Molecular key to understand the gastric cancer biology in elderly patients-The role of microsatellite instability.

Abstract:

BACKGROUND AND OBJECTIVES:Microsatellite instability (MSI) in gastric cancer (GC) is associated with older age. We present the clinicopathological results of younger and older patients with MSI GC. METHODS:We analyzed 472 patients with GC. MSI analysis was done on fresh frozen tissue using five quasimonomorphic mononucleotide repeats: NR-21, NR-24, NR-27, BAT-25, and BAR-26. Clinical and pathological analysis was performed for different age groups. RESULTS:We observed better survival in elderly MSI GC patients compared to younger patients. The percentage of MSI GC increases gradually with increasing age, accounting for 48% of patients over the age of 85 years. A difference in survival was seen between MSI and MSS groups of patients older than 65 years, while no statistical difference was seen for younger groups. Multivariate analysis revealed that MSI status has a significant prognostic factor in patients aged over 70 years (MSS vs. MSI; HR 1.82, P = 0.013). CONCLUSION:MSI is an important prognostic factor above all in elderly GC patients. It is associated with favorable prognosis and may help in planning different approaches to treatment in this subgroup. J. Surg. Oncol. 2017;115:344-350. © 2016 Wiley Periodicals, Inc.

journal_name

J Surg Oncol

authors

Polom K,Marrelli D,Roviello G,Pascale V,Voglino C,Rho H,Marini M,Macchiarelli R,Roviello F

doi

10.1002/jso.24513

subject

Has Abstract

pub_date

2017-03-01 00:00:00

pages

344-350

issue

3

eissn

0022-4790

issn

1096-9098

journal_volume

115

pub_type

杂志文章
  • Increased estrogen receptor and epidermal growth factor receptor gene product co-expression in surgically resected gastric adenocarcinomas.

    abstract:BACKGROUND:Evidence exists that estrogens influence the action of epidermal growth factor (EGF) and its receptor (EGF-R) at multiple levels. Estrogen and antiestrogen action on gastric and other gastrointestinal malignancies has been evaluated by several groups with conflicting results, and EGF-R has been implicated in...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/(SICI)1096-9098(199611)63:3<166::AID-JSO6>

    authors: Koullias GJ,Kouraklis GP,Raftopoulos IS,Davaris PS,Papadopoulos SA,Golematis BC

    更新日期:1996-11-01 00:00:00

  • A national quality improvement effort: cancer registry data.

    abstract::Cancer registries are sources of epidemiological, patterns-of-care, and outcome data for local, regional, state, and national studies of patients with cancer. Since 1976, these registries have formed a voluntary network of contributors to annual patient care studies under the aegis of the National Cancer Data Committe...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930580304

    authors: Clive RE,Ocwieja KM,Kamell L,Hoyler SS,Seiffert JE,Young JL,Henson DE,Winchester DP,Osteen RT,Menck HR

    更新日期:1995-03-01 00:00:00

  • Reconstructing diaphyseal tumors using radiated (50 Gy) autogenous tumor bone graft.

    abstract:AIMS:Establish oncologic safety using 50 Gy to sterilize tumor bearing bone before reimplantation in primary diaphyseal high grade extremity tumors, determine extracorporeal radiotherapy (ECRT) graft survival, and analyze factors that affect union at osteotomy sites. MATERIALS AND METHODS:Seventy non metastatic patien...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.25092

    authors: Puri A,Byregowda S,Gulia A,Patil V,Crasto S,Laskar S

    更新日期:2018-07-01 00:00:00

  • Is the sentinel node biopsy clinically applicable for limited lymphadenectomy and modified gastric resection in gastric cancer? A meta-analysis of feasibility studies.

    abstract:BACKGROUND:Sentinel node biopsies (SNBs) have been clinically applied in melanoma and breast cancer for limited lymphadenectomy. However, the use of SNB remains controversial in gastric cancer due to unsatisfactory sensitivity and variability. This meta-analysis was performed to determine the sensitivity of SNB in gast...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章,meta分析

    doi:10.1002/jso.21995

    authors: Ryu KW,Eom BW,Nam BH,Lee JH,Kook MC,Choi IJ,Kim YW

    更新日期:2011-11-01 00:00:00

  • Association between patient age and the risk of mortality following local recurrence of a sacral chordoma.

    abstract:BACKGROUND:Local recurrence (LR) of sacral chordoma is a difficult problem and the mortality risk associated with LR remains poorly described. The purpose of this study was to evaluate the risk of mortality in patients with LR and determine if patient age is associated with mortality. METHODS:A total of 218 patients (...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.25774

    authors: Houdek MT,Hevesi M,Schwab JH,Yaszemski MJ,Griffin AM,Healey JH,Ferguson PC,Hornicek FJ,Boland PJ,Sim FH,Rose PS,Wunder JS

    更新日期:2019-11-22 00:00:00

  • Semi-end-to-end esophagojejunostomy after laparoscopy-assisted total gastrectomy better reduces stricture and leakage than the conventional end-to-side procedure: A retrospective study.

    abstract:BACKGROUND AND OBJECTIVE:Laparoscopy-assisted total gastrectomy (LATG) has not gained popularity due to the technical difficulty of esophagojejunostomy (EJ) and the high incidence of EJ-related complications. Herein, we compared two types of EJ for Roux-en-Y reconstruction to determine whether semi-end-to-end (SETE) EJ...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.24637

    authors: Duan W,Liu K,Fu X,Shen X,Chen J,Su C,Yu P,Zhao Y

    更新日期:2017-08-01 00:00:00

  • Hexamethylmelamine and melphalan as salvage therapy in advanced ovarian carcinoma.

    abstract::Ten patients with advanced ovarian carcinoma were treated with hexamethylmelamine and melphalan after failing first-line combination chemotherapy. In eight patients residual disease was evident only at second-look laparotomy. Surgical debulking was accomplished in four patients but only two patients had residual disea...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930210305

    authors: Tempero MA,Kessinger A

    更新日期:1982-11-01 00:00:00

  • Importance of resection for locoregional disease control in Masaoka stage IVA thymic neoplasms.

    abstract:BACKGROUND AND OBJECTIVES:It is unclear if a specific strategy for simultaneous treatment of primary thymic neoplasms and pleural metastases confers benefit for Masaoka stage IVA disease. We reviewed our experience with thymic neoplasms with concurrent pleural metastases to identify factors influencing outcomes. METHO...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.25981

    authors: Corsini EM,Mitchell KG,Hofstetter WL,Mehran RJ,Roth JA,Sepesi B,Swisher SG,Vaporciyan AA,Walsh GL,Antonoff MB,Rice DC

    更新日期:2020-09-01 00:00:00

  • Steroid receptors in sarcomatous lesions.

    abstract::Clinical observations showed that the natural history of sarcomatous lesions may be different among males and females, and it may be influenced by hormonal factors. Estrogen receptors (ER) were measured on biopsy specimens of melanoma (two patients), soft-tissue sarcoma (four patients), cystosarcoma phylloides (five p...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930110405

    authors: Lee YT,Markland FS

    更新日期:1979-01-01 00:00:00

  • Myosarcomas of the small and large intestine: a clinicopathologic study.

    abstract::A retrospective study was made of 38 myosarcomas of the small and large intestines (34 leiomyosarcomas and 4 malignant leiomyoblastomas). Endoenteric, small, and noninvasive tumors were successfully treated by simple wedge excision, cautery snare removal, or segmental bowel resection with a high 5-yr cure rate of 86% ...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930240116

    authors: Shiu MH,Farr GH,Egeli RA,Quan SH,Hajdu SI

    更新日期:1983-09-01 00:00:00

  • Histoculture of human breast cancers.

    abstract::Breast cancers from 53 patients were explanted in culture, and 39 with two-year or more follow-up and documentable tissue forms of cancer in culture (histoculture) are the subject of this report. Clinicopathologic findings have been correlated with dynamic aspects of the cancers in short-term histocultures, including ...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930130103

    authors: Sherwin RP,Richters A,Yellin AE,Donovan AJ

    更新日期:1980-01-01 00:00:00

  • Severe tumor budding is a risk factor for lateral lymph node metastasis in early rectal cancers.

    abstract:BACKGROUND:Lateral lymph node (LLN) metastasis sometimes occurs in patients with early rectal cancer that has invaded the submucosa (SM) and muscularis propria (MP). This study aims to identify the risk factor(s) for LLN metastasis in such patients. METHOD:We retrospectively analyzed 65 patients with pathological SM o...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.21606

    authors: Homma Y,Hamano T,Otsuki Y,Shimizu S,Kobayashi H,Kobayashi Y

    更新日期:2010-09-01 00:00:00

  • Predictors of costs associated with radical cystectomy for bladder cancer: A population-based retrospective cohort study in the province of Quebec, Canada.

    abstract:BACKGROUND AND OBJECTIVES:There is paucity of studies on the predictors of bladder cancer (BC) management costs. We aimed to determine predictors of costs associated with radical cystectomy (RC) for BC. METHODS:We conducted a retrospective analysis in a cohort of 2,759 patients who underwent RC for BC between 2000 and...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.24132

    authors: Santos F,Dragomir A,Zakaria AS,Kassouf W,Aprikian A

    更新日期:2016-02-01 00:00:00

  • A novel preoperative risk score to predict lymph node positivity for rectal neuroendocrine tumors: An NCDB analysis to guide operative technique.

    abstract:BACKGROUND/OBJECTIVE:Staging and type of resection for rectal neuroendocrine tumors (R-NETS) relies on preoperative identification of lymph node (LN) involvement. Study objective was to develop a Preoperative Rectal Stratification Score (PReSS) for LN-positivity and to assess the association of PReSS with overall survi...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.25679

    authors: Gamboa AC,Liu Y,Lee RM,Zaidi MY,Staley CA,Russell MC,Cardona K,Sullivan PS,Maithel SK

    更新日期:2019-11-01 00:00:00

  • Oncoplastic breast conservation surgery: the new paradigm.

    abstract::Oncoplastic surgery combines plastic surgical techniques with sound surgical oncologic principles. The goal is to completely excise the cancer, with wide surgical margins while maintaining or improving cosmesis. For large, poorly defined, or unfavorably situated tumors, standard lumpectomies may lead to unacceptable c...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章,评审

    doi:10.1002/jso.23641

    authors: Silverstein MJ,Mai T,Savalia N,Vaince F,Guerra L

    更新日期:2014-07-01 00:00:00

  • Venous thromboembolism prophylaxis during neoadjuvant therapy for resectable and borderline resectable pancreatic cancer-Is it indicated?

    abstract:PURPOSE:To describe venous thromboembolism (VTE) rates in patients with pancreatic cancer (PC) during neoadjuvant therapy. METHODS:Factors associated with VTE were evaluated using multivariable logistic regression modeling in patients with resectable and BLR PC treated with neoadjuvant therapy between 2009 and 2014. ...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.24361

    authors: Krepline AN,Christians KK,George B,Ritch PS,Erickson BA,Tolat P,Evans DB,Tsai S

    更新日期:2016-10-01 00:00:00

  • The role of robotic aortic lymphadenectomy in gynecological cancer: surgical and oncological outcome in a single institution experience.

    abstract:BACKGROUND AND OBJECTIVE:This study aims to investigate the surgical outcomes observed in robotic transperitoneal aortic lymphadenectomy (AL) in gynecological cancer patients. METHODS:Retrospective data were collected and analyzed on 71 patients undergoing robotic surgical procedures for gynecological cancers, includi...

    journal_title:Journal of surgical oncology

    pub_type: 临床试验,杂志文章

    doi:10.1002/jso.25335

    authors: Gallotta V,Federico A,Gaballa K,D'Indinosante M,Conte C,Giudice MT,Naldini A,Lodoli C,Rotolo S,Gallucci V,Tortorella L,Romanò B,Scambia G,Ferrandina G

    更新日期:2019-03-01 00:00:00

  • Elevated preoperative serum carcinoembrionic antigen level may be an effective indicator for needing adjuvant chemotherapy after potentially curative resection of stage II colon cancer.

    abstract:BACKGROUND:To determine the prognostic factors and to rationalize adjuvant therapy, the clinicopathologic data of patients with a stage II colon cancer were analyzed retrospectively. PATIENTS AND METHODS:A total of 392 patients underwent potentially curative resection at the Kurume University Hospital between 1982 and...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.21161

    authors: Ogata Y,Murakami H,Sasatomi T,Ishibashi N,Mori S,Ushijima M,Akagi Y,Shirouzu K

    更新日期:2009-01-01 00:00:00

  • Acute appendicitis as a sign of a colorectal carcinoma.

    abstract::The relationship of acute appendicitis occurring previous to cancer in colon and rectum was studied in the consecutive records of 561 patients, of 40 years of age and older, operated upon with an appendectomy because of acute appendicitis. Sixteen (2.9%) of these patients were readmitted within three years because of ...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930200105

    authors: Arnbjörnsson E

    更新日期:1982-05-01 00:00:00

  • Creatine kinase isoenzyme (CK-BB) by RIA as a follow-up marker in stage D cancer of the prostate: comparison with PAP RIA.

    abstract::Fifty-nine patients with stage D carcinoma of the prostate under different modalities of treatment were studied for creatine phosphokinase isoenzyme BB (CK-BB) and prostatic acid phosphatase (PAP) levels in serum by radioimmunoassay (RIA) technique, in order to study the possible use of CK-BB as a follow-up marker com...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930280319

    authors: El-Shribiny A,Bharvaga A,Fitzpatrick J,Murphy GP

    更新日期:1985-03-01 00:00:00

  • Identification of a single nucleotide polymorphism in the MMP-1 promoter in chondrosarcoma.

    abstract::Matrix metalloproteinases (MMPs) are a group of at least 26 enzymes that facilitate cellular invasion via the degradation of the extracellular matrix. Specifically, the ability to degrade collagen types III and I is important in tumor invasion and metastasis. Over expression of the MMP-1 gene has been shown to correla...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.20100

    authors: Dickey ID,Scully SP

    更新日期:2004-09-01 00:00:00

  • Immunotherapy and whole-body hyperthermia as combined modality treatment of a subcutaneous murine sarcoma.

    abstract::Interleukin-2 and hyperthermia have been used individually to treat a variety of tumors in both experimental and human trials. Combined adoptive immunotherapy and hyperthermia is an exciting new line of investigation. Previous work in our laboratory has shown that combined local hyperthermia and rIL-2 therapy can sign...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930530310

    authors: Geehan DM,Fabian DF,Lefor AT

    更新日期:1993-07-01 00:00:00

  • The relevance of the Siewert classification in the era of multimodal therapy for adenocarcinoma of the gastro-oesophageal junction.

    abstract:INTRODUCTION:The Siewert classification has been used to plan treatment for tumours of the gastro-oesophageal junction since its proposal in the 1980s. The purpose of this study was to assess its continued relevance by evaluating whether there were differences in the biology and clinical characteristics of adenocarcino...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.23484

    authors: Curtis NJ,Noble F,Bailey IS,Kelly JJ,Byrne JP,Underwood TJ

    更新日期:2014-03-01 00:00:00

  • Surgical management of ovarian carcinoma metastatic to the breast and axilla: A role for metastasectomy?

    abstract::As patients with ovarian cancer are living longer, surgeons will be faced with the management of metastatic lesions amenable to resection more frequently. We present two patients with ovarian cancer metastatic to the breast who underwent resection for their metastases, but their outcomes differed significantly. After ...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.24055

    authors: Rossfeld KK,Carson WE 3rd

    更新日期:2015-11-01 00:00:00

  • Metastatic spinal cord compression as initial presentation of follicular thyroid carcinoma.

    abstract::Follicular thyroid carcinoma, initially presenting as spinal cord compression due to metastatic lesions, is a less reported event. We present two cases of well-differentiated thyroid carcinoma that led to spinal cord compression. A thorough search of the literature revealed only five similar cases. We summarize the cl...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章,评审

    doi:10.1002/(sici)1096-9098(199803)67:3<186::aid-jso8>

    authors: Goldberg H,Stein ME,Ben-Itzhak O,Duek D,Ravkin A,Gaitini D

    更新日期:1998-03-01 00:00:00

  • Screening for lung cancer: the US studies.

    abstract::Efforts in lung cancer screening with chest X-ray (CXR) and sputum cytology in the 1970s and 1980s were negative. In the ensuing decade, the early lung cancer action project (ELCAP), and the Mayo screening study showed the promise of low-dose CT. These and other studies led to the National lung screening study (NLST),...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章,评审

    doi:10.1002/jso.23391

    authors: Midthun DE,Jett JR

    更新日期:2013-10-01 00:00:00

  • Intraperitoneal immunotherapy to prevent peritoneal carcinomatosis in patients with advanced gastrointestinal malignancies.

    abstract::Prognosis of peritoneal carcinomatosis (PC) from GI tract cancers remains poor. As 30% of patients develop PC after curative surgery, prevention of PC during cancer resection would be desirable. Regarding physiopathology of PC and intraperitoneal immunology, intraoperative application of trifunctional antibodies offer...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章,评审

    doi:10.1002/jso.21338

    authors: Ströhlein MA,Heiss MM

    更新日期:2009-09-15 00:00:00

  • Argyrophilic nucleolar organizer regions: their value and correlation with clinical prognostic factors in breast carcinoma.

    abstract:BACKGROUND AND OBJECTIVES:Argyrophilic nucleolar organizer regions (AgNORs) have been recently identified as a marker of proliferative index in various tumors. These were evaluated in 46 patients with primary breast carcinoma and were correlated with clinical prognostic parameters of breast cancer. Ten patients with be...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/(sici)1096-9098(199707)65:3<201::aid-jso10

    authors: Kumar A,Kushwaha AK,Kumar M,Gupta S

    更新日期:1997-07-01 00:00:00

  • Distribution and patterns of lymph nodes metastases and micrometastases in the mesorectum of rectal cancer.

    abstract:BACKGROUND AND OBJECTIVES:Facts buried in the mesorectum remain to be unveiled. This study investigated the number, size, and detailed distribution of lymph nodes metastases and micrometastases within the mesorectum of rectal cancer. METHODS:Thirty-one patients who underwent total mesorectal excision (TME) were treate...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.20826

    authors: Zheng YC,Zhou ZG,Li L,Lei WZ,Deng YL,Chen DY,Liu WP

    更新日期:2007-09-01 00:00:00

  • Palliative isolated limb perfusion for advanced limb disease in stage IV melanoma patients.

    abstract:INTRODUCTION:Two to three percent of the patients with extremity melanoma develop in-transit metastases in the course of their disease. When local treatments fail, isolated limb perfusion (ILP) is a reasonable option, but is generally only applied to patients without evidence of distant metastases. We assessed the valu...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.20297

    authors: Takkenberg RB,Vrouenraets BC,van Geel AN,Nieweg OE,Noorda EM,Eggermont AM,Kroon BB

    更新日期:2005-08-01 00:00:00