Abstract:
:In our previous study on liposome-mediated transfection of the human interferon-beta (HuIFN-beta) gene into subcutaneously implanted human gliomas in nude mice, we found that HuIFN-beta was produced and secreted by the tumor cells and that the growth of solid tumors was completely inhibited. The present study investigated the growth-inhibitory effect of liposomes containing the HuIFN-beta gene inserted into a vector (pSV2IFN-beta) on T9 rat glioma implanted into the brains of rats. Tumor cells and liposomes containing pSV2IFN-beta or other additives were simultaneously injected into the brains of rats. HuIFN-beta was detected in solid gliomas growing in the brains of rats injected with liposomes and magnetic resonance imaging (MRI) showed that tumor growth was inhibited. In addition, the latent period until the appearance of neurological symptoms was significantly prolonged in rats treated with liposomes containing pSV2IFN-beta. However, the survival time of the treated rats was not significantly increased.
journal_name
J Surg Oncoljournal_title
Journal of surgical oncologyauthors
Harada K,Yoshida J,Mizuno M,Kurisu K,Uozumi Tdoi
10.1002/jso.2930590207subject
Has Abstractpub_date
1995-06-01 00:00:00pages
105-9issue
2eissn
0022-4790issn
1096-9098journal_volume
59pub_type
杂志文章abstract:BACKGROUND AND OBJECTIVES:Lymphedema is a condition of localized fluid retention and tissue swelling caused by a compromised lymphatic system. Lymphaticovenular anastomoses (LVA) and multiple lymphatic-venous anastomoses (MLVAs) have been recognized as efficient methods to treat chronic lymphedema. Because few models f...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.25234
更新日期:2018-11-01 00:00:00
abstract::The rare finding of heterotopic ossification in a case of primary rectal adenocarcinoma is described along with a review of the literature. Immunohistochemistry for a bone morphogenic protein (BMP-2) and fibroblast growth factor (FGF-2), both of which induce and stimulate bone formation, was performed and revealed ove...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.10181
更新日期:2003-02-01 00:00:00
abstract::The growth of knowledge and complexity now seen in General Surgery, has led to the sub-specialization of the discipline. Although it is considered by some to have led to the fragmentation of General Surgery and the erosion of the specialty as we know it today, others would argue that it has and will continue to lead t...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.20176
更新日期:2005-03-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Several tumor-related antigen peptides that are recognized by autologous cytolytic T cells (CTL) have been reported. However, most human solid tumors, including gastric carcinoma, are only weakly immunogenic. In this study, we focused on interleukin (IL)-12 and interferon-gamma (IFN-gamma) as ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/(sici)1096-9098(199801)67:1<11::aid-jso3>3
更新日期:1998-01-01 00:00:00
abstract::Efforts in lung cancer screening with chest X-ray (CXR) and sputum cytology in the 1970s and 1980s were negative. In the ensuing decade, the early lung cancer action project (ELCAP), and the Mayo screening study showed the promise of low-dose CT. These and other studies led to the National lung screening study (NLST),...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.23391
更新日期:2013-10-01 00:00:00
abstract:BACKGROUND:Prognosis with current management strategies continues to be dismal in metastatic gastric cancer (MGC) patients. We aimed to evaluate the role of metastasectomy in improving survival. METHODS:A comprehensive search of MEDLINE, EMBASE, SCOPUS, and Cochrane central databases (1965 to present) was performed. A...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,meta分析,评审
doi:10.1002/jso.23945
更新日期:2015-07-01 00:00:00
abstract::Twenty-six patients with esophageal carcinoma at stage pT4 underwent esophagectomy with lymph node dissection leaving part of the tumor in adjacent organs. Several plastic catheters were fixed to the tumor bed and led to the outside of the thorax for postoperative brachytherapy. Using these catheters, the patients und...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/(SICI)1096-9098(199607)62:3<214::AID-JSO12
更新日期:1996-07-01 00:00:00
abstract::Immunoproliferative small intestinal disease (IPSID), most common in Mediterranean countries, is characterized by lymphomatous infiltration of the small intestine and is usually associated with the synthesis of anomalous immunoglobulin alpha heavy chains. Flow cytometric analysis of DNA content, S phase fraction, and ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930580106
更新日期:1995-01-01 00:00:00
abstract:PURPOSE:Little is known about long-term radiographic findings after treatment with accelerated partial breast irradiation (APBI). METHODS:Univariate and multivariate analysis of factors leading to formation and resolution of seroma were performed in patients treated with lumpectomy and APBI. RESULTS:Post-treatment im...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.24646
更新日期:2017-08-01 00:00:00
abstract:BACKGROUND:Retroperitoneal sarcomas are connective tissue tumors arising in the retroperitoneum. Surgical resection is the mainstay of treatment. Debate has arisen over extent of resection, changes in histological classification/grading, and interest in incorporating radiotherapy. Therefore, we reviewed our institution...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.24256
更新日期:2016-07-01 00:00:00
abstract::A 50-year-old man presented with verrucous carcinoma on the sole of the foot. This unusual tumor, also called an epithelioma cuniculatum plantare, was successfully treated employing wide surgical excision. ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930140407
更新日期:1980-01-01 00:00:00
abstract::Little information is available regarding acute upper gastrointestinal bleeding as a presenting sign of gastric carcinoma. Of 427 patients with gastric cancer, 36 (8.4%) underwent early endoscopy due to hematemesis. The hemorrhage was self-limited in 16 patients (44.4%), most of whom underwent elective surgery. Twenty...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930360212
更新日期:1987-10-01 00:00:00
abstract:BACKGROUND:Retroperitoneal lymphangiomatosis (RL) is a rare form of primary lymphedema featuring aberrant retroperitoneal lymphatic proliferation. It causes recurrent cellulitis, repeated interventions, and poor life quality. This study aimed to investigate proper diagnositc criteria and surgical outcomes for RL with e...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.25514
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Limb salvage is viable in the majority of patients with malignant bone tumors, but especially in case of extensive tumors and bad soft tissue conditions, it is challenging in upper extremity. OBJECTIVES/METHOD:The clinical and radiological results of 21 patients, who had free vascularized fibular grafts (VF...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.20326
更新日期:2006-08-01 00:00:00
abstract::The records of 111 consecutive cases of carcinoma of the breast were reviewed and yielded 66 patients who had undergone liver scanning and determination of the serum alkaline phosphatase (alk p'tase), lactic dehydrogenase (LDH), and serum glutamic oxaloacetic transaminase (SGOT). Four of the 66 patients (6.1%) had a f...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930130313
更新日期:1980-01-01 00:00:00
abstract::We investigated the incidence of thyroid nodules in female uremic patients on maintenance hemodialysis using a high-frequency sonographic scanner. In 47 (21.0%) of the 224 female normal controls and 33 (55.0%) of the 60 female patients, thyroid nodules were detected. The difference in these incidences between controls...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930540405
更新日期:1993-12-01 00:00:00
abstract::The results of treatment with intracavitary bleomycin are reported in twenty patients with a malignant pleural effusion and five patients with malignant ascites. The control rate was 17/20 (85%) patients with malignant pleural effusions and 3/5 (60%) patients with malignant ascites. Toxicities were minimal with fever ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930160312
更新日期:1981-01-01 00:00:00
abstract:INTRODUCTION:Alpha-fetoprotein (AFP) has a valuable role in postoperative surveillance for hepatocellular carcinoma (HCC) recurrence. The utility of pretreatment or baseline AFP remains controversial. The present study hypothesized that elevated baseline AFP levels are associated with worse overall survival in HCC pati...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.24742
更新日期:2017-12-01 00:00:00
abstract:BACKGROUND:Hepatocellular carcinoma (HCC) is one of the most malignant cancers in the world. The effect of preoperative transarterial chemoembolization (TACE) for resectable HCC is still controversial and cost-associated treatments are unknown. METHODS:We retrospectively compared clinical outcomes and resource utiliza...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.21248
更新日期:2009-05-01 00:00:00
abstract::Although the incidence of locally recurrent colorectal cancer has been reduced by improved surgical techniques and the frequent use of multimodality therapy, pelvic recurrence remains a significant problem. Radiation or chemotherapy may provide palliation but it is often short-lived. For fit candidates without evidenc...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.21571
更新日期:2010-06-15 00:00:00
abstract:OBJECTIVE:We investigate the neutrophil to lymphocyte ratio (NLR) as a potential prognostic factor for patients undergoing curative liver resection for colorectal liver metastasis (CRLM). METHODS:We identified patients who underwent liver resection, via our prospectively accumulated surgical database at the Royal Mars...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.23845
更新日期:2015-03-15 00:00:00
abstract:BACKGROUND:Evidence regarding the prognostic value of perineural invasion (PNI) in oral squamous cell carcinoma (OSCC) and whether PNI alone warrants consideration of adjuvant therapy is controversial. We evaluated whether histopathological sub-categorization of PNI improves risk stratification. METHODS:PNI was evalua...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.23821
更新日期:2015-03-01 00:00:00
abstract::Primary lymphoma of bone (PLB) is an uncommon clinical entity and a rare presentation of non-Hodgkin's lymphoma. At the Tata Memorial Hospital, over a period of 10 years from 1976 to 1985, 39 cases with a diagnosis of PLB were seen. Twenty-seven cases completed the prescribed treatment and were evaluable for treatment...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930440408
更新日期:1990-08-01 00:00:00
abstract:BACKGROUND:A prospective randomized controlled trial has established the efficacy of targeted intraoperative radiotherapy (TARGIT) in the management of invasive breast cancer treated with breast-conserving surgery (BCS). The purpose of this analysis is to evaluate the efficacy of TARGIT in the management of ductal carc...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.25347
更新日期:2019-03-01 00:00:00
abstract::We report a patient with a large apocrine hidrocystoma. These tumors are almost always under 10 mm in diameter. In this 40-year-old man the tumor measured 20 mm. Apocrine hidrocystoma must be considered when evaluating a patient with a large cystic lesion of the face. Surgical management is similar to that of other be...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930270304
更新日期:1984-11-01 00:00:00
abstract:OBJECTIVE:To evaluate the patients with invasive cervical cancer found in simple hysterectomy and who were subjected to radical parametrectomy and upper vaginectomy with therapeutic lymphadenectomy. METHODS:Twenty-seven patients who underwent the radical parametrectomy and upper vaginectomy with therapeutic lymphadene...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.20550
更新日期:2006-07-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Malignant cartilage tumors demonstrate chemotherapeutic resistance through undetermined mechanisms. P-glycoprotein is the protein product of the multiple drug resistance gene 1 (MDR-1) and confers multidrug chemotherapeutic resistance in a variety of malignancies. METHODS:MDR-1 expression was...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/(sici)1096-9098(199706)65:2<95::aid-jso5>3
更新日期:1997-06-01 00:00:00
abstract::Twenty-two inflammatory, benign, or malignant parotid lesions were studied by means of the specific red cell adherence test (SRCA), a modification of the Coombs' mixed cell agglutination reaction. In 22 normal parotid tissues the acinar structures were devoid of red cell agglutination, but it was present in ductal epi...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930240306
更新日期:1983-11-01 00:00:00
abstract:BACKGROUND:Adjuvant radiation is rarely used to treat medullary thyroid carcinoma (MTC). We hypothesized that external beam radiation therapy (EBRT) would improve overall survival (OS) in MTC patients. METHODS:The Surveillance, Epidemiology, and End Results (SEER) database identified patients who underwent total thyro...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.21557
更新日期:2010-08-01 00:00:00
abstract::The ability to redefine risk factors and to predict prognosis in patients with malignant melanoma at the time they manifest nodal metastasis can be a benefit to the patient emotionally and to the physician therapeutically. A retrospective review of 1,273 patients with stage II malignant melanoma was performed at our i...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930390302
更新日期:1988-11-01 00:00:00