Management and outcomes among patients with mixed hepatocholangiocellular carcinoma: A population-based analysis.


BACKGROUND:We sought to define the management of mixed hepatocellular carcinoma-intrahepatic cholangiocarcinoma (HCC-ICC) as well as characterize short- and long-term outcomes of patients with mixed HCC-ICC. METHODS:Patients diagnosed with HCC-ICC, HCC, or ICC between 2004 and 2015 were identified from the National Cancer Data Base using the International Classification of Diseases for Oncology codes. Short- and long-term outcomes were assessed using univariate and multivariate analyses. RESULTS:Among 174 454 patients, 86.8% had HCC, 12.1% ICC, and 1.1% HCC-ICC. The incidence of lymphadenectomy was 55.6% among ICC patients vs 15.1% and 34.2% for HCC and HCC-ICC patients, respectively (P < 0.001). A 90-day mortality was comparable among patients with HCC (9.1%), ICC (8.8%), and HCC-ICC (10.5%) (all P > 0.2). While 42.0% of ICC patients received adjuvant chemotherapy, adjuvant chemotherapy among HCC and HCC-ICC patients was 13.1% and 27.4%, respectively (P < 0.001). A 5-year survival was 43.5% (95% CI, 42.5-44.5), 33.3% (95% CI, 31.4-35.3), 34.4% (95% CI, 29.1-39.8) for HCC, ICC, and HCC-ICC patients, respectively. CONCLUSION:Patients who underwent resection of mixed HCC-ICC had a prognosis that was comparable to ICC, yet worse than HCC. Utilization of lymphadenectomy and adjuvant therapy were low. HCC-ICC remains a rare disease with a guarded prognosis that should be treated in a multidisciplinary setting.


J Surg Oncol


Spolverato G,Bagante F,Tsilimigras D,Ejaz A,Cloyd J,Pawlik TM




Has Abstract


2019-03-01 00:00:00












  • Soft tissue sarcoma of the head & neck: nomogram validation and analysis of staging systems.

    abstract:BACKGROUND AND OBJECTIVES:Soft tissue sarcomas of the head and neck (STSHN) comprise a rare group of malignancies. Our objective is to determine the utility of soft tissue sarcoma staging systems within the head and neck, and to validate an individualized soft tissue sarcoma nomogram within head and neck primary sites....

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章


    authors: Shuman AG,Brennan MF,Palmer FL,Kuk D,Moraco N,Singer S,Shah JP,Patel SG

    更新日期:2015-05-01 00:00:00

  • Robotic trans-axillary and retro-auricular thyroid surgery.

    abstract::Remote access approaches for thyroid surgery using surgical incisions placed outside the neck, including the axillary, chest and the retro-auricular region have gained interest due to the social stigmatization of young females with a visible neck scar. These novel approaches have been reported to be safe and feasible ...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章,评审


    authors: Mohamed HE,Kandil E

    更新日期:2015-09-01 00:00:00

  • Aberrant crypt foci as precursors in colorectal cancer progression.

    abstract::Colorectal cancer progression originates when accumulated genetic and epigenetic alterations cause genomic instability and a malignant phenotype. Subsequent molecular pathway deregulation leads to histopathologic changes that are clinically evident as aberrant crypt foci (ACF) and visualized by high-magnification chro...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章,评审


    authors: Orlando FA,Tan D,Baltodano JD,Khoury T,Gibbs JF,Hassid VJ,Ahmed BH,Alrawi SJ

    更新日期:2008-09-01 00:00:00

  • Molecular imaging of adrenal neoplasms.

    abstract::The adrenal glands are complex structures from which a variety of benign and malignant tumors may arise and are a common site of metastatic disease. Several radiopharmaceuticals are used for imaging the adrenals, including I-123/I-131 metaiodobenzylguanidine (MIBG), norcholesterol derivatives, In-111 pentetreotide and...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章,评审


    authors: Chen CC,Carrasquillo JA

    更新日期:2012-10-01 00:00:00

  • Regional chemotherapy is indicated after surgical resection of colorectal metastases to the liver: a debate.

    abstract::Surgical resection for selected patients with hepatic metastases from colorectal cancer can cure approximately one-fourth of these patients. The addition of regional chemotherapy as an attempt to improve this statistic has been extensively investigated in clinical trials. As part of a multidisciplinary educational pro...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章,评审


    authors: Khushalani NI,McKinley BP,Gibbs JF,Leichman CG,Petrelli NJ

    更新日期:2003-01-01 00:00:00

  • Expression of extracellular matrix molecules in brain metastasis.

    abstract:BACKGROUND AND OBJECTIVES:The objectives of this study were to investigate the role of growth factors and matrix metalloproteinases in the brain metastasis. METHODS:Tumors from 40 patients with brain metastasis (30 lung cancer, 10 breast cancer) were studied to investigate the expression-patterns of EGFR, MT1-MMP, MMP...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章


    authors: Yoshida S,Takahashi H

    更新日期:2009-07-01 00:00:00

  • Molecular fluorescence-guided surgery of peritoneal carcinomatosis of colorectal origin: A narrative review.

    abstract::Patients with peritoneal carcinomatosis (PC) from colorectal origin may undergo cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) as a curative approach. One major prognostic factor that affects survival is completeness of cytoreduction. Molecular Fluorescence Guided Surgery (MFGS) is ...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章,评审


    authors: Hentzen JEKR,de Jongh SJ,Hemmer PHJ,van der Plas WY,van Dam GM,Kruijff S

    更新日期:2018-08-01 00:00:00

  • Insulin metabolism in depancreatized dogs during hemorrhagic shock.

    abstract::This study was done to determine why the plasma insulin remained elevated during shock. Mongrel Female dogs (12-15 kg) were depancreatized and maintained on a constant intraportal infusion of porcine insulin while they were bled to reduce and maintain the mean arterial blood pressure at 50 mm Hg for 165 min. Blood sam...

    journal_title:Journal of surgical oncology

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  • The quality of life trajectory of resected gastric cancer.

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    journal_title:Journal of surgical oncology

    pub_type: 杂志文章


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  • Preliminary results of phase I/II study of high-dose-rate intraoperative radiation therapy for pediatric tumors.

    abstract::Ten children with locally advanced or recurrent tumors were treated on a Phase I/II study to assess the feasibility and toxicity of intraoperative radiotherapy (IORT) for primary and recurrent pediatric solid malignancies at high risk for local recurrence. Eligible patients include all primary and recurrent pediatric ...

    journal_title:Journal of surgical oncology

    pub_type: 临床试验,杂志文章


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  • Isolated limb infusion as a model to test new agents to treat metastatic melanoma.

    abstract::The limb model of in-transit disease can expand our understanding of treating melanoma because of the ease of obtaining tissue biopsies for correlative studies and the availability of preclinical animal models that allow validation of novel therapeutic strategies. This review will focus on regional therapy for in-tran...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章,评审


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  • The management of breast carcinoma in pregnancy and lactation.

    abstract::Until recent years, the prognosis for breast cancer in pregnancy and lactation was regarded as grave. The current new data suggest that pregnant women with early breast carcinoma may be treated in the same way as nonpregnant women without affecting pregnancy. However, women with breast cancer in their first trimester ...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章


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  • Leiomyosarcoma of the scrotum.

    abstract::A case of leiomyosarcoma arising from the dartos muscle of the scrotum is described. Review of the literature reveals only eight other cases, and aspects of management of these and our case are discussed. ...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章,评审


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    更新日期:1987-03-01 00:00:00

  • Vulvar carcinoma with 0.5 mm of invasion and associated inguinal lymph node metastasis.

    abstract::A case of vulvar carcinoma with 0.5 mm of invasion treated by radical wide local excision only, which later developed ipsilateral inguinal lymph node recurrence, is presented. This represents the least amount of invasion reported resulting in inguinal lymph node metastasis. Review of the literature of stage I vulvar c...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章


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  • Neoadjuvant systemic treatment of breast cancer.

    abstract::Neoadjuvant systemic breast cancer therapy is the administration of systemic therapy to eligible breast cancer patients prior to surgery. This treatment modality was developed out of necessity to downstage inoperable tumors, but it has evolved into a tool for breast conservation surgery. The neoadjuvant approach is al...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章,评审


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    更新日期:2011-03-15 00:00:00

  • Technique for placement of a totally implantable venous access device.

    abstract::A totally implantable venous access system is described which greatly improved the ability to gain long-term venous access in selected patients. The external jugular approach has been demonstrated to be a safe and simple technique. The only major problem associated with the implantable venous access system was the dev...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章


    authors: Kondi ES,Pietrafitta JJ,Barriola JA

    更新日期:1988-04-01 00:00:00

  • Desmoplastic melanoma - the step-child in the melanoma family?

    abstract:BACKGROUND AND OBJECTIVES:Desmoplastic melanoma (DM) is a rare variant of cutaneous melanoma. Our goal was to study the surgical management of DM, identify prognostic factors, and impact of treatment options. METHODS:Patients with DM (n = 1,735) were identified from the Surveillance, Epidemiology, and End Results data...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章


    authors: Wasif N,Gray RJ,Pockaj BA

    更新日期:2011-02-01 00:00:00

  • Modified radical lymphadenectomy without splenectomy in patients with proximal gastric cancer: comparison with standard D2 lymphadenectomy for distal gastric cancer.

    abstract:BACKGROUND AND OBJECTIVES:We assessed the optimal extent of lymph node dissection and the effect of splenectomy in patients with proximal gastric cancer. METHOD:Recurrence and survival rates were compared between 881 patients with proximal gastric cancer who underwent modified radical lymphadenectomy and 3,098 patient...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章


    authors: Cheong O,Kim BS,Yook JH,Oh ST,Park YK,Ryu SY

    更新日期:2008-12-01 00:00:00

  • Analysis of lymph node metastasis in early gastric cancer: rationale of limited surgery.

    abstract:BACKGROUND:Since the majority of patients with early gastric cancer show long-term survival after surgery, a special attention must be directed to preserving gastric function in these patients. Little is known about the protocol of surgical treatment appropriate for early gastric cancer patients. This study was designe...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章


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  • Long-term morbidity of patients with early breast cancer after sentinel lymph node biopsy compared to axillary lymph node dissection.

    abstract:BACKGROUND AND OBJECTIVES:Sentinel lymph node biopsy (SLNB) is widely accepted as an excellent method in the management of early breast cancer in patients with clinically negative axillary lymph nodes. Since SLNB requires less traumatic surgery to the axilla than axillary lymph node dissection (ALND), it was assumed to...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章


    authors: Schulze T,Mucke J,Markwardt J,Schlag PM,Bembenek A

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  • Survival of operated bronchus carcinoma patients: a prospective study.

    abstract::Maximum diameter, tumour volume, and inflammatory response of host tissue in 282 surgical specimens with primary carcinoma of the bronchus were measured. Cell type, pT- and pN-stage, maximum diameter and volume of the primaries, and inflammatory response of host tissue were analyzed in respect to survival of the patie...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章


    authors: Kayser KW,Bülzebruck H,Merkle N,Vogt-Moykopf I

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  • Malignant bowel obstruction.

    abstract::Malignant bowel obstruction (MBO) is a common problem for patients with advanced malignancy, especially colorectal and ovarian cancers. Symptoms include pain, bloating, nausea and vomiting, and inability to eat. Treatment options consist of a wide range of surgical and nonsurgical interventions (medications, endoscopi...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章,评审


    authors: Krouse RS

    更新日期:2019-07-01 00:00:00

  • Recurrence patterns after resection of retroperitoneal sarcomas: An eight-institution study from the US Sarcoma Collaborative.

    abstract:BACKGROUND AND OBJECTIVES:Resection of primary retroperitoneal sarcomas (RPS) has a high incidence of recurrence. This study aims to identify patterns of recurrence and its impact on overall survival. METHODS:Adult patients with primary retroperitoneal soft tissue sarcomas who underwent resection in 2000-2016 at eight...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章,多中心研究


    authors: Chouliaras K,Senehi R,Ethun CG,Poultsides G,Tran T,Grignol V,Gamblin TC,Roggin KK,Tseng J,Fields RC,Weber SM,Russell GB,Levine EA,Cardona K,Votanopoulos K

    更新日期:2019-09-01 00:00:00

  • What is a sentinel node? Re-evaluating the 10% rule for sentinel lymph node biopsy in melanoma.

    abstract:INTRODUCTION:Many surgeons use the "10% rule" to define whether a lymph node is a sentinel node (SLN) when staging malignant melanoma. However, this increases the number of SLN removed and the time and cost of the procedure. We examined the impact of raising this threshold on the accuracy of the procedure. METHODS:We ...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章


    authors: Kroon HM,Lowe L,Wong S,Fullen D,Su L,Cimmino V,Chang AE,Johnson T,Sabel MS

    更新日期:2007-06-15 00:00:00

  • Studies of tumor implants in immunologically privileged sites.

    abstract::Wilms' tumor, renal cell carcinoma, and neuroblastoma in animals were transplanted from donors to recipients with strong histocompatibility differences. No strong evidence of the privileged site theory was found in this study and no obvious evidence of an immunosuppressive effect of testosterone was found. The most im...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章


    authors: Wajsman Z,Williams P,McGarry M,Murphy GP

    更新日期:1980-01-01 00:00:00

  • Chemo-irradiation induced aortoesophageal fistula.

    abstract::A patient with squamous cell carcinoma of the esophagus developed fatal aortoesophageal (AE) fistula following a preoperative course of combined chemotherapy plus radiation therapy. This is the first reported case of AE fistula following preoperative chemoradiotherapy. This complication is potentially correctable if s...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章


    authors: Gabrail NY,Harrison BR,Sunwoo YC

    更新日期:1991-11-01 00:00:00

  • Roles of the transforming growth factor beta 1 and its type I and II receptors in the development of a pulmonary adenocarcinoma: results of an immunohistochemical study.

    abstract:BACKGROUND:In the United States, pulmonary adenocarcinomas have recently replaced squamous cell carcinomas as the most frequent type of lung cancer encountered. The incidence of pulmonary adenocarcinoma continued to increase worldwide. METHOD:To determine the roles of the transforming growth factor-beta 1 (TGF-beta 1)...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章


    authors: Takanami I,Tanaka F,Hashizume T,Kodaira S

    更新日期:1997-04-01 00:00:00

  • An unusual late radiotherapy-related complication requiring surgery in anal canal carcinoma.

    abstract::We herein describe an unusual late radiation-related complication requiring surgery in a 60-year-old male affected by anal epidermoid carcinoma. The patient presented with obstructed defecation and ulcerated perianal lesions. The perianal biopsies were positive for anal squamous carcinoma. Transanal diagnostic investi...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章


    authors: Cicchini C,Stazi A,Ciardi A,Ghini C,Indinnimeo M

    更新日期:2000-06-01 00:00:00

  • Expression of X-linked inhibitor of apoptosis protein in human colorectal cancer and its correlation with prognosis.

    abstract:BACKGROUND:X-linked inhibitor of apoptosis protein (XIAP) is a member of the inhibitor of apoptosis family of proteins and deregulation of XIAP can result in tumorigenicity. The objective of this study was to evaluate the prognostic significance of XIAP expression in colorectal cancer (CRC). METHODS:RT-PCR was perform...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章


    authors: Xiang G,Wen X,Wang H,Chen K,Liu H

    更新日期:2009-12-15 00:00:00

  • Yttrium-90 microspheres (TheraSphere) treatment of unresectable hepatocellular carcinoma: downstaging to resection, RFA and bridge to transplantation.

    abstract:PURPOSE:To present the clinical data of 35 patients with T3 unresectable hepatocellular carcinoma (HCC) that were treated with (90)Y with the specific intent of downstaging to resection, radiofrequency ablation (RFA) candidate, United Network for Organ Sharing (UNOS) stage T2 or liver transplantation. MATERIALS AND ME...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章


    authors: Kulik LM,Atassi B,van Holsbeeck L,Souman T,Lewandowski RJ,Mulcahy MF,Hunter RD,Nemcek AA Jr,Abecassis MM,Haines KG 3rd,Salem R

    更新日期:2006-12-01 00:00:00