Abstract：
BACKGROUND:Rates of nonoperative management of acute appendicitis and appendiceal adenocarcinoma have increased over a decade, but the presentation and outcomes of appendiceal adenocarcinoma over this period is not well-characterized. METHODS:Patients with surgically resected Stage I-III appendiceal adenocarcinoma were identified from the 2006 to 2015 National Cancer Data Base and classified into two cohorts, 2006-2010 and 2011-2015, based on year of diagnosis. Three-year overall survival (OS) was analyzed using Cox proportional hazards regression and Kaplan-Meier survival estimates. RESULTS:Of 4233 patients, 1369 (32.3%) and 2864 (67.7%) were diagnosed in 2006-2010 and 2011-2015, respectively. Following multivariable analysis, patients in 2011-2015 were more likely to be <40 years of age (6.4% vs. 4.7%, odds ratio [OR] 1.53, p .015), present with pT4 tumors (40.2% vs. 34.4%, OR 1.46, p .004), and undergo hyperthermic intraperitoneal chemotherapy (4.4% vs. 2.4%, OR 1.97, p .001). Comparing patients diagnosed in 2011-2015 to 2006-2010, adjusted 3-year OS was no different among all patients (81.1% vs. 79%, p .778). CONCLUSIONS:There has been an increase in the proportion of patients with pT4 appendix tumors over time, primarily among older (≥60 years) patients. Even so, these shifts in presentation have not resulted in differences in survival outcomes.
journal_name
J Surg Oncoljournal_title
Journal of surgical oncologyauthors
Shannon AB,Song Y,Roses RE,Fraker DL,Miura JT,Karakousis GCdoi
10.1002/jso.26295subject
Has Abstractpub_date
2020-11-10 00:00:00eissn
0022-4790issn
1096-9098pub_type
杂志文章abstract：BACKGROUND:The optimal approach to biliary drainage for patients with supra-ampullary cholangiocarcinoma remains undetermined. Violation of sphincter of Oddi results in bacterial colonization of bile ducts and may increase postdrainage infectious complications. We sought to determine if rates of cholangitis are affecte...
journal_title：Journal of surgical oncology
pub_type： 杂志文章
doi：10.1002/jso.25485
更新日期：2019-08-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:Accumulating epidemiological and molecular evidence suggests that inflammation is an important component in the etiology of PCa. Macrophage migration inhibitory factor (MIF) plays an important role in the pro- and anti-inflammatory response to infection. This study is aimed at investigating th...
journal_title：Journal of surgical oncology
pub_type： 杂志文章
doi：10.1002/jso.21304
更新日期：2009-08-01 00:00:00
abstract：:DNA nuclear content and PCNA index (proportion of PCNA reactive cells) have been studied by flow cytometry in eight pancreatic lesions producing hyperinsulinemic hypoglycemia to assess DNA ploidy and tumoral growth fraction. Adult nesidioblastosis had a diploid DNA index, two adenomas were near diploid, and four of th...
journal_title：Journal of surgical oncology
pub_type： 杂志文章
doi：10.1002/jso.2930590105
更新日期：1995-05-01 00:00:00
abstract：BACKGROUND:The role of postmastectomy radiation therapy (PMRT) after neoadjuvant chemotherapy (NAC) and mastectomy is unclear, especially in patients that have post-treatment tumor negative axillary nodes (ypN0). METHODS:The National Cancer Data Base was used to identify women that had PMRT after NAC and mastectomy fo...
journal_title：Journal of surgical oncology
pub_type： 杂志文章
doi：10.1002/jso.24551
更新日期：2017-05-01 00:00:00
abstract：OBJECTIVE:To evaluate the patients with invasive cervical cancer found in simple hysterectomy and who were subjected to radical parametrectomy and upper vaginectomy with therapeutic lymphadenectomy. METHODS:Twenty-seven patients who underwent the radical parametrectomy and upper vaginectomy with therapeutic lymphadene...
journal_title：Journal of surgical oncology
pub_type： 杂志文章
doi：10.1002/jso.20550
更新日期：2006-07-01 00:00:00
abstract：:There is no information available in the literature on the blood levels of tamoxifen in patients with decreased renal function. As serious side effects of tamoxifen administered at high doses have been reported, a patient with decreased renal function and metastatic breast cancer was studied to determine the blood lev...
journal_title：Journal of surgical oncology
pub_type： 杂志文章
doi：10.1002/jso.2930270404
更新日期：1984-12-01 00:00:00
abstract：BACKGROUND:Subtotal stomach preserving pancreaticoduodenectomy (SSPPD) is compared retrospectively with pylorus preserving pancreaticoduodenectomy (PPPD). METHODS:During 2002-2005, 21 patients (13 female, 8 male) underwent SSPPD. The mean age was 64.3 (range 33-80). PPPD was performed for 12 patients after 1999. Days ...
journal_title：Journal of surgical oncology
pub_type： 杂志文章
doi：10.1002/jso.20608
更新日期：2007-02-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:Long noncoding RNAs (lncRNAs) play key roles in carcinoma metastasis. We aimed to investigate lncRNA LINC01133 in oral squamous cell carcinoma (OSCC) metastasis. METHODS:The RNA levels of LINC01133 and growth and differentiation factor 15 (GDF15) in tissue samples from OSCC patients, and OSCC...
journal_title：Journal of surgical oncology
pub_type： 杂志文章
doi：10.1002/jso.25278
更新日期：2018-12-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Laparoscopy-assisted total gastrectomy (LATG) has not gained popularity due to the technical difficulty of esophagojejunostomy (EJ) and the high incidence of EJ-related complications. Herein, we compared two types of EJ for Roux-en-Y reconstruction to determine whether semi-end-to-end (SETE) EJ...
journal_title：Journal of surgical oncology
pub_type： 杂志文章
doi：10.1002/jso.24637
更新日期：2017-08-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:In this study, we identified matrix metalloproteinase (MMP)-2 and 9 expression in exophytic papilloma (EP), inverted papilloma (IP) with dysplasia, IP with carcinoma, and invasive squamous cell carcinoma (SCC). We also compared the presence of MMP-2 and 9 with human papilloma virus (HPV) infec...
journal_title：Journal of surgical oncology
pub_type： 杂志文章
doi：10.1002/jso.20386
更新日期：2006-01-01 00:00:00
abstract：:A 29-year-old female was diagnosed with a symptomatic, extra-abdominal desmoid tumor during the first trimester of pregnancy. Computerized tomography (CT) and transabdominal ultrasound (US) noted a mass within the left rectus sheath measuring up to 15 cm in greatest diameter, with mild compression of the uterus. Preop...
journal_title：Journal of surgical oncology
pub_type： 杂志文章
doi：10.1002/jso.20189
更新日期：2005-02-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:Although race and socioeconomic status have been shown to affect outcomes in pancreatic ductal adenocarcinoma (PDAC), the impact of rural residence on the delivery of adjuvant therapy (AT) has not been studied. METHODS:Patients with resected PDAC were identified using the National Cancer Data...
journal_title：Journal of surgical oncology
pub_type： 杂志文章
doi：10.1002/jso.25060
更新日期：2018-06-01 00:00:00
abstract：:The choice of palliative therapy in patients with carcinoma of the lower esophagus and cardia is mainly between irradiation and surgery. The present report is a retrospective analysis of 40 consecutive patients who recovered after resection of the tumor. The operation was considered to be palliative in all patients. T...
journal_title：Journal of surgical oncology
pub_type： 杂志文章
doi：10.1002/jso.2930320402
更新日期：1986-08-01 00:00:00
abstract：:The records of 30 patients with primary gastric lymphoma and a minimum of 5 years of follow-up were reviewed and clinical and pathologic prognostic factors analyzed. The overall 5-year survival was 40% (median 23 months). No significant relationship between surgical and patient age, sex, duration of symptoms, macrosco...
journal_title：Journal of surgical oncology
pub_type： 杂志文章
doi：10.1002/jso.2930540306
更新日期：1993-11-01 00:00:00
abstract：:The Noble rat prostatic adenocarcinoma, Nb-Pr-A.I.-II, an androgen-insensitive tumor, is the subject of this experiment. Dose responses were carried out with treatment of these tumors with three doses of adriamycin and two doses of methotrexate. Adriamycin treatment resulted in decreased tumor volume and decreased num...
journal_title：Journal of surgical oncology
pub_type： 杂志文章
doi：10.1002/jso.2930240315
更新日期：1983-11-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:Reports of clinicopathological features and prognosis in patients with mucinous gastric carcinoma (MGC) are conflicting. The aim was to describe the clinicopathological features and prognosis of patients with MGC in comparison with nonmucinous gastric carcinoma (NMGC). METHODS:We reviewed the...
journal_title：Journal of surgical oncology
pub_type： 杂志文章
doi：10.1002/jso.21533
更新日期：2010-07-01 00:00:00
abstract：:To search for possible untoward effects of ethanol injection into a malignant tumor, a series of experiments was carried out using the model of RBT-1 carcinoma. Ten days after the inoculation of RBT-1 carcinoma into the rat liver, the animals were separated into three groups: Group A, ethanol injection during relaparo...
journal_title：Journal of surgical oncology
pub_type： 杂志文章
doi：10.1002/jso.2930540105
更新日期：1993-09-01 00:00:00
abstract：:Laparoscopic resection of colon cancer became mired in controversy when it appeared that the technique might be associated with an increased risk of tumor recurrence within the surgical incisions. This was not a uniform finding among all surgeons, however, and other evidence suggested that this did not occur in experi...
journal_title：Journal of surgical oncology
pub_type： 杂志文章,评审
doi：10.1002/jso.20921
更新日期：2007-12-15 00:00:00
abstract：:The human tumor stem cell assay (HTSCA) was applied to 103 primary and metastatic colorectal carcinomas. Thirty-four carcinomas could not be evaluated for colony formation (clonogenicity) because of microbial contamination. Of the remaining 69 carcinomas, 18 (26%) demonstrated clonal growth in vitro. Colony formation ...
journal_title：Journal of surgical oncology
pub_type： 杂志文章
doi：10.1002/jso.2930200311
更新日期：1982-07-01 00:00:00
abstract：:The hanging liver maneuver is a useful technique to guide the transection of liver parenchyma by lifting a tape passed between the anterior surface of the inferior vena cava and the liver. Modified hanging liver maneuvers have been described in different types of liver resection. Surgical resection of hilar cholangioc...
journal_title：Journal of surgical oncology
pub_type： 杂志文章
doi：10.1002/jso.24154
更新日期：2016-03-01 00:00:00
abstract：:A 65-year-old man presented with supraclavicular, mediastinal, and retroperitoneal lymphadenopathy clinically thought to be due to malignant lymphoma. Biopsy of a supraclavicular lymph node revealed metastatic adenocarcinoma positive for prostatic-specific antigen. This site of the primary tumor was confirmed by needl...
journal_title：Journal of surgical oncology
pub_type： 杂志文章
doi：10.1002/jso.2930350210
更新日期：1987-06-01 00:00:00
abstract：:A poorly differentiated transitional cell carcinoma in C3H/He mice results from the oral ingestion of the urinary tract carcinogen FANFT. This model, designated MBT2, is readily transplantable into syngeneic animals and has proven to be very useful in the development of chemotherapy. Prior to the use of this model for...
journal_title：Journal of surgical oncology
pub_type： 杂志文章
doi：10.1002/jso.2930240113
更新日期：1983-09-01 00:00:00
abstract：:The results of treatment of 106 consecutive nephrectomized cases with metastatic renal adenocarcinoma were analyzed. Over 50% of the patients were dead at 1 year and more than 80% at 2 years from the first metastases. The corresponding 5-year survival rate was 7.3%. Fourteen patients demonstrated a response to radioth...
journal_title：Journal of surgical oncology
pub_type： 杂志文章
doi：10.1002/jso.2930260213
更新日期：1984-06-01 00:00:00
abstract：UNLABELLED:Application of subatmospheric pressure to sites injected with doxorubicin prevented ulcer formation in treated sites (0 ulcers/16 sites) compared to control wounds (10 ulcers/16 sites) in a pig model. BACKGROUND AND OBJECTIVES:Extravasation of doxorubicin hydrochloride (Adriamycin) frequently causes chronic...
journal_title：Journal of surgical oncology
pub_type： 杂志文章
doi：10.1002/(sici)1096-9098(199909)72:1<14::aid-jso4>3
更新日期：1999-09-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:Soft tissue sarcomas of the head and neck (STSHN) comprise a rare group of malignancies. Our objective is to determine the utility of soft tissue sarcoma staging systems within the head and neck, and to validate an individualized soft tissue sarcoma nomogram within head and neck primary sites....
journal_title：Journal of surgical oncology
pub_type： 杂志文章
doi：10.1002/jso.23868
更新日期：2015-05-01 00:00:00
abstract：:Xenografts of a human pancreatic carcinoma cell line, HPC-YS, which reacted with the monoclonal antibody (MAb) A7, were used to investigate the in vivo localization of radioiodinated MAb A7 after intraperitoneal injection. MAb A7 localized to the tumor 4 days and 8 days after injection with a tissue/blood ratio of 1.4...
journal_title：Journal of surgical oncology
pub_type： 杂志文章
doi：10.1002/jso.2930500309
更新日期：1992-07-01 00:00:00
abstract：:The ability to redefine risk factors and to predict prognosis in patients with malignant melanoma at the time they manifest nodal metastasis can be a benefit to the patient emotionally and to the physician therapeutically. A retrospective review of 1,273 patients with stage II malignant melanoma was performed at our i...
journal_title：Journal of surgical oncology
pub_type： 杂志文章
doi：10.1002/jso.2930390302
更新日期：1988-11-01 00:00:00
abstract：:Malignant arterial tumor emboli large enough to cause ischemia or organ infarction are a rare, but often fatal, complication of neoplastic disease. The majority of arterial emboli are associated with primary or secondary pulmonary malignancies. The sites where they impact are similar in distribution to arterioscleroti...
journal_title：Journal of surgical oncology
pub_type： 杂志文章,评审
doi：10.1002/jso.2930520317
更新日期：1993-03-01 00:00:00
abstract：BACKGROUND:The role of surgical resection in the treatment of patients with metastatic/recurrent gastrointestinal stromal tumors (GIST) is unclear. The aim of this study was to identify preoperative factors associated with oncologic outcomes for recurrent/metastatic GIST after tyrosine kinase inhibitor (TKI) therapy. ...
journal_title：Journal of surgical oncology
pub_type： 杂志文章
doi：10.1002/jso.24988
更新日期：2018-04-01 00:00:00
abstract：:Significant destruction of the Pollard III rat prostate adenocarcinoma was achieved by treatment with rhodamine 123 at a dosage of 15 mg/kg every other day for 33 to 38 days. Injection of tumor remnants into untreated animals produced no tumor regrowth. Our data have demonstrated rhodamine 123 to be a significant drug...
journal_title：Journal of surgical oncology
pub_type： 杂志文章
doi：10.1002/jso.2930440209
更新日期：1990-06-01 00:00:00
