mainstay is surgical resection with negative margins ± adjuvant treatment. Fluorescence-guided surgical (FGS) resection can delineate intraoperative margins; FGS has improved oncologic outcomes in other malignancies. This novel...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.24950
更新日期:2018-05-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Stages II and III rectal tumors are known as locally advanced rectal cancer (LARC) because they are characterized by a high incidence of local and distant relapses and a low probability of long-term survival. Adjuvant treatments have been advocated to ameliorate overall survival (OS), local re...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/1096-9098(200005)74:1<2::aid-jso2>3.0.co;2
更新日期:2000-05-01 00:00:00
abstract::Most solid tumors have now been reported to contain stem cell-like cells called cancer stem cells (CSCs). These cells are endowed with high tumorigenic capacity and may be the cells that drive tumor formation, maintain tumor homeostasis, and mediate tumor metastasis. Since these self-renewing cancer cells may be the s...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.21806
更新日期:2011-05-01 00:00:00
abstract::Of 49 patients with midgut and hindgut carcinoids, second primary distinct carcinomas occurred in 12. The most aggressive carcinoids were the 24 that arose in the distal small bowel and cecum. Of the patients affected, 15 had lymph node metastases and eight had liver metastases at the time of diagnosis. That only five...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930110309
更新日期:1979-01-01 00:00:00
abstract::A patient with metastasizing glucagonoma producing multiple molecular forms of glucagon is reported. The patient responded to symptomatic treatment with a somatostatin analogue (SMS 201-995). Glucagonoma tumour cells were studied in two tissue culture systems: intraocular transplants of immunosuppressed rats and long-...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930440313
更新日期:1990-07-01 00:00:00
abstract::Since February, 1977, 735 patients having a history of receiving radiation therapy for benign conditions of the head and neck areas during infancy and childhood were examined in a thyroid screening program, and 159 patients were found to have palpable thyroid nodules. These patients had thyroid function tests and indi...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930140316
更新日期:1980-01-01 00:00:00
abstract:BACKGROUND:Staging laparoscopy (SL) is used to avoid resection failure and thus increase the curative resection rate. SL utilization in extra-hepatic biliary tumors (EHBT) is variable. METHODS:Data from 1090 patients with potentially resectable EHBT including gallbladder (GBC), distal (DC), and hilar (HC) subtypes wer...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,多中心研究
doi:10.1002/jso.25323
更新日期:2019-03-01 00:00:00