Biological significance of the maximum standardized uptake values on positron emission tomography in non-small cell lung cancer.

Abstract:

BACKGROUND:The 2-[18F]-fluoro-2-deoxy-D-glucose positron emission tomography (FDG-PET) has recently become an important non-invasive tool for the diagnosis and staging in several cancers. The standardized uptake value (SUV) of primary tumor has been reported to relate to cancer progression and prognosis, however, biological mechanism is still unclear. METHOD:Seventy-nine patients with non-small cell lung cancer (NSCLC) who had undergone preoperative FDG-PET and a surgical resection were enrolled in this study. NSCLC tissue samples prepared from the surgical specimens were subjected to an immunohistochemical analysis for the expression of Ki-67 and vascular endothelial growth factor (VEGF) proteins. The relationships between the expression status of these proteins and SUV(max) of primary tumors were evaluated. RESULT:Concerning the relationship with various clinicopathological findings, SUV(max) of primary tumors was associated with histology, tumor proliferation, pleural or vascular invasion, and pathological stage. A significant correlation was observed between the SUV(max) and either the Ki-67 or VEGF expression (P < 0.001, P = 0.006), respectively. Cases with both Ki-67-negative and VEGF-negative findings exhibited a significantly lower SUV(max) than those with single positive or double positive cases (P = 0.006, P < 0.001). CONCLUSION:The SUV(max) was associated with the expression of Ki-67 and VEGF in NSCLC. These findings indicated that the SUV(max) of primary tumors might therefore reflect the biological malignant potential in NSCLC.

journal_name

J Surg Oncol

authors

Takenaka T,Yano T,Ito K,Morodomi Y,Miura N,Kawano D,Shoji F,Abe K,Honda H,Maehara Y

doi

10.1002/jso.21386

subject

Has Abstract

pub_date

2009-12-15 00:00:00

pages

688-92

issue

8

eissn

0022-4790

issn

1096-9098

journal_volume

100

pub_type

杂志文章
  • Rat glioma cell death induced by cationic liposome-mediated transfer of the herpes simplex virus thymidine kinase gene followed by ganciclovir treatment.

    abstract:BACKGROUND AND OBJECTIVES:We studied antitumor effects and cell death induced by cationic liposome-mediated gene transfer of the herpes simplex virus thymidine kinase (HSV-tk) gene followed by ganciclovir treatment in cultured rat T9 glioma cells and in experimental gliomas produced from this cell line. METHODS:To tra...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/1096-9098(200101)76:1<19::aid-jso1004>3.0.

    authors: Yoshida T,Mizuno M,Taniguchi K,Nakayashiki N,Wakabayashi T,Yoshida J

    更新日期:2001-01-01 00:00:00

  • Identifying the barriers to gastric cancer care at safety-net hospitals: A novel comparison of a safety-net hospital to a neighboring quaternary referral academic center in the same healthcare system.

    abstract:BACKGROUND:The three-delays model describes delays in seeking, reaching, and receiving care for vulnerable populations needing treatment. The dominant delay for patients with gastric adenocarcinoma (GAC) is unknown. We aimed to define patients with GAC who reached and received care at our regional safety-net hospital (...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.25299

    authors: Zaidi MY,Rappaport JM,Ethun CG,Gillespie T,Hawk N,Chawla S,Cardona K,Maithel SK,Russell MC

    更新日期:2019-01-01 00:00:00

  • Malignant melanoma and carcinoma of the breast.

    abstract::Five patients with breast cancer and malignant melanoma are reported. Two patients had a third primary malignancy. In 4 out of 5 patients the breast tumor was the initial tumor discovered, and in 4 out of 5 the second tumor evolved metachronously. No specific carcinogenic factor could be established. The low malignanc...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930070305

    authors: Lokich JJ

    更新日期:1975-01-01 00:00:00

  • Barriers to rehabilitation following surgery for primary breast cancer.

    abstract::Surgery is a mainstay of primary breast cancer therapy. Alterations in surgical technique have reduced normal tissue injury, yet pain and functional compromise continue to occur following treatment. A tenuous evidence base bolstered by considerable expert opinion suggests that early intervention with conventional reha...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章,评审

    doi:10.1002/jso.20782

    authors: Cheville AL,Tchou J

    更新日期:2007-04-01 00:00:00

  • Intracavitary bleomycin for the control of malignant effusions.

    abstract::The results of treatment with intracavitary bleomycin are reported in twenty patients with a malignant pleural effusion and five patients with malignant ascites. The control rate was 17/20 (85%) patients with malignant pleural effusions and 3/5 (60%) patients with malignant ascites. Toxicities were minimal with fever ...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930160312

    authors: Bitran JD,Brown C,Desser RK,Kozloff MF,Shapiro C,Billings AA

    更新日期:1981-01-01 00:00:00

  • Immunophenotypic and prognostic analysis of PAX8 and TTF-1 expressions in neuroendocrine carcinomas of thymic origin: A comparative study with their pulmonary counterparts.

    abstract:OBJECTIVES:To investigate the immunoreactivity of TTF-1 and PAX8 in neuroendocrine carcinoma of thymic (TNEC) and pulmonary origins (PNEC), and whether their immunophenotyping could be used to distinguish between NEC of the two sites, as well as prognosis of patients with TNEC. METHODS:Twenty-two cases of TNEC and 20 ...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.24393

    authors: Bi Y,Deng Y,Li S,Zhou X,Chen Y,Ma D,Mao X,Guan Y,Chen J,Meng Y

    更新日期:2016-11-01 00:00:00

  • Is gastrectomy mandatory for all residual or recurrent gastric cancer following endoscopic resection? A large-scale Korean multi-center study.

    abstract:BACKGROUND AND OBJECTIVES:To clarify optimal treatment guidelines for residual or local recurrence after endoscopic resection (ER). METHODS:Eighty-six patients underwent gastrectomy due to incomplete ER and local recurrence after ER. The pathological findings of ER and gastrectomy specimens were analyzed. RESULTS:The...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1002/jso.21074

    authors: Song KY,Hyung WJ,Kim HH,Han SU,Cho GS,Ryu SW,Lee HJ,Kim MC,Korean Laparoscopic Gastrointestinal Surgery Study (KLASS) Group.

    更新日期:2008-07-01 00:00:00

  • Surgical management of ovarian carcinoma metastatic to the breast and axilla: A role for metastasectomy?

    abstract::As patients with ovarian cancer are living longer, surgeons will be faced with the management of metastatic lesions amenable to resection more frequently. We present two patients with ovarian cancer metastatic to the breast who underwent resection for their metastases, but their outcomes differed significantly. After ...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.24055

    authors: Rossfeld KK,Carson WE 3rd

    更新日期:2015-11-01 00:00:00

  • Primary gastric lymphoma.

    abstract::The records of 30 patients with primary gastric lymphoma and a minimum of 5 years of follow-up were reviewed and clinical and pathologic prognostic factors analyzed. The overall 5-year survival was 40% (median 23 months). No significant relationship between surgical and patient age, sex, duration of symptoms, macrosco...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930540306

    authors: Secco GB,Fardelli R,Campora E,Munizzi F,Aste H,Nicolò G

    更新日期:1993-11-01 00:00:00

  • Isolated limb infusion as a model to test new agents to treat metastatic melanoma.

    abstract::The limb model of in-transit disease can expand our understanding of treating melanoma because of the ease of obtaining tissue biopsies for correlative studies and the availability of preclinical animal models that allow validation of novel therapeutic strategies. This review will focus on regional therapy for in-tran...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章,评审

    doi:10.1002/jso.23502

    authors: Lidsky ME,Speicher PJ,Jiang B,Tsutsui M,Tyler DS

    更新日期:2014-03-01 00:00:00

  • Effect of impaired renal function on tamoxifen.

    abstract::There is no information available in the literature on the blood levels of tamoxifen in patients with decreased renal function. As serious side effects of tamoxifen administered at high doses have been reported, a patient with decreased renal function and metastatic breast cancer was studied to determine the blood lev...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930270404

    authors: Sutherland CM,Sternson LA,Muchmore JH,Ball JE,Cerise EJ

    更新日期:1984-12-01 00:00:00

  • Prognostic significance of blood vessel invasion in carcinoma of the breast in women.

    abstract::Prognostic significance of blood vessel invasion in carcinoma of the female breast has been evaluated by study of 242 cases of radical mastectomy done at the Tata Memorial Hospital. The significance of axillary node involvement with the disease has been simultaneously evaluated. In the absence of blood vessel invasion...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930090613

    authors: Sampat MB,Sirsat MV,Gangadharan P

    更新日期:1977-01-01 00:00:00

  • Phase II study of a modified combination of etoposide, doxorubicin, and cisplatin for patients with advanced gastric cancer.

    abstract:BACKGROUND:Based on the promising results of EAP (etoposide, doxorubicin, and cisplatin) combination, a phase II study of modified EAP combination was performed in patients with advanced gastric cancer to evaluate the response, toxicity, and survival. METHOD:Fifty-two consecutive patients with measurable or evaluable ...

    journal_title:Journal of surgical oncology

    pub_type: 临床试验,杂志文章

    doi:10.1002/(sici)1096-9098(199704)64:4<318::aid-jso13

    authors: Içli F,Karaoguz H,Akbulut H,Dinçol D,Demirkazik A,Cay F

    更新日期:1997-04-01 00:00:00

  • Lactation following conservation surgery and radiotherapy for breast cancer.

    abstract::A 38-year-old woman with early stage invasive breast cancer was treated with wide excision of the tumor, axillary lymph node dissection, and breast irradiation. Three years later, she gave birth to a normal baby. She attempted breast feeding and had full lactation from the untreated breast. The irradiated breast under...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930460214

    authors: Varsos G,Yahalom J

    更新日期:1991-02-01 00:00:00

  • Combining independently effective anticancer agents may not augment the independent antitumor effects: a study using human digestive organ cancer xenograft lines in nude mice.

    abstract::Five human digestive organ cancer xenograft lines were subcutaneously transplanted in nude mice, and 7 anticancer agents (ACAs) were intravenously administered singly or in combinations at 4 times the standard clinical doses. Cisplatin (P) was effective in 4 lines and 5-fluorouracil (F) was effective in 3 lines. A tot...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930480408

    authors: Nio Y,Tseng CC,Tsubono M,Kawabata K,Masai Y,Shiraishi T,Fukumoto M,Tobe T

    更新日期:1991-12-01 00:00:00

  • Synchronous primary tumors of the extrahepatic bile duct and gallbladder.

    abstract:BACKGROUND AND OBJECTIVES:This study aims to clarify clinicopathologic characteristics of synchronous primaries of the extrahepatic bile duct and gallbladder. Understanding multiplicity and its histologic confirmation is an important step for successful surgical management. METHODS:Of the 190 cases of resection of bil...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/(sici)1096-9098(199708)65:4<258::aid-jso6>

    authors: Kurosaki I,Watanabe H,Tsukada K,Hatakeyama K

    更新日期:1997-08-01 00:00:00

  • The role of robotic aortic lymphadenectomy in gynecological cancer: surgical and oncological outcome in a single institution experience.

    abstract:BACKGROUND AND OBJECTIVE:This study aims to investigate the surgical outcomes observed in robotic transperitoneal aortic lymphadenectomy (AL) in gynecological cancer patients. METHODS:Retrospective data were collected and analyzed on 71 patients undergoing robotic surgical procedures for gynecological cancers, includi...

    journal_title:Journal of surgical oncology

    pub_type: 临床试验,杂志文章

    doi:10.1002/jso.25335

    authors: Gallotta V,Federico A,Gaballa K,D'Indinosante M,Conte C,Giudice MT,Naldini A,Lodoli C,Rotolo S,Gallucci V,Tortorella L,Romanò B,Scambia G,Ferrandina G

    更新日期:2019-03-01 00:00:00

  • Prognostic models for RPS patients-Attempting to predict patient outcomes.

    abstract::Retroperitoneal sarcoma (RPS) patients can have variable of outcomes after surgery. The chance to recur locally or at distant sites varies according to tumor grade, histologic subtype, and other patient- and tumor-related characteristics. The relative contribution of each prognostic variable on the oncological outcome...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章,评审

    doi:10.1002/jso.24903

    authors: Callegaro D,Miceli R,Gladdy RA

    更新日期:2018-01-01 00:00:00

  • Actual 10-year survivors and 10-year recurrence free survivors after primary liver resection for hepatocellular carcinoma in the 21st century: A single institution contemporary experience.

    abstract:BACKGROUND:At present, the majority of outcome studies of survival of hepatocellular carcinoma (HCC) post-liver resection (post-LR) present actuarial survival data, which often results in overestimation of survival. We sought to evaluate the actual 10-year survival post-LR for HCC and identify variables that are associ...

    journal_title:Journal of surgical oncology

    pub_type: 临床试验,杂志文章

    doi:10.1002/jso.26259

    authors: Linn YL,Chee MY,Koh YX,Teo JY,Cheow PC,Chow PKH,Chan CY,Chung AYF,Ooi LLPJ,Goh BKP

    更新日期:2021-01-01 00:00:00

  • Factors related to re-excision procedures following primary breast-conserving surgery for women with breast cancer in the U.S. Military Health System.

    abstract:BACKGROUND AND OBJECTIVES:Re-excision surgery is undertaken to obtain clear margins after breast-conserving surgery (BCS) for localized breast cancer. This study examines patient and tumor characteristics related to re-excision surgery in the universal-access Military Health System (MHS). METHODS:Retrospective analysi...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.25788

    authors: Eaglehouse YL,Georg MW,Jatoi I,Shriver CD,Zhu K

    更新日期:2019-11-29 00:00:00

  • Surgical resection of pulmonary metastases from gastric cancer.

    abstract:BACKGROUND AND OBJECTIVES:There are no reports concerning surgical treatment on pulmonary metastases from gastric cancer. The aims of this study were to characterize patients with pulmonary metastasis from gastric cancer and to determine the efficacy of surgical therapy. METHODS:Between 1977 and 1993, 3,076 patients u...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/(sici)1096-9098(199811)69:3<147::aid-jso5>

    authors: Kanemitsu Y,Kondo H,Katai H,Nakayama H,Asamura H,Tsuchiya R,Naruke T

    更新日期:1998-11-01 00:00:00

  • Enhancement of metastasis development by BCG immunotherapy.

    abstract::When BALB/c mice bearing growing transplants of a syngeneic colon carcinoma--Colon Tumor 26 (CT 26)--were treated with Bacillus Calmette-Guerin (BCG), no effect on tumor growth rate or survival time was observed compared to untreated controls. However, after excision of primary tumor transplants, enhanced development ...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930150307

    authors: Colmerauer ME,Koziol JA,Pilch YH

    更新日期:1980-01-01 00:00:00

  • Addition of adjuvant hepatic artery infusion to systemic chemotherapy following resection of colorectal liver metastases is associated with reduced liver-related mortality.

    abstract:BACKGROUND:After resection of colorectal liver metastases (CRLM), recurrent disease in the liver is a major cause of death but may be reduced with the addition of adjuvant hepatic arterial infusion (HAI) chemotherapy to systemic chemotherapy (SYS). OBJECTIVE:This study investigates organ-specific causes of death in pa...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.25916

    authors: Srouji R,Narayan R,Boerner T,Buisman F,Seier K,Gonen M,Balachandran VP,Drebin J,Jarnagin WR,Kingham TP,Wei A,Kemeny NE,D'Angelica M

    更新日期:2020-06-01 00:00:00

  • Therapeutic significance of palliative operations for gastric cancer for survival and quality of life.

    abstract:BACKGROUND AND OBJECTIVES:There have been few reports on the objective assessment of quality of life (QOL) in patients with gastric cancer following palliative operations. The benefit of a palliative operation for survival and QOL of patients with gastric cancer is not clear. METHODS:Survival and hospital-free surviva...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/(sici)1096-9098(199809)69:1<41::aid-jso8>3

    authors: Ouchi K,Sugawara T,Ono H,Fujiya T,Kamiyama Y,Kakugawa Y,Mikuni J,Yamanami H

    更新日期:1998-09-01 00:00:00

  • Nonsteroid antiinflammatory drugs and tamoxifen for desmoid tumors and carcinoma of the stomach.

    abstract::The results of treatment of desmoid tumor patients with nonsteroid antiinflammatory drugs alone or in combination with tamoxifen are described. Tumor growth was inhibited in six of seven patients. Nonsteroid antiinflammatory drugs administered along with 5-fluorouracil and cyclophosphamide and other inhibitors of T-su...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930220314

    authors: Waddell WR,Gerner RE,Reich MP

    更新日期:1983-03-01 00:00:00

  • Defining the optimal timing of adjuvant therapy for resected pancreatic adenocarcinoma: A statewide cancer registry analysis.

    abstract:BACKGROUND:Long-term results of the ESPAC-3 trial suggest that while completing adjuvant therapy (AT) is necessary after resection of pancreatic ductal adenocarcinoma (PDAC), early initiation (within 8 weeks) may not be associated with improved overall survival (OS). The primary aim of this study was to evaluate the OS...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.24314

    authors: Saeed H,Hnoosh D,Huang B,Durbin EB,McGrath PC,Desimone P,Maynard E,Anthony LB,Dineen SP,Hosein PJ,Tzeng CW

    更新日期:2016-09-01 00:00:00

  • Effect of tumor size on monoclonal antibody uptake in a metastatic model.

    abstract::We studied the effect of tumor size on monoclonal antibody (mAb) in a murine hepatic model. Intrasplenic injection of HT-29 LMM metastatic human colon cancer cell line reproducibility results in hepatic metastases formation in congenitally athymic mice. HT-29-15, a murine mAb of the IgG1 class reactive with the HT-29 ...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930490409

    authors: Yoshida K,Rivoire ML,Divgi CR,Niedzwiechi D,Cohen AM,Sigurdson ER

    更新日期:1992-04-01 00:00:00

  • Early postoperative outcomes among patients with delayed surgeries after preoperative positive test for SARS-CoV-2: A case-control study from a single institution.

    abstract:BACKGROUND:There are limited data on surgical complications for patients that have delayed surgery after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. We aimed to analyze the surgical outcomes of patients submitted to surgery after recovery from SARS-CoV-2 infection. METHODS:Asymptomatic pati...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.26377

    authors: Baiocchi G,Aguiar S Jr,Duprat JP,Coimbra FJF,Makdissi FB,Vartanian JG,Zequi SC,Gross JL,Nakagawa SA,Yazbek G,Diniz TP,Gonçalves BT,Zurstrassen CE,Campos HGDA,Joaquim EHG,França E Silva IA,Kowalski LP

    更新日期:2021-01-11 00:00:00

  • Transsternal thoracotomy for bilateral pulmonary metastasis.

    abstract::Advances in the surgical treatment of primary malignancies and the recent chemotherapy have led to an expansion of the surgical treatment of metastatic lung tumors. However, multiple pulmonary metastases are often found and may affect both lungs. It is difficult to reach tumors in the posterior parts of the lung when ...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930500210

    authors: Shimizu N,Ando A,Matsutani T,Maruyama S,Date H,Teramoto S

    更新日期:1992-06-01 00:00:00

  • Adjuvant chemotherapy after neoadjuvant chemoradiation and curative resection for rectal cancer: is it necessary for all patients?

    abstract:BACKGROUND:The benefit of adjuvant chemotherapy for patients with locally advanced rectal cancer who have received neoadjuvant concurrent chemoradiation therapy (CCRT) and undergone curative resection remains unclear. METHODS:This study was a retrospective review of prospectively collected data. Patients with locally ...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.23835

    authors: Jung KU,Kim HC,Park JO,Park YS,Park HC,Choi DH,Cho YB,Yun SH,Lee WY,Chun HK

    更新日期:2015-03-15 00:00:00