Antibiotic prophylaxis for prevention of wound infections after soft tissue sarcoma resection: A retrospective cohort study.

Abstract:

BACKGROUND AND OBJECTIVES:The use of antibiotic prophylaxis for soft tissue sarcoma resection varies widely while little evidence on this topic exists. The aim of this study was to determine the impact of antibiotic prophylaxis on the occurrence of wound infections. METHODS:A single institutional retrospective cohort study was performed on patients who underwent truncal or extremity soft tissue sarcoma resection. The use of antibiotic prophylaxis was assessed and univariate and multivariate analysis of predictors of wound infections was performed. RESULTS:Nine hundred and fifty-eight patients could be included. Thirty-two percent of patients had no antibiotic prophylaxis, 44% of patients received single-shot prophylaxis, and 24% of patients received single-shot plus continued antibiotic treatment. Wound infections occurred in 140 patients (15%). Independent risk factors for wound infections upon multivariate analysis were obesity, high American Society of Anesthesiologists (ASA) status, high tumor size and grade, operation time over 120 minutes, and other complications. Antibiotic prophylaxis could not be identified as a protective factor in univariate or multivariate analysis. CONCLUSIONS:A favorable effect of antibiotic prophylaxis on the occurrence of wound infections could not be observed. Although more studies on this subject are needed, our data do not support the general use of antibiotic prophylaxis for soft tissue sarcoma resection.

journal_name

J Surg Oncol

authors

Dadras M,Koepp P,Wagner JM,Wallner C,Sogorski A,Lehnhardt M,Harati K,Behr B

doi

10.1002/jso.26188

subject

Has Abstract

pub_date

2020-12-01 00:00:00

pages

1685-1692

issue

8

eissn

0022-4790

issn

1096-9098

journal_volume

122

pub_type

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