Abstract:
:The purpose of this study was to test the hypotheses that (1) surgical wounding can enhance the xenotransplantability of a human soft tissue sarcoma (HSTS26T) into subcutaneous (s.c.) tissue of nude mice, and (2) Indomethacin may reduce the xenotransplantability of this human tumor in the surgical wounding animal model by suppressing angiogenesis. The experimental method was to employ the quantitative transplantation assays (TD50, the number of tumor cells that, on average, would be expected to induce a tumor in 50% of the recipients). After an incisional wound (1.0-1.2 cm long) was made on the right leg of each experimental mouse, tumor cells were inoculated into the surgical wound, or into the contralateral leg at 24 and 72 hr postincision, and in another group tumor cells were inoculated into the wound at 72 hr postincision, plus daily s.c. injection of indomethacin, 2 mg/kg body weight for 8 consecutive days in a separate experiment. Nonincisional mice received the same inoculation as the control groups. The TD50s of surgically wounded groups were 3.5-10.7 times lower than that of the control groups. Significantly lower TD50 values were found in groups of cells inoculated into the surgical wound at 72 hr postincision (P < 0.05 or P < 0.01) and into the contralateral leg at 24 hr postincision (P = 0.05). No significant difference was found between the TD50 values in mice that received cells inoculated at 72 hr postincision plus indomethacin treatment, and those with no wound controls. Our conclusion is that the surgical wound can enhance the xenotransplantability of HSTS26T in nude mice. Indomethacin can decrease this enhancing effect level similar to that in no-wound controls and may prevent tumor recurrence in a surgical wound.
journal_name
J Surg Oncoljournal_title
Journal of surgical oncologyauthors
Huang P,Allam A,Taghian A,Ruka W,Freeman J,Duffy M,Suit HDdoi
10.1002/jso.2930580412subject
Has Abstractpub_date
1995-04-01 00:00:00pages
257-62issue
4eissn
0022-4790issn
1096-9098journal_volume
58pub_type
杂志文章abstract::A 57-year-old man first noted tender subcutaneous nodules on his extremities and abdomen. Six months later symptoms of insulin hypersecretion became evident and hyperinsulinemia was documented. An exploratory laparotomy revealed an islet cell tumor measuring 12 cm in diameter extending anteriorly from head of the panc...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930160402
更新日期:1981-01-01 00:00:00
abstract:BACKGROUND:After resection of colorectal liver metastases (CRLM), recurrent disease in the liver is a major cause of death but may be reduced with the addition of adjuvant hepatic arterial infusion (HAI) chemotherapy to systemic chemotherapy (SYS). OBJECTIVE:This study investigates organ-specific causes of death in pa...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.25916
更新日期:2020-06-01 00:00:00
abstract::566 stage-II melanoma patients treated at the National Cancer Institute of Milan, Italy, were analyzed to evaluate the prognosis. Among the criteria considered, four were significantly associated with survival when considered as single factors: growth pattern, levels of invasion, the number of involved lymph nodes, an...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930250404
更新日期:1984-04-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Lymphedema is a condition of localized fluid retention and tissue swelling caused by a compromised lymphatic system. Lymphaticovenular anastomoses (LVA) and multiple lymphatic-venous anastomoses (MLVAs) have been recognized as efficient methods to treat chronic lymphedema. Because few models f...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.25234
更新日期:2018-11-01 00:00:00
abstract::A jaundiced patient due to inoperable bile duct carcinoma was treated by a combination of surgery, radiotherapy, and chemotherapy. At the operation an intra-abdominal, extra-choledochal bypass of the tumor was performed with a T-tube obstruction 10 months after diagnosis, and no evidence of malignancy was seen. The T-...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930130308
更新日期:1980-01-01 00:00:00
abstract::The T N M staging system created by a surgeon in the 1950s continues to be a major benchmark for assessing long-term outcomes in adult solid tumors. Although several major changes have occurred in this anatomical staging system, the tenets of TNM staging remain constant. Recently molecular markers and biologic modifie...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.23704
更新日期:2014-10-01 00:00:00
abstract::Sentinel lymph node (sN) biopsy has gained special attention among surgical and medical oncologists as it represents an accepted technique for detecting occult nodal disease in regional lymph nodes of patients with melanoma and breast cancer. The histopathologic examination of the sN may well predict regional lymph no...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.20031
更新日期:2004-03-01 00:00:00
abstract:BACKGROUND:Long term patient-reported symptoms and quality of life (QOL) are important outcome metrics following cancer operations, but have been poorly described in patients who have previously undergone pancreatectomy. METHODS:We conducted a cross-sectional survey of recurrence-free survivors of pancreatic ductal ad...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.24499
更新日期:2017-02-01 00:00:00
abstract:BACKGROUND:The aim of this study was to investigate the effect of age on CAL and its associated mortality. METHODS:Data were derived from the Dutch ColoRectal Audit. All patients undergoing resection for colorectal cancer in the Netherlands between January 2011 and December 2016 were included. Univariable and multivar...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.25108
更新日期:2018-07-01 00:00:00
abstract::Laparoscopic resection of colon cancer became mired in controversy when it appeared that the technique might be associated with an increased risk of tumor recurrence within the surgical incisions. This was not a uniform finding among all surgeons, however, and other evidence suggested that this did not occur in experi...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.20921
更新日期:2007-12-15 00:00:00
abstract::Prophylactic intravesical chemotherapy (IVC) reduces recurrence rates of superficial transitional cell carcinoma (TCC) of the urinary bladder. The patient cohort existed of 86 individuals (stage TaN0M0 or T1N0M0) superficial carcinoma of various grades of malignancy. Following initial transuretheral resection or diagn...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930600310
更新日期:1995-11-01 00:00:00
abstract:BACKGROUND:Fine-needle aspiration biopsy (FNAB) is an emerging technique for diagnosis of bone and soft tissue lesions. While multiple studies have demonstrated efficacy, cost-effectiveness, and convenience, none have attempted to determine if the modality leads to an increased rate of local recurrence. Our objective w...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.21552
更新日期:2010-06-01 00:00:00
abstract:BACKGROUND:Subtotal stomach preserving pancreaticoduodenectomy (SSPPD) is compared retrospectively with pylorus preserving pancreaticoduodenectomy (PPPD). METHODS:During 2002-2005, 21 patients (13 female, 8 male) underwent SSPPD. The mean age was 64.3 (range 33-80). PPPD was performed for 12 patients after 1999. Days ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.20608
更新日期:2007-02-01 00:00:00
abstract:BACKGROUND:Studies for patients with pelvic chondrosarcomas are limited. This study determines the outcome of patients with pelvic chondrosarcomas, and whether there is any association with tumors' grade, type, stage, margins and pelvic location. MATERIALS AND METHODS:We retrospectively studied 215 patients with pelvi...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.23351
更新日期:2013-07-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:The aim of this study was to investigate the potential role of indocyanine green (ICG) fluorescence imaging after intraoperative intravenous (IV) injection for the "ex vivo" detection of metastatic lymph nodes (mLNs) of colorectal cancer origin. METHODS:Fresh-fixed LNs in cassettes and/or par...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.24318
更新日期:2016-09-01 00:00:00
abstract::A case of qualitative platelet dysfunction following cancer chemotherapy is documented. Besides the numerical reduction defect, there appear to be functional changes in the platelets leading to bleeding diathesis. The present case was thoroughly evaluated, and it was observed that there is suppression of the platelet ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930250308
更新日期:1984-03-01 00:00:00
abstract::Fibronectin (FN) was investigated in 75 stroma from lung adenocarcinoma patients. Distribution of FN was classified into three patterns based on immunohistochemical evidence: dense, moderate, and sparse distribution. The incidence of the sparse pattern in both stage I and stage III disease was significantly greater in...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930430208
更新日期:1990-02-01 00:00:00
abstract::Australia has the world's highest incidence of skin cancer. Despite excellent prevention and early diagnosis education programs and an increasing percentage of the population with darker and more UV tolerant skins, skin cancer remains a major and expensive community medical problem. However, primary and secondary prev...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.20086
更新日期:2004-07-01 00:00:00
abstract::Thirty-eight cases of advanced upper gastrointestinal cancer were assessed for their immune status prior to any form of therapy. Cell-mediated immunity, as tested by absolute lymphocyte count, T-cell count and delayed cutaneous hypersensitivity reactions to purified protein derivative and phytohemagglutinin showed sev...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930290113
更新日期:1985-05-01 00:00:00
abstract:BACKGROUND:Amongst various options of vascularized lymph node transfers, the submental flap has the lowest risk for iatrogenic lymphedema. The aim of this study was to gain insight into distribution, number, and size of lymph nodes along the mandible using computed tomography angiography (CTA). METHODS:A total of 52 C...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.26117
更新日期:2020-07-15 00:00:00
abstract:BACKGROUND:Hepatocellular carcinoma (HCC) is one of the most malignant cancers in the world. The effect of preoperative transarterial chemoembolization (TACE) for resectable HCC is still controversial and cost-associated treatments are unknown. METHODS:We retrospectively compared clinical outcomes and resource utiliza...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.21248
更新日期:2009-05-01 00:00:00
abstract::Type-2 adenovirus was shown to inhibit the growth of transplantable hamster melanoma in 70% of Syrian hamsters without any injurious effect to the host. Greatest inhibition of tumor formation was seen when animals were injected with 10(6) TCD50 of adenovirus and 2.5 x 10(5) tumor cells, or 10(6) TCD50 of virus and 5.0...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930070514
更新日期:1975-01-01 00:00:00
abstract::A retrospective study of 74 cases of cancer of the mobile tongue and floor of the mouth, diagnosed between 1949 and 1975, with a two-year minimum follow-up was undertaken. The lesions were TNM staged, stages I and II accounting for 56 cases (76%) and stages III and IV accounting for 18 cases (24%). The analysis was ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930100408
更新日期:1978-01-01 00:00:00
abstract::The use of preoperative imaging has become routine for many reconstructive microsurgeons to help localize perforators for planning of microvascular free flaps. However, with advancements in imaging technology, perforator mapping represents only one potential benefit as virtual planning and medical modeling, and flap t...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.25194
更新日期:2018-10-01 00:00:00
abstract:BACKGROUND:Adrenal venous sampling (AVS) is the definitive evaluation for primary aldosteronism (PA). Pre-AVS cross-sectional imaging does not reduce the need for AVS. The goal of this study was to examine whether performing AVS prior to imaging could decrease the use of imaging in the evaluation of PA at a high volume...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.23963
更新日期:2015-08-01 00:00:00
abstract::The results of treatment of desmoid tumor patients with nonsteroid antiinflammatory drugs alone or in combination with tamoxifen are described. Tumor growth was inhibited in six of seven patients. Nonsteroid antiinflammatory drugs administered along with 5-fluorouracil and cyclophosphamide and other inhibitors of T-su...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930220314
更新日期:1983-03-01 00:00:00
abstract:BACKGROUND:Recurrent adrenocortical carcinoma (ACC) has a poor prognosis with minimal clinical and biochemical factors to guide management. The aim of this study was to evaluate the prognostic significance of systemic inflammatory response in patients with recurrent ACC. METHODS:Patients who underwent resection for re...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.25760
更新日期:2019-12-01 00:00:00
abstract::We present a review of the incidence, differential diagnoses, mechanism of rupture, laboratory findings, and signs and symptoms of splenic rupture in leukemia. The types of leukemia most often associated with ruptured spleen are described. The treatment of splenic rupture in leukemia is splenectomy, with careful evalu...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.2930410312
更新日期:1989-07-01 00:00:00
abstract:BACKGROUND:For tumours of the adrenal gland different surgical retroperitoneal approaches have been established, including the lateral and the dorsal approach. It is still unclear if the lateral or the dorsal approach should be preferred. PATIENTS AND METHODS:A retrospective comparison between 21 patients who underwen...
journal_title:Journal of surgical oncology
pub_type: 信件
doi:10.1002/jso.20793
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:There is paucity of studies on the predictors of bladder cancer (BC) management costs. We aimed to determine predictors of costs associated with radical cystectomy (RC) for BC. METHODS:We conducted a retrospective analysis in a cohort of 2,759 patients who underwent RC for BC between 2000 and...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.24132
更新日期:2016-02-01 00:00:00