Preoperative assessment of hilar cholangiocarcinoma by dual-modality PET/CT.

Abstract:

BACKGROUND:The purpose of the current study was to evaluate the accuracy of (18)F-FDG PET/CT in staging hilar cholangiocarcinoma. MATERIALS AND METHODS:From June 2004 to December 2007, patients evaluated for surgical treatment of hilar cholangiocarcinoma were entered into a prospective database. Dual modality (18)F-FDG PET/CT was performed before surgery. The report was reviewed with comparison to the operative and pathological results in each case for tumour-node-metastasis staging. RESULTS:Seventeen patients (6 women, 11 men) of a median age of 62 years were included in the study. Radical tumour resection was performed on seven patients. Ten patients underwent surgical exploration. The sensitivity of PET/CT in detecting primary tumour was found to be 58.8% (25% in T2 tumour, 70% in T3 tumour, 66.7% in T4 tumour). The sensitivity/specificity of PET/CT in detecting lymph node metastasis and distant metastasis were 41.7%/80% and 55.6%/87.5%, respectively. Positive (18)F-FDG uptake in the bile duct was found to be associated with surgical non-resectability (P = 0.05). CONCLUSION:Dual-modality PET/CT imaging was found to have a high specificity in detection of lymph node and distant metastasis in hilar cholangiocarcinoma, with a limited value in correct judgement of surgical resectability for tumours in stadium UICC I-III.

journal_name

J Surg Oncol

authors

Li J,Kuehl H,Grabellus F,Müller SP,Radunz S,Antoch G,Nadalin S,Broelsch CE,Gerken G,Paul A,Kaiser GM

doi

10.1002/jso.21136

subject

Has Abstract

pub_date

2008-11-01 00:00:00

pages

438-43

issue

6

eissn

0022-4790

issn

1096-9098

journal_volume

98

pub_type

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