Immunohistochemically demonstrated expression of HLA-DR antigen in colorectal adenocarcinomas and its relation to clinicopathological features.


:We studied 148 colorectal adenocarcinomas to clarify any correlation between HLA-DR antigen expression on tumor cells and histopathological features. Paraffin sections of formalin-fixed tissues were stained with HLA-DR antigen using the indirect immunoperoxidase technique. All the tumor tissues were divided into two groups, depending on the incidence of HLA-DR-positive cells (greater and lesser than 50%). Carcinoma tissues with a higher incidence showed less mural invasion, lymphoductal invasion, venous invasion, lymphonodular metastasis, and peritoneal metastasis. Tissues with a high HLA-DR reactivity were more often observed for Dukes' A and B stages, whereas those with a low HLA-DR positivity were frequently Dukes' C and D stages. As for the cumulative survival rate, the group with high HLA-DR expression demonstrated significantly better survival. We speculate that HLA-DR expression by colorectal cancer cells exerts a favorable influence on clinical course.


J Surg Oncol


Morita M,Tanaka K,Kawanishi H,Tsuji M,Ookusa T,Takada H,Okamura A,Hioki K




Has Abstract


1995-08-01 00:00:00












  • Extended lymph node dissection in gastrointestinal cancer.

    abstract::We reviewed the literature concerning the effect of extended lymph node dissection on survival in patients with gastrointestinal cancer. Most retrospective and/or prospective nonrandomized comparative studies have claimed that extended lymph node dissection significantly improves survival rate in patients with esophag...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章,评审


    authors: Noguchi M,Miyazaki I

    更新日期:1997-05-01 00:00:00

  • When is hemiarthroplasty preferable to intramedullary prophylactic fixation of malignant lesions of the proximal femur?

    abstract:BACKGROUND:Malignant hip lesions can be managed operatively by intramedullary (IM) nail fixation and hemiarthroplasty. METHODS:A retrospective review was performed on 86 patients who underwent hemiarthroplasty (n = 22) or IM nail fixation (n = 64) for prophylactic treatment of impending pathologic fracture due to mali...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章


    authors: Lin JS,Santiago-Torres JE,Everhart JS,Zayan NE,Mayerson JL,Scharschmidt TJ

    更新日期:2017-12-01 00:00:00

  • Prediction of microvascular invasion before curative resection of hepatocellular carcinoma.

    abstract:BACKGROUND:The accurate staging of hepatocellular carcinoma (HCC) is important in establishing treatment strategies and prognosis. Among tumor factors, microvascular invasion, one of TNM staging components and prognostic factors, is underestimated preoperatively, due to inaccuracy of imaging modalities. We investigated...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章


    authors: Kim BK,Han KH,Park YN,Park MS,Kim KS,Choi JS,Moon BS,Chon CY,Moon YM,Ahn SH

    更新日期:2008-03-01 00:00:00

  • Human papillomavirus-related cell cycle markers can predict survival outcomes following a transoral lateral oropharyngectomy for tonsillar squamous cell carcinoma.

    abstract:OBJECTIVES:To identify the prognostic implications of human papillomavirus (HPV)-related cell cycle marker profiles in patients who have received a transoral lateral oropharyngectomy (TLO) as a primary treatment for tonsillar squamous cell carcinoma (TSCC). PATIENTS AND METHODS:Immunohistochemical profiles of HPV-rela...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章


    authors: Ryu CH,Ryu J,Cho KH,Moon SH,Yun T,Lee SH,Choi MK,Park WS,Jung YS

    更新日期:2014-09-01 00:00:00

  • Long-term outcomes in treatment of retroperitoneal sarcomas: A 15 year single-institution evaluation of prognostic features.

    abstract:BACKGROUND:Retroperitoneal sarcomas are connective tissue tumors arising in the retroperitoneum. Surgical resection is the mainstay of treatment. Debate has arisen over extent of resection, changes in histological classification/grading, and interest in incorporating radiotherapy. Therefore, we reviewed our institution...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章


    authors: Abdelfatah E,Guzzetta AA,Nagarajan N,Wolfgang CL,Pawlik TM,Choti MA,Schulick R,Montgomery EA,Meyer C,Thornton K,Herman J,Terezakis S,Frassica D,Ahuja N

    更新日期:2016-07-01 00:00:00

  • Local recurrence after radical nephrectomy for kidney cancer: management and prediction of outcomes. a multi-institutional study.

    abstract:BACKGROUND:Local recurrence (LR) after radical nephrectomy (RN) for kidney cancer is uncommon. Our objectives were to analyse characteristics and therapeutic options of LR after RN and to identify survival prognostic factors. MATERIALS AND METHODS:From a multi-institutional retrospective database, we identified 72 pat...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章,多中心研究


    authors: Paparel P,Bigot P,Matillon X,Bensalah K,Salomon L,Baumert H,Bastide C,Thuret R,Karsenty G,Long JA,Ammi M,Bessede T,Bin S,Roux A,Escudier B,Rioux Leclercq N,Pignot G,Soulie M,Patard JJ

    更新日期:2014-02-01 00:00:00

  • The effects of urea treatment in combination with curettage in extensive lip cancers.

    abstract::Thirty cases of lip cancer in 28 patients, 23 of which were extensive or very extensive, were treated with local urea injections in combination with curettage. Out of the 30 cases there were 26 squamous cell carcinomas, three basal cell carcinomas extending to the mucosa from the skin of the lips, and one adenocarcino...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章


    authors: Danopoulos ED,Danopoulou IE,Besbeas S,Ramantanis G

    更新日期:1982-03-01 00:00:00

  • Determinants of unresectability and outcome of patients with occult colorectal hepatic metastases.

    abstract:BACKGROUND:Patients chosen for liver resection of colorectal liver metastases are a select group with minimal disease, favorable tumor biology and earlier presentation when compared to unresectable patients. Despite intense preoperative assessments, operative detection of occult unresectable disease is inevitable for a...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章


    authors: Bennett JJ,Cao D,Posner MC

    更新日期:2005-10-01 00:00:00

  • Malignant neoplasms of the major salivary glands.

    abstract::Between January 1, 1968 and December 31, 1978, 42 patients with malignant lesions involving the major salivary glands were seen at the Medical College of Virginia. A 60% 2-year survival and a 42% 5-year survival were noted. Histologic type was the major determinant of survival. Symptoms other than a painless mass, a l...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章


    authors: Lawrence WT,Lawrence W Jr

    更新日期:1981-01-01 00:00:00

  • Severe tumor budding is a risk factor for lateral lymph node metastasis in early rectal cancers.

    abstract:BACKGROUND:Lateral lymph node (LLN) metastasis sometimes occurs in patients with early rectal cancer that has invaded the submucosa (SM) and muscularis propria (MP). This study aims to identify the risk factor(s) for LLN metastasis in such patients. METHOD:We retrospectively analyzed 65 patients with pathological SM o...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章


    authors: Homma Y,Hamano T,Otsuki Y,Shimizu S,Kobayashi H,Kobayashi Y

    更新日期:2010-09-01 00:00:00

  • Interstitial laser thermotherapy in the treatment of colorectal liver metastases.

    abstract::Metastatic liver disease is the commonest cause of death in patients with colorectal cancer. A small proportion of these patients (10%) may be treated by surgical resection with five year survival approaching 35-40%. Alternative treatment modalities for localised hepatic disease include in situ ablative techniques tha...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章,评审


    authors: Muralidharan V,Christophi C

    更新日期:2001-01-01 00:00:00

  • Can the ACS-NSQIP surgical risk calculator predict post-operative complications in patients undergoing flap reconstruction following soft tissue sarcoma resection?

    abstract:INTRODUCTION:The ACS-NSQIP surgical risk calculator is an open-access on-line tool that estimates the risk of adverse post-operative outcomes for a wide range of surgical procedures. Wide surgical resection of soft tissue sarcoma (STS) often requires complex reconstructive procedures that can be associated with relativ...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章


    authors: Slump J,Ferguson PC,Wunder JS,Griffin A,Hoekstra HJ,Bagher S,Zhong T,Hofer SO,O'Neill AC

    更新日期:2016-10-01 00:00:00

  • Safety of rectum anastomosis after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy.

    abstract:BACKGROUND AND OBJECTIVES:In highly selected patients with peritoneal carcinomatosis, cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC) can be an aggressive but worthwhile treatment regimen. Resection of the rectosigmoid is frequently performed with CRS. The aim of the study wa...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章


    authors: von Breitenbuch P,Piso P,Schlitt HJ

    更新日期:2018-09-01 00:00:00

  • Association between patient age and the risk of mortality following local recurrence of a sacral chordoma.

    abstract:BACKGROUND:Local recurrence (LR) of sacral chordoma is a difficult problem and the mortality risk associated with LR remains poorly described. The purpose of this study was to evaluate the risk of mortality in patients with LR and determine if patient age is associated with mortality. METHODS:A total of 218 patients (...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章


    authors: Houdek MT,Hevesi M,Schwab JH,Yaszemski MJ,Griffin AM,Healey JH,Ferguson PC,Hornicek FJ,Boland PJ,Sim FH,Rose PS,Wunder JS

    更新日期:2019-11-22 00:00:00

  • Cytodiagnosis of soft tissue tumors.

    abstract::The only acceptable definitive diagnosis of a soft tissue mass is histologic or cytologic examination. In recent years, fine-needle aspiration cytology is used in more and more centers for diagnosis of soft tissue masses. We studied 196 aspiration cytologies performed on soft tissue lesions. Out of these, in 48 cases ...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章


    authors: Oland J,Rosen A,Reif R,Sayfan J,Orda R

    更新日期:1988-03-01 00:00:00

  • Treatment of metastatic melanoma with electrochemotherapy.

    abstract::Superficially metastatic melanoma still represents a challenging situation for oncologists and a distressing condition for patients. In this circumstance, local treatment by electrochemotherapy, that is, the combination of brief permeabilizing electric pulses with a low‐toxicity anticancer drug, can be a valuable trea...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章,评审


    authors: Campana LG,Testori A,Mozzillo N,Rossi CR

    更新日期:2014-03-01 00:00:00

  • Combination therapy with mitomycin C, 5-fluorouracil, and cytosine arabinoside for nonresectable malignant tumor in man.

    abstract::The effectiveness of MFC (mitomycin C, 5-fluorouracil and cytosine arabinoside) therapy for nonresectable cancers and cancers recurring after surgery was investigated in 60 patients with solid cancers aged 26 to 69 years. Treatment was effective in 28 patients (47%) including seven (12%) who showed a very good respons...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章


    authors: Yamaguchi T,Nakamura M

    更新日期:1978-01-01 00:00:00

  • Unusual origins of Pseudomyxoma peritonei.

    abstract::Pseudomyxoma peritonei is a rare neoplastic condition in that gelatinous intraperitoneal fluid collections and mucinous implants on the peritoneal surfaces and omentum are found. The pathological origin is usually an adenoma or well-differentiated adenocarcinoma of the appendix. A smaller number of cases arises from o...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章


    authors: de Bree E,Witkamp A,Van De Vijver M,Zoetmulde F

    更新日期:2000-12-01 00:00:00

  • Comparative analysis of immunohistochemical markers with invasiveness and histologic differentiation in squamous cell carcinoma and basal cell carcinoma of the skin.

    abstract:BACKGROUND:This study evaluates several tumor-related markers to examine the expression pattern of markers according to the invasiveness and histopathologic differentiation of squamous cell carcinoma and basal cell carcinoma. METHODS:Ninety-four cases of squamous cell carcinoma and 108 cases of basal cell carcinoma us...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章


    authors: Son KD,Kim TJ,Lee YS,Park GS,Han KT,Lim JS,Kang CS

    更新日期:2008-06-01 00:00:00

  • Significance of palliative gastrectomy for late-stage gastric cancer patients.

    abstract:PURPOSE:To investigate the significance of palliative gastrectomy for different types of metastatic gastric cancer patients displaying peritoneal dissemination, hepatic metastasis, distant lymph node metastasis occurring locally during late-stage disease, and multi-organ metastases. METHODS:We performed a retrospectiv...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章


    authors: Chen S,Li YF,Feng XY,Zhou ZW,Yuan XH,Chen YB

    更新日期:2012-12-01 00:00:00

  • Interleukin-10 and interferon-gamma levels within the peritoneal cavity of patients with gastric cancer.

    abstract:BACKGROUND AND OBJECTIVES:Immune status in the peritoneal cavity of patients with gastric cancer remains largely unknown. To clarify the clinical significance of the host immune response within the peritoneal cavity, we examined the levels of interferon-gamma (IFN-gamma), a type 1 cytokine, and interleukin-10 (IL-10), ...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章


    authors: Majima T,Ichikura T,Seki S,Takayama E,Hiraide H,Mochizuki H

    更新日期:2001-10-01 00:00:00

  • Genetic polymorphism of urokinase-type plasminogen activator is interacting with plasminogen activator inhibitor-1 to raise risk of cervical neoplasia.

    abstract:BACKGROUND AND OBJECTIVES:To evaluate the impact of plasminogen activator (PA) system genes, including urokinase plasminogen activator (uPA), uPA receptor (uPAR), and plasminogen activator inhibitor-1 (PAI-1) gene polymorphisms in patients with the cervical neoplasia. METHODS:In total, 336 blood samples were collected...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章


    authors: Tee YT,Wang PH,Tsai HT,Lin LY,Lin HT,Yang SF,Hsieh YH,Ying TH

    更新日期:2012-08-01 00:00:00

  • Analysis of germline and tumor mutations of p53 gene in familial occurrence of soft tissue sarcomas.

    abstract:BACKGROUND:Familial soft tissue sarcomas are extremely rare. There is little information available on the clinical features and molecular findings of the hereditary occurrence of mesenchymal tumor. PATIENTS AND METHODS:A woman and her younger brother had malignant fibrous histiocytoma (pleomorphic type) and liposarcom...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章


    authors: Kudawara I,Matsumine A,Ohzono K

    更新日期:2007-03-15 00:00:00

  • Acute appendicitis as a sign of a colorectal carcinoma.

    abstract::The relationship of acute appendicitis occurring previous to cancer in colon and rectum was studied in the consecutive records of 561 patients, of 40 years of age and older, operated upon with an appendectomy because of acute appendicitis. Sixteen (2.9%) of these patients were readmitted within three years because of ...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章


    authors: Arnbjörnsson E

    更新日期:1982-05-01 00:00:00

  • Carcinoembryonic antigen (CEA) as prognostic marker in colonic cancer.

    abstract::Radioimmunoassay for serum carcinoembryonic antigen (CEA) was performed in 49 colonic cancer patients. The test results were positive in 42 patients (85.7%) in whom tumor was present at the time of assay. Preoperatively, CEA level suggested the extent and the prognosis of the disease. Strongly positive CEA test result...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章


    authors: Alsabti E

    更新日期:1979-01-01 00:00:00

  • Rapid and accurate method for delineating cancer lesions in laparoscopic colectomy using activated carbon injection.

    abstract::The aim of our study was to evaluate the clinical efficacy of preoperative injection of activated carbon in delineation of cancer location in laparoscopic colectomy. Activated carbon particles were injected during endoscopy into the normal colonic wall surrounding cancer lesions in five cases of early colon cancer, pr...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章


    authors: Kitamura K,Yamane T,Oyama T,Shimotsuma M,Hagiwara A,Yamaguchi T,Sawai K,Takahashi T

    更新日期:1995-01-01 00:00:00

  • Failure of subcutaneous mastectomy to prevent the development of breast cancer.

    abstract::Three patients treated with bilateral subcutaneous mastectomies and implants for fibrocystic disease or carcinoma in situ subsequently developed invasive breast carcinoma. These cases emphasize that subcutaneous mastectomy does not prevent the development of breast cancer. If the circumstances in an individual patient...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章


    authors: Goodnight JE Jr,Quagliana JM,Morton DL

    更新日期:1984-07-01 00:00:00

  • Neutrophil to lymphocyte ratio predicts pattern of recurrence in patients undergoing liver resection for colorectal liver metastasis and thus the overall survival.

    abstract:OBJECTIVE:We investigate the neutrophil to lymphocyte ratio (NLR) as a potential prognostic factor for patients undergoing curative liver resection for colorectal liver metastasis (CRLM). METHODS:We identified patients who underwent liver resection, via our prospectively accumulated surgical database at the Royal Mars...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章


    authors: Giakoustidis A,Neofytou K,Khan AZ,Mudan S

    更新日期:2015-03-15 00:00:00

  • Expression of X-linked inhibitor of apoptosis protein in human colorectal cancer and its correlation with prognosis.

    abstract:BACKGROUND:X-linked inhibitor of apoptosis protein (XIAP) is a member of the inhibitor of apoptosis family of proteins and deregulation of XIAP can result in tumorigenicity. The objective of this study was to evaluate the prognostic significance of XIAP expression in colorectal cancer (CRC). METHODS:RT-PCR was perform...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章


    authors: Xiang G,Wen X,Wang H,Chen K,Liu H

    更新日期:2009-12-15 00:00:00

  • Sentinel lymph node biopsy and aberrant lymphatic drainage in recurrent breast cancer: Findings likely to change treatment decisions.

    abstract:BACKGROUND AND OBJECTIVES:It is not clear whether sentinel lymph node biopsy (SLNB) can be applied to patients with a second breast cancer or recurrence occurring at previously treated breast. The purpose of this study was to assess the feasibility of SLNB procedure in patients with recurrent breast cancer. METHODS:Pa...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章


    authors: Karanlik H,Ozgur I,Kilic B,Fathalizadeh A,Sanli Y,Onder S,Saip P,Sen F,Gulluoglu BM

    更新日期:2016-12-01 00:00:00