Immunohistochemically demonstrated expression of HLA-DR antigen in colorectal adenocarcinomas and its relation to clinicopathological features.


:We studied 148 colorectal adenocarcinomas to clarify any correlation between HLA-DR antigen expression on tumor cells and histopathological features. Paraffin sections of formalin-fixed tissues were stained with HLA-DR antigen using the indirect immunoperoxidase technique. All the tumor tissues were divided into two groups, depending on the incidence of HLA-DR-positive cells (greater and lesser than 50%). Carcinoma tissues with a higher incidence showed less mural invasion, lymphoductal invasion, venous invasion, lymphonodular metastasis, and peritoneal metastasis. Tissues with a high HLA-DR reactivity were more often observed for Dukes' A and B stages, whereas those with a low HLA-DR positivity were frequently Dukes' C and D stages. As for the cumulative survival rate, the group with high HLA-DR expression demonstrated significantly better survival. We speculate that HLA-DR expression by colorectal cancer cells exerts a favorable influence on clinical course.


J Surg Oncol


Morita M,Tanaka K,Kawanishi H,Tsuji M,Ookusa T,Takada H,Okamura A,Hioki K




Has Abstract


1995-08-01 00:00:00












  • Trends in the surgical treatment of pathological proximal femur fractures in the United States.

    abstract:BACKGROUND AND OBJECTIVES:Large scale data on the treatment of pathologic proximal femur fractures (PPFFs) are lacking. The purpose of this study was to evaluate trends in patient demographics, complication rates, and relative utilization rates of various techniques associated with PPFFs. METHODS:The American College ...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章,多中心研究


    authors: Varady NH,Ameen BT,Schwab PE,Yeung CM,Chen AF

    更新日期:2019-11-01 00:00:00

  • Osteosarcoma near joints: assessment and implications.

    abstract:BACKGROUND:The choice of performing surgery when tumors encroach onto joints remains a challenging and controversial issue. Pre-operative assessment by magnetic resonance imaging (MRI) is of critical importance in dictating surgical management and subsequent functional outcome. METHODS:We examined archival samples fro...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章


    authors: Quan GM,Slavin JL,Schlicht SM,Smith PJ,Powell GJ,Choong PF

    更新日期:2005-09-01 00:00:00

  • Impact of intraoperative remifentanil on postoperative pain and opioid use in thyroid surgery.

    abstract:BACKGROUND AND OBJECTIVES:Remifentanil infusion is used as an intraoperative anesthetic for thyroidectomy, but has been associated with acute opioid tolerance and hyperalgesia. A national shortage of remifentanil provided an opportunity to study postoperative pain in patients undergoing thyroidectomy. METHODS:Retrospe...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章


    authors: Wu JX,Assel M,Vickers A,Afonso AM,Twersky RS,Simon BA,Cohen MA,Rieth EF,Cracchiolo JR

    更新日期:2019-12-01 00:00:00

  • p53 alteration correlates with negative ER, negative PgR, and high histologic grade in breast cancer.

    abstract::Seventy tumors of invasive ductal carcinoma of the breast were examined for p53 alteration by the RT-PCR-SSCP method. Sixty-five samples (92.9%) were investigated in the regions of codons 101-200 and 201-300. In total, 16 samples (24.6%) showed p53 gene alteration. We found that p53 gene alteration showed a correlatio...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章


    authors: Sasa M,Kondo K,Komaki K,Morimoto T,Monden Y

    更新日期:1994-05-01 00:00:00

  • Epiphyseal fractures in children treated for osteosarcoma of the femur with chemotherapy, tumourresection, and endoprosthesis: report of four fractures in two children.

    abstract::This paper reports on two patients, who both were under treatment for osteosarcoma of the femur. Treatment consisted of chemotherapy, resection of the tumour, and reconstruction with an endoprosthesis . Both patients sustained an epiphyseal fracture on two occasions after a minor trauma. Careful observations of the x-...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章


    authors: Veth RP,De Graaf SS,Den Heeten GJ,Oldhoff J,Hoekstra HJ,Schraffordt Koops H,Nielsen HK

    更新日期:1984-05-01 00:00:00

  • Intra-abdominal chylovenous bypass treats retroperitoneal lymphangiomatosis.

    abstract:BACKGROUND:Retroperitoneal lymphangiomatosis (RL) is a rare form of primary lymphedema featuring aberrant retroperitoneal lymphatic proliferation. It causes recurrent cellulitis, repeated interventions, and poor life quality. This study aimed to investigate proper diagnositc criteria and surgical outcomes for RL with e...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章


    authors: Chen C,Chu SY,Lin C,Liu KH,Cheng MH

    更新日期:2020-01-01 00:00:00

  • Use of serum copper/zinc ratio in patients with large bowel cancer.

    abstract::The serum copper/zinc ratio was measured in 44 patients bearing primary large bowel malignancies. Measurements were repeated following removal of the primary tumour and again at the time of development of clinical evidence of cancer recurrence in order to evaluate the clinical value of the ratio to accurately reflect ...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章


    authors: Gray BN,Walker C,Barnard R

    更新日期:1982-12-01 00:00:00

  • Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy: Technical considerations and the learning curve.

    abstract::Over the past decade, there has been a considerable increase in the utilization of cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) in the management of patients with peritoneal metastases. This is due to improved safety and favorable oncologic outcomes, including curative potential. C...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章,评审


    authors: Vining CC,Izquierdo F,Eng OS,Turaga KK

    更新日期:2020-07-01 00:00:00

  • The second-time flap from the previously used anterior thigh donor site for head and neck microsurgical reconstruction.

    abstract:BACKGROUND:Multiple free tissue transfer from the same donor site is not well described for microsurgical head and neck reconstruction. METHODS:Between (8/2011 and 11/2012), 103 patients received 103 free ALT flaps for head and neck reconstruction; flaps were called first-time ALT flaps. Intra-operative findings were ...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章


    authors: Al Deek NF,Liao CT,Huang SF,Kan CJ,Chang KP,Fang KH,Tsao CK

    更新日期:2017-03-01 00:00:00

  • Impact of pancreatectomy on long-term patient-reported symptoms and quality of life in recurrence-free survivors of pancreatic and periampullary neoplasms.

    abstract:BACKGROUND:Long term patient-reported symptoms and quality of life (QOL) are important outcome metrics following cancer operations, but have been poorly described in patients who have previously undergone pancreatectomy. METHODS:We conducted a cross-sectional survey of recurrence-free survivors of pancreatic ductal ad...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章


    authors: Cloyd JM,Tran Cao HS,Petzel MQ,Denbo JW,Parker NH,Nogueras-González GM,Liles JS,Kim MP,Lee JE,Vauthey JN,Aloia TA,Fleming JB,Katz MH

    更新日期:2017-02-01 00:00:00

  • Metastatic extramammary Paget's disease: dramatic response to combined modality treatment.

    abstract::A case of extramammary Paget's disease is reported. The distinguishing features of the case are: (1) localization of the primary lesion to the scrotum, (2) development of metastases in the absence of a recognizable underlying carcinoma, and (3) response of the systemic disease to a combination of radiation therapy and...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章


    authors: Balducci L,Athar M,Smith GF,Khansur T,McKenzie D,Crawford ED

    更新日期:1988-05-01 00:00:00

  • Saphenous vein graft conduits for insertion of hepatic arterial infusion pumps in patients with abnormal hepatic arterial anatomy.

    abstract:BACKGROUND AND OBJECTIVES:Hepatic arterial infusion (HAI) chemotherapy offers improved hepatic control for liver metastases from colon cancer. Optimal catheter insertion requires an adequate gastroduodenal artery (GDA). Limited data exists on using saphenous vein grafts (SVG) as conduits when native vasculature is inad...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章


    authors: Yezhelyev M,Osgood M,Egnatashvili V,Lumsden A,Staley CA,Kooby DA

    更新日期:2008-01-01 00:00:00

  • Elevated CA19-9 as the most significant prognostic factor in advanced colorectal carcinoma.

    abstract::Tumor markers such as carcinoembryonic antigen (CEA) and CA19-9 were analyzed as response indicators and prognostic factors in advanced colorectal carcinoma. Eighty-five patients participated in a phase II chemotherapy study from October 1984 to July 1990. A three-drug schedule was administered including low dose epir...

    journal_title:Journal of surgical oncology

    pub_type: 临床试验,杂志文章


    authors: Kouri M,Pyrhönen S,Kuusela P

    更新日期:1992-02-01 00:00:00

  • Axillary reverse mapping with indocyanine fluorescence imaging in patients with breast cancer.

    abstract:BACKGROUND:The ARM technique was proposed to prevent arm lymphedema after ALND and/or SLN biopsy. However, several problems remain to be resolved in the practical application of this technique. METHODS:The fluorescent ARM nodes and/or lymphatics were identified using a fluorescence imaging system with subdermal inject...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章


    authors: Noguchi M,Yokoi M,Nakano Y

    更新日期:2010-03-01 00:00:00

  • Autologous diaphragm reconstruction with the pedicled latissimus dorsi flap.

    abstract::The latissimus dorsi (LD) muscle has been previously described to repair diaphragmatic defects, but as a "reverse" flap, relying on secondary blood supply from the perforating lumbar vessels rather than primary inflow from the dominant thoracodorsal artery. We report resection of a retroperitoneal synovial sarcoma, wi...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章


    authors: McConkey MO,Temple CL,McFadden S,Temple WJ

    更新日期:2006-09-01 00:00:00

  • Robot-assisted retroperitoneal lymph node dissection in testicular cancer.

    abstract::Robotic surgical techniques are now being applied in the setting of retroperitoneal lymphadenectomy (RPLND) for testicular cancer. While laparoscopic RPLND has not been widely accepted, reports of robot assisted RPLND (RARPLND) are emerging. This manuscript will review the application of RPLND for testicular cancer, e...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章,评审


    authors: Abdul-Muhsin HM,L'esperance JO,Fischer K,Woods ME,Porter JR,Castle EP

    更新日期:2015-12-01 00:00:00

  • Semi-automated delineation of breast cancer tumors and subsequent materialization using three-dimensional printing (rapid prototyping).

    abstract:OBJECTIVE:Three-dimensional (3D) printing has become widely available, and a few cases of its use in clinical practice have been described. The aim of this study was to explore facilities for the semi-automated delineation of breast cancer tumors and to assess the feasibility of 3D printing of breast cancer tumors. ME...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章


    authors: Schulz-Wendtland R,Harz M,Meier-Meitinger M,Brehm B,Wacker T,Hahn HK,Wagner F,Wittenberg T,Beckmann MW,Uder M,Fasching PA,Emons J

    更新日期:2017-03-01 00:00:00

  • Adjuvant chemotherapy in resectable synovial sarcoma.

    abstract:INTRODUCTION:The role of adjuvant chemotherapy (AC) for synovial sarcoma (SS) is controversial. Using a large national dataset we evaluate the impact of AC on overall survival (OS) following curative-intent resection of SS. METHODS:Patients with stage I-III SS 2004-2012 undergoing resection were identified in the Nati...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章


    authors: Vining CC,Sinnamon AJ,Ecker BL,Kelz RR,Fraker DL,Roses RE,Karakousis GC

    更新日期:2017-09-01 00:00:00

  • Prognostic implications of serum microRNA-21 in colorectal cancer.

    abstract:BACKGROUND AND OBJECTIVES:MicroRNAs (miRNAs) are small, noncoding RNAs that are involved in carcinogenesis through postranscriptional gene regulatory activity. Few studies have focused on the detection of miR-21 in serum rather than in tissue. The current study aimed to measure serum miR-21 expression levels and to eva...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章


    authors: Menéndez P,Padilla D,Villarejo P,Palomino T,Nieto P,Menéndez JM,Rodríguez-Montes JA

    更新日期:2013-11-01 00:00:00

  • Detubularized rectosigmoid neobladder in women after cystectomy for bladder cancer.

    abstract:BACKGROUND AND OBJECTIVES:We present the long-term functional results of a new technique for bladder substitution after cystectomy for bladder cancer in women. METHODS:Between 1991 and 1995, 10 women underwent radical cystectomy for bladder cancer with a new technique. We created a detubularized rectosigmoid neobladde...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章


    authors: Mearini E,Mearini L,Zucchi A,Costantini E,Goracci G,Porena M

    更新日期:2000-05-01 00:00:00

  • Treatment of gastric cancer with peritoneal carcinomatosis by cytoreductive surgery and HIPEC: a systematic review of survival, mortality, and morbidity.

    abstract::Gastric cancer with peritoneal carcinomatosis has an extremely poor prognosis, which may be improved with cytoreductive surgery (CRS) combined with heated intraperitoneal chemotherapy (HIPEC). We systematically reviewed the literature regarding the efficacy of CRS + HIPEC in these patients. Electronic databases were s...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章,评审


    authors: Gill RS,Al-Adra DP,Nagendran J,Campbell S,Shi X,Haase E,Schiller D

    更新日期:2011-11-01 00:00:00

  • Modern reconstructive techniques for abdominal wall defects after oncologic resection.

    abstract::Resection of abdominal wall tumors often leaves patients with debilitating soft tissue defects. Modern reconstructive techniques can be used to restore abdominal wall integrity. In this article, we present an overview of preoperative patient evaluation, analysis of the defect, surgical planning, and the spectrum of av...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章,评审


    authors: Khansa I,Janis JE

    更新日期:2015-04-01 00:00:00

  • Clinicopathologic characteristics and prognostic significance of EGFR and p53 mutations in surgically resected lung adenocarcinomas ≤2 cm in maximal dimension.

    abstract:BACKGROUND AND OBJECTIVES:Small lung adenocarcinomas are detected more frequently than in the past. However, the clinicopathologic characteristics and prognostic significance of EGFR/p53 mutations in these tumors remains unclear. METHODS:We evaluated the correlation of EGFR/p53 mutations with clinicopathologic charact...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章


    authors: Lin MW,Wu CT,Shih JY,Chang YL,Yang PC

    更新日期:2014-08-01 00:00:00

  • Aberrant crypt foci as precursors in colorectal cancer progression.

    abstract::Colorectal cancer progression originates when accumulated genetic and epigenetic alterations cause genomic instability and a malignant phenotype. Subsequent molecular pathway deregulation leads to histopathologic changes that are clinically evident as aberrant crypt foci (ACF) and visualized by high-magnification chro...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章,评审


    authors: Orlando FA,Tan D,Baltodano JD,Khoury T,Gibbs JF,Hassid VJ,Ahmed BH,Alrawi SJ

    更新日期:2008-09-01 00:00:00

  • Recurrent pleomorphic adenoma of the parotid gland: Institutional experience and review of the literature.

    abstract:BACKGROUND:Recurrent pleomorphic adenoma (PA) of the parotid gland is a challenging surgical issue with controversy regarding management and long term outcome. METHODS:All patients who were operated for recurrent PA of the parotid gland between the years 1991 and 2013 were reviewed. Patient demographics, clinicopathol...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章


    authors: Abu-Ghanem Y,Mizrachi A,Popovtzer A,Abu-Ghanem N,Feinmesser R

    更新日期:2016-11-01 00:00:00

  • Wilms' tumor--treatment and results: a five-decade experience.

    abstract::During the past 53 years, 105 patients with Wilms' Tumor have been treated at the Children's Hospital of Buffalo. Prospective and retrospective staging of these cases has allowed comparison with other reported series. All-stage survival improved from 37% with operation alone to 46% with operation and planned radiother...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章


    authors: Allen JE,Brecher MJ,Karp MP,Cooney DR,Jewett TC Jr

    更新日期:1985-12-01 00:00:00

  • An apparent danazol-induced primary hepatocellular carcinoma: case report.

    abstract::This paper presents an apparent case of danazol-induced primary hepatocellular carcinoma in a 49-year-old patient, following two years of continuous therapy with this inhibitor of pituitary gonadotrophin. Discontinuation of the drug failed to cause regression of the tumour. ...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章


    authors: Buamah PK

    更新日期:1985-02-01 00:00:00

  • Patterns of failure following surgery alone for colorectal carcinoma.

    abstract::Two hundred fifty-one patients with colorectal carcinoma were studied following complete primary resection to determine patterns of failure. Seventy-two patients (29%) subsequently developed failures: Local failure (LF) occurred as the only failure in 49% of the failure group and as some component in 81%; distant meta...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章


    authors: Chung CK,Stryker JA,Demuth WE Jr

    更新日期:1983-01-01 00:00:00

  • Comparative analysis of immunohistochemical markers with invasiveness and histologic differentiation in squamous cell carcinoma and basal cell carcinoma of the skin.

    abstract:BACKGROUND:This study evaluates several tumor-related markers to examine the expression pattern of markers according to the invasiveness and histopathologic differentiation of squamous cell carcinoma and basal cell carcinoma. METHODS:Ninety-four cases of squamous cell carcinoma and 108 cases of basal cell carcinoma us...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章


    authors: Son KD,Kim TJ,Lee YS,Park GS,Han KT,Lim JS,Kang CS

    更新日期:2008-06-01 00:00:00

  • Bacterial adherence to bladder tumors in the mouse.

    abstract::Mice with intravesical urothelial tumors (MBT-2) were challenged with E coli inoculated intravesically. Adherence of bacteria measured at 15 min or persistent infection at 24 h was significantly greater in the tumor-bearing bladders than in normal non-tumor-bearing mice. The tumor-bearing portion of the bladder contai...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章


    authors: Bagley DH,Velanovich V,Jones KW,Heggers JP

    更新日期:1983-08-01 00:00:00