DNA index by image analysis in advanced endometrial carcinoma.

Abstract:

BACKGROUND:Endometrial carcinoma is the most common gynecologic malignancy in developed countries, affecting an estimated 140,000 women. More than 32,000 women will be diagnosed with endometrial cancer this year in the United States, and approximately 6,000 will die from this disease. METHODS:Twenty consecutive patients, surgically treated, with advanced endometrial cancer, were evaluated for their DNA index (DI), time to recurrence, peritoneal cytology, depth of invasion, lymphovascular space invasion, as well as FIGO stage, grade, and histology. DI was determined using image analysis. RESULTS:Ten of the 20 patients had recurrence of their disease within the 3-year observation period of the study. A DI of > or = 1.2 strongly predicted recurrence of disease (P = 0.002). Increasing histologic grade and an increasing DI were related (P = 0.01). CONCLUSION:Independent of other prognostic indicators, including lymphovascular space invasion, depth of invasion, and histologic type, a tumor with a DI of > or = 1.2, had a significantly increased chance of recurring within the 3-year observation period.

journal_name

J Surg Oncol

authors

Geisler JP,Wiemann MC,Zhou Z,Miller GA,Geisler HE

doi

10.1002/(SICI)1096-9098(199610)63:2<91::AID-JSO4>3

subject

Has Abstract

pub_date

1996-10-01 00:00:00

pages

91-4

issue

2

eissn

0022-4790

issn

1096-9098

pii

10.1002/(SICI)1096-9098(199610)63:2<91::AID-JSO4>3

journal_volume

63

pub_type

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