Abstract:
BACKGROUND:Extrapleural pneumonectomy for malignant pleural mesothelioma is considered an aggressive procedure, but symptomatic and quality of life changes are unknown. METHODS:Between 1997 and 2004, 16 consecutive patients underwent extrapleural pneumonectomy for mesothelioma followed by chemo-radiotherapy. Tumor-related symptoms and quality of life (Short-Form-36 and St. George's questionnaires) were assessed pre, 3, 6, 12, and 24 months postoperatively. RESULTS:Thirty-day postoperative major morbidity was 31% with no mortality. At 3 months postoperatively, dyspnea improved in 10 patients (62%), pain in 12 (75%), cough in 10 (62%), fever in 11 (68%), Karnofsky-index in 10 (62%), Short-Form-36 physical-component-summary in 8, mental-component-summary in 5 and total St. George score in 8 (50%). At 1 year 10 (62%) patients were alive and majority of improved parameters were still stable. Thereafter they usually started to decline. Survival was influenced by nonepithelial histology (P < 0.01) and N2-disease (P < 0.01), which showed to be the only prognosticator at Cox regression (P < 0.0001, Odd ratio 5.4). Among symptomatic variables, a 3-month postoperative Short-Form-36 physical-component-summary above the median value correlated significantly with a better prognosis (P < 0.02). CONCLUSIONS:Extrapleural pneumonectomy may rapidly improve symptoms as well as quality of life, especially in physical domains. Other than biological factors, postoperative Short-Form-36 physical component as well, significantly influenced the prognosis.
journal_name
J Surg Oncoljournal_title
Journal of surgical oncologyauthors
Ambrogi V,Mineo D,Gatti A,Pompeo E,Mineo TCdoi
10.1002/jso.21261subject
Has Abstractpub_date
2009-09-01 00:00:00pages
199-204issue
3eissn
0022-4790issn
1096-9098journal_volume
100pub_type
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journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930110309
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journal_title:Journal of surgical oncology
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journal_title:Journal of surgical oncology
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journal_title:Journal of surgical oncology
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journal_title:Journal of surgical oncology
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journal_title:Journal of surgical oncology
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journal_title:Journal of surgical oncology
pub_type: 杂志文章
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更新日期:1983-08-01 00:00:00
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journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930570312
更新日期:1994-11-01 00:00:00
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journal_title:Journal of surgical oncology
pub_type: 杂志文章
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更新日期:1987-02-01 00:00:00
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journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930540316
更新日期:1993-11-01 00:00:00
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journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.23151
更新日期:2012-12-01 00:00:00
abstract::The results of treatment of 106 consecutive nephrectomized cases with metastatic renal adenocarcinoma were analyzed. Over 50% of the patients were dead at 1 year and more than 80% at 2 years from the first metastases. The corresponding 5-year survival rate was 7.3%. Fourteen patients demonstrated a response to radioth...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930260213
更新日期:1984-06-01 00:00:00
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journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930430106
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journal_title:Journal of surgical oncology
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更新日期:2021-01-01 00:00:00
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journal_title:Journal of surgical oncology
pub_type: 杂志文章,多中心研究
doi:10.1002/jso.25669
更新日期:2019-11-01 00:00:00
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journal_title:Journal of surgical oncology
pub_type: 杂志文章
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journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/(sici)1096-9098(199810)69:2<83::aid-jso7>3
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更新日期:2018-06-01 00:00:00
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pub_type: 杂志文章,meta分析
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更新日期:2011-11-01 00:00:00
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journal_title:Journal of surgical oncology
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pub_type: 杂志文章,评审
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更新日期:2011-03-15 00:00:00