Abstract:
BACKGROUND AND OBJECTIVES:Malignant cartilage tumors demonstrate chemotherapeutic resistance through undetermined mechanisms. P-glycoprotein is the protein product of the multiple drug resistance gene 1 (MDR-1) and confers multidrug chemotherapeutic resistance in a variety of malignancies. METHODS:MDR-1 expression was examined in 55 benign and malignant cartilage tumor specimens by immunohistochemistry using C219, C494, and JSB-1 antibodies, and by in situ hybridization with an MDR-1 specific oligonucleotide cDNA probe. RESULTS:Constitutive expression of P-glycoprotein was observed in all benign and malignant cartilage tumor specimens with a similar pattern of immunohistochemical staining present with all three antibodies. In benign tumors and low grade chondrosarcomas, the staining pattern was weak to intermediate and localized to clusters of cells. However, higher grade-tumors (Grade II and III) expressed P-glycoprotein in a higher percentage of cells and with more intense staining. P-glycoprotein expression was absent in normal human articular cartilage, but was focally present in costal and growth plate cartilage. The immunohistochemistry results were confirmed by in situ hybridization in 10 cases. CONCLUSIONS:P-glycoprotein is expressed constitutively in cartilaginous tumors, with greatest expression in high grade malignancies. The findings may account for the resistance of cartilage tumors to chemotherapeutic agents.
journal_name
J Surg Oncoljournal_title
Journal of surgical oncologyauthors
Rosier RN,O'Keefe RJ,Teot LA,Fox EJ,Nester TA,Puzas JE,Reynolds PR,Hicks DGdoi
10.1002/(sici)1096-9098(199706)65:2<95::aid-jso5>3subject
Has Abstractpub_date
1997-06-01 00:00:00pages
95-105issue
2eissn
0022-4790issn
1096-9098pii
10.1002/(SICI)1096-9098(199706)65:2<95::AID-JSO5>3journal_volume
65pub_type
杂志文章abstract:BACKGROUND:The choice of performing surgery when tumors encroach onto joints remains a challenging and controversial issue. Pre-operative assessment by magnetic resonance imaging (MRI) is of critical importance in dictating surgical management and subsequent functional outcome. METHODS:We examined archival samples fro...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.20268
更新日期:2005-09-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:The diagnosis of invasive breast cancer is most commonly made on image-guided core biopsy (CB). The presence of extensive intraductal component (EIC), as identified on subsequent lumpectomy, is associated with an increased risk of positive margins and need for further surgery. CBs demonstratin...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.20242
更新日期:2005-05-01 00:00:00
abstract:BACKGROUND:The aim of this study is to describe the influence of geography, socio-economic development, and demographic shift on the trends in global incidence, mortality, and prevalence of liver cancer (LC). METHODS:Data (2012-2030) relating to LC and demographic shifts based on WHO regions and HDI areas were extract...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.24518
更新日期:2017-04-01 00:00:00
abstract::A patient-specific 3-dimensional printed model (3DPM) of a woman with breast cancer was created. Mastectomy was favored as BCS would necessitate significant breast size alteration due to the extent of disease. After review of the 3D printed model, the patient and surgeon agreed on breast-conserving surgery. Use of pat...
journal_title:Journal of surgical oncology
pub_type:
doi:10.1002/jso.25680
更新日期:2019-11-01 00:00:00
abstract:BACKGROUND:In patients undergoing total mesorectal excision (TME), the clinical variables most relevant to anastomotic recurrence have not been identified. We evaluated factors associated with anastomotic recurrence in patients undergoing TME and the impact of a reduced distal margin on anastomotic recurrence. METHODS...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.21166
更新日期:2009-01-01 00:00:00
abstract::Of 134 patients with thymoma, 79 (59%) also had myasthenia gravis (MG). The thymoma with MG differed from that in the absence of MG in the following aspects: The ratio of lymphocytes to epithelial cells in the tumor was larger, the polygonal cell type was more prominent (i.e., in 83% of the MG patients this cell type ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930380305
更新日期:1988-07-01 00:00:00
abstract:BACKGROUND:Retroperitoneal lymphangiomatosis (RL) is a rare form of primary lymphedema featuring aberrant retroperitoneal lymphatic proliferation. It causes recurrent cellulitis, repeated interventions, and poor life quality. This study aimed to investigate proper diagnositc criteria and surgical outcomes for RL with e...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.25514
更新日期:2020-01-01 00:00:00
abstract::Immunoproliferative small intestinal disease (IPSID), most common in Mediterranean countries, is characterized by lymphomatous infiltration of the small intestine and is usually associated with the synthesis of anomalous immunoglobulin alpha heavy chains. Flow cytometric analysis of DNA content, S phase fraction, and ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930580106
更新日期:1995-01-01 00:00:00
abstract::Intraperitoneal (IP) cisplatin administered at the time of intraabdominal malignancies such as gastric cancer may prevent or delay intraabdominal recurrence. Perioperative IP cisplatin raises concerns regarding systemic toxicity and retardation of wound healing. Systemic cisplatin toxicity may be reduced by administer...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930520415
更新日期:1993-04-01 00:00:00
abstract:BACKGROUND:Esophageal anastomotic leak is associated with high morbidity and mortality and potentially lethal if not recognized promptly and treated aggressively. While many studies have attempted to delineate the surgical techniques associated with lower rates of anastomotic leak, few have attempted to determine its l...
journal_title:Journal of surgical oncology
pub_type: 临床试验,杂志文章
doi:10.1002/jso.23902
更新日期:2015-06-01 00:00:00
abstract:BACKGROUND:Receptor-binding cancer antigen expressed on SiSO cells (RCAS1) has been reported to act as a ligand for a receptor present on normal peripheral lymphocytes and to induce apoptotic cell death. We aimed to elucidate the significance of RCAS1 expression in human esophageal squamous cell carcinomas (ESCC). MET...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.20249
更新日期:2005-05-01 00:00:00
abstract::A poorly differentiated transitional cell carcinoma in C3H/He mice results from the oral ingestion of the urinary tract carcinogen FANFT. This model, designated MBT2, is readily transplantable into syngeneic animals and has proven to be very useful in the development of chemotherapy. Prior to the use of this model for...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930240113
更新日期:1983-09-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:It has been estimated that approximately 5% of middle and low rectal adenocarcinomas are amenable to local therapy. However, these treatment modalities are limited by their failure to identify and treat regional nodal metastases. METHODS:This study was undertaken to evaluate the role of tumor...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/(sici)1096-9098(199802)67:2<99::aid-jso5>3
更新日期:1998-02-01 00:00:00
abstract:INTRODUCTION:Patients with Stage IV melanoma have limited therapeutic options with few long-term survivors. Our goal was to study the impact of metastasectomy on survival in these patients. METHODS:Patients with Stage IV melanoma were identified from the Surveillance, Epidemiology, and End Results (SEER) database (198...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.21903
更新日期:2011-08-01 00:00:00
abstract:BACKGROUND:Reconstruction after excision of the humeral malignancy is a challenging issue for the reconstructive surgeon. The combined use of a fibular flap and allograft can provide a reliable reconstructive option. This article describes the authors' experience with this technique for the treatment of segmental bone ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.21922
更新日期:2011-09-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Two staged tissue expander-implant with acellular dermal matrix (TE/I + ADM) and deep inferior epigastric perforator (DIEP) flap are the most common implant and autologous methods of reconstruction in the U.S. Implant-based techniques are disproportionally more popular, partially due to its pr...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.24692
更新日期:2017-09-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Interleukin (IL)-1α and hepatocyte growth factor (HGF) play an important role in pancreatic cancer proliferation, angiogenesis, and invasiveness. The aim of this study was to investigate the cooperative role of HGF and IL-1α in metastatic processes promoted by interactions between pancreatic c...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.21530
更新日期:2010-10-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:The study of pathology and prognosis for patients with ovarian tumors of low malignant potential (LMP) has been well documented. The treatment, particularly the secondary surgery, for recurrent disease is less documented. This study was conducted to investigate the role of secondary surgical c...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.20280
更新日期:2005-07-01 00:00:00
abstract:BACKGROUND:Scoring systems were developed to stratify patients with colorectal liver metastases considered for liver resection into different risk groups. Such scores have never been evaluated in recurrent liver metastases. The aim of this study was to evaluate whether these scores are applicable to patients with recur...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.24959
更新日期:2018-05-01 00:00:00
abstract::To gauge the impact of screening mammography and opinions regarding surgical procedures on the pattern of primary surgical care of breast cancer, tumor registry statistics from 1980-81 were compared to those from 1987 at a large community hospital. Over the course of six years, there was a significant increase in the ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930450104
更新日期:1990-09-01 00:00:00
abstract::Early postoperative intraperitoneal chemotherapy (EPIC) and intraoperative peritoneal hypertermic chemotherapy (IPHC) are used in addition with cytoreductive surgery to treat with curative intent peritoneal carcinomatosis arising from colorectal adenocarcinomas. Three patients with such a disease were treated with per...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.20267
更新日期:2005-07-01 00:00:00
abstract::Wilms' tumor, renal cell carcinoma, and neuroblastoma in animals were transplanted from donors to recipients with strong histocompatibility differences. No strong evidence of the privileged site theory was found in this study and no obvious evidence of an immunosuppressive effect of testosterone was found. The most im...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930140111
更新日期:1980-01-01 00:00:00
abstract:OBJECTIVES:To document radical cystectomy (RC) outcomes in patients over 80 years old across Quebec during the years 2000-2009 and to examine potentially related factors. METHODS:Within Quebec health insurance medical services database, we identified patients over 80 years who underwent RC. The outcomes analyzed were ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.23887
更新日期:2015-06-01 00:00:00
abstract:BACKGROUND:An increasing proportion of patients are presenting with colorectal cancer at an early age. A proportion of these occur with genetic syndromes; however the majority present as sporadic. The purpose of this study is to investigate the prognosis and treatment of young patients with sporadic metastatic colorect...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.24181
更新日期:2016-04-01 00:00:00
abstract::Surgical procedures for breast cancer were compared in 468 cases with in-situ and 4,967 cases with invasive lesions. The cases were obtained from the Michigan Cancer Foundation Registry, a Surveillance, Epidemiology, and End Results (SEER) participant, and were incident-resident cases diagnosed from 1973-1978. For sin...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930200207
更新日期:1982-06-01 00:00:00
abstract::The tumor registry of a community hospital has been reviewed, and 60 patients with untreated colon and rectal cancer have been identified. Thirty-four patients were black and 26 patients were white. Sixty-five percent of black patients had specified colonic lesions primarily distributed in the right colon and proximal...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930290314
更新日期:1985-07-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:The aim of this study was to analyze the stage migration and survival of endometrial cancer by the revised FIGO 2008 staging system compared with the 1988 staging system. METHODS:A total of 355 patients with endometrial cancer, who underwent complete surgical staging, were enrolled. We compar...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.23203
更新日期:2012-12-01 00:00:00
abstract:OBJECTIVE:Significant controversy exists concerning the factors affecting survival after secondary cytoreduction (SCR) in recurrent ovarian cancer. This study aims to identify factors independently associated with survival after SCR. METHODS:We retrospectively retrieved 39 patients with recurrent ovarian cancer. All p...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.21686
更新日期:2010-11-01 00:00:00
abstract:BACKGROUND:The optimal approach to biliary drainage for patients with supra-ampullary cholangiocarcinoma remains undetermined. Violation of sphincter of Oddi results in bacterial colonization of bile ducts and may increase postdrainage infectious complications. We sought to determine if rates of cholangitis are affecte...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.25485
更新日期:2019-08-01 00:00:00
abstract:BACKGROUND:Identification of functional lymphatic vessels and localization of lymphatic vessels are important for lymphaticovenular anastomosis (LVA). Indocyanine green (ICG) lymphography is useful for localization of superficial lymphatic vessels where dermal backflow is not observed, but not for lymphatic vessels in ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.24812
更新日期:2018-02-01 00:00:00