Abstract:
BACKGROUND:Giant cell tumor of bone (GCTB) is an aggressive benign bone tumor with poor prognosis whose neoplastic component is stromal cells (SCs). Tumor stem-like cells (TSCs) have been demonstrated as precursors for tumor genesis and growth. The aim of this study is to identify TSCs in GCTB. METHODS:Stro-1(+) and Stro-1(-) cells were isolated by fluorescence-activated cell sorting (FACS). Stem-like properties of both Stro-1(+) and Stro-1(-) subpopulations were assessed using MTT colorimetric assays, cell cycle analyses, sphere formation assays, and differentiation assays. Molecular profiles were analyzed by flow cytometry, immunofluorescence, and qRT-PCR. RESULTS:The existence of rare Stro-1(+) cells was confirmed in vitro using FACS and in vivo by immunohistochemistry. These Stro-1(+) cells exhibited higher proliferative and cisplatin-resistant potentials than Stro-1(-) cells. In serum-free suspension cultures, Stro-1(+) SCs could form cell spheres and maintain self-renewal. Furthermore, Stro-1(+) SCs could differentiate into two mesenchymal lineage cells: osteoblasts and adipocytes. Cell surface markers CD44, CD117, and CD133 and stem cell-associated genes OCT3/4, NANOG, and ABCG2 were significantly higher in the Stro-1(+) subpopulation. CONCLUSIONS:This study demonstrates that Stro-1(+) SCs in GCTB possess stem-like biological and molecular phenotypes, indicating that they are the TSCs of GCTB.
journal_name
J Surg Oncoljournal_title
Journal of surgical oncologyauthors
Lan J,Liu X,Rong W,Wei F,Jiang L,Yu H,Dang G,Liu Zdoi
10.1002/jso.23151subject
Has Abstractpub_date
2012-12-01 00:00:00pages
826-36issue
7eissn
0022-4790issn
1096-9098journal_volume
106pub_type
杂志文章abstract::Twenty gastrointestinal lipomata in 18 patients are reviewed: 15 located in the colon, 3 in the distal ileum, one in the duodenum, and one in the stomach. They were found most frequently in European-born, elderly women and presented with variable abdominal symptomatology. Four lipomata were removed during endoscopy, t...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930470307
更新日期:1991-07-01 00:00:00
abstract::A new combined cancer chemotherapy regimen of mitomycin C (MMC) and cisplatin (DDP) showed synergistic antitumor activity against human gastric cancer xenografts St-40 and SC-1-NU in BALB/c nu/nu mice. The drugs were administered intraperitoneally at doses of 2 or 4 mg/kg for MMC and 3 or 6 mg/kg for DDP, respectively...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930560408
更新日期:1994-08-01 00:00:00
abstract::The growth of knowledge and complexity now seen in General Surgery, has led to the sub-specialization of the discipline. Although it is considered by some to have led to the fragmentation of General Surgery and the erosion of the specialty as we know it today, others would argue that it has and will continue to lead t...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.20176
更新日期:2005-03-01 00:00:00
abstract::The purpose of this study was to test the hypotheses that (1) surgical wounding can enhance the xenotransplantability of a human soft tissue sarcoma (HSTS26T) into subcutaneous (s.c.) tissue of nude mice, and (2) Indomethacin may reduce the xenotransplantability of this human tumor in the surgical wounding animal mode...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930580412
更新日期:1995-04-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Tumor thickness is considered the single most important predictor of survival in clinically localized malignant melanoma. A recent study found tumor volume a more sensitive predictor of survival than thickness. Volume measurement, however, is complicated, time consuming, and based on biologica...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/(sici)1096-9098(199810)69:2<83::aid-jso7>3
更新日期:1998-10-01 00:00:00
abstract::Up to 50% of patients with colorectal cancer will develop metastatic disease in the liver. While surgical extirpation remains the best option for long-term survival, several complementary modalities such as laparoscopy, radiofrequency ablation, and microwave coagulation have gained wide acceptance as primary and adjun...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.21720
更新日期:2010-12-15 00:00:00
abstract:INTRODUCTION:Patients with Stage IV melanoma have limited therapeutic options with few long-term survivors. Our goal was to study the impact of metastasectomy on survival in these patients. METHODS:Patients with Stage IV melanoma were identified from the Surveillance, Epidemiology, and End Results (SEER) database (198...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.21903
更新日期:2011-08-01 00:00:00
abstract::Tumor-associated antigen(s) from a specimen of human malignant melanoma and from spent culture medium of a melanoma cell line were extracted and purified. The incidence of antibody activity to these antigens, in sera from cancer patients with neoplasms of various histologic types, was higher (65--83%) than normal dono...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930130112
更新日期:1980-01-01 00:00:00
abstract::A comparative study of breast cancer was made among black and white populations admitted to two inner-city hospitals from 1971 through 1976, inclusive. There were 306 patients in the study group of which 162 were black and 144 were white. Age, sex, color, duration of illness, different quadrants of breast involved, st...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930150104
更新日期:1980-01-01 00:00:00
abstract::The effectiveness of MFC (mitomycin C, 5-fluorouracil and cytosine arabinoside) therapy for nonresectable cancers and cancers recurring after surgery was investigated in 60 patients with solid cancers aged 26 to 69 years. Treatment was effective in 28 patients (47%) including seven (12%) who showed a very good respons...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930100507
更新日期:1978-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:The reported risk of nodal metastasis in hard palate and upper gingival squamous cell carcinoma (SCC) has been inconsistent with inadequate consensus regarding the utility of neck dissection in the clinically negative (cN0) neck. MATERIALS AND METHODS:Using the National Cancer Database, cN0 p...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.25706
更新日期:2019-12-01 00:00:00
abstract::Inflammatory carcinoma of the breast is rare and lethal. Since the early 1940s, operation except for biopsy has been contraindicated in patients with inflammatory breast cancer. Results with radiotherapy alone and with radiotherapy and chemotherapy are reviewed. Results of treating patients with initial chemotherapy a...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930230408
更新日期:1983-08-01 00:00:00
abstract:PURPOSE:To describe venous thromboembolism (VTE) rates in patients with pancreatic cancer (PC) during neoadjuvant therapy. METHODS:Factors associated with VTE were evaluated using multivariable logistic regression modeling in patients with resectable and BLR PC treated with neoadjuvant therapy between 2009 and 2014. ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.24361
更新日期:2016-10-01 00:00:00
abstract::Treatment of gastric cancer has evolved with the advent of randomized trials demonstrating chemotherapeutic agents with efficacy in advanced disease. Level I evidence supports delivering chemotherapy in the neoadjuvant setting; the data shows improvement in progression-free and overall survival. A clinical response to...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.21483
更新日期:2010-03-15 00:00:00
abstract:BACKGROUND AND METHOD:The association between margin width and ipsilateral breast tumour recurrence (IBTR, defined as invasive recurrence) was investigated in a population-based nationwide cohort of 11,900 patients undergoing breast-conserving therapy for invasive cancer. RESULTS:The median follow-up was 4.9 years. Th...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.24224
更新日期:2016-05-01 00:00:00
abstract::The records of 30 patients with primary gastric lymphoma and a minimum of 5 years of follow-up were reviewed and clinical and pathologic prognostic factors analyzed. The overall 5-year survival was 40% (median 23 months). No significant relationship between surgical and patient age, sex, duration of symptoms, macrosco...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930540306
更新日期:1993-11-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) can offer long-term survival to patients with resectable peritoneal metastasis (PM) from colorectal cancer (CRC), a condition with otherwise dismal prognosis. This study describes short- and long-term outcome in ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.24290
更新日期:2016-08-01 00:00:00
abstract:OBJECTIVES:We reviewed the clinical characteristics and outcomes of patients treated for alveolar soft part sarcoma (ASPS) and analyzed the effect of surgery for patients presenting with and without metastatic disease (DM). METHODS:The SEER Registry was queried for patients with ASPS from 1973-2012. The Kaplan-Meier e...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.24183
更新日期:2016-04-01 00:00:00
abstract::The Author describes criteria for selection of patients who might be eligible for entry into a clinical trial of definitive Radiation Therapy for adenocarcinoma of the pancreas. Most emphasis is placed on careful surgical staging, target volume and location, and the use of bypass procedures when appropriate. ...
journal_title:Journal of surgical oncology
pub_type: 临床试验,杂志文章
doi:10.1002/jso.2930070208
更新日期:1975-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:The aim of this study was to evaluate the expression and prognostic roles of human ether à go-go related gene (hERG1) potassium channels in resected esophageal squamous cell carcinoma. METHODS:Expression of hERG1 protein and mRNA was detected by immunohistochemistry and reverse transcription ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.20891
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:A person-centered approach to co-decision-making using tailored information respects each woman's preferences and may heighten breast reconstruction satisfaction. METHODS:Women seeking breast reconstruction underwent initial and follow-up consultations wherein suitable options were discussed, and take-away ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.23721
更新日期:2014-12-01 00:00:00
abstract::Australia has the world's highest incidence of skin cancer. Despite excellent prevention and early diagnosis education programs and an increasing percentage of the population with darker and more UV tolerant skins, skin cancer remains a major and expensive community medical problem. However, primary and secondary prev...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.20086
更新日期:2004-07-01 00:00:00
abstract:PURPOSE:To present the clinical data of 35 patients with T3 unresectable hepatocellular carcinoma (HCC) that were treated with (90)Y with the specific intent of downstaging to resection, radiofrequency ablation (RFA) candidate, United Network for Organ Sharing (UNOS) stage T2 or liver transplantation. MATERIALS AND ME...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.20609
更新日期:2006-12-01 00:00:00
abstract:BACKGROUND:It was observed that new presentations of anaplastic carcinoma of the thyroid had become infrequent in the last two decades. METHODS:All cases of thyroid cancer seen at our centre between 1969-1993 (n = 2921) were classified as papillary 49%, follicular 34%, medullary 7.5%, anaplastic 4.7%, and other 4.8%. ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/(SICI)1096-9098(199612)63:4<251::AID-JSO7>
更新日期:1996-12-01 00:00:00
abstract::A transplantable mammary adenocarcinoma, grown in Balb/c mice, with a marked enhancement in its draining lymph node metastatic ability (MM3LN), was obtained through an in vivo procedure from a variant tumor moderately metastatic to lymph nodes (MM3). Both MM3 and MM3LN presented a similar latency and tumor growth rate...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930450312
更新日期:1990-11-01 00:00:00
abstract::566 stage-II melanoma patients treated at the National Cancer Institute of Milan, Italy, were analyzed to evaluate the prognosis. Among the criteria considered, four were significantly associated with survival when considered as single factors: growth pattern, levels of invasion, the number of involved lymph nodes, an...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930250404
更新日期:1984-04-01 00:00:00
abstract::Patients undergoing neoadjuvant therapy for esophageal cancer are at a high risk for malnutrition due to the effects of chemoradiation, dysphagia, and malignancy induced cachexia. Preparation for esophagectomy requires careful assessment of nutritional risk and adequate supplementation as indicated. Supplementation vi...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.21289
更新日期:2009-07-01 00:00:00
abstract::In settings when it is biologically plausible that some patients are cured after definitive treatment, cure models present an alternative to conventional survival analysis. Cure models can inform on the group of patients cured, by estimating the probability of cure, and identifying factors that influence it; while sim...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.23411
更新日期:2013-11-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Data on outcomes after liver-directed therapy for intrahepatic cholangiocarcinoma (ICC) are limited due to the rarity of the disease. We sought to define overall utilization and temporal trends of liver-directed therapy for ICC. METHODS:We identified 5,388 patients with ICC using the Surveill...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.23605
更新日期:2014-08-01 00:00:00
abstract::A new simplified system for updating a cancer registry has been developed in the Biostatistics Department of Roswell Park Memorial Institute. It was designed to serve the needs of maintaining a registry for a cooperative cancer research group. The Data-Update Procedure at a Remote Terminal (DUPART) system has general ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930070508
更新日期:1975-01-01 00:00:00