Immunophenotypic and prognostic analysis of PAX8 and TTF-1 expressions in neuroendocrine carcinomas of thymic origin: A comparative study with their pulmonary counterparts.

Abstract:

OBJECTIVES:To investigate the immunoreactivity of TTF-1 and PAX8 in neuroendocrine carcinoma of thymic (TNEC) and pulmonary origins (PNEC), and whether their immunophenotyping could be used to distinguish between NEC of the two sites, as well as prognosis of patients with TNEC. METHODS:Twenty-two cases of TNEC and 20 cases of PNEC were selected for immunohistochemical analysis using PAX8 and TTF-1. Clinical data and follow-up information were obtained for survival analyses. RESULTS:TTF-1 immunoreactivity was seen in 19 PNEC cases (95%) and 13 TNEC cases (59.1%). PAX8 was negative in all pulmonary tumors while positive in 19 thymic cases (86.4%). TTF-1 positivity was associated with high sensitivity but low specificity for PNEC, and adding PAX8 negativity significantly increased the specificity. PAX8 positivity alone showed essentially 100% specificity and 86.4% sensitivity for TNEC. Survival analysis showed lung metastasis as a significant prognostic factor in TNEC. CONCLUSION:Our study demonstrated that TTF-1/PAX8 immunophenotyping may be helpful for differential diagnosis of NECs of pulmonary and thymic origins. TTF-1+/PAX8- immunophenotyping showed high specificity for PNECs, while PAX8+ alone showed a good diagnostic accuracy for TNEC. Lung metastasis was a predictive factor that associated with survival of TNEC patients. J. Surg. Oncol. 2016;114:697-702. © 2016 Wiley Periodicals, Inc.

journal_name

J Surg Oncol

authors

Bi Y,Deng Y,Li S,Zhou X,Chen Y,Ma D,Mao X,Guan Y,Chen J,Meng Y

doi

10.1002/jso.24393

subject

Has Abstract

pub_date

2016-11-01 00:00:00

pages

697-702

issue

6

eissn

0022-4790

issn

1096-9098

journal_volume

114

pub_type

杂志文章
  • Prognostic factors in alveolar soft part sarcoma: A SEER analysis.

    abstract:OBJECTIVES:We reviewed the clinical characteristics and outcomes of patients treated for alveolar soft part sarcoma (ASPS) and analyzed the effect of surgery for patients presenting with and without metastatic disease (DM). METHODS:The SEER Registry was queried for patients with ASPS from 1973-2012. The Kaplan-Meier e...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.24183

    authors: Wang H,Jacobson A,Harmon DC,Choy E,Hornicek FJ,Raskin KA,Chebib IA,DeLaney TF,Chen YL

    更新日期:2016-04-01 00:00:00

  • Factors predicting oncologic outcomes in patients with fewer than 12 lymph nodes retrieved after curative resection for colon cancer.

    abstract:PURPOSE:The aim of this study was to determine which clinicopathological factors influenced the long-term survival after potentially curative resection of patients with colon cancer having fewer than 12 retrieved lymph nodes. METHODS:Prospective data were collected from 179 patients who had fewer than 12 resected lymp...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.22072

    authors: Huh JW,Kim CH,Kim HR,Kim YJ

    更新日期:2012-02-01 00:00:00

  • Staging invasive bladder tumors.

    abstract::Staging of bladder tumors is based primarily on the depth of tumor invasion (T-category). Stage is important to treatment planning and prognosis. The problem is that clinical evaluation by T-category alone often understages the pathologic extent of disease and does not reliably predict treatment results. The current a...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章,评审

    doi:10.1002/jso.2930510403

    authors: Herr HW

    更新日期:1992-12-01 00:00:00

  • Are the axillary lymph nodes treated by standard tangent breast fields?

    abstract:BACKGROUND AND OBJECTIVES:With the increasing use of sentinel lymph node biopsy, a growing proportion of women with early-stage invasive breast cancer are undergoing breast conserving surgery without a formal axillary lymph node dissection. A frequent question raised is whether the level I-II axillary lymph nodes are t...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.10148

    authors: McCormick B,Botnick M,Hunt M,Petrek J

    更新日期:2002-09-01 00:00:00

  • Combination chemotherapy for soft-tissue sarcomas: a phase III study.

    abstract::A total of 144 patients with advanced sarcomas were entered into a randomized prospective protocol with four treatment arms utilizing different combinations of chemotherapeutic agents. Of these, 120 patients (83%) were judged acceptable. Treatment 1: actinomycin-D (Act-D), 0.01 mg/kg IV, days 1--5; phenylalanine must...

    journal_title:Journal of surgical oncology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1002/jso.2930110406

    authors: Cruz AB Jr,Thames EA Jr,Aust JB,Metter G,Ramirez G,Fletcher WS,Altman SJ,Frelick RW,Hill GJ 2nd

    更新日期:1979-01-01 00:00:00

  • Giant cell tumors combined with secondary aneurysmal bone cysts are more likely to develop postoperative recurrence: A retrospective study of 256 cases.

    abstract:PURPOSE:The epidemiology and clinicopathology of aneurysmal bone cysts (ABCs) secondary to giant cell tumors of bone (GCTBs) have been well documented in the previous literature. However, reports on whether secondary ABCs could affect the postoperative recurrence of GCTBs are rare. This study analyzed the effects of se...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.25588

    authors: Tang H,Moro A,Feng W,Lai Y,Xiao Z,Liu Y,Wang K

    更新日期:2019-09-01 00:00:00

  • Extended lymphadenectomy in the surgery of pancreatic adenocarcinoma and its relation to quality improvement issues.

    abstract::Extended lymphadenectomy has been proposed for loco-regional control of pancreatic adenocarcinoma. While retrospective series suggested a benefit, subsequent prospective trials have not shown a survival benefit. Methods to improve loco-regional control of pancreatic body/tail cancer have not been extensively investiga...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章,评审

    doi:10.1002/jso.21210

    authors: Rupp CC,Linehan DC

    更新日期:2009-03-15 00:00:00

  • Leveraging the increased rates of pathologic complete response after neoadjuvant treatment in breast cancer to de-escalate surgical treatments.

    abstract:INTRODUCTION:Breast conservative surgery (BCS) and sentinel lymph node biopsy (SLNB) after neoadjuvant treatment (NAT) is safe and effective for selected patients. This aim of this study is to evaluate the impact of anatomic site of response on outcomes and to assess the real population who may benefit from nonsurgical...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.26236

    authors: Esgueva A,Siso C,Espinosa-Bravo M,Sobrido C,Miranda I,Salazar JP,Rubio IT

    更新日期:2021-01-01 00:00:00

  • Comparison of two methods of reconstruction for primary malignant tumors at the knee: a sequential cohort study.

    abstract:BACKGROUND AND OBJECTIVES:The purpose of this study was to compare the complications and functional outcome associated with the use of an irradiated allograft-implant composite or a bone-ingrowth modular tumor prosthesis for replacement of the knee joint after resection of a bone sarcoma from the distal femur or proxim...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.1076

    authors: Wunder JS,Leitch K,Griffin AM,Davis AM,Bell RS

    更新日期:2001-06-01 00:00:00

  • Salvage of pelvic recurrence of colorectal cancer.

    abstract::Although the incidence of locally recurrent colorectal cancer has been reduced by improved surgical techniques and the frequent use of multimodality therapy, pelvic recurrence remains a significant problem. Radiation or chemotherapy may provide palliation but it is often short-lived. For fit candidates without evidenc...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章,评审

    doi:10.1002/jso.21571

    authors: Varker KA,Wanebo HJ

    更新日期:2010-06-15 00:00:00

  • Elevated high-sensitivity C-reactive protein, a marker of advanced stage gastric cancer and postgastrectomy disease recurrence.

    abstract:BACKGROUND AND OBJECTIVES:Gastric cancer recurrence after curative surgery remains high. Although no preoperative marker of gastric cancer progression after radical gastrectomy exists, recent studies suggest that C-reactive protein (CRP) is associated with cancer progression. Our study evaluated the significance of pre...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.22129

    authors: Woo Y,Hyung WJ,Obama K,Kim HI,Pak KH,Son T,Noh SH

    更新日期:2012-03-15 00:00:00

  • Prostate cancer stem cells and their potential roles in metastasis.

    abstract::Most solid tumors have now been reported to contain stem cell-like cells called cancer stem cells (CSCs). These cells are endowed with high tumorigenic capacity and may be the cells that drive tumor formation, maintain tumor homeostasis, and mediate tumor metastasis. Since these self-renewing cancer cells may be the s...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章,评审

    doi:10.1002/jso.21806

    authors: Li H,Tang DG

    更新日期:2011-05-01 00:00:00

  • Peritoneal papillary serous carcinoma: study of 15 cases and comparison with stage III-IV ovarian papillary serous carcinoma.

    abstract:BACKGROUND AND OBJECTIVES:Peritoneal papillary serous carcinoma (PPSC) is histologically and clinically similar to stage III-IV ovarian papillary serous carcinoma (OPSC). The purpose of this study was to investigate the clinical findings, treatment, and outcome of PPSC patients compared with stage III-IV OPSC patients....

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/(sici)1096-9098(199807)68:3<173::aid-jso8>

    authors: Piura B,Meirovitz M,Bartfeld M,Yanai-Inbar I,Cohen Y

    更新日期:1998-07-01 00:00:00

  • ERCP in potentially resectable malignant biliary obstruction is frequently unsuccessful when performed outside of a comprehensive pancreaticobiliary center.

    abstract:BACKGROUND AND OBJECTIVES:ERCP prior to pancreaticoduodenectomy is unnecessary in select patients. When performed, it should be in conjunction with endoscopic ultrasound (EUS) to increase diagnostic sensitivity and allow for metal stent placement. The aim of this study was to determine differences in endoscopic practic...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.24191

    authors: Donnan E,Bentrem DJ,Komanduri S,Mahvi DM,Keswani RN

    更新日期:2016-05-01 00:00:00

  • Soft tissue sarcoma of the head & neck: nomogram validation and analysis of staging systems.

    abstract:BACKGROUND AND OBJECTIVES:Soft tissue sarcomas of the head and neck (STSHN) comprise a rare group of malignancies. Our objective is to determine the utility of soft tissue sarcoma staging systems within the head and neck, and to validate an individualized soft tissue sarcoma nomogram within head and neck primary sites....

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.23868

    authors: Shuman AG,Brennan MF,Palmer FL,Kuk D,Moraco N,Singer S,Shah JP,Patel SG

    更新日期:2015-05-01 00:00:00

  • The surgeon and chemotherapy: twenty five years personal experience.

    abstract::The realm of cancer chemotherapy is complex and often conflicting. The massive use of cytotoxic agents during the past 25 years has now reached a point where major decisions have to be made. The respective roles of regional techniques, systemic therapy for metastatic disease and adjuvant cytotoxic chemotherapy, all ne...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930300411

    authors: Burn I

    更新日期:1985-12-01 00:00:00

  • The role of preoperative positron emission tomography/computed tomography (PET/CT) in patients with high-risk melanoma.

    abstract:BACKGROUND:Positron emission tomography/computed tomography (PET/CT) scanning is commonly used for the preoperative staging of patients with at least intermediate thickness (>1 mm) melanomas. Its role in staging at initial diagnosis for clinically asymptomatic patients is not yet established. METHODS:We examined recor...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.23549

    authors: Barsky M,Cherkassky L,Vezeridis M,Miner TJ

    更新日期:2014-06-01 00:00:00

  • Distribution of fibronectin in adenocarcinoma of the lung: classification and prognostic significance.

    abstract::Fibronectin (FN) was investigated in 75 stroma from lung adenocarcinoma patients. Distribution of FN was classified into three patterns based on immunohistochemical evidence: dense, moderate, and sparse distribution. The incidence of the sparse pattern in both stage I and stage III disease was significantly greater in...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930430208

    authors: Nishino T,Ishida T,Oka T,Yasumoto K,Sugimachi K

    更新日期:1990-02-01 00:00:00

  • The versatility of the thoracodorsal artery based composite flaps with vascularized rib and a systematic review of the literature.

    abstract::Pedicled and free composite flaps derived from the thoracodorsal artery system, including the latissimus dorsi-rib (LD-R) and the serratus anterior-rib (SA-R) osteo-muscular or osteo-myocutaneous flaps, are potential options to address head and neck, thorax, upper and lower extremity bone, and soft tissue defects' rec...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.25579

    authors: Elia R,Di Taranto G,Amorosi V,Ngamcherd S,Alamouti R,Liao LY,Maruccia M,Giudice G,Chen HC

    更新日期:2019-09-01 00:00:00

  • Pancreatic ductal cell carcinoma producing pancreatic elastase 1.

    abstract::The elevation of plasma pancreatic elastase 1 in patients with pancreatic cancer is caused by concomitant pancreatitis. There is no report that pancreatic ductal cell carcinoma tissue itself produced elastase 1. A 54-year-old woman underwent total pancreatectomy for pancreatic ductal cell carcinoma. Her plasma elastas...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930540316

    authors: Iwase K,Miyata M,Yamaguchi T,Kawaguchi T,Tanaka Y,Matsuda H

    更新日期:1993-11-01 00:00:00

  • Overall survival by pattern of recurrence following curative intent surgery for colorectal liver metastasis.

    abstract:BACKGROUND:Following curative intent surgery (CIS) for colorectal liver metastasis (CRLM), patterns of recurrence and subsequent survival outcomes are not widely reported. METHODS:An institutional database (January 2002-December 2012) was reviewed to evaluate patterns of recurrence following CIS for CRLM. RESULTS:163...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.23756

    authors: Kulaylat AN,Schubart JR,Stokes AL,Bhayani NH,Wong J,Kimchi ET,O'Carroll KF,Kaifi JT,Gusani NJ

    更新日期:2014-12-01 00:00:00

  • Technical feasibility and safety of laparoscopy-assisted total gastrectomy in gastric cancer: a comparative study with laparoscopy-assisted distal gastrectomy.

    abstract:BACKGROUND AND OBJECTIVE:Only a few surgeons with much experience of laparoscopic surgery perform laparoscopy-assisted total gastrectomy (LATG), because of its technical difficulty and concern about subsequent complications. The aim of this study was to evaluate the technical feasibility and safety of LATG as compared ...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.21345

    authors: Lee SE,Ryu KW,Nam BH,Lee JH,Kim YW,Yu JS,Cho SJ,Lee JY,Kim CG,Choi IJ,Kook MC,Park SR,Kim MJ,Lee JS

    更新日期:2009-10-01 00:00:00

  • Molecular key to understand the gastric cancer biology in elderly patients-The role of microsatellite instability.

    abstract:BACKGROUND AND OBJECTIVES:Microsatellite instability (MSI) in gastric cancer (GC) is associated with older age. We present the clinicopathological results of younger and older patients with MSI GC. METHODS:We analyzed 472 patients with GC. MSI analysis was done on fresh frozen tissue using five quasimonomorphic mononu...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.24513

    authors: Polom K,Marrelli D,Roviello G,Pascale V,Voglino C,Rho H,Marini M,Macchiarelli R,Roviello F

    更新日期:2017-03-01 00:00:00

  • Treatment failure following complete cytoreductive surgery and perioperative intraperitoneal chemotherapy for peritoneal dissemination from colorectal or appendiceal mucinous neoplasms.

    abstract:BACKGROUND:Peritonectomy combined with perioperative intraperitoneal chemotherapy is a successful treatment option for patients with peritoneal dissemination of appendiceal and colorectal malignancy. Despite its efficacy, recurrences remain a common problem. METHODS:Patients with peritoneal dissemination from appendic...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.21084

    authors: Bijelic L,Yan TD,Sugarbaker PH

    更新日期:2008-09-15 00:00:00

  • Modified radical lymphadenectomy without splenectomy in patients with proximal gastric cancer: comparison with standard D2 lymphadenectomy for distal gastric cancer.

    abstract:BACKGROUND AND OBJECTIVES:We assessed the optimal extent of lymph node dissection and the effect of splenectomy in patients with proximal gastric cancer. METHOD:Recurrence and survival rates were compared between 881 patients with proximal gastric cancer who underwent modified radical lymphadenectomy and 3,098 patient...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.21137

    authors: Cheong O,Kim BS,Yook JH,Oh ST,Park YK,Ryu SY

    更新日期:2008-12-01 00:00:00

  • Pigmented villonodular synovitis of joints.

    abstract:OBJECTIVES:The objective of this study is to present two series of cases of pigmented villonodular disease of joints (PVNS) treated at different periods. The 215 cases from our hospital are current (1972-2009) and those 62 from the Jaffe collection from 1920 to 1968. METHODS:By use of our computerized tumor data syste...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.21835

    authors: Mankin H,Trahan C,Hornicek F

    更新日期:2011-04-01 00:00:00

  • Regional chemotherapy is indicated after surgical resection of colorectal metastases to the liver: a debate.

    abstract::Surgical resection for selected patients with hepatic metastases from colorectal cancer can cure approximately one-fourth of these patients. The addition of regional chemotherapy as an attempt to improve this statistic has been extensively investigated in clinical trials. As part of a multidisciplinary educational pro...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章,评审

    doi:10.1002/jso.10171

    authors: Khushalani NI,McKinley BP,Gibbs JF,Leichman CG,Petrelli NJ

    更新日期:2003-01-01 00:00:00

  • Long survival following combined treatment of inoperable cholangiocarcinoma: surgery, radiotherapy, and chemotherapy.

    abstract::A jaundiced patient due to inoperable bile duct carcinoma was treated by a combination of surgery, radiotherapy, and chemotherapy. At the operation an intra-abdominal, extra-choledochal bypass of the tumor was performed with a T-tube obstruction 10 months after diagnosis, and no evidence of malignancy was seen. The T-...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930130308

    authors: Hashmonai M,Lev L,Schramek A,Ben-Arieh Y,Robinson E

    更新日期:1980-01-01 00:00:00

  • Malignant pheochromocytoma and paraganglioma: a population level analysis of long-term survival over two decades.

    abstract:BACKGROUND AND OBJECTIVES:Pheochromocytoma (PHEO) and paraganglioma (PGL) are rare tumors. Aims of this study were to describe and to compare demographic, clinical, pathologic, and survival characteristics of malignant PHEO and PGL. METHODS:Patients were identified in SEER, 1988-2009. Analyses included chi-square, ANO...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.23297

    authors: Goffredo P,Sosa JA,Roman SA

    更新日期:2013-05-01 00:00:00

  • Macrophage-mediated tumor cytotoxicity: role of macrophage surface sialic acid.

    abstract::Cell surface sialic acid levels were compared for monocytes and macrophages obtained from normal volunteers and breast cancer patients. Equal quantities of sialic acid were found on the monocytes obtained from normal volunteers and breast cancer patients. Approximately 60% more cell surface sialic acid was found on th...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930220203

    authors: Cameron DJ

    更新日期:1983-02-01 00:00:00