Neural cell adhesion molecule (NCAM) and perineural invasion in bile duct cancer.

Abstract:

:Perineural invasion is associated with tumor spreading and an unfavorable prognosis in a variety of cancers. Recently, neural cell adhesion molecule (NCAM) has been reported to be affinitive to neural tissues, which suggests some relationship between NCAM and perineural invasion. This study was designed to elucidate the role of the expression of NCAM on the development of perineural invasion in bile duct cancer. A histopathologic study was performed on 24 patients with bile duct carcinoma who underwent resections. The overall incidence of NCAM expression in the resected specimen was 66.7% and that of perineural invasion was 87.5%. Furthermore, NCAM expression was shown to be positive in 16 (76%) out of 21 cases in whom perineural invasion was observed. A significant positive correlation was found between the expression of NCAM and perineural invasion in bile duct cancer. These results highlight an important role of NCAM in the development of perineural invasion in bile duct cancer.

journal_name

J Surg Oncol

authors

Seki H,Tanaka J,Sato Y,Kato Y,Umezawa A,Koyama K

doi

10.1002/jso.2930530205

subject

Has Abstract

pub_date

1993-06-01 00:00:00

pages

78-83

issue

2

eissn

0022-4790

issn

1096-9098

journal_volume

53

pub_type

杂志文章
  • Prognostic impact of extra-nodal extension in thyroid cancer: A meta-analysis.

    abstract:BACKGROUND AND OBJECTIVES:Lymph node involvement is common in thyroid cancer, but the system of staging does not consider the histological features of lymph node metastases. We conducted a meta-analysis to investigate the prognostic role of extranodal extension (ENE) in thyroid cancer patients. METHODS:We ran PubMed a...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/jso.24070

    authors: Veronese N,Luchini C,Nottegar A,Kaneko T,Sergi G,Manzato E,Solmi M,Scarpa A

    更新日期:2015-12-01 00:00:00

  • Interlaboratory variation in oxygen tension measurement by Eppendorf "Histograph" and comparison with hypoxic marker.

    abstract:BACKGROUND AND OBJECTIVES:The median of pO2 values in tumor measured by Eppendorf "Histograph" with a needle-type electrode has been used as a prognostic indicator in cancer patients. However, it is not established that a pretreatment measured pO2 value can be used as a universal predictor of local control probability,...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/(sici)1096-9098(199709)66:1<30::aid-jso7>3

    authors: Nozue M,Lee I,Yuan F,Teicher BA,Brizel DM,Dewhirst MW,Milross CG,Milas L,Song CW,Thomas CD,Guichard M,Evans SM,Koch CJ,Lord EM,Jain RK,Suit HD

    更新日期:1997-09-01 00:00:00

  • Combining independently effective anticancer agents may not augment the independent antitumor effects: a study using human digestive organ cancer xenograft lines in nude mice.

    abstract::Five human digestive organ cancer xenograft lines were subcutaneously transplanted in nude mice, and 7 anticancer agents (ACAs) were intravenously administered singly or in combinations at 4 times the standard clinical doses. Cisplatin (P) was effective in 4 lines and 5-fluorouracil (F) was effective in 3 lines. A tot...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930480408

    authors: Nio Y,Tseng CC,Tsubono M,Kawabata K,Masai Y,Shiraishi T,Fukumoto M,Tobe T

    更新日期:1991-12-01 00:00:00

  • The impact of re-excision of inadequately resected soft tissue sarcomas on surgical therapy, results, and prognosis: A single institution experience with 682 patients.

    abstract:BACKGROUND AND OBJECTIVES:Due to their rare incidence soft tissue sarcomas (STS) are often resected without clear margins. The aim of this study was to investigate the impact of re-excision of STS on survival. METHODS:Out of 752 patients with STS (406 men and 346 women, average age 51 years), 310 patients were referre...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.21639

    authors: Funovics PT,Vaselic S,Panotopoulos J,Kotz RI,Dominkus M

    更新日期:2010-11-01 00:00:00

  • Spinal metastases of basal cell carcinoma.

    abstract::A case of spine metastasis of basal cell carcinoma and review of the literature are presented. The treatment approach is discussed. ...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930250109

    authors: Weshler Z,Leviatan A,Peled I,Wexler M

    更新日期:1984-01-01 00:00:00

  • Outcomes in operative management of pancreatic cancer.

    abstract::Pancreatic cancer is a highly lethal malignancy that often presents at an advanced stage. Surgical resection can prolong survival and offers the only potential for cure. However, pancreatectomy is associated with significant morbidity and mortality. This article reviews perioperative outcomes, post-resection long-term...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章,评审

    doi:10.1002/jso.23744

    authors: Bliss LA,Witkowski ER,Yang CJ,Tseng JF

    更新日期:2014-10-01 00:00:00

  • Peritoneal papillary serous carcinoma: study of 15 cases and comparison with stage III-IV ovarian papillary serous carcinoma.

    abstract:BACKGROUND AND OBJECTIVES:Peritoneal papillary serous carcinoma (PPSC) is histologically and clinically similar to stage III-IV ovarian papillary serous carcinoma (OPSC). The purpose of this study was to investigate the clinical findings, treatment, and outcome of PPSC patients compared with stage III-IV OPSC patients....

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/(sici)1096-9098(199807)68:3<173::aid-jso8>

    authors: Piura B,Meirovitz M,Bartfeld M,Yanai-Inbar I,Cohen Y

    更新日期:1998-07-01 00:00:00

  • Immunohistochemically demonstrated expression of HLA-DR antigen in colorectal adenocarcinomas and its relation to clinicopathological features.

    abstract::We studied 148 colorectal adenocarcinomas to clarify any correlation between HLA-DR antigen expression on tumor cells and histopathological features. Paraffin sections of formalin-fixed tissues were stained with HLA-DR antigen using the indirect immunoperoxidase technique. All the tumor tissues were divided into two g...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930590407

    authors: Morita M,Tanaka K,Kawanishi H,Tsuji M,Ookusa T,Takada H,Okamura A,Hioki K

    更新日期:1995-08-01 00:00:00

  • Acute appendicitis as a sign of a colorectal carcinoma.

    abstract::The relationship of acute appendicitis occurring previous to cancer in colon and rectum was studied in the consecutive records of 561 patients, of 40 years of age and older, operated upon with an appendectomy because of acute appendicitis. Sixteen (2.9%) of these patients were readmitted within three years because of ...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930200105

    authors: Arnbjörnsson E

    更新日期:1982-05-01 00:00:00

  • Impact of delayed care on surgical management of patients with gastric cancer in a low-resource setting.

    abstract:BACKGROUND:Gastric cancer is the fifth most common cancer in Eastern Africa. Diagnostic delays in low-resource countries result in advanced disease presentation. We describe perioperative management of gastric cancer in Rwanda. METHODS:A retrospective review of records at three hospitals was performed to identify gast...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章,多中心研究

    doi:10.1002/jso.25286

    authors: Martin AN,Silverstein A,Ssebuufu R,Lule J,Mugenzi P,Fehr A,Mpunga T,Shulman LN,Park PH,Costas-Chavarri A

    更新日期:2018-12-01 00:00:00

  • Macrophage-mediated tumor cytotoxicity: role of macrophage surface sialic acid.

    abstract::Cell surface sialic acid levels were compared for monocytes and macrophages obtained from normal volunteers and breast cancer patients. Equal quantities of sialic acid were found on the monocytes obtained from normal volunteers and breast cancer patients. Approximately 60% more cell surface sialic acid was found on th...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930220203

    authors: Cameron DJ

    更新日期:1983-02-01 00:00:00

  • Carcinoembryogenic antigen and lysosomal enzymes in gastric juice as an aid in the diagnosis of gastric cancer.

    abstract::Malignant transformation in cells is accompanied by enzymatic changes that may be useful markers of malignancy. Studies of oncofetal antigens in gastric juice show an increased concentration in patients with gastric carcinoma. The object of the present study was to test if the concentration of lysosomal enzymes and ca...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930240320

    authors: Graffner H,Hultberg B

    更新日期:1983-11-01 00:00:00

  • Adjuvant, specific, active immunotherapy for resectable squamous cell lung carcinoma: a 5-year survival analysis.

    abstract::In 1976 Stewart et al. (Annals of the New York Academy of Sciences 277:436-466) reported the effectiveness of adjuvant specific active immunotherapy of lung carcinoma in improving the postoperative survival of stage I lung carcinoma patients in a phase II study using lung carcinoma-associated antigen (TAA) and complet...

    journal_title:Journal of surgical oncology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1002/jso.2930460104

    authors: Takita H,Hollinshead AC,Adler RH,Bhayana J,Ramundo M,Moskowitz R,Rao UN,Raman S

    更新日期:1991-01-01 00:00:00

  • Expression of interleukin (IL)-12 mRNA in gastric carcinoma specimens: cellular antitumor immune responses.

    abstract:BACKGROUND AND OBJECTIVES:Several tumor-related antigen peptides that are recognized by autologous cytolytic T cells (CTL) have been reported. However, most human solid tumors, including gastric carcinoma, are only weakly immunogenic. In this study, we focused on interleukin (IL)-12 and interferon-gamma (IFN-gamma) as ...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/(sici)1096-9098(199801)67:1<11::aid-jso3>3

    authors: Katano M,Nakamura M,Kuwahara A,Fujimoto K,Matsunaga H,Miyazaki K,Morisaki T

    更新日期:1998-01-01 00:00:00

  • Multidetector computed tomography for preoperative prediction of postsurgical prognosis of patients with extrahepatic biliary cancer.

    abstract:BACKGROUND:Preoperative prognostic information to select a treatment strategy is important especially in patients who need highly aggressive surgery, such as those with biliary cancer. We evaluated various prognostic factors and non-curative surgical factors using multidetector computed tomography (MDCT). METHODS:We r...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.21501

    authors: Kobayashi S,Nagano H,Marubashi S,Wada H,Eguchi H,Takeda Y,Tanemura M,Kim T,Doki Y,Mori M

    更新日期:2010-04-01 00:00:00

  • Discrepancy between PNMT presence and relative lack of adrenaline production in extra-adrenal pheochromocytoma.

    abstract::Among catecholamine synthesizing enzymes, phenylethanolamine-N-methyltransferase (PNMT) exists only in adrenal and extra-adrenal pheochromocytoma has been believed not to produce adrenaline. However, adrenaline production is clinically active in some extra-adrenal cases. To investigate this controversy, the localizati...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930570312

    authors: Funahashi H,Imai T,Tanaka Y,Tobinaga J,Wada M,Matsuyama T,Tsukamura K,Yamada F,Takagi H,Narita T

    更新日期:1994-11-01 00:00:00

  • Histiocytoid carcinoma: a variant of breast cancer.

    abstract::The history of a patient presenting with metachronous bilateral breast cancer displaying histiocytoid features is reviewed. Although regional metastases were noted, this patient has not demonstrated an aggressive systemic disease pattern. In the past, histiocytoid breast cancer has been classified as either a lipid-ri...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930310410

    authors: Eisenberg BL,Bagnall JW,Harding CT 3rd

    更新日期:1986-04-01 00:00:00

  • Immune status in advanced upper gastrointestinal cancers.

    abstract::Thirty-eight cases of advanced upper gastrointestinal cancer were assessed for their immune status prior to any form of therapy. Cell-mediated immunity, as tested by absolute lymphocyte count, T-cell count and delayed cutaneous hypersensitivity reactions to purified protein derivative and phytohemagglutinin showed sev...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930290113

    authors: Singh G,Das SN,Khanna NN

    更新日期:1985-05-01 00:00:00

  • Frequent K-ras mutations and absence of p53 mutations in mucin-producing tumors of the pancreas.

    abstract::Mucin-producing tumors of the pancreas (MPT) are characterized by the production of much mucin and a benign course after surgical treatment. We examined 16 cases of MPT and 20 cases of "common" pancreatic duct cell carcinomas (DCC) in regard to K-ras and p53 mutations. The mutations were detected by constant denaturan...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930550205

    authors: Hoshi T,Imai M,Ogawa K

    更新日期:1994-02-01 00:00:00

  • Characteristics of rectal carcinomas that predict the presence of lymph node metastases: implications for patient selection for local therapy.

    abstract:BACKGROUND AND OBJECTIVES:It has been estimated that approximately 5% of middle and low rectal adenocarcinomas are amenable to local therapy. However, these treatment modalities are limited by their failure to identify and treat regional nodal metastases. METHODS:This study was undertaken to evaluate the role of tumor...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/(sici)1096-9098(199802)67:2<99::aid-jso5>3

    authors: Zenni GC,Abraham K,Harford FJ,Potocki DM,Herman C,Dobrin PB

    更新日期:1998-02-01 00:00:00

  • Application of 99mTc labeled chimeric Fab fragments of monoclonal antibody A7 for immunoscintigraphy of pancreatic carcinoma.

    abstract:BACKGROUND:One of the reasons for the poor prognosis of pancreatic carcinoma is the difficulty of obtaining an early diagnosis of pancreatic carcinoma. One possibility is the application of radioimmunoscintigraphy using radiolabeled monoclonal antibodies (Mabs). METHODS:We labeled chimeric (human/mouse) Fab fragments ...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.10311

    authors: Otsuji E,Matsumura H,Okamoto K,Toma A,Kuriu Y,Ichikawa D,Hagiwara A,Yamagishi H

    更新日期:2003-11-01 00:00:00

  • Gastric cancer molecular classification and adjuvant therapy: Is there a different benefit according to the subtype?

    abstract:BACKGROUND:Gastric cancer (GC) has been defined in distinct molecular subtypes with different therapeutic implications. However, its clinical significance and prognosis regarding standard chemotherapy (CMT) remains unclear. This study aimed to analyze the impact of perioperative or adjuvant treatment among subtypes of ...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.25792

    authors: Ramos MFKP,Pereira MA,Amorim LC,de Mello ES,Faraj SF,Ribeiro U,Hoff PMG,Cecconello I,de Castria TB

    更新日期:2020-04-01 00:00:00

  • Semi-end-to-end esophagojejunostomy after laparoscopy-assisted total gastrectomy better reduces stricture and leakage than the conventional end-to-side procedure: A retrospective study.

    abstract:BACKGROUND AND OBJECTIVE:Laparoscopy-assisted total gastrectomy (LATG) has not gained popularity due to the technical difficulty of esophagojejunostomy (EJ) and the high incidence of EJ-related complications. Herein, we compared two types of EJ for Roux-en-Y reconstruction to determine whether semi-end-to-end (SETE) EJ...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.24637

    authors: Duan W,Liu K,Fu X,Shen X,Chen J,Su C,Yu P,Zhao Y

    更新日期:2017-08-01 00:00:00

  • Autologous transfusions for cancer patients undergoing elective ablative surgery.

    abstract::Patients who have cancer are exposed to the adverse consequences of blood transfusions, such as transmissible diseases. This study presents an examination of a program of autologous blood deposit for cancer patients undergoing elective surgical procedures. Over a 3-year period, 235 patients deposited 388 units of auto...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930430106

    authors: Lichtiger B,Huh YO,Armintor M,Fischer HE

    更新日期:1990-01-01 00:00:00

  • Rapid genetic counseling and testing in newly diagnosed breast cancer: Patients' and health professionals' attitudes, experiences, and evaluation of effects on treatment decision making.

    abstract:BACKGROUND:Rapid genetic counseling and testing (RGCT) in newly diagnosed high-risk breast cancer (BC) patients may influence surgical treatment decisions. To successfully integrate RGCT in practice, knowledge of professionals', and patients' attitudes toward RGCT is essential. METHODS:Between 2008 and 2010, we perfor...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.24763

    authors: Wevers MR,Aaronson NK,Bleiker EMA,Hahn DEE,Brouwer T,van Dalen T,Theunissen EB,van Ooijen B,de Roos MA,Borgstein PJ,Vrouenraets BC,Vriens E,Bouma WH,Rijna H,Vente JP,Kuenen MA,van der Sanden-Melis J,Witkamp AJ,Rutgers

    更新日期:2017-12-01 00:00:00

  • Intra-abdominal chylovenous bypass treats retroperitoneal lymphangiomatosis.

    abstract:BACKGROUND:Retroperitoneal lymphangiomatosis (RL) is a rare form of primary lymphedema featuring aberrant retroperitoneal lymphatic proliferation. It causes recurrent cellulitis, repeated interventions, and poor life quality. This study aimed to investigate proper diagnositc criteria and surgical outcomes for RL with e...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.25514

    authors: Chen C,Chu SY,Lin C,Liu KH,Cheng MH

    更新日期:2020-01-01 00:00:00

  • Malignancy and differentiation of neoplastic epithelial cells of thymoma.

    abstract::Fifteen fetal thymuses and 100 thymomas were examined concerning the degree of differentiation of thymic epithelial cells by light and electron microscopy. The following results were obtained. The embryologic process of the fetal thymus was categorized into four stages (8, 12, 15, and 17 weeks or more of gestation) ba...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930310212

    authors: Monden Y,Tanioka T,Maeda M,Masaoka A,Nakahara K,Kawashima Y,Kitamura H

    更新日期:1986-02-01 00:00:00

  • Contiguous invasion per se does not affect prognosis in colon cancer.

    abstract:BACKGROUND:Locally advanced colon cancer can result in serious clinical conditions unless treated appropriately. The aim of this study was to examine the feasibility of en bloc resection and the significance of depth of invasion by analyzing the outcomes of the procedure in colon cancer invading adjacent organs. METHO...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.21165

    authors: Oh SY,Kim YB,Paek OJ,Suh KW

    更新日期:2009-01-01 00:00:00

  • Technique for placement of a totally implantable venous access device.

    abstract::A totally implantable venous access system is described which greatly improved the ability to gain long-term venous access in selected patients. The external jugular approach has been demonstrated to be a safe and simple technique. The only major problem associated with the implantable venous access system was the dev...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930370413

    authors: Kondi ES,Pietrafitta JJ,Barriola JA

    更新日期:1988-04-01 00:00:00

  • Nutritional management during neoadjuvant therapy for esophageal cancer.

    abstract::Patients undergoing neoadjuvant therapy for esophageal cancer are at a high risk for malnutrition due to the effects of chemoradiation, dysphagia, and malignancy induced cachexia. Preparation for esophagectomy requires careful assessment of nutritional risk and adequate supplementation as indicated. Supplementation vi...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章,评审

    doi:10.1002/jso.21289

    authors: Bower MR,Martin RC 2nd

    更新日期:2009-07-01 00:00:00