Characteristics of rectal carcinomas that predict the presence of lymph node metastases: implications for patient selection for local therapy.

Abstract:

BACKGROUND AND OBJECTIVES:It has been estimated that approximately 5% of middle and low rectal adenocarcinomas are amenable to local therapy. However, these treatment modalities are limited by their failure to identify and treat regional nodal metastases. METHODS:This study was undertaken to evaluate the role of tumor size, depth of penetration into the rectal wall, degree of histologic differentiation, DNA ploidy status, and their combination on the presence or absence of metastases in perirectal lymph nodes. Logistic regression was used to quantitatively predict the probability of positive lymph nodes. RESULTS:Tumor size did not correlate with the presence of nodal involvement; however, worsening degree of differentiation, increasing depth of wall penetration and aneuploidy did statistically correlate with the presence of nodal metastases. For any combination of tumor traits, aneuploidy markedly increased the probability of positive lymph nodes over that observed with diploid tumors. CONCLUSIONS:The combination of degree of differentiation, depth of penetration, and ploidy status may be used to identify patients whose tumors may be adequately treated with local measures. For any combination of tumor traits, aneuploidy markedly increased the probability of positive lymph nodes over that observed with diploid tumors.

journal_name

J Surg Oncol

authors

Zenni GC,Abraham K,Harford FJ,Potocki DM,Herman C,Dobrin PB

doi

10.1002/(sici)1096-9098(199802)67:2<99::aid-jso5>3

subject

Has Abstract

pub_date

1998-02-01 00:00:00

pages

99-103

issue

2

eissn

0022-4790

issn

1096-9098

pii

10.1002/(SICI)1096-9098(199802)67:2<99::AID-JSO5>3

journal_volume

67

pub_type

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