Abstract:
:Forty-one patients with marginally resectable stage III M0 non-small cell lung cancer (NSCLC) were entered into a study evaluating neoadjuvant cyclophosphamide, adriamycin, and cisplatin chemotherapy (CAP) followed by radiotherapy and subsequent resection. Postoperative radiotherapy and additional CAP were also administered. The objective disease regression rate prior to surgery was 72% (2 complete, 12 partial, and 7 minimal responses). Thoracotomy was carried out in 37 patients (90%), with resection of all gross disease in 36 patients (97%). Relapse occurred in 22 (61%) of the resected patients, involving chest only (four patients), chest and extra thoracic (nine patients), and extra thoracic only (nine patients). Subsequent CNS relapse developed in 9 (25%) of 36 postop patients in association with other sites of relapse (five patients) or as a solitary location (four patients). Only one of seven patients receiving prophylactic cranial irradiation (PCI) developed CNS relapse compared with 7 (26%) of 27 patients not receiving PCI. The median long-term follow-up for 14 living patients is 53+ months, with a rang of 38+ to 71+ months. Median survival for all patients is 32 months, with 1-year survival being 75%. The survival curve shows a plateau of 31% from 3 to 5+ years. Using a log rank test, no prognostic subgroups could be identified that significantly affected response rate, disease-free survival, or overall survival. While neoadjuvant CAP followed by radiotherapy appears to improve survival, more effective chemotherapy along with randomized studies are needed to determine the role of initial chemotherapy in marginally resectable NSCLC.
journal_name
J Surg Oncoljournal_title
Journal of surgical oncologyauthors
Skarin A,Jochelson M,Sheldon T,Malcolm A,Oliynyk P,Overholt R,Hunt M,Frei E 3rddoi
10.1002/jso.2930400413subject
Has Abstractpub_date
1989-04-01 00:00:00pages
266-74issue
4eissn
0022-4790issn
1096-9098journal_volume
40pub_type
杂志文章abstract:BACKGROUND AND OBJECTIVES:The poorer outcome amongst younger breast cancer patients continues to be an issue of debate. In order to clarify the prognostic value of patient age, we retrospectively analyzed the data of 1098 breast cancer patients. METHODS:Patients were divided into two groups based on the age 35 (Group ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.10088
更新日期:2002-05-01 00:00:00
abstract::This review evaluates the use of robotic-assisted laparoscopic surgery in the treatment of gynecologic malignancies and objectively evaluates the use of these systems in performing radical hysterectomies and surgical staging of gynecologic malignancies. The review focuses on surgical length, blood loss, complications,...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.22080
更新日期:2012-04-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:This multicenter study, which was conducted in northern Kanto, Japan, aimed to assess the efficacy of imatinib mesylate against advanced or recurrent gastrointestinal stromal tumors (GIST). METHODS:The clinicopathological data of 234 GIST patients who were treated at one of the 11 participati...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,多中心研究
doi:10.1002/jso.23773
更新日期:2014-12-01 00:00:00
abstract:BACKGROUND:Gastric cancer (GC) in Israel remains incompletely characterized. The aim of this study was to define the clinical and pathological characteristics of GC in Israel and to compare them to the general Western population. PATIENTS AND METHODS:This is a retrospective analysis of 461 consecutive GC patients trea...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.22078
更新日期:2012-03-01 00:00:00
abstract:BACKGROUND:One of the reasons for the poor prognosis of pancreatic carcinoma is the difficulty of obtaining an early diagnosis of pancreatic carcinoma. One possibility is the application of radioimmunoscintigraphy using radiolabeled monoclonal antibodies (Mabs). METHODS:We labeled chimeric (human/mouse) Fab fragments ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.10311
更新日期:2003-11-01 00:00:00
abstract::Oncoplastic surgery combines plastic surgical techniques with sound surgical oncologic principles. The goal is to completely excise the cancer, with wide surgical margins while maintaining or improving cosmesis. For large, poorly defined, or unfavorably situated tumors, standard lumpectomies may lead to unacceptable c...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.23641
更新日期:2014-07-01 00:00:00
abstract::Intra-abdominal visceral sarcomas are a rare group of mesenchymal tumors that require the use of distinct surgical principles and a multidisciplinary approach in order to optimize treatment. Surgery remains the only potentially curative treatment. Management and outcomes vary for the different sarcomas arising from vi...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.23803
更新日期:2015-04-01 00:00:00
abstract::High-quality data support multiple clinical benefits of integrating palliative care into routine oncology care. Though these data come largely from the medical oncology literature, data from surgical oncology populations support similar associations between palliative care integration and improved clinical outcomes, a...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.25454
更新日期:2019-07-01 00:00:00
abstract:BACKGROUND:Esophageal cancer is increasingly recognized in younger patients. We compared clinicopathological characteristics, treatment, and survival of patients aged ≤50 years with patients aged >50 years diagnosed with esophageal cancer in the Netherlands. METHODS:From the nationwide Netherlands Cancer Registry we i...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.23533
更新日期:2014-05-01 00:00:00
abstract::Cell surface sialic acid levels were compared for monocytes and macrophages obtained from normal volunteers and breast cancer patients. Equal quantities of sialic acid were found on the monocytes obtained from normal volunteers and breast cancer patients. Approximately 60% more cell surface sialic acid was found on th...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930220203
更新日期:1983-02-01 00:00:00
abstract:INTRODUCTION:The Siewert classification has been used to plan treatment for tumours of the gastro-oesophageal junction since its proposal in the 1980s. The purpose of this study was to assess its continued relevance by evaluating whether there were differences in the biology and clinical characteristics of adenocarcino...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.23484
更新日期:2014-03-01 00:00:00
abstract::This is a review of a rare case of acute appendicitis secondary to metastatic nasopharyngeal carcinoma (NPC) that had never before been reported in the literature. The clinical presentation did not differ from usual cases of acute appendicitis, but the pathology caused us to re-evaluate the NPC stage of the patient. ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930600213
更新日期:1995-10-01 00:00:00
abstract:BACKGROUND:We evaluated whether electrothermal bipolar coagulation (Ligasure) for pelvic exenterations decreases operative morbidity. METHODS:All cases of pelvic exenterations, for all malignancies, performed at Moffitt Cancer Center from 1999 to 2008, were identified through retrospective review of medical records. E...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.21372
更新日期:2009-11-01 00:00:00
abstract::The only acceptable definitive diagnosis of a soft tissue mass is histologic or cytologic examination. In recent years, fine-needle aspiration cytology is used in more and more centers for diagnosis of soft tissue masses. We studied 196 aspiration cytologies performed on soft tissue lesions. Out of these, in 48 cases ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930370307
更新日期:1988-03-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Long noncoding RNAs (lncRNAs) play key roles in carcinoma metastasis. We aimed to investigate lncRNA LINC01133 in oral squamous cell carcinoma (OSCC) metastasis. METHODS:The RNA levels of LINC01133 and growth and differentiation factor 15 (GDF15) in tissue samples from OSCC patients, and OSCC...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.25278
更新日期:2018-12-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:The propeller flap is a reliable option for reconstruction after soft tissue sarcoma resection. However, some parts of the resection margin may move away from its original position during flap rotation and thus can be excluded from the clinical target volume of adjuvant radiotherapy. This stud...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.26076
更新日期:2020-06-28 00:00:00
abstract::Prognostic significance of blood vessel invasion in carcinoma of the female breast has been evaluated by study of 242 cases of radical mastectomy done at the Tata Memorial Hospital. The significance of axillary node involvement with the disease has been simultaneously evaluated. In the absence of blood vessel invasion...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930090613
更新日期:1977-01-01 00:00:00
abstract::This is a retrospective study of 462 patients who had masectomy and axillary dissection for carcinoma of the breast during 1971-1980. Actuarial analysis of relapse rates up to 5 years showed that the extent of involvement of axillary lymph nodes was the most important prognostic factor. Among patients without any axil...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930270109
更新日期:1984-09-01 00:00:00
abstract::The results of treatment with intracavitary bleomycin are reported in twenty patients with a malignant pleural effusion and five patients with malignant ascites. The control rate was 17/20 (85%) patients with malignant pleural effusions and 3/5 (60%) patients with malignant ascites. Toxicities were minimal with fever ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930160312
更新日期:1981-01-01 00:00:00
abstract:BACKGROUND:In patients undergoing total mesorectal excision (TME), the clinical variables most relevant to anastomotic recurrence have not been identified. We evaluated factors associated with anastomotic recurrence in patients undergoing TME and the impact of a reduced distal margin on anastomotic recurrence. METHODS...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.21166
更新日期:2009-01-01 00:00:00
abstract::Prevention of cancer is now divided into primary and secondary prevention. Primary prevention is that set of interventions that keeps a cancerous process from ever developing and includes health counseling and education, environmental controls. and product safety as examples. Secondary prevention is that set of interv...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930180302
更新日期:1981-01-01 00:00:00
abstract:BACKGROUND:Gastric cancer (GC) has been defined in distinct molecular subtypes with different therapeutic implications. However, its clinical significance and prognosis regarding standard chemotherapy (CMT) remains unclear. This study aimed to analyze the impact of perioperative or adjuvant treatment among subtypes of ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.25792
更新日期:2020-04-01 00:00:00
abstract::Malignant arterial tumor emboli large enough to cause ischemia or organ infarction are a rare, but often fatal, complication of neoplastic disease. The majority of arterial emboli are associated with primary or secondary pulmonary malignancies. The sites where they impact are similar in distribution to arterioscleroti...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.2930520317
更新日期:1993-03-01 00:00:00
abstract:BACKGROUND:Increased activity of Src has been found in several human cancers, and often is associated with poor clinical outcome. The present study aimed to determine whether Src activity is increased in gastrointestinal stromal tumors (GIST), and whether it correlates with established tumor or patient characteristics ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.23544
更新日期:2014-05-01 00:00:00
abstract::Upper extremity malignancies have the potential to create significant functional impairment, and as such represent an opportunity for collaborative reconstruction to minimize potential morbidity. Given the increased complexity and array of potential reconstruction solutions, functional limb preservation is overwhelmin...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.24196
更新日期:2016-06-01 00:00:00
abstract::Colorectal cancer progression originates when accumulated genetic and epigenetic alterations cause genomic instability and a malignant phenotype. Subsequent molecular pathway deregulation leads to histopathologic changes that are clinically evident as aberrant crypt foci (ACF) and visualized by high-magnification chro...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.21106
更新日期:2008-09-01 00:00:00
abstract::Treatment of gastric cancer has evolved with the advent of randomized trials demonstrating chemotherapeutic agents with efficacy in advanced disease. Level I evidence supports delivering chemotherapy in the neoadjuvant setting; the data shows improvement in progression-free and overall survival. A clinical response to...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.21483
更新日期:2010-03-15 00:00:00
abstract:BACKGROUND AND OBJECTIVES:The study of pathology and prognosis for patients with ovarian tumors of low malignant potential (LMP) has been well documented. The treatment, particularly the secondary surgery, for recurrent disease is less documented. This study was conducted to investigate the role of secondary surgical c...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.20280
更新日期:2005-07-01 00:00:00
abstract::Significant destruction of the Pollard III rat prostate adenocarcinoma was achieved by treatment with rhodamine 123 at a dosage of 15 mg/kg every other day for 33 to 38 days. Injection of tumor remnants into untreated animals produced no tumor regrowth. Our data have demonstrated rhodamine 123 to be a significant drug...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930440209
更新日期:1990-06-01 00:00:00
abstract:BACKGROUND:At present, the majority of outcome studies of survival of hepatocellular carcinoma (HCC) post-liver resection (post-LR) present actuarial survival data, which often results in overestimation of survival. We sought to evaluate the actual 10-year survival post-LR for HCC and identify variables that are associ...
journal_title:Journal of surgical oncology
pub_type: 临床试验,杂志文章
doi:10.1002/jso.26259
更新日期:2021-01-01 00:00:00