Abstract:
AIMS:Establish oncologic safety using 50 Gy to sterilize tumor bearing bone before reimplantation in primary diaphyseal high grade extremity tumors, determine extracorporeal radiotherapy (ECRT) graft survival, and analyze factors that affect union at osteotomy sites. MATERIALS AND METHODS:Seventy non metastatic patients underwent reconstruction with intercalary ECRT grafts sterilized with 50 Gy. Diagnosis included osteosarcoma (38) and Ewing's sarcoma (32). At last follow-up-49 patients were alive, 19 had died and 2 were lost to follow up. Survivors had minimum follow up of 3 years (range 39-127 months). RESULTS:Ninty one percent metaphyseal osteotomies united without additional intervention compared to 71% diaphyseal osteotomies. Additional small plate at diaphyseal osteotomy apparently reduced incidence of non-union (17% vs 31%) (P = 0.49). Addition of morsellised allograft did not help union. There were seven (10%) local recurrences, all in soft tissue. Seventeen of 69 patients (25%) needed removal of ECRT graft. Five year survival for ECRT graft (removal for all causes) was 79% and 84% (excluding removal for local recurrence). CONCLUSIONS:Reimplanting sterilized tumor bone using 50 Gy for tumor ablation is an easily applicable, oncologically safe, biological reconstruction option for primary diaphyseal extremity tumors.
journal_name
J Surg Oncoljournal_title
Journal of surgical oncologyauthors
Puri A,Byregowda S,Gulia A,Patil V,Crasto S,Laskar Sdoi
10.1002/jso.25092subject
Has Abstractpub_date
2018-07-01 00:00:00pages
138-143issue
1eissn
0022-4790issn
1096-9098journal_volume
118pub_type
杂志文章abstract::The T N M staging system created by a surgeon in the 1950s continues to be a major benchmark for assessing long-term outcomes in adult solid tumors. Although several major changes have occurred in this anatomical staging system, the tenets of TNM staging remain constant. Recently molecular markers and biologic modifie...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.23704
更新日期:2014-10-01 00:00:00
abstract:BACKGROUND:Retroperitoneal lymphangiomatosis (RL) is a rare form of primary lymphedema featuring aberrant retroperitoneal lymphatic proliferation. It causes recurrent cellulitis, repeated interventions, and poor life quality. This study aimed to investigate proper diagnositc criteria and surgical outcomes for RL with e...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.25514
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:This study assessed the outcomes of Yttrium-90 (90 Y) radiation segmentectomy for hepatic metastases unamenable to resection or ablation. MATERIALS AND METHODS:Over 6 years, 36 patients with 53 tumors underwent segmental radioembolization. Patients were not candidates for surgical resection o...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,多中心研究
doi:10.1002/jso.26223
更新日期:2021-01-01 00:00:00
abstract::Sarcoma diagnosis continues to evolve as new information is discovered. Certain tumors have been downgraded (dermal leiomyosarcoma) and an atypical category designed for others. Recently entities include myxoinflammatory fibroblastic sarcoma, myoepithelioma, and pseudomyogenic hemangioendothelioma. The terms malignant...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.23853
更新日期:2015-04-01 00:00:00
abstract::Xenografts of a human pancreatic carcinoma cell line, HPC-YS, which reacted with the monoclonal antibody (MAb) A7, were used to investigate the in vivo localization of radioiodinated MAb A7 after intraperitoneal injection. MAb A7 localized to the tumor 4 days and 8 days after injection with a tissue/blood ratio of 1.4...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930500309
更新日期:1992-07-01 00:00:00
abstract:BACKGROUND:The aim of this study is to investigate clinical significance of miR-155 expression in breast cancer. METHODS:TaqMan real-time RT-PCR was performed to detect miR-155 expression in breast cancer tissues. The correlation of miR-155 expression with clinicopathological factors and prognosis of breast cancer pat...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.22153
更新日期:2012-09-01 00:00:00
abstract::A massive lymphatic leak developed following radical retroperitoneal lymph node dissection for recurrent extragonadal seminoma. Chylous ascites persisted for over 3 months, with an average daily external drainage of 1.5 liters, and was successfully treated with a peritoneovenous shunt. ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930360315
更新日期:1987-11-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Microsatellite instability (MSI) in gastric cancer (GC) is associated with older age. We present the clinicopathological results of younger and older patients with MSI GC. METHODS:We analyzed 472 patients with GC. MSI analysis was done on fresh frozen tissue using five quasimonomorphic mononu...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.24513
更新日期:2017-03-01 00:00:00
abstract::Laparoscopic resection of colon cancer became mired in controversy when it appeared that the technique might be associated with an increased risk of tumor recurrence within the surgical incisions. This was not a uniform finding among all surgeons, however, and other evidence suggested that this did not occur in experi...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.20921
更新日期:2007-12-15 00:00:00
abstract::With the rapid uptake of the robotic approach in gynecologic surgery, a thorough understanding of the technology, including its uses and limitations, is critical to maximize patient outcomes and safety. This review discusses the role of training modalities and development of curricula for robotic surgery. Furthermore,...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.24006
更新日期:2015-12-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Stage III malignant melanoma is a heterogeneous disease where those cases deemed marginally resectable or irresecatble are frequently incurable by surgery alone. Targeted therapy takes advantage of the high incidence of BRAF mutations in melanomas, most notably the V600E mutation. These agents...
journal_title:Journal of surgical oncology
pub_type: 临床试验,杂志文章
doi:10.1002/jso.24744
更新日期:2017-12-01 00:00:00
abstract::Leiomyosarcoma of the colon is a rare neoplasm. It is widely known that primary malignant lesions may present either simultaneously (synchronous tumor) or at different times (metachronous tumor). The incidence of metachronous colonic mucosal carcinoma is generally considered to range from 3 to 5%. Metachronous leiomyo...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930320403
更新日期:1986-08-01 00:00:00
abstract:OBJECTIVES:To document radical cystectomy (RC) outcomes in patients over 80 years old across Quebec during the years 2000-2009 and to examine potentially related factors. METHODS:Within Quebec health insurance medical services database, we identified patients over 80 years who underwent RC. The outcomes analyzed were ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.23887
更新日期:2015-06-01 00:00:00
abstract:BACKGROUND:Increased activity of Src has been found in several human cancers, and often is associated with poor clinical outcome. The present study aimed to determine whether Src activity is increased in gastrointestinal stromal tumors (GIST), and whether it correlates with established tumor or patient characteristics ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.23544
更新日期:2014-05-01 00:00:00
abstract::A survival study for squamous carcinomas of the distal esophagus treated by the Southern California Permanente Medical Group in the interval of 1954 to 1988 was undertaken. We found radiation therapy and surgery equally efficacious in terms of cure for patients without distant disease and performance status sufficient...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930460206
更新日期:1991-02-01 00:00:00
abstract::Intrahepatic cholangiocarcinoma (iCCA) is the second most common primary hepatic cancer in the United States. Currently, curative treatment involves aggressive surgery. Chemotherapy and radiation treatments have been used for unresectable tumors with some success. Optimizing the use of current and developing novel mul...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.24093
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Facts buried in the mesorectum remain to be unveiled. This study investigated the number, size, and detailed distribution of lymph nodes metastases and micrometastases within the mesorectum of rectal cancer. METHODS:Thirty-one patients who underwent total mesorectal excision (TME) were treate...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.20826
更新日期:2007-09-01 00:00:00
abstract::To define more precisely the prognostic index for patients with primary carcinoma of the gallbladder in Taiwan, we retrospectively reviewed the data of 74 patients with gallbladder carcinoma treated over a period of 15 years, from 1979 to 1993. Of these patients, 75% had Nevin stage V gallbladder cancer. The most comm...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/(SICI)1096-9098(199601)61:1<49::AID-JSO11>
更新日期:1996-01-01 00:00:00
abstract:BACKGROUND:The purpose of the current study was to evaluate the accuracy of (18)F-FDG PET/CT in staging hilar cholangiocarcinoma. MATERIALS AND METHODS:From June 2004 to December 2007, patients evaluated for surgical treatment of hilar cholangiocarcinoma were entered into a prospective database. Dual modality (18)F-FD...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.21136
更新日期:2008-11-01 00:00:00
abstract::Metastatic colorectal cancer (mCRC) continues to show poor outcomes, with many patients exhausting effective standard-of-care therapy. To explore the current landscape of clinical trials for mCRC, we reviewed over 600 clinical trials that are currently ongoing for mCRC patients. Immunotherapeutic agents form approxima...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.25441
更新日期:2019-04-01 00:00:00
abstract::This paper presents an apparent case of danazol-induced primary hepatocellular carcinoma in a 49-year-old patient, following two years of continuous therapy with this inhibitor of pituitary gonadotrophin. Discontinuation of the drug failed to cause regression of the tumour. ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930280209
更新日期:1985-02-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Fibrolamellar carcinoma (FLC) presents in young, otherwise-healthy individuals. This study examined recurrence and survival characteristics after surgical resection for FLC by utilizing an international multi-institutional database. METHODS:Consecutive patients undergoing hepatectomy for FLC ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.23658
更新日期:2014-09-01 00:00:00
abstract::A total of 144 patients with advanced sarcomas were entered into a randomized prospective protocol with four treatment arms utilizing different combinations of chemotherapeutic agents. Of these, 120 patients (83%) were judged acceptable. Treatment 1: actinomycin-D (Act-D), 0.01 mg/kg IV, days 1--5; phenylalanine must...
journal_title:Journal of surgical oncology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/jso.2930110406
更新日期:1979-01-01 00:00:00
abstract::Patients who have cancer are exposed to the adverse consequences of blood transfusions, such as transmissible diseases. This study presents an examination of a program of autologous blood deposit for cancer patients undergoing elective surgical procedures. Over a 3-year period, 235 patients deposited 388 units of auto...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930430106
更新日期:1990-01-01 00:00:00
abstract:BACKGROUND:Receptor-binding cancer antigen expressed on SiSO cells (RCAS1) has been reported to act as a ligand for a receptor present on normal peripheral lymphocytes and to induce apoptotic cell death. We aimed to elucidate the significance of RCAS1 expression in human esophageal squamous cell carcinomas (ESCC). MET...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.20249
更新日期:2005-05-01 00:00:00
abstract::Anastomotic complications are responsible for significant morbidity and mortality following esophagectomy for cancer. Conflicting reports exist regarding the superiority of hand-sewn versus stapled techniques. This systematic review identified eight randomized clinical trials examining this issue. None of the studies ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.21510
更新日期:2010-05-01 00:00:00
abstract:BACKGROUND:Cardiac myxoma, the most common primary tumor in the adult, is less often encountered in infants and children. We reviewed our series of children with cardiac myxoma over a 22-year period and present the long-term results of surgical resection of the tumor. PATIENTS AND METHODS:From January 1985 to December...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.21175
更新日期:2009-01-01 00:00:00
abstract::The effectiveness of MFC (mitomycin C, 5-fluorouracil and cytosine arabinoside) therapy for nonresectable cancers and cancers recurring after surgery was investigated in 60 patients with solid cancers aged 26 to 69 years. Treatment was effective in 28 patients (47%) including seven (12%) who showed a very good respons...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930100507
更新日期:1978-01-01 00:00:00
abstract::Carcinoma of the lung should be considered in the search for an unknown primary lesion when there is evidence of cervical lymph node involvement. Of 1,686 patients with a final diagnosis of bronchogenic carcinoma seen during a 10-year period at the University of Louisville Hospitals, 26 presented one or more clinicall...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930090513
更新日期:1977-01-01 00:00:00
abstract::Robotic surgical techniques are now being applied in the setting of retroperitoneal lymphadenectomy (RPLND) for testicular cancer. While laparoscopic RPLND has not been widely accepted, reports of robot assisted RPLND (RARPLND) are emerging. This manuscript will review the application of RPLND for testicular cancer, e...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.24018
更新日期:2015-12-01 00:00:00