Abstract:
:Liver metastasis represents a common systemic complication of colorectal cancers (CRCs). Partial liver resection has been demonstrated to result in long-term survival in certain well-selected patients with otherwise well-controlled systemic disease. Neoadjuvant therapy has been demonstrated to result in improved resectability and potentially longer survival in patients with liver metastases from CRC. The addition of biologic agents to chemotherapy has been shown to improve response rates and overall survival in patients with metastatic CRC. Here, we are discussing the role of biologic agents in the treatment of patients with liver metastases from CRC. We also discuss the role of biomarkers for response and resistance to such novel therapies.
journal_name
J Surg Oncoljournal_title
Journal of surgical oncologyauthors
Wanebo HJ,Berz Ddoi
10.1002/jso.21691subject
Has Abstractpub_date
2010-12-15 00:00:00pages
891-7issue
8eissn
0022-4790issn
1096-9098journal_volume
102pub_type
杂志文章,评审abstract::We reviewed the literature concerning the effect of extended lymph node dissection on survival in patients with gastrointestinal cancer. Most retrospective and/or prospective nonrandomized comparative studies have claimed that extended lymph node dissection significantly improves survival rate in patients with esophag...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/(sici)1096-9098(199705)65:1<57::aid-jso12>
更新日期:1997-05-01 00:00:00
abstract:OBJECTIVES:To investigate predictors of occult nipple-areolar complex (NAC) involvement in patients with carcinoma in situ (CIS) and to validate an online probability calculator (CancerMath; www.lifemath.net/cancer/breastcancer/nipplecalc/index.php). METHODS:Mastectomized patients with CIS (n = 104) were retrospective...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.24768
更新日期:2017-12-01 00:00:00
abstract::Significant destruction of the Pollard III rat prostate adenocarcinoma was achieved by treatment with rhodamine 123 at a dosage of 15 mg/kg every other day for 33 to 38 days. Injection of tumor remnants into untreated animals produced no tumor regrowth. Our data have demonstrated rhodamine 123 to be a significant drug...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930440209
更新日期:1990-06-01 00:00:00
abstract:BACKGROUND:The optimal treatment strategy for patients with esophageal adenocarcinoma (EAC) remains undetermined. This study compared outcomes in patients undergoing neoadjuvant chemotherapy (nCT) and neoadjuvant chemoradiotherapy (nCRT) for EAC. METHODS:Patients who underwent nCT or nCRT followed by surgery for EAC w...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.25089
更新日期:2018-06-01 00:00:00
abstract::A study was carried out to determine the interrelationship between the inhalation of nitrogen dioxide (0.4 +/- 0.50 ppm), lung metastases development from circulating cancer cells, and death rate from such metastases. C57 BL/6J mice were used in these experiments. Animals were divided into control and NO2-exposed grou...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930280115
更新日期:1985-01-01 00:00:00
abstract:BACKGROUND:A paucity of data exists regarding the natural history and outcome measures of adenosquamous carcinoma of the pancreas (ASCP), a histology distinct from pancreatic adenocarcinoma (PDAC). The aim of this study is to characterize the clinicopathological features of ASCP in a large cohort of patients comparing ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.25112
更新日期:2018-07-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Differences in the expression levels of Thyroglobulin (Tg), Thyroid peroxidase (TPO) and thyrotropin receptor (TSH-R) in primary and recurrent specimens under a suppressive serum TSH condition were elucidated in 26 papillary carcinoma patients. METHODS:Immunohistochemical detection was perfor...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/1096-9098(200010)75:2<108::aid-jso7>3.0.co
更新日期:2000-10-01 00:00:00
abstract::Biopsies from 61 women with breast cancer were assessed for various histological features. These results were statistically analyzed for associations of gross tumor size, patient age, stage of disease, tumor hormone receptor status, with accepted systems of nuclear and histological grading for differentiation. Tumors ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930310109
更新日期:1986-01-01 00:00:00
abstract:BACKGROUND:Skip metastasis to mediastinal lymph nodes is a well-known phenomenon in non-small cell lung cancer (NSCLC). Little is reported in the literature about its clinical importance. It is still under discussion whether any prognostic differences exist between resected NSCLC with either skip metastases or continuo...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.10219
更新日期:2003-04-01 00:00:00
abstract:OBJECTIVE:To determine whether the presence of prostate stem cell antigen (PSCA) mRNA in peripheral blood can predict biochemical recurrence (BCR) after radical prostatectomy in patients with high-risk prostate cancer. METHODS:High-risk disease was defined based on the presence of any one of the following three risk f...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.21445
更新日期:2010-02-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Neoadjuvant chemotherapy (nCMT) has been increasingly used in advanced gastric cancer (GC). However, the prognostic impact of tumor response remains unclear. This study aimed to evaluate if tumor response at the primary site and lymph nodes (LN) correlate with survival in GC patients after nCMT...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.25785
更新日期:2020-04-01 00:00:00
abstract:BACKGROUND:Radiofrequency ablation (RF) is emerging as new therapeutic method for the management of hepatic tumors. So far the RF-assisted hepatectomy has been described using an electrode initially designed for ablation of unresectable tumors. Herein, we describe a new technique for liver resection using a bipolar rad...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.20770
更新日期:2007-09-01 00:00:00
abstract::A case of synovial sarcoma in the abdominal wall of a 50-year-old Iraq female is reported. The ultrastructure of the tumor has been studied. Eight other cases of synovial sarcoma in the abdominal wall which reported in the English literature up to 1978 have been reviewed. Synovial sarcomas in the abdominal wall tend t...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930180403
更新日期:1981-01-01 00:00:00
abstract::Remote access approaches for thyroid surgery using surgical incisions placed outside the neck, including the axillary, chest and the retro-auricular region have gained interest due to the social stigmatization of young females with a visible neck scar. These novel approaches have been reported to be safe and feasible ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.23955
更新日期:2015-09-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:In North America, preoperative combination chemoradiation is the most commonly recommended and utilized approach to locally advanced rectal cancer. There is increasing interest in the use of induction chemotherapy (IC) before radiation and surgery in locally advanced rectal cancer. How widely ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.25474
更新日期:2019-08-01 00:00:00
abstract::Cecal carcinoma has been associated with a poorer prognosis than other colon carcinomas because of the presumed longstanding obscure symptoms. In a combined study of three Dutch hospitals, a total of 166 patients with cecal carcinoma were evaluated after right hemicolectomy. Special emphasis was placed on clinical sym...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930440309
更新日期:1990-07-01 00:00:00
abstract::The hanging liver maneuver is a useful technique to guide the transection of liver parenchyma by lifting a tape passed between the anterior surface of the inferior vena cava and the liver. Modified hanging liver maneuvers have been described in different types of liver resection. Surgical resection of hilar cholangioc...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.24154
更新日期:2016-03-01 00:00:00
abstract:BACKGROUND:Rates of nonoperative management of acute appendicitis and appendiceal adenocarcinoma have increased over a decade, but the presentation and outcomes of appendiceal adenocarcinoma over this period is not well-characterized. METHODS:Patients with surgically resected Stage I-III appendiceal adenocarcinoma wer...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.26295
更新日期:2020-11-10 00:00:00
abstract::A case of bilateral seminoma of the testis is presented that occurred after a lag period of six years following right orchiectomy, even with correct cobalt therapy. The question of early detection of seminoma in the other testis is posed. A common consensus for repeat biopsies to detect new tumor growth should be dete...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930240204
更新日期:1983-10-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:The aggressiveness and greater malignant potential of cancers are characterized by several biological phenomena such as accelerated growth invasiveness, and the ability to form distant metastasis. Thus, knowledge of such biological difference may be a more accurate prognosticator for cancer pa...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.20309
更新日期:2005-12-15 00:00:00
abstract:OBJECTIVES:To identify the prognostic implications of human papillomavirus (HPV)-related cell cycle marker profiles in patients who have received a transoral lateral oropharyngectomy (TLO) as a primary treatment for tonsillar squamous cell carcinoma (TSCC). PATIENTS AND METHODS:Immunohistochemical profiles of HPV-rela...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.23672
更新日期:2014-09-01 00:00:00
abstract::Malignant arterial tumor emboli large enough to cause ischemia or organ infarction are a rare, but often fatal, complication of neoplastic disease. The majority of arterial emboli are associated with primary or secondary pulmonary malignancies. The sites where they impact are similar in distribution to arterioscleroti...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.2930520317
更新日期:1993-03-01 00:00:00
abstract::Wilms' tumor, renal cell carcinoma, and neuroblastoma in animals were transplanted from donors to recipients with strong histocompatibility differences. No strong evidence of the privileged site theory was found in this study and no obvious evidence of an immunosuppressive effect of testosterone was found. The most im...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930140111
更新日期:1980-01-01 00:00:00
abstract::Follicular thyroid carcinoma, initially presenting as spinal cord compression due to metastatic lesions, is a less reported event. We present two cases of well-differentiated thyroid carcinoma that led to spinal cord compression. A thorough search of the literature revealed only five similar cases. We summarize the cl...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/(sici)1096-9098(199803)67:3<186::aid-jso8>
更新日期:1998-03-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Lymph node involvement is common in thyroid cancer, but the system of staging does not consider the histological features of lymph node metastases. We conducted a meta-analysis to investigate the prognostic role of extranodal extension (ENE) in thyroid cancer patients. METHODS:We ran PubMed a...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,meta分析,评审
doi:10.1002/jso.24070
更新日期:2015-12-01 00:00:00
abstract::Robotic surgical techniques are now being applied in the setting of retroperitoneal lymphadenectomy (RPLND) for testicular cancer. While laparoscopic RPLND has not been widely accepted, reports of robot assisted RPLND (RARPLND) are emerging. This manuscript will review the application of RPLND for testicular cancer, e...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.24018
更新日期:2015-12-01 00:00:00
abstract:BACKGROUND:Recurrent adrenocortical carcinoma (ACC) has a poor prognosis with minimal clinical and biochemical factors to guide management. The aim of this study was to evaluate the prognostic significance of systemic inflammatory response in patients with recurrent ACC. METHODS:Patients who underwent resection for re...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.25760
更新日期:2019-12-01 00:00:00
abstract::Intrahepatic cholangiocarcinoma (iCCA) is the second most common primary hepatic cancer in the United States. Currently, curative treatment involves aggressive surgery. Chemotherapy and radiation treatments have been used for unresectable tumors with some success. Optimizing the use of current and developing novel mul...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.24093
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:The purpose of this study was to determine whether LAPTM4B over-expression is associated with the prognosis and chemotherapy resistance in patients with stages III and IV epithelial ovarian carcinoma, i.e., patients with peritoneal metastasis or lymph node metastasis of epithelial ovarian carcinoma. METHODS...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.21912
更新日期:2011-07-01 00:00:00
abstract::Twenty-six patients with esophageal carcinoma at stage pT4 underwent esophagectomy with lymph node dissection leaving part of the tumor in adjacent organs. Several plastic catheters were fixed to the tumor bed and led to the outside of the thorax for postoperative brachytherapy. Using these catheters, the patients und...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/(SICI)1096-9098(199607)62:3<214::AID-JSO12
更新日期:1996-07-01 00:00:00