Abstract:
BACKGROUND:The purpose of this study was to determine whether LAPTM4B over-expression is associated with the prognosis and chemotherapy resistance in patients with stages III and IV epithelial ovarian carcinoma, i.e., patients with peritoneal metastasis or lymph node metastasis of epithelial ovarian carcinoma. METHODS:LAPTM4B expression was evaluated in 10 normal ovarian and 113 stages III-IV ovarian carcinomas specimens by Western blotting analyses and immunohistochemistry. Univariate and multivariate analyses were performed to determine the association between LAPTM4B expression and prognosis and the relationship between LAPTM4B over-expression and chemotherapy resistance. RESULTS:Western blotting analysis demonstrated that LAPTM4B was overexpressed in ovarian cancers, and immunohistochemistry results revealed that 80 patients were LAPTM4B over-expression. The five-year overall survival (OS) rates for patients with high LAPTM4B expression and low LAPTM4B expression were 27.36% and 90.7%, respectively (hazard ratio = 20.611, 95% CI: 5.916-71.808, P < 0.0001). The five-year progression-free survival (PFS) rate was 17.68% for patients in the high-expression group and 84.42% for patients in the low-expression group (hazard ratio = 17.852, 95% CI: 6.31-5.935, P < 0.0001); The presence of chemotherapy resistance was significantly associated with LAPTM4B expression (OR: 36.609, 95% CI: 4.737-282.941, P = 0.0006). CONCLUSIONS:LAPTM4B over-expression is an independent factor in stages III-IV epithelial ovarian carcinoma prognosis and chemotherapy resistance, and it may be an important potential biomarker.
journal_name
J Surg Oncoljournal_title
Journal of surgical oncologyauthors
Yin M,Li C,Li X,Lou G,Miao B,Liu X,Meng F,Zhang H,Chen X,Sun M,Ling Q,Zhou Rdoi
10.1002/jso.21912subject
Has Abstractpub_date
2011-07-01 00:00:00pages
29-36issue
1eissn
0022-4790issn
1096-9098journal_volume
104pub_type
杂志文章abstract:BACKGROUND AND OBJECTIVE:The psychosocial impact of local-regional thyroid cancer recurrence is not known. The aim of this study was to explore thyroid cancer patients' experiences relating to diagnosis and treatment of local-regional disease recurrence. METHODS:We conducted 15 semi-structured interviews with survivor...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.23345
更新日期:2013-07-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:The aim of this study was to investigate the potential role of indocyanine green (ICG) fluorescence imaging after intraoperative intravenous (IV) injection for the "ex vivo" detection of metastatic lymph nodes (mLNs) of colorectal cancer origin. METHODS:Fresh-fixed LNs in cassettes and/or par...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.24318
更新日期:2016-09-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Data on outcomes after liver-directed therapy for intrahepatic cholangiocarcinoma (ICC) are limited due to the rarity of the disease. We sought to define overall utilization and temporal trends of liver-directed therapy for ICC. METHODS:We identified 5,388 patients with ICC using the Surveill...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.23605
更新日期:2014-08-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Primary retroperitoneal tumors constitute a rather uncommon disease with an incidence of 2 in 100,000. Local recurrence after surgical resection is reported between 60% and 90% at 10 yr. The aim of this study was to present the problem of satellite tumors around the main tumor mass and their p...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/(sici)1096-9098(199805)68:1<30::aid-jso7>3
更新日期:1998-05-01 00:00:00
abstract::Robotic surgical techniques are now being applied in the setting of retroperitoneal lymphadenectomy (RPLND) for testicular cancer. While laparoscopic RPLND has not been widely accepted, reports of robot assisted RPLND (RARPLND) are emerging. This manuscript will review the application of RPLND for testicular cancer, e...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.24018
更新日期:2015-12-01 00:00:00
abstract::Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) is a T-cell neoplasm that arises in the capsule around breast implants. While an association with implants has been proposed, no causal link has been identified and the pathophysiology and natural history of BIA-ALCL remain unknown. A literature revie...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.25626
更新日期:2019-09-01 00:00:00
abstract:BACKGROUND:The aim of this study is to describe the influence of geography, socio-economic development, and demographic shift on the trends in global incidence, mortality, and prevalence of liver cancer (LC). METHODS:Data (2012-2030) relating to LC and demographic shifts based on WHO regions and HDI areas were extract...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.24518
更新日期:2017-04-01 00:00:00
abstract:PURPOSE:To investigate the significance of palliative gastrectomy for different types of metastatic gastric cancer patients displaying peritoneal dissemination, hepatic metastasis, distant lymph node metastasis occurring locally during late-stage disease, and multi-organ metastases. METHODS:We performed a retrospectiv...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.23158
更新日期:2012-12-01 00:00:00
abstract::Lymphoproliferative activity was assessed by 3H-thymidine incorporation in spleen cells of mammary tumor bearing BALB/c mice, mice which had their tumors surgically removed, and mice with sham surgery after stimulation in vitro with a soluble extract of syngeneic tumor antigens. Surgical removal of tumors caused an av...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930350102
更新日期:1987-05-01 00:00:00
abstract:BACKGROUND:Positron emission tomography/computed tomography (PET/CT) scanning is commonly used for the preoperative staging of patients with at least intermediate thickness (>1 mm) melanomas. Its role in staging at initial diagnosis for clinically asymptomatic patients is not yet established. METHODS:We examined recor...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.23549
更新日期:2014-06-01 00:00:00
abstract::Between January 1, 1968 and December 31, 1978, 42 patients with malignant lesions involving the major salivary glands were seen at the Medical College of Virginia. A 60% 2-year survival and a 42% 5-year survival were noted. Histologic type was the major determinant of survival. Symptoms other than a painless mass, a l...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930170204
更新日期:1981-01-01 00:00:00
abstract:BACKGROUND:Preoperative prognostic information to select a treatment strategy is important especially in patients who need highly aggressive surgery, such as those with biliary cancer. We evaluated various prognostic factors and non-curative surgical factors using multidetector computed tomography (MDCT). METHODS:We r...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.21501
更新日期:2010-04-01 00:00:00
abstract::A 50-year-old man presented with verrucous carcinoma on the sole of the foot. This unusual tumor, also called an epithelioma cuniculatum plantare, was successfully treated employing wide surgical excision. ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930140407
更新日期:1980-01-01 00:00:00
abstract:BACKGROUND:Proper tip position is a major determinant of totally implantable venous access device (TIVAD) outcome. The aim of this study is to analyze the potential utilization of intravenous electrocardiography (IV-ECG) to help inexperienced operators for TIVAD placement. PATIENTS AND METHODS:This is a retrospective,...
journal_title:Journal of surgical oncology
pub_type: 临床试验,杂志文章
doi:10.1002/jso.23000
更新日期:2012-06-15 00:00:00
abstract::A case of extramammary Paget's disease is reported. The distinguishing features of the case are: (1) localization of the primary lesion to the scrotum, (2) development of metastases in the absence of a recognizable underlying carcinoma, and (3) response of the systemic disease to a combination of radiation therapy and...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930380111
更新日期:1988-05-01 00:00:00
abstract::A consecutive series of 100 patients affected by gastrointestinal malignancies entered a prospective controlled study of liver metastases performed by ultrasound echography, CEA, hepatic enzymes (only alkaline phosphatase (AP) was found to be somehow significant). Laparotomic inspection and palpation were taken as obj...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930280302
更新日期:1985-03-01 00:00:00
abstract:BACKGROUND:Local recurrence (LR) of sacral chordoma is a difficult problem and the mortality risk associated with LR remains poorly described. The purpose of this study was to evaluate the risk of mortality in patients with LR and determine if patient age is associated with mortality. METHODS:A total of 218 patients (...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.25774
更新日期:2019-11-22 00:00:00
abstract:OBJECTIVES:This study investigated late toxicity and infield progression-free survival in patients with locally recurrent rectal cancer (LRRC) who had previously received irradiation to the pelvis. METHODS:Twenty-two patients were treated by reirradiation to the pelvis between January 2000 and August 2007. All patient...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.23023
更新日期:2012-06-01 00:00:00
abstract:BACKGROUND:Following curative intent surgery (CIS) for colorectal liver metastasis (CRLM), patterns of recurrence and subsequent survival outcomes are not widely reported. METHODS:An institutional database (January 2002-December 2012) was reviewed to evaluate patterns of recurrence following CIS for CRLM. RESULTS:163...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.23756
更新日期:2014-12-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:We evaluated the clinicopathological associations and prognostic implications of promyelocytic leukemia gene (PML) expressions in patients with esophageal squamous cell carcinomas (ESCC) receiving primary surgery. METHODS:Expression patterns of PML and tumor protein 53 (TP53) of 132 cases of ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.21855
更新日期:2011-06-01 00:00:00
abstract::A case of desmoid tumor of 17 years' duration associated with cystosarcoma phyllodes of 17 months' duration is presented. Good initial response to radiation therapy of the desmoid tumor was shown. Poor response of cytosarcoma phyllodes to radiation therapy was noted. A comparison between the similarities and differenc...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930080107
更新日期:1976-01-01 00:00:00
abstract:BACKGROUND:Recent changes in adjuvant therapies improved the prognosis of metastatic colorectal cancers. Curative resection may be considered, even for both pulmonary and hepatic metastases, but prognostic factors are not well identified. METHODS:From 1995 to 2010, 69 patients had curative resection of pulmonary metas...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.23385
更新日期:2013-09-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:The most common cause of failure in large segment bone allografts used for oncologic reconstruction is allograft fracture. Reinforcement with pressurized intramedullary cement may improve the mechanical properties of allografts. METHODS:We reviewed the prospectively collected records of 45 pa...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.10316
更新日期:2003-12-01 00:00:00
abstract::Although the radioreceptor method is widely used for estrogen receptor assay in human tissue, it has several limitations and a number of alternative methods are being explored. An immunohistochemical method of estrogen receptor assay using a specific antibody to estradiol has been proposed as a suitable alternative. T...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930330206
更新日期:1986-10-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:To evaluate the impact of plasminogen activator (PA) system genes, including urokinase plasminogen activator (uPA), uPA receptor (uPAR), and plasminogen activator inhibitor-1 (PAI-1) gene polymorphisms in patients with the cervical neoplasia. METHODS:In total, 336 blood samples were collected...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.23072
更新日期:2012-08-01 00:00:00
abstract::Tumor-associated neovascularization allows tumor cells to express their critical growth advantage, whereas lymphatic invasion is crucial for the metastatic process. Various growth factors stimulate blood and lymphatic neovascularization and modulate vessel permeability in tumors. The first anti-angiogenic drugs are al...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.21808
更新日期:2011-05-01 00:00:00
abstract::Lymphedema is a common condition frequently seen in cancer patients who have had lymph node dissection +/- radiation treatment. Traditional management is mainly non-surgical and unsatisfactory. Surgical treatment has relied on excisional techniques in the past. Physiologic operations have more recently been devised to...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.24337
更新日期:2017-01-01 00:00:00
abstract::Analysis of functional status of 197 breast cancer patients three years after curative radical mastectomy indicated a cumulative probability of disability of 25%, whereas the probability of death regardless of prior disability was 40.5%. Analysis of functional status by patient characteristics indicated that nonwhites...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930110408
更新日期:1979-01-01 00:00:00
abstract::A unique association between meningioma and breast cancer has recently been observed. A review of the literature reveals 33 such cases. Certain similarities exist between these two tumors. They each occur more frequently in women in the fifth and sixth decade, and pregnancy accelerates the symptoms of both entities. F...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930310309
更新日期:1986-03-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:The propeller flap is a reliable option for reconstruction after soft tissue sarcoma resection. However, some parts of the resection margin may move away from its original position during flap rotation and thus can be excluded from the clinical target volume of adjuvant radiotherapy. This stud...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.26076
更新日期:2020-06-28 00:00:00