Discrepancy between PNMT presence and relative lack of adrenaline production in extra-adrenal pheochromocytoma.

Abstract:

:Among catecholamine synthesizing enzymes, phenylethanolamine-N-methyltransferase (PNMT) exists only in adrenal and extra-adrenal pheochromocytoma has been believed not to produce adrenaline. However, adrenaline production is clinically active in some extra-adrenal cases. To investigate this controversy, the localization of catecholamine synthesizing enzymes was studied by immunohistochemical staining in extra-adrenal and adrenal cases. The results showed that PNMT was expressed not only in many cases of adrenal pheochromocytoma, but also in extra-adrenal pheochromocytoma. It is suspected that little adrenaline production in extra-adrenal cases is attributable to a lack of a good environment for the activation of PNMT by a high concentration of glucocorticoids.

journal_name

J Surg Oncol

authors

Funahashi H,Imai T,Tanaka Y,Tobinaga J,Wada M,Matsuyama T,Tsukamura K,Yamada F,Takagi H,Narita T

doi

10.1002/jso.2930570312

subject

Has Abstract,Author List Incomplete

pub_date

1994-11-01 00:00:00

pages

196-200

issue

3

eissn

0022-4790

issn

1096-9098

journal_volume

57

pub_type

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