Abstract:
:Mucin-producing tumors of the pancreas (MPT) are characterized by the production of much mucin and a benign course after surgical treatment. We examined 16 cases of MPT and 20 cases of "common" pancreatic duct cell carcinomas (DCC) in regard to K-ras and p53 mutations. The mutations were detected by constant denaturant gel electrophoresis in combination with other techniques using PCR products amplified from the samples microdissected from the tissue sections. K-ras codon 12 mutations were identified in all MPT and in 95% of DCC. On the other hand, p53 mutations were found in four of 20 (20%) DCC, and p53 was immunocytochemically overexpressed in 3 of the 4 mutated cases. However, no p53 mutations and no p53 overexpression were identified in the 16 MPT. These results indicate that, although the K-ras codon 12 mutations may be almost essential for the development of both MPT and DCC, p53 mutations seemed to be involved mainly to the latters.
journal_name
J Surg Oncoljournal_title
Journal of surgical oncologyauthors
Hoshi T,Imai M,Ogawa Kdoi
10.1002/jso.2930550205subject
Has Abstractpub_date
1994-02-01 00:00:00pages
84-91issue
2eissn
0022-4790issn
1096-9098journal_volume
55pub_type
杂志文章abstract:OBJECTIVES:We reviewed the clinical characteristics and outcomes of patients treated for alveolar soft part sarcoma (ASPS) and analyzed the effect of surgery for patients presenting with and without metastatic disease (DM). METHODS:The SEER Registry was queried for patients with ASPS from 1973-2012. The Kaplan-Meier e...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.24183
更新日期:2016-04-01 00:00:00
abstract::Thirty cases of lip cancer in 28 patients, 23 of which were extensive or very extensive, were treated with local urea injections in combination with curettage. Out of the 30 cases there were 26 squamous cell carcinomas, three basal cell carcinomas extending to the mucosa from the skin of the lips, and one adenocarcino...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930190303
更新日期:1982-03-01 00:00:00
abstract::Patients with advanced glottic cancer, in whom there is extensive subglottic disease and/or low cervical lymph node metastasis, have a high incidence of recurrence in and about the tracheal stoma. Stoma recurrences can be prevented by immediate postoperative megavoltage radiotherapy when the stoma is included in the i...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930070303
更新日期:1975-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Current NCCN guidelines recommend epirubicin (E), cisplatin (C), and 5-fluorouracil (F) as a first-line therapeutic approach for operable gastric adenocarcinoma (GC). Molecular profiling (MP) was used to evaluate the expression of chemotherapy targeted biomarkers associated with ECF therapy an...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.23639
更新日期:2014-09-01 00:00:00
abstract::The journey of gastrinomas had its beginnings in 1955 when Zollinger and Ellison published their seminal paper (Zollinger and Ellison, Ann Surg 1955; 142: 709-723). The evolution of the diagnosis and management of this syndrome has paralleled many important advances in medicine, including the development of various di...
journal_title:Journal of surgical oncology
pub_type: 历史文章,杂志文章,评审
doi:10.1002/jso.21359
更新日期:2009-10-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:We assessed the optimal extent of lymph node dissection and the effect of splenectomy in patients with proximal gastric cancer. METHOD:Recurrence and survival rates were compared between 881 patients with proximal gastric cancer who underwent modified radical lymphadenectomy and 3,098 patient...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.21137
更新日期:2008-12-01 00:00:00
abstract:OBJECTIVES:This study investigated disparities in the delivery of definitive therapy for early stage non-small-cell lung cancer (ESNSCLC) between Caucasian (CS) and African American (AA) populations. METHODS:The National Cancer Data Base was queried for AA and CS patients, diagnosed with c stage I Non small cell lung ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.26206
更新日期:2020-12-01 00:00:00
abstract::High-quality data support multiple clinical benefits of integrating palliative care into routine oncology care. Though these data come largely from the medical oncology literature, data from surgical oncology populations support similar associations between palliative care integration and improved clinical outcomes, a...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.25454
更新日期:2019-07-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Long noncoding RNAs (lncRNAs) play key roles in carcinoma metastasis. We aimed to investigate lncRNA LINC01133 in oral squamous cell carcinoma (OSCC) metastasis. METHODS:The RNA levels of LINC01133 and growth and differentiation factor 15 (GDF15) in tissue samples from OSCC patients, and OSCC...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.25278
更新日期:2018-12-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:This study assessed the outcomes of Yttrium-90 (90 Y) radiation segmentectomy for hepatic metastases unamenable to resection or ablation. MATERIALS AND METHODS:Over 6 years, 36 patients with 53 tumors underwent segmental radioembolization. Patients were not candidates for surgical resection o...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,多中心研究
doi:10.1002/jso.26223
更新日期:2021-01-01 00:00:00
abstract::Infertility because of testicular damage is a distressing problem for survivors of cancer chemotherapy. We have previously described a cytoprotective effect of temporary testicular circulatory isolation (TCI) during doxorubicin administration in the rat. In this report we define the relationship between duration of TC...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930390410
更新日期:1988-12-01 00:00:00
abstract:BACKGROUND:Rapid genetic counseling and testing (RGCT) in newly diagnosed high-risk breast cancer (BC) patients may influence surgical treatment decisions. To successfully integrate RGCT in practice, knowledge of professionals', and patients' attitudes toward RGCT is essential. METHODS:Between 2008 and 2010, we perfor...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.24763
更新日期:2017-12-01 00:00:00
abstract:BACKGROUND:Radical surgery is the only curative treatment for carcinoma of gallbladder. This study aimed to evaluate the outcome of patients with carcinoma of gallbladder managed in a single institution over 16 years. METHODS:From April 1988 to November 2003, 86 patients (29 males, 57 females) were diagnosed to have c...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.20885
更新日期:2008-02-01 00:00:00
abstract::Maximum diameter, tumour volume, and inflammatory response of host tissue in 282 surgical specimens with primary carcinoma of the bronchus were measured. Cell type, pT- and pN-stage, maximum diameter and volume of the primaries, and inflammatory response of host tissue were analyzed in respect to survival of the patie...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930360203
更新日期:1987-10-01 00:00:00
abstract:BACKGROUND:Inflammation plays an important role in the progression and prognosis of hepatocellular carcinoma (HCC). Our aim is to explore the prognostic value of preoperative and postoperative peripheral lymphocyte differences and to develop a dynamic prognosis nomogram in hepatitis B virus-related HCC patients. METHO...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.26195
更新日期:2020-12-01 00:00:00
abstract:BACKGROUND:Reconstruction after excision of the humeral malignancy is a challenging issue for the reconstructive surgeon. The combined use of a fibular flap and allograft can provide a reliable reconstructive option. This article describes the authors' experience with this technique for the treatment of segmental bone ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.21922
更新日期:2011-09-01 00:00:00
abstract:OBJECTIVE:To evaluate the patients with invasive cervical cancer found in simple hysterectomy and who were subjected to radical parametrectomy and upper vaginectomy with therapeutic lymphadenectomy. METHODS:Twenty-seven patients who underwent the radical parametrectomy and upper vaginectomy with therapeutic lymphadene...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.20550
更新日期:2006-07-01 00:00:00
abstract:BACKGROUND:The aim of this study was to investigate if immunohistochemical expression and mutational status of KIT and PDGFRA in GISTs are associated with the clinical course and disease-free survival after curative resection of the primary tumor without adjuvant systemic therapy. METHODS:Paraffin-embedded tumor secti...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.21905
更新日期:2011-07-01 00:00:00
abstract:BACKGROUND:Local recurrence (LR) after radical nephrectomy (RN) for kidney cancer is uncommon. Our objectives were to analyse characteristics and therapeutic options of LR after RN and to identify survival prognostic factors. MATERIALS AND METHODS:From a multi-institutional retrospective database, we identified 72 pat...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,多中心研究
doi:10.1002/jso.23473
更新日期:2014-02-01 00:00:00
abstract::A case of qualitative platelet dysfunction following cancer chemotherapy is documented. Besides the numerical reduction defect, there appear to be functional changes in the platelets leading to bleeding diathesis. The present case was thoroughly evaluated, and it was observed that there is suppression of the platelet ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930250308
更新日期:1984-03-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Tumor thickness is considered the single most important predictor of survival in clinically localized malignant melanoma. A recent study found tumor volume a more sensitive predictor of survival than thickness. Volume measurement, however, is complicated, time consuming, and based on biologica...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/(sici)1096-9098(199810)69:2<83::aid-jso7>3
更新日期:1998-10-01 00:00:00
abstract::The cases of 42 patients with malignant ascites treated with a peritoneal venous shunt over a 5-year period are reviewed to establish the incidence of surgical and postsurgical complications. Although the yield of malignant cells found in the peripheral blood was increased after shunting, no new hematogenous metastase...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930330109
更新日期:1986-09-01 00:00:00
abstract::During the past 53 years, 105 patients with Wilms' Tumor have been treated at the Children's Hospital of Buffalo. Prospective and retrospective staging of these cases has allowed comparison with other reported series. All-stage survival improved from 37% with operation alone to 46% with operation and planned radiother...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930300410
更新日期:1985-12-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Despite precipitous drop in the incidence of gastric carcinoma in Japan, it is still one of the leading causes of death associated with malignant disease. Once the contiguous organs are involved the prognosis becomes dismal. Prognostic factors governing the survival of patients with T4 gastric...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.1046
更新日期:2001-04-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Lymphedema is a condition of localized fluid retention and tissue swelling caused by a compromised lymphatic system. Lymphaticovenular anastomoses (LVA) and multiple lymphatic-venous anastomoses (MLVAs) have been recognized as efficient methods to treat chronic lymphedema. Because few models f...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.25234
更新日期:2018-11-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Preoperative positivity of serum tumor markers has been reported to be a prognostic factor in several neoplasms. The aim of this longitudinal study was to evaluate the correlation between CEA, CA 19-9, and CA 72-4 preoperative serum levels and the site of recurrence after curative surgery for ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.1163
更新日期:2001-12-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Among several long-term effects, people treated for cancer may experience an altered appearance. Our study aims to identify how visible body changes following surgical treatment affect the life and identity of primary bone sarcoma survivors 3-10 years after diagnosis. A qualitative, phenomenol...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.24138
更新日期:2016-02-01 00:00:00
abstract:BACKGROUND:Patients chosen for liver resection of colorectal liver metastases are a select group with minimal disease, favorable tumor biology and earlier presentation when compared to unresectable patients. Despite intense preoperative assessments, operative detection of occult unresectable disease is inevitable for a...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.20341
更新日期:2005-10-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Two staged tissue expander-implant with acellular dermal matrix (TE/I + ADM) and deep inferior epigastric perforator (DIEP) flap are the most common implant and autologous methods of reconstruction in the U.S. Implant-based techniques are disproportionally more popular, partially due to its pr...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.24692
更新日期:2017-09-01 00:00:00
abstract::This paper presents an apparent case of danazol-induced primary hepatocellular carcinoma in a 49-year-old patient, following two years of continuous therapy with this inhibitor of pituitary gonadotrophin. Discontinuation of the drug failed to cause regression of the tumour. ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930280209
更新日期:1985-02-01 00:00:00