Abstract:
:Interleukin-2 and hyperthermia have been used individually to treat a variety of tumors in both experimental and human trials. Combined adoptive immunotherapy and hyperthermia is an exciting new line of investigation. Previous work in our laboratory has shown that combined local hyperthermia and rIL-2 therapy can significantly decrease the rate of tumor growth. In this study, we investigated the effect of combined whole-body hyperthermia (WBHT) and rIL-2 on the growth of subcutaneous MCA-105 murine tumors in C57BL/6 mice. Treatment of both microscopic (day 3) and macroscopic (day 10) tumors was evaluated. In the treatment of microscopic tumors, animals received either no treatment; rIL-2 (3 x 10(5) IU ip tid) on days 3-7; plus WBHT (41 degrees C for 30 min) on days 3, 5, and 7; or WBHT only days 3, 5, and 7. In treating macroscopic tumors, animals received either no treatment; rIL-2 on days 10-14; plus WBHT on days 10, 12, and 14; or WBHT only on days 10, 12, and 14. While combined treatment and WBHT alone had no significant effect on the growth of microscopic tumors, combined IL-2 and WBHT significantly reduced the rate of tumor growth of macroscopic tumors. These results suggest that the tumor microenvironment plays a critical role in combined WBHT and rIL-2 therapy, and may be due to effects of WBHT on the tumor vasculature.
journal_name
J Surg Oncoljournal_title
Journal of surgical oncologyauthors
Geehan DM,Fabian DF,Lefor ATdoi
10.1002/jso.2930530310subject
Has Abstractpub_date
1993-07-01 00:00:00pages
180-3issue
3eissn
0022-4790issn
1096-9098journal_volume
53pub_type
杂志文章abstract::Cancer of the oral cavity remains a major problem in the United States as well as in many other countries, some of which record as much as 30% of all their cancers to be in the oral region. Despite numerous advances in the fields of epidemiology and etiology, little is known of the molecular basis of oral cancer. Adva...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.2930470209
更新日期:1991-06-01 00:00:00
abstract::We studied survival and prognostic factors in all cases of hepatocellular carcinoma seen at a Midwestern teaching hospital from 1947 through 1986. Of the 70 cases, 56 were diagnosed during life and 14 at autopsy. There were 47 males and 23 females with age at diagnosis ranging from 14 to 88. Median survival for the 56...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930450409
更新日期:1990-12-01 00:00:00
abstract::Quality of care measurement and reporting at the provider, hospital, or health system level has become increasingly common in health systems around the world. Health system performance reports, whether they be confidentially distributed to the provider or made available to the public, are not only used as a stimulus f...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.21188
更新日期:2009-06-15 00:00:00
abstract::From 1974 to 1985, 161 patients were followed by at least one colonoscopy following a polypectomy for an adenomatous polyp. These patients had had a previous curative resection performed for colorectal carcinoma. The median follow-up time after surgery was 54 months. A polyp within 65 cm from the anal verge or from a ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930380204
更新日期:1988-06-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:There have been few reports on the objective assessment of quality of life (QOL) in patients with gastric cancer following palliative operations. The benefit of a palliative operation for survival and QOL of patients with gastric cancer is not clear. METHODS:Survival and hospital-free surviva...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/(sici)1096-9098(199809)69:1<41::aid-jso8>3
更新日期:1998-09-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:The psychosocial impact of local-regional thyroid cancer recurrence is not known. The aim of this study was to explore thyroid cancer patients' experiences relating to diagnosis and treatment of local-regional disease recurrence. METHODS:We conducted 15 semi-structured interviews with survivor...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.23345
更新日期:2013-07-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:The genetic alterations involved in extrahepatic bile duct (EHBD) cancer are poorly understood. Our aim was to identify aberrations of the K-ras, p53, and APC genes in EHBD cancer. METHODS:We investigated aberrations of these genes in 52 EHBD cancers using polymerase chain reaction (PCR) sing...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/(sici)1096-9098(200003)73:3<158::aid-jso9>
更新日期:2000-03-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Local control of disease is one of the main goals of osteosarcoma management. We conducted a retrospective evaluation of 95 operated cases of osteosarcoma over 7 years to know about the factors associated with local recurrence in resource-challenged environment of the developing world. METHOD...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.24602
更新日期:2017-04-01 00:00:00
abstract::Twenty-two inflammatory, benign, or malignant parotid lesions were studied by means of the specific red cell adherence test (SRCA), a modification of the Coombs' mixed cell agglutination reaction. In 22 normal parotid tissues the acinar structures were devoid of red cell agglutination, but it was present in ductal epi...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930240306
更新日期:1983-11-01 00:00:00
abstract:BACKGROUND:Endometrial carcinoma is the most common gynecologic malignancy in developed countries, affecting an estimated 140,000 women. More than 32,000 women will be diagnosed with endometrial cancer this year in the United States, and approximately 6,000 will die from this disease. METHODS:Twenty consecutive patien...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/(SICI)1096-9098(199610)63:2<91::AID-JSO4>3
更新日期:1996-10-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:The purpose of this paper is to evaluate the utility of positron emission tomography (PET) with fluorine-18-labeled fluoro-deoxyglucose (FDG) in the preoperative differential diagnosis of gallbladder tumors. We performed PET studies of gallbladder tumors in order to predict the malignancy of t...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.10295
更新日期:2003-10-01 00:00:00
abstract::Tumors attached or adjacent to critical structures can often not be completely resected or resected with adequate surgical margins. Sites involving major blood vessels, the paravertebral spaces, or critical abdominal structures often present technical difficulties for standard brachytherapy procedures using I-125 or I...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930420112
更新日期:1989-09-01 00:00:00
abstract::Metastatic colorectal cancer (mCRC) continues to show poor outcomes, with many patients exhausting effective standard-of-care therapy. To explore the current landscape of clinical trials for mCRC, we reviewed over 600 clinical trials that are currently ongoing for mCRC patients. Immunotherapeutic agents form approxima...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.25441
更新日期:2019-04-01 00:00:00
abstract:BACKGROUND:After resection of colorectal liver metastases (CRLM), recurrent disease in the liver is a major cause of death but may be reduced with the addition of adjuvant hepatic arterial infusion (HAI) chemotherapy to systemic chemotherapy (SYS). OBJECTIVE:This study investigates organ-specific causes of death in pa...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.25916
更新日期:2020-06-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:The aggressiveness and greater malignant potential of cancers are characterized by several biological phenomena such as accelerated growth invasiveness, and the ability to form distant metastasis. Thus, knowledge of such biological difference may be a more accurate prognosticator for cancer pa...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.20309
更新日期:2005-12-15 00:00:00
abstract:BACKGROUND:The aim of this study was to investigate if immunohistochemical expression and mutational status of KIT and PDGFRA in GISTs are associated with the clinical course and disease-free survival after curative resection of the primary tumor without adjuvant systemic therapy. METHODS:Paraffin-embedded tumor secti...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.21905
更新日期:2011-07-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Microsatellite instability (MSI) in gastric cancer (GC) is associated with older age. We present the clinicopathological results of younger and older patients with MSI GC. METHODS:We analyzed 472 patients with GC. MSI analysis was done on fresh frozen tissue using five quasimonomorphic mononu...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.24513
更新日期:2017-03-01 00:00:00
abstract::A retrospective review to elucidate the rationale of preoperative irradiation was made on 18 carcinomas of the head of the pancreas area. After 50 Gy/25 fractions of 10 MV X-ray was given, all 18 tumors decreased from 3.3 +/- 0.8 cm to 2.0 +/- 0.7 cm. At the surgical operation, 16 patients (89%) received pancreatic re...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930400303
更新日期:1989-03-01 00:00:00
abstract::Wilms' tumor, renal cell carcinoma, and neuroblastoma in animals were transplanted from donors to recipients with strong histocompatibility differences. No strong evidence of the privileged site theory was found in this study and no obvious evidence of an immunosuppressive effect of testosterone was found. The most im...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930140111
更新日期:1980-01-01 00:00:00
abstract:BACKGROUND:The aim of this study was to develop a prediction model for the presence and location of lymph node metastasis (LNM) in early gastric cancer. METHOD:We reviewed medical records of 4 929 patients who underwent radical gastrectomy for early gastric cancer. Variables of age, sex, lymphatic invasion, depth of i...
journal_title:Journal of surgical oncology
pub_type: 临床试验,杂志文章
doi:10.1002/jso.25628
更新日期:2019-09-01 00:00:00
abstract:OBJECTIVE:Gastrointestinal stromal tumors (GISTs) occur rarely in the duodenum. The characteristics of duodenal GIST have not been well clarified. The aim of this study is to clarify the characteristics and surgical prognosis of patients with primary duodenal GIST. METHODS:Data of patients with surgically treated prim...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.21378
更新日期:2009-12-01 00:00:00
abstract:OBJECTIVE:To determine whether the presence of prostate stem cell antigen (PSCA) mRNA in peripheral blood can predict biochemical recurrence (BCR) after radical prostatectomy in patients with high-risk prostate cancer. METHODS:High-risk disease was defined based on the presence of any one of the following three risk f...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.21445
更新日期:2010-02-01 00:00:00
abstract::In patients with stage I Clark's level III and IV malignant melanoma (MM), recurrence rates of 30-60% can be expected after resection of the primary lesion. If metastatic disease could be detected early and treated in such patients, survival might be prolonged. Ninety patients (37 males and 53 females) with newly diag...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930350304
更新日期:1987-07-01 00:00:00
abstract:BACKGROUND:Rates of nonoperative management of acute appendicitis and appendiceal adenocarcinoma have increased over a decade, but the presentation and outcomes of appendiceal adenocarcinoma over this period is not well-characterized. METHODS:Patients with surgically resected Stage I-III appendiceal adenocarcinoma wer...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.26295
更新日期:2020-11-10 00:00:00
abstract:INTRODUCTION:Discovery of positive lymph nodes (LNs) in patients with cervix cancer is important prognostically, may direct adjuvant therapy, and may have therapeutic benefit. The purpose of this Surveillance Epidemiology and End Results (SEER) analysis was to assess the value of lymphadenectomy (LND) in patients with ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.21330
更新日期:2009-10-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:To evaluate the impact of plasminogen activator (PA) system genes, including urokinase plasminogen activator (uPA), uPA receptor (uPAR), and plasminogen activator inhibitor-1 (PAI-1) gene polymorphisms in patients with the cervical neoplasia. METHODS:In total, 336 blood samples were collected...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.23072
更新日期:2012-08-01 00:00:00
abstract::Delphian node (DN) refers to the pre-laryngeal or pre-cricoid nodal tissue often identified during laryngeal or thyroid surgery. The original nomenclature is based on the assumption that metastasis to this node was predictive of aggressive disease and poor outcome for patients. In this article, we review the existing ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.21640
更新日期:2010-09-15 00:00:00
abstract::A total of 239 determinations of CEA plasma levels were performed for 83 breast cancer patients during chemotherapy or follow-up. In addition, 137 plasma samples were assayed for interferon levels. Patient clinical status was carefully scored according to objective criteria and recorded at each evaluation. Liver funct...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930220409
更新日期:1983-04-01 00:00:00
abstract::Pedicled and free composite flaps derived from the thoracodorsal artery system, including the latissimus dorsi-rib (LD-R) and the serratus anterior-rib (SA-R) osteo-muscular or osteo-myocutaneous flaps, are potential options to address head and neck, thorax, upper and lower extremity bone, and soft tissue defects' rec...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.25579
更新日期:2019-09-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:It has been estimated that approximately 5% of middle and low rectal adenocarcinomas are amenable to local therapy. However, these treatment modalities are limited by their failure to identify and treat regional nodal metastases. METHODS:This study was undertaken to evaluate the role of tumor...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/(sici)1096-9098(199802)67:2<99::aid-jso5>3
更新日期:1998-02-01 00:00:00