A multicenter long-term study of imatinib treatment for Japanese patients with unresectable or recurrent gastrointestinal stromal tumors.

Abstract:

BACKGROUND AND OBJECTIVES:This multicenter study, which was conducted in northern Kanto, Japan, aimed to assess the efficacy of imatinib mesylate against advanced or recurrent gastrointestinal stromal tumors (GIST). METHODS:The clinicopathological data of 234 GIST patients who were treated at one of the 11 participating hospitals from 2001-2011 were retrospectively reviewed. Imatinib was administered as a first-line therapy in cases involving unresectable disease or postoperative recurrence (41 cases). The median follow-up period was 4.0 years. RESULTS:After a median follow-up period of 4.0 years, the patients treated with imatinib (n = 41) exhibited 1-, 3-, and 5-year overall survival (OS) rates of 92.3%, 74.9%, and 53.8%, respectively. In univariate and multivariate analyses, imatinib dose reduction and achieving a complete or partial response were found to be associated with increased OS. CONCLUSIONS:Long-term imatinib treatment is recommended for patients with non-progressive disease. If patients experience significant toxicities, temporary dose reduction might be useful.

journal_name

J Surg Oncol

authors

Ogata K,Mochiki E,Ojima H,Haga N,Fukuchi M,Aihara R,Ando H,Uchida N,Toyomasu Y,Suzuki M,Kimura A,Kogure N,Yokobori T,Ohno T,Kuwano H

doi

10.1002/jso.23773

subject

Has Abstract

pub_date

2014-12-01 00:00:00

pages

942-6

issue

8

eissn

0022-4790

issn

1096-9098

journal_volume

110

pub_type

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