Abstract:
:This report reviews the methods and goals of treatment of gastrointestinal stromal tumor (GIST), the most common mesenchymal tumor of the gastrointestinal tract. GISTs express CD117, which serves as an immunohistochemical diagnostic marker. Surgical excision is the definitive treatment for all primary GISTs greater than 2 cm without evidence of peritoneal seeding or metastasis. Preoperative or intraoperative biopsy is not indicated except when the differential diagnosis includes another type of malignancy. Resection may be performed by traditional open surgery or by laparoscopic or laparoscopy-assisted procedures. Regardless of the approach, oncological precautions must be strictly observed. Tumor disruption is to be avoided at all costs; tumor enucleation leaves a tumor-seeded pseudocapsule behind and is considered insufficient. Because GISTs rarely metastasize through the lymphatics, routine lymphadenectomy is not indicated. The importance of achieving negative microscopic margins is controversial, although patients who undergo incomplete microscopic resection may be at greater risk of locoregional recurrence. Other factors, such as tumor grade and size, may play a more significant role in predicting recurrence. Cases of advanced disease or involvement of adjacent structures should be evaluated on an individual basis by a multidisciplinary team.
journal_name
J Surg Oncoljournal_title
Journal of surgical oncologyauthors
Everett M,Gutman Hdoi
10.1002/jso.21030subject
Has Abstractpub_date
2008-12-15 00:00:00pages
588-93issue
8eissn
0022-4790issn
1096-9098journal_volume
98pub_type
杂志文章,评审abstract:BACKGROUND:Retroperitoneal sarcomas are connective tissue tumors arising in the retroperitoneum. Surgical resection is the mainstay of treatment. Debate has arisen over extent of resection, changes in histological classification/grading, and interest in incorporating radiotherapy. Therefore, we reviewed our institution...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.24256
更新日期:2016-07-01 00:00:00
abstract:AIMS:Establish oncologic safety using 50 Gy to sterilize tumor bearing bone before reimplantation in primary diaphyseal high grade extremity tumors, determine extracorporeal radiotherapy (ECRT) graft survival, and analyze factors that affect union at osteotomy sites. MATERIALS AND METHODS:Seventy non metastatic patien...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.25092
更新日期:2018-07-01 00:00:00
abstract::Lymphoproliferative activity was assessed by 3H-thymidine incorporation in spleen cells of mammary tumor bearing BALB/c mice, mice which had their tumors surgically removed, and mice with sham surgery after stimulation in vitro with a soluble extract of syngeneic tumor antigens. Surgical removal of tumors caused an av...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930350102
更新日期:1987-05-01 00:00:00
abstract::Non-GIST soft tissue sarcomas are a heterogeneous grouping of mesenchymal tumors that comprise less than 1% of adult malignancies. Treatment continues to be based on cytotoxic chemotherapy regimens. However, characterization of the molecular pathway deregulations that drive these tumors has led to the emergence of mor...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.23802
更新日期:2015-04-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:MicroRNAs (miRNAs) are small, noncoding RNAs that are involved in carcinogenesis through postranscriptional gene regulatory activity. Few studies have focused on the detection of miR-21 in serum rather than in tissue. The current study aimed to measure serum miR-21 expression levels and to eva...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.23415
更新日期:2013-11-01 00:00:00
abstract::The classical concepts pertaining to the natural history of mammary carcinoma and its treatment must be reviewed if survival rate is to be improved. By the time diagnosis is established, a fair amount of cases of carcinoma of the breast present distant, clinically undetectable micrometastases, which will not be affect...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930140211
更新日期:1980-01-01 00:00:00
abstract:BACKGROUND:Few studies describe quality of life (QoL) outcomes following gastrectomy for gastric cancer using a validated instrument. The gastric cancer module for the Functional Assessment of Cancer Therapy system of QoL measurement tools (FACT-Ga) was utilized to determine the changes in QoL following gastrectomy, an...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.22139
更新日期:2012-03-15 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Tumor-associated macrophages (TAMs) are well known to have distinct roles in tumor progression and metastasis. However, the role of TAMs in chemoresistance has not been fully investigated. The aim of this study is to examine whether TAMs, especially M2 macrophages, are associated with the tumor...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.23881
更新日期:2015-05-01 00:00:00
abstract:BACKGROUND:Subtotal stomach preserving pancreaticoduodenectomy (SSPPD) is compared retrospectively with pylorus preserving pancreaticoduodenectomy (PPPD). METHODS:During 2002-2005, 21 patients (13 female, 8 male) underwent SSPPD. The mean age was 64.3 (range 33-80). PPPD was performed for 12 patients after 1999. Days ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.20608
更新日期:2007-02-01 00:00:00
abstract:BACKGROUND:Since the majority of patients with early gastric cancer show long-term survival after surgery, a special attention must be directed to preserving gastric function in these patients. Little is known about the protocol of surgical treatment appropriate for early gastric cancer patients. This study was designe...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/(sici)1096-9098(199701)64:1<42::aid-jso9>3
更新日期:1997-01-01 00:00:00
abstract:BACKGROUND:The aim of this study was to investigate if immunohistochemical expression and mutational status of KIT and PDGFRA in GISTs are associated with the clinical course and disease-free survival after curative resection of the primary tumor without adjuvant systemic therapy. METHODS:Paraffin-embedded tumor secti...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.21905
更新日期:2011-07-01 00:00:00
abstract:BACKGROUND:Unresectable tumors of the pancreatic head are encountered in up to 20% of patients taken for resection. The objective of this study was to evaluate the complications and outcome associated with palliative surgical procedures to help guide management decisions in these patients. METHODS:Patients with pancre...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.23560
更新日期:2014-06-01 00:00:00
abstract:OBJECTIVES:This study investigated late toxicity and infield progression-free survival in patients with locally recurrent rectal cancer (LRRC) who had previously received irradiation to the pelvis. METHODS:Twenty-two patients were treated by reirradiation to the pelvis between January 2000 and August 2007. All patient...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.23023
更新日期:2012-06-01 00:00:00
abstract:BACKGROUND:A tracheobronchial injury is an uncommon complication of an esophagectomy. Differences in outcomes may exist for patients with injuries detected intraoperatively and postoperatively. METHODS:A retrospective review was performed for patients who underwent an esophagectomy for cancer at Jackson Memorial Hospi...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.23577
更新日期:2014-06-01 00:00:00
abstract::Cancer of the oral cavity remains a major problem in the United States as well as in many other countries, some of which record as much as 30% of all their cancers to be in the oral region. Despite numerous advances in the fields of epidemiology and etiology, little is known of the molecular basis of oral cancer. Adva...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.2930470209
更新日期:1991-06-01 00:00:00
abstract::The complications of percutaneous intraarterial infusion chemotherapy of the head-and-neck-cancer patient has dampened enthusiasm for this approach. A totally implantable infusion pump system circumvents many of these complications and will in the long term enhance the opportunity to expand upon the advantages of infu...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930210213
更新日期:1982-10-01 00:00:00
abstract::A review of our 247 patients with adenocarcinoma of the lung revealed the overall five year survival rate to be only 0.81%. Lung resection offers the chance of cure if the lesion is peripherally located and without lymph node involvement. Direct chest wall invasion by tumor is not contraindication to surgery. Radiatio...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930070306
更新日期:1975-01-01 00:00:00
abstract::Between 1979 and 1993, 665 Japanese patients with advanced gastric cancer underwent surgery at our hospital. These patients were divided into two groups, consisting of 102 patients with Borrmann type IV carcinoma, and the remaining 563 patients with all other types of gastric carcinoma, which were then compared clinic...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930580208
更新日期:1995-02-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Local control of disease is one of the main goals of osteosarcoma management. We conducted a retrospective evaluation of 95 operated cases of osteosarcoma over 7 years to know about the factors associated with local recurrence in resource-challenged environment of the developing world. METHOD...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.24602
更新日期:2017-04-01 00:00:00
abstract:BACKGROUND:The ARM technique was proposed to prevent arm lymphedema after ALND and/or SLN biopsy. However, several problems remain to be resolved in the practical application of this technique. METHODS:The fluorescent ARM nodes and/or lymphatics were identified using a fluorescence imaging system with subdermal inject...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.21473
更新日期:2010-03-01 00:00:00
abstract::Surgery is a mainstay of primary breast cancer therapy. Alterations in surgical technique have reduced normal tissue injury, yet pain and functional compromise continue to occur following treatment. A tenuous evidence base bolstered by considerable expert opinion suggests that early intervention with conventional reha...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.20782
更新日期:2007-04-01 00:00:00
abstract::A retrospective review is presented of 20 evaluable patients who underwent surgical resection or biopsy for limited stage thyroid carcinoma at two institutions between 1963 and 1983. The majority had external radiotherapy to the whole neck and upper mediastinum and the total dose given varied from 3,800 to 6,000 rads....
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930300205
更新日期:1985-10-01 00:00:00
abstract:BACKGROUND:This study aimed to compare voiding and male sexual dysfunction between open and laparoscopic rectal cancer surgery. METHODS:Ninety-seven patients (62 male and 35 female) who underwent open (n = 41) or laparoscopic (n = 56) surgery for rectal cancer were prospectively enrolled. Urine flowmetry, the internat...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.23435
更新日期:2013-12-01 00:00:00
abstract::A totally implantable venous access system is described which greatly improved the ability to gain long-term venous access in selected patients. The external jugular approach has been demonstrated to be a safe and simple technique. The only major problem associated with the implantable venous access system was the dev...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930370413
更新日期:1988-04-01 00:00:00
abstract::We report here on two female patients who had permanent pacemakers implanted in their chests and who developed carcinoma of the breast subsequently. An association is suspected between the breast cancer and the pacemaker, which is implanted in an area which borders with the mammary gland or is even right within it. Th...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930110103
更新日期:1979-01-01 00:00:00
abstract:BACKGROUND:There are limited data on surgical complications for patients that have delayed surgery after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. We aimed to analyze the surgical outcomes of patients submitted to surgery after recovery from SARS-CoV-2 infection. METHODS:Asymptomatic pati...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.26377
更新日期:2021-01-11 00:00:00
abstract:BACKGROUNDS AND OBJECTIVES:The aim of this study was to describe the epidemiology and treatment of skin adnexal carcinoma (SAC) in the Netherlands and to identify prognostic factors for survival in patients with SAC. METHODS:We used population-based nationwide data from the Netherlands Cancer Registry with cases diagn...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.23331
更新日期:2013-06-01 00:00:00
abstract:OBJECTIVE:To propose a distinct anatomical classification for the superior thyroid pole that may serve as a surgical landmark and could help reduce complications in thyroid surgery. MATERIALS AND METHODS:A comprehensive anatomical study based on existing literature and surgical observations. RESULTS:The proposed supe...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.23950
更新日期:2015-07-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:This study assessed the outcomes of Yttrium-90 (90 Y) radiation segmentectomy for hepatic metastases unamenable to resection or ablation. MATERIALS AND METHODS:Over 6 years, 36 patients with 53 tumors underwent segmental radioembolization. Patients were not candidates for surgical resection o...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,多中心研究
doi:10.1002/jso.26223
更新日期:2021-01-01 00:00:00
abstract:BACKGROUND:Local recurrence (LR) of sacral chordoma is a difficult problem and the mortality risk associated with LR remains poorly described. The purpose of this study was to evaluate the risk of mortality in patients with LR and determine if patient age is associated with mortality. METHODS:A total of 218 patients (...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.25774
更新日期:2019-11-22 00:00:00