Abstract:
BACKGROUND AND OBJECTIVES:Stages II and III rectal tumors are known as locally advanced rectal cancer (LARC) because they are characterized by a high incidence of local and distant relapses and a low probability of long-term survival. Adjuvant treatments have been advocated to ameliorate overall survival (OS), local recurrence-free survival (LRFS), and metastasis-free survival (MFS) without a univocal beneficial trend. The aim of this study was to identify the independent predictive factors of OS, LRFS, and MFS which could best select patients for adjuvant treatment of LARC. METHODS:Of 153 rectal cancer cases seen consecutively from 1991 to 1998, we studied the main clinical and pathological parameters of 73 LARCs. Clinical and pathological variables were studied by univariate analysis, and independent predictive factors were identified by multivariate analysis. RESULTS:Stages II and III rectal cancer have shown not statistically different rates of OS, LRFS, and MFS. Factors independently associated with increasing OS and MFS were low preoperative carcinoembryonic antigen level (CEA), low number of metastatic lymph nodes, low percentage of metastatic lymph nodes out of the total number of lymph nodes excised, and adjuvant treatment. Increased staging and distal resection margins < or =1 cm were shown to be independent detrimental risk factors regarding OS and MFS, respectively. Independent prognostic factors associated with a reduction in LRFS were advanced age, Hartman's resection, distal resection margins < or =1 cm, and fewer than 14 resected nodes. CONCLUSIONS:Whereas stage I rectal cancer can be treated with a good probability of cure by surgery alone, avoiding adverse effects of adjuvant regimens, the outcome of LARC appears to be positively influenced by adjuvant therapies. In LARC, an accurate study of risk factors would be useful to identify which subset of patients could be favorably influenced by postoperative radiochemotherapy.
journal_name
J Surg Oncoljournal_title
Journal of surgical oncologyauthors
Bufalari A,Boselli C,Giustozzi G,Moggi Ldoi
10.1002/1096-9098(200005)74:1<2::aid-jso2>3.0.co;2subject
Has Abstractpub_date
2000-05-01 00:00:00pages
2-10issue
1eissn
0022-4790issn
1096-9098pii
10.1002/1096-9098(200005)74:1<2::AID-JSO2>3.0.CO;2journal_volume
74pub_type
杂志文章abstract::The growth of knowledge and complexity now seen in General Surgery, has led to the sub-specialization of the discipline. Although it is considered by some to have led to the fragmentation of General Surgery and the erosion of the specialty as we know it today, others would argue that it has and will continue to lead t...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.20176
更新日期:2005-03-01 00:00:00
abstract:OBJECTIVES:We reviewed the clinical characteristics and outcomes of patients treated for alveolar soft part sarcoma (ASPS) and analyzed the effect of surgery for patients presenting with and without metastatic disease (DM). METHODS:The SEER Registry was queried for patients with ASPS from 1973-2012. The Kaplan-Meier e...
journal_title:Journal of surgical oncology
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更新日期:2016-04-01 00:00:00
abstract:BACKGROUND:Patients chosen for liver resection of colorectal liver metastases are a select group with minimal disease, favorable tumor biology and earlier presentation when compared to unresectable patients. Despite intense preoperative assessments, operative detection of occult unresectable disease is inevitable for a...
journal_title:Journal of surgical oncology
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doi:10.1002/jso.20341
更新日期:2005-10-01 00:00:00
abstract::A primary retroperitoneal dermoid cyst (benign cystic teratoma) is described in a 64-year-old male, who died postoperatively of a leaking grafted abdominal aortic aneurysm. The asymptomatic tumor, measuring 12 cm in greatest diameter, showed an extensive sclerosing lipogranulomatous reaction in its wall and wide-sprea...
journal_title:Journal of surgical oncology
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abstract:BACKGROUND:Few studies have focused on distribution of lymph node metastasis. The aim of this study is to evaluate the prognostic significance of the location of involved lymph nodes in patients with advanced mid or low rectal cancer. METHODS:We defined proximal lymph node involvement (PLNp) as superior rectal and inf...
journal_title:Journal of surgical oncology
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更新日期:2011-10-01 00:00:00
abstract:BACKGROUND:The ARM technique was proposed to prevent arm lymphedema after ALND and/or SLN biopsy. However, several problems remain to be resolved in the practical application of this technique. METHODS:The fluorescent ARM nodes and/or lymphatics were identified using a fluorescence imaging system with subdermal inject...
journal_title:Journal of surgical oncology
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abstract:BACKGROUND AND OBJECTIVE:This study aims to investigate the surgical outcomes observed in robotic transperitoneal aortic lymphadenectomy (AL) in gynecological cancer patients. METHODS:Retrospective data were collected and analyzed on 71 patients undergoing robotic surgical procedures for gynecological cancers, includi...
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pub_type: 临床试验,杂志文章
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更新日期:2019-03-01 00:00:00
abstract::Follicular thyroid carcinoma, initially presenting as spinal cord compression due to metastatic lesions, is a less reported event. We present two cases of well-differentiated thyroid carcinoma that led to spinal cord compression. A thorough search of the literature revealed only five similar cases. We summarize the cl...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/(sici)1096-9098(199803)67:3<186::aid-jso8>
更新日期:1998-03-01 00:00:00
abstract::Five human digestive organ cancer xenograft lines were subcutaneously transplanted in nude mice, and 7 anticancer agents (ACAs) were intravenously administered singly or in combinations at 4 times the standard clinical doses. Cisplatin (P) was effective in 4 lines and 5-fluorouracil (F) was effective in 3 lines. A tot...
journal_title:Journal of surgical oncology
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doi:10.1002/jso.2930480408
更新日期:1991-12-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:We retrospectively compared surgical outcomes between patients with intra-thoracic and extra-thoracic (cervical and abdominal) lymph-node metastasis. METHODS:The study population comprised 96 patients with lymph-node metastasis who had undergone curative esophagectomy for thoracic esophageal ...
journal_title:Journal of surgical oncology
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更新日期:2010-01-01 00:00:00
abstract::Extended lymphadenectomy has been proposed for loco-regional control of pancreatic adenocarcinoma. While retrospective series suggested a benefit, subsequent prospective trials have not shown a survival benefit. Methods to improve loco-regional control of pancreatic body/tail cancer have not been extensively investiga...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.21210
更新日期:2009-03-15 00:00:00
abstract::Sentinel lymph node (sN) biopsy has gained special attention among surgical and medical oncologists as it represents an accepted technique for detecting occult nodal disease in regional lymph nodes of patients with melanoma and breast cancer. The histopathologic examination of the sN may well predict regional lymph no...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.20031
更新日期:2004-03-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:The reported risk of nodal metastasis in hard palate and upper gingival squamous cell carcinoma (SCC) has been inconsistent with inadequate consensus regarding the utility of neck dissection in the clinically negative (cN0) neck. MATERIALS AND METHODS:Using the National Cancer Database, cN0 p...
journal_title:Journal of surgical oncology
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abstract:BACKGROUND AND OBJECTIVES:It has been estimated that approximately 5% of middle and low rectal adenocarcinomas are amenable to local therapy. However, these treatment modalities are limited by their failure to identify and treat regional nodal metastases. METHODS:This study was undertaken to evaluate the role of tumor...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
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更新日期:1998-02-01 00:00:00
abstract::Intraoperative radiation therapy (IORT) was delivered to remnant rat liver after partial hepatectomy to determine the chronic effects of treatment on survival, blood chemistry, liver weight, and histology. Survival at one year was 100%. Remnant liver weight was markedly increased in all animals. Liver function appeare...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930500205
更新日期:1992-06-01 00:00:00
abstract::DNA ploidy of tumor cells and the degree of infiltration of dendritic cells were determined in 93 gastric cancer tissue specimens, and the mechanisms of tumor-host interaction on the prognosis were investigated. DNA ploidy patterns were grouped into low and high ploidy, and the degree of infiltration of dendritic cell...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930520402
更新日期:1993-04-01 00:00:00
abstract::The clinicopathologic features of 118 granular cell tumors (GCT) encountered at two affiliated hospitals were reviewed. A total of 110 patients were affected over this 32-year period of study (71 men, 39 women), and in 5% GCT were multiple. Patients ranged in age from 16 to 58 years (average 32 years) and were symptom...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930130405
更新日期:1980-01-01 00:00:00
abstract::A retrospective analysis of 328 cases of Hodgkin's Disease (HD) subjected to a staging laparotomy at the Tata Memorial Hospital, Bombay, India, from 1974 to 1986 was undertaken to assess its relevance to our setup. Eighty percent of the patients were from clinical stages (CS) I and II, 38% with lymphocyte predominance...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930490110
更新日期:1992-01-01 00:00:00
abstract:BACKGROUND:The median survival for patients with stage IV metastatic melanoma is usually limited to approximately 1 year. In the case of liver metastasis, resection and ablation can achieve long-term survival. This study aimed to describe the outcomes after liver resection or ablation for metastatic melanoma to the liv...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.23929
更新日期:2015-06-01 00:00:00
abstract::We retrospectively studied the relationship between nutritional status as indicated by the presence or absence of the cutaneous delayed hypersensitivity response and treatment-related morbidity, disease recurrence, and survival at 2 years in 67 consecutive patients with head and neck carcinoma. Serial nutritional asse...
journal_title:Journal of surgical oncology
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abstract:BACKGROUND AND OBJECTIVES:The single-arm ROSiA study evaluated frontline bevacizumab for advanced ovarian cancer. We explored how discordant surgically and radiologically assessed postoperative residual disease affects outcomes. METHODS:After debulking surgery, 1021 patients received 4 to 8 cycles of carboplatin-pacli...
journal_title:Journal of surgical oncology
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abstract:BACKGROUND:Cardiac myxoma, the most common primary tumor in the adult, is less often encountered in infants and children. We reviewed our series of children with cardiac myxoma over a 22-year period and present the long-term results of surgical resection of the tumor. PATIENTS AND METHODS:From January 1985 to December...
journal_title:Journal of surgical oncology
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更新日期:2009-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:The purpose of this study was to find out the risk factors associated with non-sentinel lymph node metastasis and determine the incidence of non-sentinel lymph node metastasis according to risk groups in sentinel lymph node (SLN)-positive endometrial cancer patients. METHODS:Patients who unde...
journal_title:Journal of surgical oncology
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更新日期:2020-12-01 00:00:00
abstract::To compare toxicity and efficacy of both salvage prostatectomy and salvage radiotherapy for prostate cancer a retrospective analysis was conducted. Thirty-two and 41 patients were treated with external beam radiotherapy or prostatectomy for cT1c-T2 prostate cancer later requiring salvage surgery or radiotherapy. Salva...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.20967
更新日期:2008-04-01 00:00:00
abstract::Of 134 patients with thymoma, 79 (59%) also had myasthenia gravis (MG). The thymoma with MG differed from that in the absence of MG in the following aspects: The ratio of lymphocytes to epithelial cells in the tumor was larger, the polygonal cell type was more prominent (i.e., in 83% of the MG patients this cell type ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930380305
更新日期:1988-07-01 00:00:00
abstract::A case of leiomyosarcoma arising from the dartos muscle of the scrotum is described. Review of the literature reveals only eight other cases, and aspects of management of these and our case are discussed. ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.2930340309
更新日期:1987-03-01 00:00:00
abstract:BACKGROUND:Gallbladder adenocarcinoma is often incidentally identified following cholecystectomy. We hypothesized that intraoperative bile spillage would be a negative prognostic factor. METHODS:A retrospective review of patients treated at a cancer center with histologically confirmed gallbladder adenocarcinoma, 2009...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.25617
更新日期:2019-09-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Neoadjuvant chemotherapy (nCMT) has been increasingly used in advanced gastric cancer (GC). However, the prognostic impact of tumor response remains unclear. This study aimed to evaluate if tumor response at the primary site and lymph nodes (LN) correlate with survival in GC patients after nCMT...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.25785
更新日期:2020-04-01 00:00:00
abstract:BACKGROUND:The benefit of adjuvant chemotherapy for patients with locally advanced rectal cancer who have received neoadjuvant concurrent chemoradiation therapy (CCRT) and undergone curative resection remains unclear. METHODS:This study was a retrospective review of prospectively collected data. Patients with locally ...
journal_title:Journal of surgical oncology
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更新日期:2015-03-15 00:00:00
abstract::This article reviews immediate and delayed breast reconstruction with prosthetic implants, and the effect of irradiation therapy. Despite widespread use of breast conserving surgery for early breast cancer, many breast cancer patients still undergo mastectomy. Some of these patients choose breast reconstruction. Over ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.20484
更新日期:2006-11-01 00:00:00