Adjuvant external beam radiation for medullary thyroid carcinoma.

Abstract:

BACKGROUND:Adjuvant radiation is rarely used to treat medullary thyroid carcinoma (MTC). We hypothesized that external beam radiation therapy (EBRT) would improve overall survival (OS) in MTC patients. METHODS:The Surveillance, Epidemiology, and End Results (SEER) database identified patients who underwent total thyroidectomy and lymph nodes excision for MTC between 1988 and 2004. The Kaplan-Meier method was used for univariate comparisons of OS. Multivariate Cox proportional hazards models controlled for gender, age, lymph node status, tumor size, extent of disease, and EBRT. RESULTS:After 12 years, EBRT did not significantly improve OS (log rank, P < 0.14). In node-positive patients, univariate analysis demonstrated an OS benefit with EBRT (log rank, P < 0.05). In a multivariate model of node-positive patients, only increasing age (P < 0.001) and tumor size (P < 0.001) significantly influenced OS. CONCLUSIONS:The OS benefit attributed to EBRT in node-positive patients by univariate analysis could not be duplicated when controlling for known prognostic factors.

journal_name

J Surg Oncol

authors

Martinez SR,Beal SH,Chen A,Chen SL,Schneider PD

doi

10.1002/jso.21557

subject

Has Abstract

pub_date

2010-08-01 00:00:00

pages

175-8

issue

2

eissn

0022-4790

issn

1096-9098

journal_volume

102

pub_type

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