Abstract：
:A total of 144 patients with advanced sarcomas were entered into a randomized prospective protocol with four treatment arms utilizing different combinations of chemotherapeutic agents. Of these, 120 patients (83%) were judged acceptable. Treatment 1: actinomycin-D (Act-D), 0.01 mg/kg IV, days 1--5; phenylalanine mustard (L-PAM), 4 mg PO, days 1--10 every six weeks. Treatment 2: Act-D, 0.01 mg/kg IV, days 1--5; L-PAM, 4 mg PO, days 1--10; vincristine, 1 mg IV, days 1, 8, 15, 22, 29, 36, repeat every six weeks. Treatment 3: Act-D, 0.01 mg/kg IV, days 1--5; L-PAM, 4 mg PO, DAYS 1--10; NSC-1026, 200 mg/kg IV, days 1--6. Treatment 4: Adriamycin, 0.4 mg/kg IV, days 1, 2, 3, 8, 9, 10, then 2XWK starting day 15 (max. 1,200 mg). There was a provision that upon progression of the disease in the first three treatment regimens, patients would be crossed over to Treatment 4. Responses were as follows: 1 - Partial Response (PR) 1/25; No Change (NC) 9/25 (36%). gF2 - NC 17/26 (65%). 3 - NC 13/25 (52%). 4 - Complete Response (CR) 1/41; PR 6/41; (15%); NC 27/41 (66%). Clearly Treatment 4 was the best arm, with a 17% response rate and an initial progression rate of 17%. The only other response was a partial in 1. The difference is statistically significant (H = 17.247, P = 0.0006). If the responders to Adriamycin were analyzed without crossovers, the response rate would be 22% (6/27). (H = 14.079, P = 0.003). Median times to progression were 12.5, 8.7 weeks for 1 and 2, and 5 weeks for 3 and 4. There was no significant difference in the median survival times among the four treatment arms. It appears that Adriamycin as a single drug is superior to the drug combinations and would probably be even more effective used in combination with known active agents.
journal_name
J Surg Oncoljournal_title
Journal of surgical oncologyauthors
Cruz AB Jr,Thames EA Jr,Aust JB,Metter G,Ramirez G,Fletcher WS,Altman SJ,Frelick RW,Hill GJ 2nddoi
10.1002/jso.2930110406subject
Has Abstractpub_date
1979-01-01 00:00:00pages
313-23issue
4eissn
0022-4790issn
1096-9098journal_volume
11pub_type
临床试验,杂志文章,随机对照试验abstract：:Thirty-five consecutive patients underwent en bloc resection of cardia cancer without thoracotomy. All tumors were adenocarcinoma. The operative procedure involved wide resection of the peri-hiatal diaphragm, dissection of the upper abdominal and lower mediastinal lymph nodes, and resection of the stomach including a ...
journal_title：Journal of surgical oncology
pub_type： 杂志文章
doi：10.1002/jso.2930540108
更新日期：1993-09-01 00:00:00
abstract：OBJECTIVE:This study aimed to investigate the association between different metastatic sites and survival in endometrial cancer (EC) patients with International Federation of Gynecology and Obstetrics (FIGO) stage IVB disease. METHODS:FIGO stage IVB patients with EC were selected from the surveillance, epidemiology, a...
journal_title：Journal of surgical oncology
pub_type： 杂志文章
doi：10.1002/jso.26102
更新日期：2020-10-01 00:00:00
abstract：:Interleukin-2 and hyperthermia have been used individually to treat a variety of tumors in both experimental and human trials. Combined adoptive immunotherapy and hyperthermia is an exciting new line of investigation. Previous work in our laboratory has shown that combined local hyperthermia and rIL-2 therapy can sign...
journal_title：Journal of surgical oncology
pub_type： 杂志文章
doi：10.1002/jso.2930530310
更新日期：1993-07-01 00:00:00
abstract：:Intrahepatic cholangiocarcinoma (iCCA) is the second most common primary hepatic cancer in the United States. Currently, curative treatment involves aggressive surgery. Chemotherapy and radiation treatments have been used for unresectable tumors with some success. Optimizing the use of current and developing novel mul...
journal_title：Journal of surgical oncology
pub_type： 杂志文章,评审
doi：10.1002/jso.24093
更新日期：2016-01-01 00:00:00
abstract：:A malignant tumor of the submandibular gland was found to consist predominately of spindle cell elements that initially suggested a primary sarcoma. Further examination revealed that the spindled malignant cells were derived from a high-grade mucoepidermoid carcinoma. ...
journal_title：Journal of surgical oncology
pub_type： 杂志文章
doi：10.1002/jso.2930310116
更新日期：1986-01-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:Arterial resection (AR) has traditionally been considered as a contraindication to pancreatic resection for locally advanced pancreatic adenocarcinoma. The objective was to evaluate if pancreatic resection with AR was worthwhile. METHODS:Between January 1990 and December 2008 the records of 2...
journal_title：Journal of surgical oncology
pub_type： 杂志文章
doi：10.1002/jso.21769
更新日期：2011-01-01 00:00:00
abstract：:A case of bilateral seminoma of the testis is presented that occurred after a lag period of six years following right orchiectomy, even with correct cobalt therapy. The question of early detection of seminoma in the other testis is posed. A common consensus for repeat biopsies to detect new tumor growth should be dete...
journal_title：Journal of surgical oncology
pub_type： 杂志文章
doi：10.1002/jso.2930240204
更新日期：1983-10-01 00:00:00
abstract：:Desmoglein I (DGI) is major component of the desmosomal membrane core that plays an important role in epithelial cell adhesion. The aim of this study was to explore the correlation between the expression of DGI and the clinicopathological findings of esophageal cancer. DGI expression was immunohistochemically examined...
journal_title：Journal of surgical oncology
pub_type： 杂志文章
doi：10.1002/jso.2930570207
更新日期：1994-10-01 00:00:00
abstract：BACKGROUND:Ovarian metastases are reported to occur in 3-8% of women undergoing surgical resection of a primary colorectal adenocarcinoma. Information on clinical outcome after metastectomy for these patients is limited. Patients and Methods A computerized search of the medical record archive at the London Regional Can...
journal_title：Journal of surgical oncology
pub_type： 杂志文章
doi：10.1002/1096-9098(200011)75:3<186::aid-jso6>3.0.co
更新日期：2000-11-01 00:00:00
abstract：:About one third of leiomyosarcomas of the gastrointestinal tract do develop metastasis; and nearly 90% of the metastasis are intra-abdominal. It is said that leiomyosarcoma rarely involves regional nodes, although two series reported 8% of leiomyosarcomas of the stomach and 7% of the small intestines had nodal metasta...
journal_title：Journal of surgical oncology
pub_type： 杂志文章
doi：10.1002/jso.2930150403
更新日期：1980-01-01 00:00:00
abstract：AIM:To evaluate the efficacy of stereotactic body radiation therapy (SBRT) in small hepatocellular carcinoma (HCC) patients. METHODS:From March 2009 to April 2015, we treated 132 small HCC patients with SBRT. Eligibility criteria included longest tumor diameter ≤5.0 cm; Child-Turcotte-Pugh (CTP) Class A or B; unfeasib...
journal_title：Journal of surgical oncology
pub_type： 杂志文章
doi：10.1002/jso.24128
更新日期：2016-02-01 00:00:00
abstract：BACKGROUND/OBJECTIVES:Destructive metastatic lesions about the acetabulum result in pain and functional limitations. We assessed whether periacetabular reconstruction (PAR) improves quality of life by examining outcome measures of pain, function, and mobility. METHODS:Thirty-seven patients with a mean follow-up of 23....
journal_title：Journal of surgical oncology
pub_type： 杂志文章
doi：10.1002/jso.21440
更新日期：2010-02-01 00:00:00
abstract：BACKGROUND:This retrospective study was conducted to compare the treatment and quality of life (QOL) results between radical surgery and definitive chemoradiotherapy (CRT) for stage II-III carcinoma of the esophagus. METHODS:Between 2000 and 2009, 128 consecutive patients were selected for this study in which 72 were ...
journal_title：Journal of surgical oncology
pub_type： 杂志文章
doi：10.1002/jso.21361
更新日期：2009-11-01 00:00:00
abstract：:A case of prostatic adenocarcinoma metastasizing to the epididymis is described, and the literature is reviewed. ...
journal_title：Journal of surgical oncology
pub_type： 杂志文章,评审
doi：10.1002/jso.2930240416
更新日期：1983-12-01 00:00:00
abstract：:A total of 239 determinations of CEA plasma levels were performed for 83 breast cancer patients during chemotherapy or follow-up. In addition, 137 plasma samples were assayed for interferon levels. Patient clinical status was carefully scored according to objective criteria and recorded at each evaluation. Liver funct...
journal_title：Journal of surgical oncology
pub_type： 杂志文章
doi：10.1002/jso.2930220409
更新日期：1983-04-01 00:00:00
abstract：:We retrospectively studied the relationship between nutritional status as indicated by the presence or absence of the cutaneous delayed hypersensitivity response and treatment-related morbidity, disease recurrence, and survival at 2 years in 67 consecutive patients with head and neck carcinoma. Serial nutritional asse...
journal_title：Journal of surgical oncology
pub_type： 杂志文章
doi：10.1002/jso.2930550110
更新日期：1994-01-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:Recent advancements in the technology of cryosurgery along with the development and refinement of intraoperative ultrasound have led to a feasible alternative for some patients with unresectable hepatic malignancy. This paper reports our first year's experience with cryosurgical ablation of un...
journal_title：Journal of surgical oncology
pub_type： 杂志文章
doi：10.1002/(sici)1096-9098(199808)68:4<242::aid-jso7>
更新日期：1998-08-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:The poorer outcome amongst younger breast cancer patients continues to be an issue of debate. In order to clarify the prognostic value of patient age, we retrospectively analyzed the data of 1098 breast cancer patients. METHODS:Patients were divided into two groups based on the age 35 (Group ...
journal_title：Journal of surgical oncology
pub_type： 杂志文章
doi：10.1002/jso.10088
更新日期：2002-05-01 00:00:00
abstract：PURPOSE:To describe venous thromboembolism (VTE) rates in patients with pancreatic cancer (PC) during neoadjuvant therapy. METHODS:Factors associated with VTE were evaluated using multivariable logistic regression modeling in patients with resectable and BLR PC treated with neoadjuvant therapy between 2009 and 2014. ...
journal_title：Journal of surgical oncology
pub_type： 杂志文章
doi：10.1002/jso.24361
更新日期：2016-10-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:Sentinel node (SN) biopsy is a new standard of care for axillary node staging in patients with early-stage, clinically node-negative breast cancer. A second operation can be avoided when the results are available intraoperatively. However, there is no standard intraoperative method for SN asse...
journal_title：Journal of surgical oncology
pub_type： 杂志文章,评审
doi：10.1002/jso.20067
更新日期：2004-06-01 00:00:00
abstract：:Fifty-nine patients with stage D carcinoma of the prostate under different modalities of treatment were studied for creatine phosphokinase isoenzyme BB (CK-BB) and prostatic acid phosphatase (PAP) levels in serum by radioimmunoassay (RIA) technique, in order to study the possible use of CK-BB as a follow-up marker com...
journal_title：Journal of surgical oncology
pub_type： 杂志文章
doi：10.1002/jso.2930280319
更新日期：1985-03-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:This study aims to investigate the surgical outcomes observed in robotic transperitoneal aortic lymphadenectomy (AL) in gynecological cancer patients. METHODS:Retrospective data were collected and analyzed on 71 patients undergoing robotic surgical procedures for gynecological cancers, includi...
journal_title：Journal of surgical oncology
pub_type： 临床试验,杂志文章
doi：10.1002/jso.25335
更新日期：2019-03-01 00:00:00
abstract：:A new simplified system for updating a cancer registry has been developed in the Biostatistics Department of Roswell Park Memorial Institute. It was designed to serve the needs of maintaining a registry for a cooperative cancer research group. The Data-Update Procedure at a Remote Terminal (DUPART) system has general ...
journal_title：Journal of surgical oncology
pub_type： 杂志文章
doi：10.1002/jso.2930070508
更新日期：1975-01-01 00:00:00
abstract：:Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) is a T-cell neoplasm that arises in the capsule around breast implants. While an association with implants has been proposed, no causal link has been identified and the pathophysiology and natural history of BIA-ALCL remain unknown. A literature revie...
journal_title：Journal of surgical oncology
pub_type： 杂志文章
doi：10.1002/jso.25626
更新日期：2019-09-01 00:00:00
abstract：:For 38 consecutive patients presenting with breast masses we compared accuracy of diagnosis, before biopsy, of the techniques of clinical examination, bilateral xeromammography, and aspiration cytology with a 10-cc syringe and a 22-gauge needle. Of the 38 patients, nine had carcinoma and 29 had benign breast disease. ...
journal_title：Journal of surgical oncology
pub_type： 杂志文章
doi：10.1002/jso.2930120409
更新日期：1979-12-01 00:00:00
abstract：BACKGROUND:After resection of colorectal liver metastases (CRLM), recurrent disease in the liver is a major cause of death but may be reduced with the addition of adjuvant hepatic arterial infusion (HAI) chemotherapy to systemic chemotherapy (SYS). OBJECTIVE:This study investigates organ-specific causes of death in pa...
journal_title：Journal of surgical oncology
pub_type： 杂志文章
doi：10.1002/jso.25916
更新日期：2020-06-01 00:00:00
abstract：:Intra-abdominal visceral sarcomas are a rare group of mesenchymal tumors that require the use of distinct surgical principles and a multidisciplinary approach in order to optimize treatment. Surgery remains the only potentially curative treatment. Management and outcomes vary for the different sarcomas arising from vi...
journal_title：Journal of surgical oncology
pub_type： 杂志文章
doi：10.1002/jso.23803
更新日期：2015-04-01 00:00:00
abstract：:A consecutive series of 73 patients treated with intraarterial infusion of 5-fluorouracil (5-FU) for liver metastases from colorectal primary was studied retrospectively using multivariate analysis in order to find determinants of survival. Nontreatment factors had a great impact on variation in survival with liver tu...
journal_title：Journal of surgical oncology
pub_type： 杂志文章
doi：10.1002/jso.2930310406
更新日期：1986-04-01 00:00:00
abstract：OBJECTIVE:To compare outcomes between thoracoscopic and thoracotomy lobectomy for patients with cN0-pN2 NSCLC. METHODS:One hundred eighty-two cN0 patients (including 29 pN2) underwent VATS lobectomy between September 2006 and December 2009, and 204 cN0 patients (including 47 pN2) underwent thoracotomy lobectomy betwee...
journal_title：Journal of surgical oncology
pub_type： 杂志文章
doi：10.1002/jso.23104
更新日期：2012-09-15 00:00:00
abstract：:Perineural invasion is associated with tumor spreading and an unfavorable prognosis in a variety of cancers. Recently, neural cell adhesion molecule (NCAM) has been reported to be affinitive to neural tissues, which suggests some relationship between NCAM and perineural invasion. This study was designed to elucidate t...
journal_title：Journal of surgical oncology
pub_type： 杂志文章
doi：10.1002/jso.2930530205
更新日期：1993-06-01 00:00:00
