The role of preoperative ultrasound scan in detecting lymph node metastasis before sentinel node biopsy in melanoma patients.

Abstract:

BACKGROUND AND OBJECTIVES:To evaluate the efficacy of preoperative ultrasound (US) scanning in identifying lymph node metastasis before sentinel node biopsy (SNB), we conducted a prospective study on 125 patients with primary cutaneous melanoma (CM). METHODS:We prospectively enrolled 125 patients with >1 mm thick CM and candidate for SNB. Preoperatively, patients underwent US scanning of regional lymphatic basins and FNA of suspected lymph nodes (LN). All patients underwent lymphatic mapping and SNB. RESULTS:Combined with fine-needle aspirate (FNA) of suspect LN, US scan allowed the correct preoperative detection of 12 out of 31 histologically positive lymphatic basins, specificity and sensitivity being 100 and 39%, respectively. The false negative rate (61%) was mainly linked to tumor deposits less than 2 mm in diameter, which can be considered the current spatial resolution limit of this technique. CONCLUSIONS:Preoperative US scan could reduce the number of SNB, thus avoiding the stress of this surgical procedure in approximately 10% of patients and reducing health care costs. As a non-invasive and relatively inexpensive technique, lymph node US scan can be part of the preoperative staging process of patients' candidate for SNB in order to avoid unnecessary surgical procedures.

journal_name

J Surg Oncol

authors

Rossi CR,Mocellin S,Scagnet B,Foletto M,Vecchiato A,Pilati P,Tregnaghi A,Zavagno G,Stramare R,Rubaltelli L,Montesco C,Borsato S,Rubello D,Lise M

doi

10.1002/jso.10248

subject

Has Abstract

pub_date

2003-06-01 00:00:00

pages

80-4

issue

2

eissn

0022-4790

issn

1096-9098

journal_volume

83

pub_type

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