Abstract:
BACKGROUND AND OBJECTIVES:Soft tissue sarcomas (STS) are mesenchymal malignancies. Treatment mainstay is surgical resection with negative margins ± adjuvant treatment. Fluorescence-guided surgical (FGS) resection can delineate intraoperative margins; FGS has improved oncologic outcomes in other malignancies. This novel strategy may minimize resection-associated morbidity while improving local tumor control. METHODS:We evaluate the tumor-targeting specificity and utility of fluorescence-imaging agents to provide disease-specific contrast. Mice with HT1080 fibrosarcoma tumors received one of five probes: cetuximab-IRDye800CW (anti-EGFR), DC101-IRDye800CW (anti-VEGFR-2), IgG-IRDye800CW, the cathepsin-activated probe Prosense750EX, or the small molecule probe IntegriSense750. Tumors were imaged daily using open- and closed-field fluorescence imaging systems. Tumor-to-background ratios (TBR) were evaluated. On peak TBR days, probe sensitivity was evaluated. Tumors were stained and imaged microscopically. RESULTS:At peak, closed-field imaging TBR of cetuximab-IRDye800CW (16.8) was significantly greater (P < 0.0001) than Integrisense750 (7.0), Prosense750EX (5.8), and DC101-IRDye800CW (3.7). All agents successfully localized as little as 1.0 mg of tumor tissue in the post-resection bed; cetuximab-IRDye800CW generated the greatest contrast (2.5). Cetuximab-IRDye800CW revealed strong tumor affinity microscopically; tumor fluorescence intensity was significantly greater (P < 0.0004) than 0.2 mm away from tumor border. CONCLUSION:This study demonstrates cetuximab-IRDye800CW superiority. FGS has the potential to improve post-resection morbidity and mortality by improving disease detection.
journal_name
J Surg Oncoljournal_title
Journal of surgical oncologyauthors
Prince AC,McGee AS,Siegel H,Rosenthal EL,Behnke NK,Warram JMdoi
10.1002/jso.24950subject
Has Abstractpub_date
2018-05-01 00:00:00pages
1179-1187issue
6eissn
0022-4790issn
1096-9098journal_volume
117pub_type
杂志文章abstract::Microsurgical techniques have revolutionized pharyngolaryngeal reconstruction. Free flap reconstruction with the free jejunal flap enables one stage reconstruction with minimal morbidity and mortality. This review will examine indications, operative technique, postoperative management, and expected outcomes for the hy...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.20483
更新日期:2006-11-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Large scale data on the treatment of pathologic proximal femur fractures (PPFFs) are lacking. The purpose of this study was to evaluate trends in patient demographics, complication rates, and relative utilization rates of various techniques associated with PPFFs. METHODS:The American College ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,多中心研究
doi:10.1002/jso.25669
更新日期:2019-11-01 00:00:00
abstract:OBJECTIVES:To develop and validate a nomogram to estimate the pretest probability of malignancy in Chinese patients with solid solitary pulmonary nodule (SPN). MATERIALS AND METHODS:A primary cohort of 1798 patients with pathologically confirmed solid SPNs after surgery was retrospectively studied at five institutions...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,多中心研究
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更新日期:2017-11-01 00:00:00
abstract:BACKGROUND:Based on the promising results of EAP (etoposide, doxorubicin, and cisplatin) combination, a phase II study of modified EAP combination was performed in patients with advanced gastric cancer to evaluate the response, toxicity, and survival. METHOD:Fifty-two consecutive patients with measurable or evaluable ...
journal_title:Journal of surgical oncology
pub_type: 临床试验,杂志文章
doi:10.1002/(sici)1096-9098(199704)64:4<318::aid-jso13
更新日期:1997-04-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:B7-H4 is a novel molecular B7 ligand that plays an important role as a negative regulator of the T cell-mediated immune response. However, the clinical significance of B7-H4 expression in gastric cancer remains uncertain. Here, we assessed B7-H4 expression in blood of patients with gastric can...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.21722
更新日期:2010-12-01 00:00:00
abstract::Xenografts of a human pancreatic carcinoma cell line, HPC-YS, which reacted with the monoclonal antibody (MAb) A7, were used to investigate the in vivo localization of radioiodinated MAb A7 after intraperitoneal injection. MAb A7 localized to the tumor 4 days and 8 days after injection with a tissue/blood ratio of 1.4...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930500309
更新日期:1992-07-01 00:00:00
abstract::Retroperitoneal sarcomas (RPS) frequently involve major vessels, which either originate from them or secondarily encase or invade them. In this field, major vascular resections result in increased morbidity. However, survival does not seem to be affected by the need for vascular resection or by this higher morbidity. ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.24920
更新日期:2018-01-01 00:00:00
abstract:OBJECTIVES:Gasless transaxillary endoscopic thyroidectomy offers a distinct advantage over the conventional open operation because it leaves no visible neck scar. Indications have expanded with the development of new surgical techniques and instruments. However, because of the two-dimensional view and the nonflexible i...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.22106
更新日期:2012-06-01 00:00:00
abstract:BACKGROUND:In patients undergoing total mesorectal excision (TME), the clinical variables most relevant to anastomotic recurrence have not been identified. We evaluated factors associated with anastomotic recurrence in patients undergoing TME and the impact of a reduced distal margin on anastomotic recurrence. METHODS...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.21166
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:The accurate staging of hepatocellular carcinoma (HCC) is important in establishing treatment strategies and prognosis. Among tumor factors, microvascular invasion, one of TNM staging components and prognostic factors, is underestimated preoperatively, due to inaccuracy of imaging modalities. We investigated...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.20953
更新日期:2008-03-01 00:00:00
abstract::This is a review of a rare case of acute appendicitis secondary to metastatic nasopharyngeal carcinoma (NPC) that had never before been reported in the literature. The clinical presentation did not differ from usual cases of acute appendicitis, but the pathology caused us to re-evaluate the NPC stage of the patient. ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930600213
更新日期:1995-10-01 00:00:00
abstract::Retroperitoneal sarcomas (RPS) have fascinated and intrigued physicians both past and present. Operative mortality rates were historically very high and complete resection was not possible for the majority of patients until only the last 2 decades. More recently, changes to the surgical approach and clinical decision-...
journal_title:Journal of surgical oncology
pub_type: 历史文章,杂志文章,评审
doi:10.1002/jso.24888
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:The aim of this study was to investigate if immunohistochemical expression and mutational status of KIT and PDGFRA in GISTs are associated with the clinical course and disease-free survival after curative resection of the primary tumor without adjuvant systemic therapy. METHODS:Paraffin-embedded tumor secti...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.21905
更新日期:2011-07-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Little data is currently available on the usefulness of peak-standardized uptake value (P-SUV) by positron emission tomography-computed tomography (PET-CT) in gastric cancer. The purpose of the present study was to evaluate the value of PET-CT for the preoperative evaluation of patients with g...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.21985
更新日期:2011-10-01 00:00:00
abstract::Malignant bowel obstruction (MBO) is a common problem for patients with advanced malignancy, especially colorectal and ovarian cancers. Symptoms include pain, bloating, nausea and vomiting, and inability to eat. Treatment options consist of a wide range of surgical and nonsurgical interventions (medications, endoscopi...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.25451
更新日期:2019-07-01 00:00:00
abstract:BACKGROUND:Prognosis with current management strategies continues to be dismal in metastatic gastric cancer (MGC) patients. We aimed to evaluate the role of metastasectomy in improving survival. METHODS:A comprehensive search of MEDLINE, EMBASE, SCOPUS, and Cochrane central databases (1965 to present) was performed. A...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,meta分析,评审
doi:10.1002/jso.23945
更新日期:2015-07-01 00:00:00
abstract:BACKGROUND:Pathological staging and regression grading may affect the clinical outcome in rectal carcinoma patients treated with neoadjuvant chemoradiation (NACRT). Oncocytic change (OC) has also been described in the residual tumor. This study assesses the correlation of degree of pathological response and OC with cli...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.22073
更新日期:2012-02-01 00:00:00
abstract:BACKGROUND:The role of surgical resection in the treatment of patients with metastatic/recurrent gastrointestinal stromal tumors (GIST) is unclear. The aim of this study was to identify preoperative factors associated with oncologic outcomes for recurrent/metastatic GIST after tyrosine kinase inhibitor (TKI) therapy. ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.24988
更新日期:2018-04-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Certain tumor-related factors like thickness increases the risk of nodal metastasis and may affect survival in patients with oral tongue cancers. The objective of this study is to identify those tumor-related prognostic predictors that can potentially influence decision for adjuvant radiothera...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.23583
更新日期:2014-06-01 00:00:00
abstract:PURPOSE:The epidemiology and clinicopathology of aneurysmal bone cysts (ABCs) secondary to giant cell tumors of bone (GCTBs) have been well documented in the previous literature. However, reports on whether secondary ABCs could affect the postoperative recurrence of GCTBs are rare. This study analyzed the effects of se...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.25588
更新日期:2019-09-01 00:00:00
abstract::Retroperitoneal sarcoma (RPS) patients can have variable of outcomes after surgery. The chance to recur locally or at distant sites varies according to tumor grade, histologic subtype, and other patient- and tumor-related characteristics. The relative contribution of each prognostic variable on the oncological outcome...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.24903
更新日期:2018-01-01 00:00:00
abstract::Since February, 1977, 735 patients having a history of receiving radiation therapy for benign conditions of the head and neck areas during infancy and childhood were examined in a thyroid screening program, and 159 patients were found to have palpable thyroid nodules. These patients had thyroid function tests and indi...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930140316
更新日期:1980-01-01 00:00:00
abstract::While hepatic resection of metastatic colorectal carcinoma is accepted as effective in selected patients, resection of metastases to other solid organs has not gained wide acceptance. We retrospectively reviewed the records of 49 patients who had resection of isolated pulmonary (18 patients) and hepatic (31 patients) ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930430303
更新日期:1990-03-01 00:00:00
abstract:BACKGROUND:There are limited data on surgical complications for patients that have delayed surgery after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. We aimed to analyze the surgical outcomes of patients submitted to surgery after recovery from SARS-CoV-2 infection. METHODS:Asymptomatic pati...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.26377
更新日期:2021-01-11 00:00:00
abstract:BACKGROUND:Gallbladder adenocarcinoma is often incidentally identified following cholecystectomy. We hypothesized that intraoperative bile spillage would be a negative prognostic factor. METHODS:A retrospective review of patients treated at a cancer center with histologically confirmed gallbladder adenocarcinoma, 2009...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.25617
更新日期:2019-09-01 00:00:00
abstract:BACKGROUND:Patients chosen for liver resection of colorectal liver metastases are a select group with minimal disease, favorable tumor biology and earlier presentation when compared to unresectable patients. Despite intense preoperative assessments, operative detection of occult unresectable disease is inevitable for a...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.20341
更新日期:2005-10-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Internal hemipelvectomy is a complex procedure used to treat malignancy that involves the pelvis. Reconstruction of the pelvis after type I or type I/IV resection remains controversial due to high complication rates and debatable functional benefit. Modern reconstruction options may provide a ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.26194
更新日期:2020-12-01 00:00:00
abstract:BACKGROUND:The majority of breast cancer patients in Mexico are treated through the public health system and >80% receive adjuvant chemotherapy. The aim of this prospective study was to characterize the impact of the Oncotype DX assay on adjuvant therapy decision making and the confidence in those decisions amongst pub...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.23794
更新日期:2015-02-01 00:00:00
abstract::We present a review of the incidence, differential diagnoses, mechanism of rupture, laboratory findings, and signs and symptoms of splenic rupture in leukemia. The types of leukemia most often associated with ruptured spleen are described. The treatment of splenic rupture in leukemia is splenectomy, with careful evalu...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.2930410312
更新日期:1989-07-01 00:00:00
abstract::Tumors attached or adjacent to critical structures can often not be completely resected or resected with adequate surgical margins. Sites involving major blood vessels, the paravertebral spaces, or critical abdominal structures often present technical difficulties for standard brachytherapy procedures using I-125 or I...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930420112
更新日期:1989-09-01 00:00:00