Sentinel lymph node biopsy during prophylactic mastectomy: is there a role?

Abstract:

PURPOSE:We investigated rates of occult malignancy in the breast and sentinel lymph nodes (SLNs) in patients undergoing prophylactic mastectomy (PM) and whether routine sentinel lymph node biopsy (SLNB) is justified. METHODS:A retrospective review of our database identified patients undergoing PMs with SLNB. Descriptive statistics were utilized for data summary. A P value of <0.05 was considered significant. RESULTS:There were 384 patients during the study period who underwent 467 PMs. Of the 467 PMs, 15 (3.2%) cancers were found on final pathology. All 6 of the invasive cancers identified were T1. A total of 682 SLNs were taken for an average of 1.46 SLNs per PM. There were 5 positive SLNs (1.1%). All were in patients undergoing contralateral PM for either history of breast cancer or new diagnosis of breast cancer. Only one patient with a positive SLN was found to have an occult breast malignancy in the PM specimen. CONCLUSION:In 467 PMs performed, 15 (3.2%) occult malignancies were found in the breast and 5 (1.1%) positive SLNs were found. Based on these results, the routine use of SLNB at the time of PM is unnecessary and does not warrant the morbidity associated with this procedure.

journal_name

J Surg Oncol

authors

Bunting PW,Cyr AE,Gao F,Margenthaler JA

doi

10.1002/jso.23575

subject

Has Abstract

pub_date

2014-06-01 00:00:00

pages

747-50

issue

8

eissn

0022-4790

issn

1096-9098

journal_volume

109

pub_type

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