Abstract:
:Tumor-associated antigen(s) from a specimen of human malignant melanoma and from spent culture medium of a melanoma cell line were extracted and purified. The incidence of antibody activity to these antigens, in sera from cancer patients with neoplasms of various histologic types, was higher (65--83%) than normal donors' (19--25%) by the complement fixation assay. These purified antigens were then used to raise antisera in rabbits and sheep. After absorption with various human normal tissues, these antisera reacted against melanoma, sarcoma, and carcinoma extracts, but not against human normal liver, skin, or muscle extracts. However, the antisera showed reactivity against a human fetal homogenate. Results indicate that the xenogeneic antisera contained antibodies to fetal antigens and to tumor-associated antigen(s). Xenogeneic antisera could be used to purify tumor-associated antigens and oncofetal antigen(s) from crude extracts by affinity chromatography.
journal_name
J Surg Oncoljournal_title
Journal of surgical oncologyauthors
Gupta RK,Silver HK,Morton DLdoi
10.1002/jso.2930130112subject
Has Abstractpub_date
1980-01-01 00:00:00pages
75-89issue
1eissn
0022-4790issn
1096-9098journal_volume
13pub_type
杂志文章abstract:BACKGROUND:Retroperitoneal sarcomas are connective tissue tumors arising in the retroperitoneum. Surgical resection is the mainstay of treatment. Debate has arisen over extent of resection, changes in histological classification/grading, and interest in incorporating radiotherapy. Therefore, we reviewed our institution...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.24256
更新日期:2016-07-01 00:00:00
abstract:BACKGROUND:CD109, a TGF-β co-receptor, is reported to be preferentially expressed during the early stages of tumorigenesis in several carcinoma types. Myxofibrosarcoma is one of the most common soft-tissue sarcomas found in elderly patients. This study aimed to elucidate the impact of CD109 expression in myxofibrosarco...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.23934
更新日期:2015-06-01 00:00:00
abstract::Several months (an average of 12.86 months) after perineal needling of the cancerous prostate for the purpose of obtaining tissue for biopsy, a tumor nodule becomes clinically evident in the subcutaneous tissue of the perineum, at the site of the needling in 0.34% of the cases. This nodule presents the same histologic...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.2930350309
更新日期:1987-07-01 00:00:00
abstract::The serum copper/zinc ratio was measured in 44 patients bearing primary large bowel malignancies. Measurements were repeated following removal of the primary tumour and again at the time of development of clinical evidence of cancer recurrence in order to evaluate the clinical value of the ratio to accurately reflect ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930210407
更新日期:1982-12-01 00:00:00
abstract:BACKGROUND:Identification of peri-operative variables predicting postoperative morbidity may improve postoperative patients' care. We aimed to identify patients' characteristics and operative factors predictive of early (≤ 30-day) and late (≤ 6-month) morbidity in cervical cancer patients undergoing surgery plus extern...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.23747
更新日期:2014-12-01 00:00:00
abstract::A comparative study of alpha-fetoprotein (AFP) and carcinoembryonic antigen (CEA) in serum was made by radioimmunoassay in 66 patients with pancreatobiliary disease with and without obstructive jaundice. biliary concentrations of these proteins were assayed in 12 patients with benign and 7 patients with malignant dise...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930190411
更新日期:1982-04-01 00:00:00
abstract:PURPOSE:We investigated rates of occult malignancy in the breast and sentinel lymph nodes (SLNs) in patients undergoing prophylactic mastectomy (PM) and whether routine sentinel lymph node biopsy (SLNB) is justified. METHODS:A retrospective review of our database identified patients undergoing PMs with SLNB. Descripti...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.23575
更新日期:2014-06-01 00:00:00
abstract::Forty-one patients with marginally resectable stage III M0 non-small cell lung cancer (NSCLC) were entered into a study evaluating neoadjuvant cyclophosphamide, adriamycin, and cisplatin chemotherapy (CAP) followed by radiotherapy and subsequent resection. Postoperative radiotherapy and additional CAP were also admini...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930400413
更新日期:1989-04-01 00:00:00
abstract::Intrahepatic cholangiocarcinoma (iCCA) is the second most common primary hepatic cancer in the United States. Currently, curative treatment involves aggressive surgery. Chemotherapy and radiation treatments have been used for unresectable tumors with some success. Optimizing the use of current and developing novel mul...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.24093
更新日期:2016-01-01 00:00:00
abstract::The use of preoperative imaging has become routine for many reconstructive microsurgeons to help localize perforators for planning of microvascular free flaps. However, with advancements in imaging technology, perforator mapping represents only one potential benefit as virtual planning and medical modeling, and flap t...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.25194
更新日期:2018-10-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Current literature may overestimate the risk of nodal metastasis from thin melanoma due to reporting of data only from lesions treated with SLNB. Our objective was to define the natural history of thin melanoma, assessing the likelihood of nodal disease, in order to guide selection for SLNB. ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.24765
更新日期:2017-12-01 00:00:00
abstract:BACKGROUND:Endometrial carcinoma is the most common gynecologic malignancy in developed countries, affecting an estimated 140,000 women. More than 32,000 women will be diagnosed with endometrial cancer this year in the United States, and approximately 6,000 will die from this disease. METHODS:Twenty consecutive patien...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/(SICI)1096-9098(199610)63:2<91::AID-JSO4>3
更新日期:1996-10-01 00:00:00
abstract::A case of symptomatic granular cell tumor of the esophagus is described. Another 32 cases collected from the English literature are analyzed. The reported cases have occurred mostly in women of less than 50 years of age presenting with dysphagia. Excision of the lesion is curative. ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930330409
更新日期:1986-12-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Near-infrared (NIR) fluorescence optical imaging is a promising technique to assess the tumor margins during cancer surgery. This technique requires targeting by specific fluorescence agents to differentiate tumor from normal surrounding tissue. We assessed the feasibility of cancer detection ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.22102
更新日期:2012-06-01 00:00:00
abstract::We investigated the incidence of thyroid nodules in female uremic patients on maintenance hemodialysis using a high-frequency sonographic scanner. In 47 (21.0%) of the 224 female normal controls and 33 (55.0%) of the 60 female patients, thyroid nodules were detected. The difference in these incidences between controls...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930540405
更新日期:1993-12-01 00:00:00
abstract:BACKGROUND:Approximately 20% of patients with thyroid carcinoma have relapse. To evaluate the factors affecting their disease-free survival and prognosis, we studied 68 patients with recurrent differentiated thyroid carcinoma, ranging in age from 5 to 73 years (mean: 47.6 years). Three-fourths of patients were followed...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/(sici)1096-9098(199703)64:3<202::aid-jso5>
更新日期:1997-03-01 00:00:00
abstract::Invasive fungal infections have emerged as a significant problem in patients with cancer with the development of better systemic therapies for malignancy and more effective antibacterial agents. The currently available world published medical literature was reviewed on invasive fungal infections in cancer patients wit...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.20115
更新日期:2004-10-01 00:00:00
abstract::Malignant transformation in cells is accompanied by enzymatic changes that may be useful markers of malignancy. Studies of oncofetal antigens in gastric juice show an increased concentration in patients with gastric carcinoma. The object of the present study was to test if the concentration of lysosomal enzymes and ca...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930240320
更新日期:1983-11-01 00:00:00
abstract::Malignant arterial tumor emboli large enough to cause ischemia or organ infarction are a rare, but often fatal, complication of neoplastic disease. The majority of arterial emboli are associated with primary or secondary pulmonary malignancies. The sites where they impact are similar in distribution to arterioscleroti...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.2930520317
更新日期:1993-03-01 00:00:00
abstract:PURPOSE:The epidemiology and clinicopathology of aneurysmal bone cysts (ABCs) secondary to giant cell tumors of bone (GCTBs) have been well documented in the previous literature. However, reports on whether secondary ABCs could affect the postoperative recurrence of GCTBs are rare. This study analyzed the effects of se...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.25588
更新日期:2019-09-01 00:00:00
abstract::The incidence of anastomotic leakage after esophagectomy for cancer and reconstruction with the stomach was analyzed with respect to the presence of coexistent atrophic chronic gastritis (ACG). Of a total of 28 operated esophageal cancer patients with ACG, 6 patients developed an anastomotic leak at the cervical esoph...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930510107
更新日期:1992-09-01 00:00:00
abstract::Intraperitoneal (IP) cisplatin administered at the time of intraabdominal malignancies such as gastric cancer may prevent or delay intraabdominal recurrence. Perioperative IP cisplatin raises concerns regarding systemic toxicity and retardation of wound healing. Systemic cisplatin toxicity may be reduced by administer...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930520415
更新日期:1993-04-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Adjuvant radiotherapy for node positive breast cancer postmastectomy has been recommended by two previously published randomized controlled trials (RCT). The local-regional recurrence rates in the control arms, however, were considered by some critics to be excessive (> 25% at 10 years). Inadeq...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.1114
更新日期:2001-09-01 00:00:00
abstract:BACKGROUND:For tumours of the adrenal gland different surgical retroperitoneal approaches have been established, including the lateral and the dorsal approach. It is still unclear if the lateral or the dorsal approach should be preferred. PATIENTS AND METHODS:A retrospective comparison between 21 patients who underwen...
journal_title:Journal of surgical oncology
pub_type: 信件
doi:10.1002/jso.20793
更新日期:2008-01-01 00:00:00
abstract::The choice of palliative therapy in patients with carcinoma of the lower esophagus and cardia is mainly between irradiation and surgery. The present report is a retrospective analysis of 40 consecutive patients who recovered after resection of the tumor. The operation was considered to be palliative in all patients. T...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930320402
更新日期:1986-08-01 00:00:00
abstract:BACKGROUND:Pathological staging and regression grading may affect the clinical outcome in rectal carcinoma patients treated with neoadjuvant chemoradiation (NACRT). Oncocytic change (OC) has also been described in the residual tumor. This study assesses the correlation of degree of pathological response and OC with cli...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.22073
更新日期:2012-02-01 00:00:00
abstract::Carcinoma of the lung should be considered in the search for an unknown primary lesion when there is evidence of cervical lymph node involvement. Of 1,686 patients with a final diagnosis of bronchogenic carcinoma seen during a 10-year period at the University of Louisville Hospitals, 26 presented one or more clinicall...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930090513
更新日期:1977-01-01 00:00:00
abstract::Fifty-four patients with advanced upper gastrointestinal cancer were assessed for their nutritional status prior to any form of therapy. Anthropometric parameters--weight loss, arm muscle circumference, skin-fold thickness--and biochemical parameters--serum albumin and delayed cutaneous hypersensitivity reactions to p...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930290417
更新日期:1985-08-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:The therapeutic role of systematic lymph node dissection (LND) remains unclear in advanced epithelial ovarian cancer (EOC), especially during interval debulking surgery (IDS) performed after neoadjuvant chemotherapy (NAC). We analyzed the therapeutic and prognostic roles of systematic LND in ad...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.24669
更新日期:2017-09-01 00:00:00
abstract:BACKGROUND:Fine-needle aspiration biopsy (FNAB) is an emerging technique for diagnosis of bone and soft tissue lesions. While multiple studies have demonstrated efficacy, cost-effectiveness, and convenience, none have attempted to determine if the modality leads to an increased rate of local recurrence. Our objective w...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.21552
更新日期:2010-06-01 00:00:00