Expression of desmoglein I in squamous cell carcinoma of the esophagus.

Abstract:

:Desmoglein I (DGI) is major component of the desmosomal membrane core that plays an important role in epithelial cell adhesion. The aim of this study was to explore the correlation between the expression of DGI and the clinicopathological findings of esophageal cancer. DGI expression was immunohistochemically examined using an anti-DGI monoclonal antibody in 139 patients with squamous cell carcinoma of the esophagus. Normal squamous epithelial cells strongly expressed DGI at their cell-cell boundaries. According to the intensity and pattern of DGI expression, the cancerous tissues were divided into three groups: DGI (++), DGI (+), and DGI (-). Of the 139 tumors, 35 (25%) were DGI (++), 65 (47%) were DGI (+), and 39 (28%) were DGI (-). A good inverse correlation between DGI expression and tumor invasion, lymph node metastasis, lymphatic invasion, and vessel invasion was observed. These results indicate that DGI expression may be a significant factor for invasion, metastasis, and prognosis of human esophageal cancer.

journal_name

J Surg Oncol

authors

Natsugoe S,Aikou T,Shimada M,Kumanohoso T,Tezuka Y,Sagara M,Yoshinaka H,Baba M,Fukumoto T

doi

10.1002/jso.2930570207

subject

Has Abstract

pub_date

1994-10-01 00:00:00

pages

105-10

issue

2

eissn

0022-4790

issn

1096-9098

journal_volume

57

pub_type

杂志文章
  • Development and validation of a nomogram to estimate the pretest probability of cancer in Chinese patients with solid solitary pulmonary nodules: A multi-institutional study.

    abstract:OBJECTIVES:To develop and validate a nomogram to estimate the pretest probability of malignancy in Chinese patients with solid solitary pulmonary nodule (SPN). MATERIALS AND METHODS:A primary cohort of 1798 patients with pathologically confirmed solid SPNs after surgery was retrospectively studied at five institutions...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章,多中心研究

    doi:10.1002/jso.24704

    authors: She Y,Zhao L,Dai C,Ren Y,Jiang G,Xie H,Zhu H,Sun X,Yang P,Chen Y,Shi S,Shi W,Yu B,Xie D,Chen C

    更新日期:2017-11-01 00:00:00

  • Application of the differential hybridization of Atlas Human expression arrays technique in the identification of differentially expressed genes in human glioblastoma multiforme tumor tissue.

    abstract:BACKGROUND AND OBJECTIVES:Several molecular biology techniques are utilized to study changes in gene expression during the genesis of human tumors. Our objective was to identify genes that showed altered expression between normal brain tissue (NBT) and glioblastoma multiforme tumor tissue (GMTT). METHODS:The technique...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/(sici)1096-9098(199804)67:4<234::aid-jso5>

    authors: Sehgal A,Boynton AL,Young RF,Vermeulen SS,Yonemura KS,Kohler EP,Aldape HC,Simrell CR,Murphy GP

    更新日期:1998-04-01 00:00:00

  • Encapsulation is a significant prognostic factor for better outcome in large hepatocellular carcinoma.

    abstract:BACKGROUND:The aim of this study was to determine the effect of tumor encapsulation of hepatocellular carcinoma (HCC) on long-term survival. METHODS:A retrospective review of 1,240 patients who underwent hepatectomy from January 1993 to June 2005 was conducted. There were 891 patients with tumor encapsulation (EC type...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.22060

    authors: Wu TH,Yu MC,Chen TC,Lee CF,Chan KM,Wu TJ,Chou HS,Lee WC,Chen MF

    更新日期:2012-01-01 00:00:00

  • Endoscopic surveillance of patients following a curative resection for colorectal cancer.

    abstract::From 1974 to 1985, 161 patients were followed by at least one colonoscopy following a polypectomy for an adenomatous polyp. These patients had had a previous curative resection performed for colorectal carcinoma. The median follow-up time after surgery was 54 months. A polyp within 65 cm from the anal verge or from a ...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930380204

    authors: Carlsson G,Petrelli NJ,Herrera L,Nava H,Mittelman A

    更新日期:1988-06-01 00:00:00

  • Preoperative positivity of serum tumor markers is a strong predictor of hematogenous recurrence of gastric cancer.

    abstract:BACKGROUND AND OBJECTIVES:Preoperative positivity of serum tumor markers has been reported to be a prognostic factor in several neoplasms. The aim of this longitudinal study was to evaluate the correlation between CEA, CA 19-9, and CA 72-4 preoperative serum levels and the site of recurrence after curative surgery for ...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.1163

    authors: Marrelli D,Pinto E,De Stefano A,de Manzoni G,Farnetani M,Garosi L,Roviello F

    更新日期:2001-12-01 00:00:00

  • Immune-competent cells of regional lymph nodes in colorectal cancer patients: II. Immunohistochemical analysis of Leu-7+ cells.

    abstract::Distribution of Leu-7+ cells in cancer tissues and regional lymph nodes was immunohistochemically examined to estimate the role of NK cells in colorectal cancer patients. Leu-7+ cells were rarely observed both in the primary and distant metastatic lesions, but the number of these cells was large in the germinal center...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930450406

    authors: Adachi W,Usuda N,Sugenoya A,Iida F

    更新日期:1990-12-01 00:00:00

  • Sarcoidosis of the pancreas.

    abstract::We report a case of pancreatic sarcoidosis in a patient with radiographic and clinical findings suggestive of pancreatic cancer. Clinically apparent involvement of the pancreas is uncommon in patients with known sarcoidosis and is distinctly unusual as the initial presentation of disease. Sarcoid involvement of the pa...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章,评审

    doi:10.1002/jso.2930540215

    authors: Brady MS,Garfein CF,Klimstra D,Brenann MF

    更新日期:1993-10-01 00:00:00

  • The role of robotic aortic lymphadenectomy in gynecological cancer: surgical and oncological outcome in a single institution experience.

    abstract:BACKGROUND AND OBJECTIVE:This study aims to investigate the surgical outcomes observed in robotic transperitoneal aortic lymphadenectomy (AL) in gynecological cancer patients. METHODS:Retrospective data were collected and analyzed on 71 patients undergoing robotic surgical procedures for gynecological cancers, includi...

    journal_title:Journal of surgical oncology

    pub_type: 临床试验,杂志文章

    doi:10.1002/jso.25335

    authors: Gallotta V,Federico A,Gaballa K,D'Indinosante M,Conte C,Giudice MT,Naldini A,Lodoli C,Rotolo S,Gallucci V,Tortorella L,Romanò B,Scambia G,Ferrandina G

    更新日期:2019-03-01 00:00:00

  • Surgical resection of pulmonary metastases from gastric cancer.

    abstract:BACKGROUND AND OBJECTIVES:There are no reports concerning surgical treatment on pulmonary metastases from gastric cancer. The aims of this study were to characterize patients with pulmonary metastasis from gastric cancer and to determine the efficacy of surgical therapy. METHODS:Between 1977 and 1993, 3,076 patients u...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/(sici)1096-9098(199811)69:3<147::aid-jso5>

    authors: Kanemitsu Y,Kondo H,Katai H,Nakayama H,Asamura H,Tsuchiya R,Naruke T

    更新日期:1998-11-01 00:00:00

  • Malignant neoplasms of the major salivary glands.

    abstract::Between January 1, 1968 and December 31, 1978, 42 patients with malignant lesions involving the major salivary glands were seen at the Medical College of Virginia. A 60% 2-year survival and a 42% 5-year survival were noted. Histologic type was the major determinant of survival. Symptoms other than a painless mass, a l...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930170204

    authors: Lawrence WT,Lawrence W Jr

    更新日期:1981-01-01 00:00:00

  • Surgery promotes implantation of disseminated tumor cells, but does not increase growth of tumor cell clusters.

    abstract:INTRODUCTION:Local recurrence and peritoneal dissemination is common after intentionally curative resection of colorectal carcinoma. It is not yet clear which mechanisms stimulate post-operative intra-abdominal tumor development. Enhanced adhesion or growth of tumor cells and/or post-operative immuno suppression may in...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.20273

    authors: Raa ST,Oosterling SJ,van der Kaaij NP,van den Tol MP,Beelen RH,Meijer S,van Eijck CH,van der Sijp JR,van Egmond M,Jeekel J

    更新日期:2005-11-01 00:00:00

  • Total abdominal colectomy, pelvic peritonectomy, and end-ileostomy for the surgical palliation of mucinous peritoneal carcinomatosis from non-gynecologic cancer.

    abstract:BACKGROUND AND OBJECTIVES:The optimal management of symptomatic advanced peritoneal carcinomatosis of non-gynecologic origin is not defined. Historic controls of surgical efforts report high postoperative mortality and morbidity rates with equivocal palliation. Novel surgical procedures need to be tested in terms of th...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.10270

    authors: Stamou KM,Karakozis S,Sugarbaker PH

    更新日期:2003-08-01 00:00:00

  • Three synchronous bilateral lung tumors: a case report.

    abstract::Two synchronous primary lung carcinomas presenting bilaterally are rare. Their presentation, predisposing factors, and treatment are similar to those of single lung carcinomas. The authors present the first reported case known to them of three synchronous primary lung carcinomas involving both lungs. These tumors fulf...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930340408

    authors: Paul SM,Bacharach B

    更新日期:1987-04-01 00:00:00

  • Initial metastatic, including micrometastatic, sites of lymph nodes in esophageal squamous cell carcinoma.

    abstract:BACKGROUND AND OBJECTIVES:It is important to identify the initial lymph node metastasis when performing less invasive surgery. The purpose of the present study was to analyze locations of solitary lymph node metastasis and micrometastasis in esophageal carcinoma. METHODS:We retrospectively analyzed the initial sites o...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.20172

    authors: Natsugoe S,Matsumoto M,Okumura H,Nakashima S,Higashi H,Uenosono Y,Ehi K,Ishigami S,Takao S,Aikou T

    更新日期:2005-01-01 00:00:00

  • Considerations appropriate to a clinical trial of definitive radiation therapy in adenocarcinoma of the pancreas.

    abstract::The Author describes criteria for selection of patients who might be eligible for entry into a clinical trial of definitive Radiation Therapy for adenocarcinoma of the pancreas. Most emphasis is placed on careful surgical staging, target volume and location, and the use of bypass procedures when appropriate. ...

    journal_title:Journal of surgical oncology

    pub_type: 临床试验,杂志文章

    doi:10.1002/jso.2930070208

    authors: Cavanaugh PJ

    更新日期:1975-01-01 00:00:00

  • Primary carcinoma of the gallbladder in Taiwan.

    abstract::To define more precisely the prognostic index for patients with primary carcinoma of the gallbladder in Taiwan, we retrospectively reviewed the data of 74 patients with gallbladder carcinoma treated over a period of 15 years, from 1979 to 1993. Of these patients, 75% had Nevin stage V gallbladder cancer. The most comm...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/(SICI)1096-9098(199601)61:1<49::AID-JSO11>

    authors: Chao TC,Wang CS,Jeng LB,Jan YY,Chen MF

    更新日期:1996-01-01 00:00:00

  • Histologic trends in thyroid cancer 1969-1993: a clinico-pathologic analysis of the relative proportion of anaplastic carcinoma of the thyroid.

    abstract:BACKGROUND:It was observed that new presentations of anaplastic carcinoma of the thyroid had become infrequent in the last two decades. METHODS:All cases of thyroid cancer seen at our centre between 1969-1993 (n = 2921) were classified as papillary 49%, follicular 34%, medullary 7.5%, anaplastic 4.7%, and other 4.8%. ...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/(SICI)1096-9098(199612)63:4<251::AID-JSO7>

    authors: Agrawal S,Rao RS,Parikh DM,Parikh HK,Borges AM,Sampat MB

    更新日期:1996-12-01 00:00:00

  • Regional chemotherapy is indicated after surgical resection of colorectal metastases to the liver: a debate.

    abstract::Surgical resection for selected patients with hepatic metastases from colorectal cancer can cure approximately one-fourth of these patients. The addition of regional chemotherapy as an attempt to improve this statistic has been extensively investigated in clinical trials. As part of a multidisciplinary educational pro...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章,评审

    doi:10.1002/jso.10171

    authors: Khushalani NI,McKinley BP,Gibbs JF,Leichman CG,Petrelli NJ

    更新日期:2003-01-01 00:00:00

  • Wilms' tumor--treatment and results: a five-decade experience.

    abstract::During the past 53 years, 105 patients with Wilms' Tumor have been treated at the Children's Hospital of Buffalo. Prospective and retrospective staging of these cases has allowed comparison with other reported series. All-stage survival improved from 37% with operation alone to 46% with operation and planned radiother...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930300410

    authors: Allen JE,Brecher MJ,Karp MP,Cooney DR,Jewett TC Jr

    更新日期:1985-12-01 00:00:00

  • Mutational status of KIT and PDGFRA and expression of PDGFRA are not associated with prognosis after curative resection of primary gastrointestinal stromal tumors (GISTs).

    abstract:BACKGROUND:The aim of this study was to investigate if immunohistochemical expression and mutational status of KIT and PDGFRA in GISTs are associated with the clinical course and disease-free survival after curative resection of the primary tumor without adjuvant systemic therapy. METHODS:Paraffin-embedded tumor secti...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.21905

    authors: Kern A,Görgens H,Dittert DD,Krüger S,Richter KK,Schackert HK,Saeger HD,Baretton G,Pistorius S

    更新日期:2011-07-01 00:00:00

  • A more sensitive detection of micrometastases of NSCLC in lymph nodes using the one-step nucleic acid amplification (OSNA) method.

    abstract:BACKGROUND:Detection of tumor cells in lymph nodes (LNs) removed during the treatment of pulmonary tumor by radical surgery is limited by the possibilities of standard histopathological methods. The goal of this study was to obtain more accurate pTNM status by a more sensitive detection of micrometastases in LNs. METH...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.24826

    authors: Vodicka J,Mukensnabl P,Vejvodova S,Spidlen V,Kulda V,Topolcan O,Pesta M

    更新日期:2018-02-01 00:00:00

  • Adjuvant, specific, active immunotherapy for resectable squamous cell lung carcinoma: a 5-year survival analysis.

    abstract::In 1976 Stewart et al. (Annals of the New York Academy of Sciences 277:436-466) reported the effectiveness of adjuvant specific active immunotherapy of lung carcinoma in improving the postoperative survival of stage I lung carcinoma patients in a phase II study using lung carcinoma-associated antigen (TAA) and complet...

    journal_title:Journal of surgical oncology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1002/jso.2930460104

    authors: Takita H,Hollinshead AC,Adler RH,Bhayana J,Ramundo M,Moskowitz R,Rao UN,Raman S

    更新日期:1991-01-01 00:00:00

  • Fine-needle aspiration cytology of abdominal masses.

    abstract::An investigation of the role of blind fine-needle aspiration cytology (FNAC) in the assessment of palpable abdominal masses was carried out on 196 patients: 124 hepatic, 30 retroperitoneal, and 42 other masses. All of the smears were stained either by Papanicolaou stain or by hematoxylin and eosin stain. The results o...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930440105

    authors: Khanna AK,Misra MK,Khanna A,Misra VK,Khanna S

    更新日期:1990-05-01 00:00:00

  • Hyperthermic regional perfusion with melphalan and a combination of melphalan and actinomycin D in the treatment of locally metastasized malignant melanomas of the extremities.

    abstract::From September 1969 through 1979, 68 patients with already locally metastasized malignant melanomas of the extremities were treated by hyperthermic regional perfusion and local excision(s). Of these, 53 patients could be evaluated after a follow-up of at least 2 years: 31 had been perfused with melphalan and 22 with m...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930200103

    authors: Martijn H,Oldhoff J,Koops HS

    更新日期:1982-05-01 00:00:00

  • Cost analysis of postmastectomy reconstruction: A comparison of two staged implant reconstruction using tissue expander and acellular dermal matrix with abdominal-based perforator free flaps.

    abstract:BACKGROUND AND OBJECTIVES:Two staged tissue expander-implant with acellular dermal matrix (TE/I + ADM) and deep inferior epigastric perforator (DIEP) flap are the most common implant and autologous methods of reconstruction in the U.S. Implant-based techniques are disproportionally more popular, partially due to its pr...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.24692

    authors: Tran BNN,Fadayomi A,Lin SJ,Singhal D,Lee BT

    更新日期:2017-09-01 00:00:00

  • Rapid and accurate method for delineating cancer lesions in laparoscopic colectomy using activated carbon injection.

    abstract::The aim of our study was to evaluate the clinical efficacy of preoperative injection of activated carbon in delineation of cancer location in laparoscopic colectomy. Activated carbon particles were injected during endoscopy into the normal colonic wall surrounding cancer lesions in five cases of early colon cancer, pr...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930580107

    authors: Kitamura K,Yamane T,Oyama T,Shimotsuma M,Hagiwara A,Yamaguchi T,Sawai K,Takahashi T

    更新日期:1995-01-01 00:00:00

  • Racial disparities in local therapy for early stage non-small-cell lung cancer.

    abstract:OBJECTIVES:This study investigated disparities in the delivery of definitive therapy for early stage non-small-cell lung cancer (ESNSCLC) between Caucasian (CS) and African American (AA) populations. METHODS:The National Cancer Data Base was queried for AA and CS patients, diagnosed with c stage I Non small cell lung ...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.26206

    authors: Lutfi W,Martinez-Meehan D,Sultan I,Evans N 3rd,Dhupar R,Luketich JD,Christie NA,Okusanya OT

    更新日期:2020-12-01 00:00:00

  • Prognostic significance of mRNA-encoding estrogen receptor and epithelial growth factor receptor in breast carcinoma progression into lymph nodes: 1. Estrogen receptor encoding mRNA.

    abstract::The main objective of this study was to differentiate between lymph nodes infiltrated by estrogen receptor-positive (ER+) and estrogen receptor-negative (ER-) breast carcinoma. Lymph nodes were obtained from 40 postmenopausal cancer patients, 10 from each disease stage. Six patients from each group had estrogen recept...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930400107

    authors: Hakim AA

    更新日期:1989-01-01 00:00:00

  • Postbiliary drainage rates of cholangitis are impacted by procedural technique for patients with supra-ampullary cholangiocarcinoma: A SEER-Medicare analysis.

    abstract:BACKGROUND:The optimal approach to biliary drainage for patients with supra-ampullary cholangiocarcinoma remains undetermined. Violation of sphincter of Oddi results in bacterial colonization of bile ducts and may increase postdrainage infectious complications. We sought to determine if rates of cholangitis are affecte...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.25485

    authors: Kariya CM,Wach MM,Ruff SM,Ayabe RI,Lo WM,Torres MB,Petrick JL,McNeel TS,Davis JL,McGlynn KA,Hernandez JM

    更新日期:2019-08-01 00:00:00

  • The impact of re-excision of inadequately resected soft tissue sarcomas on surgical therapy, results, and prognosis: A single institution experience with 682 patients.

    abstract:BACKGROUND AND OBJECTIVES:Due to their rare incidence soft tissue sarcomas (STS) are often resected without clear margins. The aim of this study was to investigate the impact of re-excision of STS on survival. METHODS:Out of 752 patients with STS (406 men and 346 women, average age 51 years), 310 patients were referre...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.21639

    authors: Funovics PT,Vaselic S,Panotopoulos J,Kotz RI,Dominkus M

    更新日期:2010-11-01 00:00:00