Abstract:
BACKGROUND:Familial soft tissue sarcomas are extremely rare. There is little information available on the clinical features and molecular findings of the hereditary occurrence of mesenchymal tumor. PATIENTS AND METHODS:A woman and her younger brother had malignant fibrous histiocytoma (pleomorphic type) and liposarcoma (pleomorphic type) in the lower limbs, respectively. Analysis of p53 mutations in exons 5-9 of the tumor and in germ-line was done. RESULTS:A guanine to adenine substitution occurred in CGC, codon 175 of exon 5 in p53 gene, to CAC in the tumor sample of Case 1. Likewise, a thymine to cytosine substitution occurred in TTT, codon 270 of exon 8 in p53 gene, to TCT in tumor sample of Case 2. Germline mutations were not seen in the either patients. CONCLUSIONS:Different missense mutations of p53 were detected in each tumor, however no germline mutations of p53 were found. The alteration of codon 175 in Case 1 is relatively common mutation. On the contrary, the mutation in codon 270 in Case 2 was extremely rare in cancers. Further molecular investigation is needed to understand the mechanism in familial occurrence of sarcomas.
journal_name
J Surg Oncoljournal_title
Journal of surgical oncologyauthors
Kudawara I,Matsumine A,Ohzono Kdoi
10.1002/jso.20720subject
Has Abstractpub_date
2007-03-15 00:00:00pages
347-50issue
4eissn
0022-4790issn
1096-9098journal_volume
95pub_type
杂志文章abstract:BACKGROUND AND OBJECTIVES:To clarify optimal treatment guidelines for residual or local recurrence after endoscopic resection (ER). METHODS:Eighty-six patients underwent gastrectomy due to incomplete ER and local recurrence after ER. The pathological findings of ER and gastrectomy specimens were analyzed. RESULTS:The...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1002/jso.21074
更新日期:2008-07-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:To report on the clinical presentation and outcome for 234 patients with extra-abdominal desmoids tumors. METHODS:Since 1977, the authors have treated 234 patients with extra-abdominal desmoid tumors. The patients had an average age of 36.7 and 61% were female. The tumors arose adjacent to muscle...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.21433
更新日期:2010-10-01 00:00:00
abstract:PURPOSE:To investigate the significance of palliative gastrectomy for different types of metastatic gastric cancer patients displaying peritoneal dissemination, hepatic metastasis, distant lymph node metastasis occurring locally during late-stage disease, and multi-organ metastases. METHODS:We performed a retrospectiv...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.23158
更新日期:2012-12-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:This study aims to investigate the surgical outcomes observed in robotic transperitoneal aortic lymphadenectomy (AL) in gynecological cancer patients. METHODS:Retrospective data were collected and analyzed on 71 patients undergoing robotic surgical procedures for gynecological cancers, includi...
journal_title:Journal of surgical oncology
pub_type: 临床试验,杂志文章
doi:10.1002/jso.25335
更新日期:2019-03-01 00:00:00
abstract::Over the past decade, there has been a considerable increase in the utilization of cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) in the management of patients with peritoneal metastases. This is due to improved safety and favorable oncologic outcomes, including curative potential. C...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.25939
更新日期:2020-07-01 00:00:00
abstract:BACKGROUND:A prospective randomized controlled trial has established the efficacy of targeted intraoperative radiotherapy (TARGIT) in the management of invasive breast cancer treated with breast-conserving surgery (BCS). The purpose of this analysis is to evaluate the efficacy of TARGIT in the management of ductal carc...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.25347
更新日期:2019-03-01 00:00:00
abstract::Forty-one patients with marginally resectable stage III M0 non-small cell lung cancer (NSCLC) were entered into a study evaluating neoadjuvant cyclophosphamide, adriamycin, and cisplatin chemotherapy (CAP) followed by radiotherapy and subsequent resection. Postoperative radiotherapy and additional CAP were also admini...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930400413
更新日期:1989-04-01 00:00:00
abstract::Perineural invasion is associated with tumor spreading and an unfavorable prognosis in a variety of cancers. Recently, neural cell adhesion molecule (NCAM) has been reported to be affinitive to neural tissues, which suggests some relationship between NCAM and perineural invasion. This study was designed to elucidate t...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930530205
更新日期:1993-06-01 00:00:00
abstract::We reviewed the records of 66 consecutive patients who underwent placement of totally implantable venous access devices (TIVADs). Fourteen patients (21%) experienced complications related to the TIVAD. Complications included hematoma, infection, pneumothorax, subclavian vein thrombosis, and chronic clavicular pain. Th...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930440112
更新日期:1990-05-01 00:00:00
abstract::A case of prostatic adenocarcinoma metastasizing to the epididymis is described, and the literature is reviewed. ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.2930240416
更新日期:1983-12-01 00:00:00
abstract:PURPOSE:The epidemiology and clinicopathology of aneurysmal bone cysts (ABCs) secondary to giant cell tumors of bone (GCTBs) have been well documented in the previous literature. However, reports on whether secondary ABCs could affect the postoperative recurrence of GCTBs are rare. This study analyzed the effects of se...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.25588
更新日期:2019-09-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Tall cell (TCV), columnar cell (CCV), insular (IC), diffuse sclerosing (DSPTC) and solid/trabecular are uncommon subtypes of thyroid cancer, which have generally been described in case reports or small series in the world literature. Due to the rarity of these thyroid cancers, their clinical b...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.20044
更新日期:2004-04-01 00:00:00
abstract::In vivo skin tests using multiple recall and primary antigens such as dinitrochlorobenzine (DNCB) have established that there is decreased cellular-mediated immune response in patients with squamous cell carcinomas of the head and neck. In vitro testing of lymphocytes using blastogenic mitogens as a measure of lymphoc...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930090111
更新日期:1977-01-01 00:00:00
abstract:BACKGROUND:It was observed that new presentations of anaplastic carcinoma of the thyroid had become infrequent in the last two decades. METHODS:All cases of thyroid cancer seen at our centre between 1969-1993 (n = 2921) were classified as papillary 49%, follicular 34%, medullary 7.5%, anaplastic 4.7%, and other 4.8%. ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/(SICI)1096-9098(199612)63:4<251::AID-JSO7>
更新日期:1996-12-01 00:00:00
abstract::A retrospective review to elucidate the rationale of preoperative irradiation was made on 18 carcinomas of the head of the pancreas area. After 50 Gy/25 fractions of 10 MV X-ray was given, all 18 tumors decreased from 3.3 +/- 0.8 cm to 2.0 +/- 0.7 cm. At the surgical operation, 16 patients (89%) received pancreatic re...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930400303
更新日期:1989-03-01 00:00:00
abstract:INTRODUCTION:Hyperthermic isolated limb perfusion (HILP) has an established role in the management of melanoma, but its role for Merkel cell carcinoma (MCC) is less well defined. METHODS:Retrospective review of our institutional experience with HILP for MCC was conducted (2009-2015). Literature search was performed th...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.24289
更新日期:2016-08-01 00:00:00
abstract::Esophageal small cell carcinoma is a highly aggressive disease, and no effective treatment has yet been reported. We present here two cases of esophageal small cell carcinoma preoperatively treated with a combination of hyperthermia, irradiation, and an intravenous infusion of cis-diammine-dichloroplatinum (CDDP). The...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930590115
更新日期:1995-05-01 00:00:00
abstract:BACKGROUND:In this non-randomized study we aimed to assess the efficacy of the addition of low molecular weight heparin (LMWH) to gemcitabine (GEM) plus cisplatinum (CDDP) combination chemotherapy on survival by prevention of thromboembolic complications in patients with advanced pancreatic cancer (APC). PATIENTS AND ...
journal_title:Journal of surgical oncology
pub_type: 临床试验,杂志文章
doi:10.1002/jso.20728
更新日期:2007-05-01 00:00:00
abstract::Delayed hypersensitivity reaction of 116 consecutive cases of urologic cancers were studied by skin tests. Ninety-one percent of those who were operable or free of diseases at least six months had positive skin reaction. All patients with inoperable or recurrent bladder, kidney, or testis tumor had negative skin react...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930070112
更新日期:1975-01-01 00:00:00
abstract::A 50-year-old man presented with verrucous carcinoma on the sole of the foot. This unusual tumor, also called an epithelioma cuniculatum plantare, was successfully treated employing wide surgical excision. ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930140407
更新日期:1980-01-01 00:00:00
abstract:BACKGROUND:The majority of breast cancer patients in Mexico are treated through the public health system and >80% receive adjuvant chemotherapy. The aim of this prospective study was to characterize the impact of the Oncotype DX assay on adjuvant therapy decision making and the confidence in those decisions amongst pub...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.23794
更新日期:2015-02-01 00:00:00
abstract::Patients with primary squamous cell epitheliomas of the oral cavity, pharynx, and larynx were stratified according to stage and site and randomized to receive either intratumoral immunotherapy with Corynebacterium parvum followed 2 weeks later by surgery and postoperative C parvum for 2 years or surgery alone. There w...
journal_title:Journal of surgical oncology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/jso.2930280215
更新日期:1985-02-01 00:00:00
abstract::This paper reports on two patients, who both were under treatment for osteosarcoma of the femur. Treatment consisted of chemotherapy, resection of the tumour, and reconstruction with an endoprosthesis . Both patients sustained an epiphyseal fracture on two occasions after a minor trauma. Careful observations of the x-...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930260110
更新日期:1984-05-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Malignant peripheral nerve sheath tumors (MPNST) are aggressive soft tissue sarcomas that present as large, invasive tumors. Our aim was to assess outcomes, identify prognostic factors, and analyze treatment strategies in a prospectively collected pediatric cohort. METHODS:Patients less than ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.26153
更新日期:2020-12-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:To determine the prognostic significance of the colposcopic tumor size in the management of cervical cancer. METHODS:Clinicopathological analysis was performed in 751 consecutive patients with stage IB squamous cervical cancer who were surgically treated in a single institute. The colposcopic...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/1096-9098(200102)76:2<133::aid-jso1024>3.0
更新日期:2001-02-01 00:00:00
abstract::Cecal carcinoma has been associated with a poorer prognosis than other colon carcinomas because of the presumed longstanding obscure symptoms. In a combined study of three Dutch hospitals, a total of 166 patients with cecal carcinoma were evaluated after right hemicolectomy. Special emphasis was placed on clinical sym...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930440309
更新日期:1990-07-01 00:00:00
abstract::Leiomyosarcoma of the colon is a rare neoplasm. It is widely known that primary malignant lesions may present either simultaneously (synchronous tumor) or at different times (metachronous tumor). The incidence of metachronous colonic mucosal carcinoma is generally considered to range from 3 to 5%. Metachronous leiomyo...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930320403
更新日期:1986-08-01 00:00:00
abstract:BACKGROUND:Some cases of mass-forming intrahepatic cholangiocarcinoma (ICC) are diagnosed as hepatocellular carcinoma (HCC) based on preoperative imaging and clinical findings. We investigated the backgrounds of such cases. METHODS:Sixty-seven patients with mass-forming ICC underwent surgery from 1980 to 2002. Twenty-...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.20091
更新日期:2004-08-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:To assess the surgical and survival outcomes after secondary cytoreductive surgery (SCRS) in patients with platinum-sensitive recurrent epithelial ovarian cancer (EOC) and to identify patients who would most benefit from SCRS. METHODS:Inclusion criteria consisted of (1) recurrent EOC; (2) dis...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.21470
更新日期:2010-04-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:We assessed the optimal extent of lymph node dissection and the effect of splenectomy in patients with proximal gastric cancer. METHOD:Recurrence and survival rates were compared between 881 patients with proximal gastric cancer who underwent modified radical lymphadenectomy and 3,098 patient...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.21137
更新日期:2008-12-01 00:00:00