Abstract:
BACKGROUND:The accurate staging of hepatocellular carcinoma (HCC) is important in establishing treatment strategies and prognosis. Among tumor factors, microvascular invasion, one of TNM staging components and prognostic factors, is underestimated preoperatively, due to inaccuracy of imaging modalities. We investigated preoperative predictors of microvascular invasion. METHODS:We reviewed 190 consecutive HCC patients given curative resection from 1999 to 2006. All were treatment-naive and monitored every 3 months after resection. Tumor recurrence, survivals, and clinicopathological factors associated with microvascular invasion were analyzed. RESULTS:The 5-year disease-free survival (DFS) rate was 39.4%(median follow-up duration: 35 months). On resection pathology, 38.9% (74/190 patients) had microvascular invasion undetected preoperatively, using liver spiral computed tomography (CT) or angiography. Independent predictors of microvascular invasion were tumor size (P = 0.043), number (P = 0.011), and Edmondson grade (P = 0.001). Patients with Edmondson grade 1 and size <5 cm had no microvascular invasion, while those with grade > or =2 had higher incidences (7/18 patients, 38.8%) even in small tumor (<2 cm). When tumors recurred, presence of microvascular invasion independently increased incidences of multiple tumors, portal vein invasion, and diffuse-infiltrative patterns significantly. CONCLUSIONS:Preoperative predictors of microvascular invasion are tumor size, number, and Edmondson grade, which may be useful for making clinical decisions in both non-surgical and surgical candidates.
journal_name
J Surg Oncoljournal_title
Journal of surgical oncologyauthors
Kim BK,Han KH,Park YN,Park MS,Kim KS,Choi JS,Moon BS,Chon CY,Moon YM,Ahn SHdoi
10.1002/jso.20953subject
Has Abstractpub_date
2008-03-01 00:00:00pages
246-52issue
3eissn
0022-4790issn
1096-9098journal_volume
97pub_type
杂志文章abstract:BACKGROUND AND OBJECTIVES:Surgical procedures can cause tumor cells to disseminate into the circulatory system. Although this spread of metastatic cells will be limited by immune activity, immunosuppression tends to be the main effect resulting from surgery. The objective of this study is to assess hormonal and immunol...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.21662
更新日期:2010-11-01 00:00:00
abstract:BACKGROUND:Familial soft tissue sarcomas are extremely rare. There is little information available on the clinical features and molecular findings of the hereditary occurrence of mesenchymal tumor. PATIENTS AND METHODS:A woman and her younger brother had malignant fibrous histiocytoma (pleomorphic type) and liposarcom...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.20720
更新日期:2007-03-15 00:00:00
abstract:BACKGROUND AND OBJECTIVES:To compare 3-year clinical outcomes of radiofrequency ablation (RFA) targeting 5- or 10-mm margins for small hepatocellular carcinomas (HCCs) in cirrhotic patients. METHODS:In total, 96 cirrhotic patients with a small solitary HCC (diameter ≤3 cm) were included in this prospective trial (ChiC...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,随机对照试验
doi:10.1002/jso.24607
更新日期:2017-06-01 00:00:00
abstract:BACKGROUND:Adjuvant radiation is rarely used to treat medullary thyroid carcinoma (MTC). We hypothesized that external beam radiation therapy (EBRT) would improve overall survival (OS) in MTC patients. METHODS:The Surveillance, Epidemiology, and End Results (SEER) database identified patients who underwent total thyro...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.21557
更新日期:2010-08-01 00:00:00
abstract:BACKGROUND:An increasing proportion of patients are presenting with colorectal cancer at an early age. A proportion of these occur with genetic syndromes; however the majority present as sporadic. The purpose of this study is to investigate the prognosis and treatment of young patients with sporadic metastatic colorect...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.24181
更新日期:2016-04-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Primary retroperitoneal tumors constitute a rather uncommon disease with an incidence of 2 in 100,000. Local recurrence after surgical resection is reported between 60% and 90% at 10 yr. The aim of this study was to present the problem of satellite tumors around the main tumor mass and their p...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/(sici)1096-9098(199805)68:1<30::aid-jso7>3
更新日期:1998-05-01 00:00:00
abstract::An unusual case of Merkel cell carcinoma of the lower lip with metastasis to the submental nodes is presented. Clinical similarities and the histopathologic and prognostic differences between this tumor and basal or squamous cell carcinomas of the head and neck area are discussed and the current thoughts for treatment...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930370212
更新日期:1988-02-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Some schwannomas in the central nervous system may demonstrate relatively aggressive behavior in pathological findings and clinical course. We evaluate the diagnostic values of telomerase activity and telomere length in the clinicopathological behavior of schwannomas. METHODS:Thirty surgical ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.10139
更新日期:2002-10-01 00:00:00
abstract:BACKGROUND:Hepatic arterial infusion chemotherapy (HAIC) has been recognized as one of the effective treatments for patients with hepatic metastatic tumor. However it is difficult to perform HAIC in the long term without complications. This report describes the laparotomic approach using the side holed catheter, which ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.20283
更新日期:2005-08-01 00:00:00
abstract::Cancer of the oral cavity remains a major problem in the United States as well as in many other countries, some of which record as much as 30% of all their cancers to be in the oral region. Despite numerous advances in the fields of epidemiology and etiology, little is known of the molecular basis of oral cancer. Adva...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.2930470209
更新日期:1991-06-01 00:00:00
abstract::The use of preoperative imaging has become routine for many reconstructive microsurgeons to help localize perforators for planning of microvascular free flaps. However, with advancements in imaging technology, perforator mapping represents only one potential benefit as virtual planning and medical modeling, and flap t...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.25194
更新日期:2018-10-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Development of second primary carcinomas after thoracic esophagectomy has become of much concern, because recently the prognosis of thoracic esophageal carcinoma after esophagectomy with extended lymph node dissection has been improving. We report our experience of diagnosing and treatment sec...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/(sici)1096-9098(199710)66:2<130::aid-jso11
更新日期:1997-10-01 00:00:00
abstract:BACKGROUND:Amongst various options of vascularized lymph node transfers, the submental flap has the lowest risk for iatrogenic lymphedema. The aim of this study was to gain insight into distribution, number, and size of lymph nodes along the mandible using computed tomography angiography (CTA). METHODS:A total of 52 C...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.26117
更新日期:2020-07-15 00:00:00
abstract::Intraoperative radiation therapy (IORT) was delivered to remnant rat liver after partial hepatectomy to determine the chronic effects of treatment on survival, blood chemistry, liver weight, and histology. Survival at one year was 100%. Remnant liver weight was markedly increased in all animals. Liver function appeare...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930500205
更新日期:1992-06-01 00:00:00
abstract::A patient with simultaneous metachronous carcinoma and polyps of the large bowel is presented. The importance of carcinoma as a predisposing cause to perforation during barium enema is stressed. In view of the considerable incidence of recurrent large bowel tumors, careful routine follow-up studies should be undertake...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930080409
更新日期:1976-01-01 00:00:00
abstract:BACKGROUND:Gastric cancer is the fifth most common cancer in Eastern Africa. Diagnostic delays in low-resource countries result in advanced disease presentation. We describe perioperative management of gastric cancer in Rwanda. METHODS:A retrospective review of records at three hospitals was performed to identify gast...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,多中心研究
doi:10.1002/jso.25286
更新日期:2018-12-01 00:00:00
abstract::The results of treatment of desmoid tumor patients with nonsteroid antiinflammatory drugs alone or in combination with tamoxifen are described. Tumor growth was inhibited in six of seven patients. Nonsteroid antiinflammatory drugs administered along with 5-fluorouracil and cyclophosphamide and other inhibitors of T-su...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930220314
更新日期:1983-03-01 00:00:00
abstract::The aim of the present study was to demonstrate the practicality of intraoperative fine needle aspiration (FNA) cytology of pancreatic lesions in 43 patients. The indication for performing this procedure was to determine the nature of pancreatic masses. Conclusive cytologic diagnoses were reached in 41 patients who re...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930460407
更新日期:1991-04-01 00:00:00
abstract::Retroperitoneal sarcomas (RPS) frequently involve major vessels, which either originate from them or secondarily encase or invade them. In this field, major vascular resections result in increased morbidity. However, survival does not seem to be affected by the need for vascular resection or by this higher morbidity. ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.24920
更新日期:2018-01-01 00:00:00
abstract::Side-effects to levamisole given as adjuvant to surgery in a consecutive series of 203 neoplastic patients are reported: Thirty-four patients (16.7%) suffered gastric adverse reactions; 8 (3.9%) allergic; 6 (2.9%) intestinal; 6 (2.9% neurologic; 4 (1.9%) severe hyperthermia (more than 40.5 degrees C); 3 (1.4%) flu-lik...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930160310
更新日期:1981-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Variability in melanoma management has prompted concerns about equitable and timely treatment. We investigated patterns of melanoma diagnosis and treatment using population-level data. METHODS:Patients with invasive cutaneous melanoma were identified retrospectively from the Ontario Cancer Re...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.24936
更新日期:2018-03-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:F-18 fluorodeoxyglucose-positron emission tomography (FDG-PET) has been used for diagnosis and staging of malignant diseases. However, the prognostic significance of FDG uptake on PET had not been sufficiently evaluated in patients with biliary carcinoma. METHODS:We performed a retrospective ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.21356
更新日期:2009-11-01 00:00:00
abstract::High-quality data support multiple clinical benefits of integrating palliative care into routine oncology care. Though these data come largely from the medical oncology literature, data from surgical oncology populations support similar associations between palliative care integration and improved clinical outcomes, a...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.25454
更新日期:2019-07-01 00:00:00
abstract:BACKGROUND:A tracheobronchial injury is an uncommon complication of an esophagectomy. Differences in outcomes may exist for patients with injuries detected intraoperatively and postoperatively. METHODS:A retrospective review was performed for patients who underwent an esophagectomy for cancer at Jackson Memorial Hospi...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.23577
更新日期:2014-06-01 00:00:00
abstract::In the twentieth century, lymph node dissection based on metastatic distribution has developed as the standard procedure for surgical management of gastrointestinal cancer [1]. The fear that invisible micrometastases might be present has encouraged aggressive resection with lymphadenectomy to control the disease. Howe...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.10065
更新日期:2002-03-01 00:00:00
abstract::The poor outcome associated with surgical resection alone for most patients with locoregional esophageal cancer has generated intensive investigation of combined-modality treatment approaches that include systemic chemotherapy. This review discusses the current role of chemotherapy in the treatment of patients with ad...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.20364
更新日期:2005-12-01 00:00:00
abstract::This is a retrospective study of 462 patients who had masectomy and axillary dissection for carcinoma of the breast during 1971-1980. Actuarial analysis of relapse rates up to 5 years showed that the extent of involvement of axillary lymph nodes was the most important prognostic factor. Among patients without any axil...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930270109
更新日期:1984-09-01 00:00:00
abstract::The treatment of metastatic colorectal cancer to the liver has been a significant problem for clinicians in the past. Recent technical advances in infusion systems in the form of the infusaid pump has allowed delivery of chemotherapeutic agents to the liver with great reliability. As more chemotherapy pumps are implan...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930270410
更新日期:1984-12-01 00:00:00
abstract::The realm of cancer chemotherapy is complex and often conflicting. The massive use of cytotoxic agents during the past 25 years has now reached a point where major decisions have to be made. The respective roles of regional techniques, systemic therapy for metastatic disease and adjuvant cytotoxic chemotherapy, all ne...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930300411
更新日期:1985-12-01 00:00:00
abstract:BACKGROUND:Cytoreductive surgery (CRS) and hyperthermic intra-peritoneal chemotherapy (HIPEC) treatment of colorectal peritoneal metastases (PM) is an established treatment alternative. The study aim was, first, to investigate the outcome of high-volume disease defined by the peritoneal cancer index (PCI) 20; second, t...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.23610
更新日期:2014-08-01 00:00:00