Abstract:
BACKGROUND:Local recurrence (LR) after radical nephrectomy (RN) for kidney cancer is uncommon. Our objectives were to analyse characteristics and therapeutic options of LR after RN and to identify survival prognostic factors. MATERIALS AND METHODS:From a multi-institutional retrospective database, we identified 72 patients who experienced LR after RN. RESULTS:Mean time to LR was 26.5 ± 3.3 months. The location of the recurrence was renal fossa, regional lymph node, homolateral adrenal and both renal fossa and regional lymph node for 43 (59.7%), 27 (37.5%), 9 (12.5%) and 7 (9.7%) patients, respectively. Patients were treated by surgery, systemic therapies, combination of therapies and palliative treatment in 24 (33.3%), 18 (25%), 24 (33.3%) and 6 (8.4%) cases, respectively. Within a mean follow-up of 26.4 ± 3.3 months from the date of local recurrence, 12 (16.6%) patients were alive without disease, 30 (41.7%) patients were alive with disease, 30 patients (41.6%) died including 28 (38.8%) from the disease. In multivariate analysis, time to recurrence <1 year (P < 0.001; HR: 4.81) and surgical treatment (P = 0.027; HR: 0.33) were predictive factors. CONCLUSIONS:Local recurrence after radical nephrectomy is associated with poor prognosis. The time to recurrence and the completeness of the surgical treatment are major prognostic factors.
journal_name
J Surg Oncoljournal_title
Journal of surgical oncologyauthors
Paparel P,Bigot P,Matillon X,Bensalah K,Salomon L,Baumert H,Bastide C,Thuret R,Karsenty G,Long JA,Ammi M,Bessede T,Bin S,Roux A,Escudier B,Rioux Leclercq N,Pignot G,Soulie M,Patard JJdoi
10.1002/jso.23473subject
Has Abstractpub_date
2014-02-01 00:00:00pages
126-31issue
2eissn
0022-4790issn
1096-9098journal_volume
109pub_type
杂志文章,多中心研究abstract:BACKGROUND:A person-centered approach to co-decision-making using tailored information respects each woman's preferences and may heighten breast reconstruction satisfaction. METHODS:Women seeking breast reconstruction underwent initial and follow-up consultations wherein suitable options were discussed, and take-away ...
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