Outcomes of hepatic resection for huge hepatocellular carcinoma (≥ 10 cm in diameter).

Abstract:

BACKGROUND:The object of the current study was to review the outcomes of hepatic resection for hepatocellular carcinoma (HCC) ≥ 10 cm. METHODS:Between 1995 and 2007, fifty-three patients with HCC ≥ 10 cm underwent hepatic resection, and clinical data were compared to those of patients with non-surgical treatment (n = 12). Surgical results for HCC ≥ 10 cm were compared to those of patients with HCC < 10 cm (n = 412). The independent poor prognostic factors of the patients with HCC ≥ 10 cm were identified. RESULTS:Overall survival was significantly better in patients with hepatic resection for HCC ≥ 10 cm than in those with non-surgical treatment (P < 0.01). Survival rates of patients with hepatic resection for HCC ≥ 10 cm were 35% at 5 years. Morbidity and mortality rate were statistically equal. The independent poor prognostic factors of patients with hepatic resection for HCC ≥ 10 cm were revealed: T4 status, macroscopic tumor thrombus in portal vein (VP+), and the use of intra-operative transfusion. CONCLUSION:Hepatic resections for HCC ≥ 10 cm are safe and efficacious. Minimizing intra-operative blood loss and the establishment of an effective systemic treatment for patients with HCC ≥ 10 cm in T4 appear to be critical.

journal_name

J Surg Oncol

authors

Yamashita Y,Taketomi A,Shirabe K,Aishima S,Tsuijita E,Morita K,Kayashima H,Maehara Y

doi

10.1002/jso.21931

subject

Has Abstract

pub_date

2011-09-01 00:00:00

pages

292-8

issue

3

eissn

0022-4790

issn

1096-9098

journal_volume

104

pub_type

杂志文章
  • The natural history of thin melanoma and the utility of sentinel lymph node biopsy.

    abstract:BACKGROUND AND OBJECTIVES:Current literature may overestimate the risk of nodal metastasis from thin melanoma due to reporting of data only from lesions treated with SLNB. Our objective was to define the natural history of thin melanoma, assessing the likelihood of nodal disease, in order to guide selection for SLNB. ...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.24765

    authors: Durham AB,Schwartz JL,Lowe L,Zhao L,Johnson AG,Harms KL,Bichakjian CK,Orsini AP,McLean SA,Bradford CR,Cohen MS,Johnson TM,Sabel MS,Wong SL

    更新日期:2017-12-01 00:00:00

  • Tenascin pattern of expression and established prognostic factors in invasive breast carcinoma.

    abstract:BACKGROUND AND OBJECTIVES:Immunohistochemical methods were used to study Tenascin (TN) expression in invasive duct cell carcinoma (IDCC) of the breast and its established prognostic factors. METHODS:We studied 115 patients with IDCC. The mean patient age was 62 years; all tumors were graded according to Scarf-Bloom an...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/(sici)1096-9098(199806)68:2<107::aid-jso7>

    authors: Iskaros BF,Hu X,Sparano JA,Fineberg SA

    更新日期:1998-06-01 00:00:00

  • Munchausen's syndrome and cancer.

    abstract::Munchausen's syndrome is a chronic factitious disorder characterized by frequent hospitalizations, self-inflicted injuries, and dramatic medical histories. People with this condition assume the role of a sick patient and submit to unnecessary invasive, painful, and even dangerous medical procedures. In review of the l...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章,评审

    doi:10.1002/jso.2930560219

    authors: Bruns AD,Fishkin PA,Johnson EA,Lee YT

    更新日期:1994-06-01 00:00:00

  • Salvage of pelvic recurrence of colorectal cancer.

    abstract::Although the incidence of locally recurrent colorectal cancer has been reduced by improved surgical techniques and the frequent use of multimodality therapy, pelvic recurrence remains a significant problem. Radiation or chemotherapy may provide palliation but it is often short-lived. For fit candidates without evidenc...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章,评审

    doi:10.1002/jso.21571

    authors: Varker KA,Wanebo HJ

    更新日期:2010-06-15 00:00:00

  • MC-38 adenocarcinoma tumor infiltrating lymphocytes: correlation of cytotoxicity with time of tumor harvest after tumor inoculation.

    abstract::Tumor infiltrating lymphocytes (TILs) are capable of mediating significant tumor regressions in vitro and in vivo in animal systems. In humans, however, many TIL cell lines are not cytotoxic in vitro, and clinical trials thus far have been less than encouraging. We attempted to correlate TIL cytotoxicity with time of ...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930430104

    authors: Lafreniere R,Borkenhagen K,Bryant LD

    更新日期:1990-01-01 00:00:00

  • Increased estrogen receptor and epidermal growth factor receptor gene product co-expression in surgically resected gastric adenocarcinomas.

    abstract:BACKGROUND:Evidence exists that estrogens influence the action of epidermal growth factor (EGF) and its receptor (EGF-R) at multiple levels. Estrogen and antiestrogen action on gastric and other gastrointestinal malignancies has been evaluated by several groups with conflicting results, and EGF-R has been implicated in...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/(SICI)1096-9098(199611)63:3<166::AID-JSO6>

    authors: Koullias GJ,Kouraklis GP,Raftopoulos IS,Davaris PS,Papadopoulos SA,Golematis BC

    更新日期:1996-11-01 00:00:00

  • Pancreatic carcinoma as a sequel to therapy of lymphoma.

    abstract::Development of a carcinoma in the pancreas of a young man who had five years previously undergone intensive radiotherapy and subsequent chemotherapy for treatment of a lymphoma suggests that induction of the second neoplasm occurred as the result of the therapy of the first. While definite proof of causality is lackin...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930080603

    authors: Jochimsen PR,Pearlman NW,Lawton RL

    更新日期:1976-01-01 00:00:00

  • Long survival following combined treatment of inoperable cholangiocarcinoma: surgery, radiotherapy, and chemotherapy.

    abstract::A jaundiced patient due to inoperable bile duct carcinoma was treated by a combination of surgery, radiotherapy, and chemotherapy. At the operation an intra-abdominal, extra-choledochal bypass of the tumor was performed with a T-tube obstruction 10 months after diagnosis, and no evidence of malignancy was seen. The T-...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930130308

    authors: Hashmonai M,Lev L,Schramek A,Ben-Arieh Y,Robinson E

    更新日期:1980-01-01 00:00:00

  • Postoperative external irradiation in thyroid carcinoma: a clinical experience of 20 treated patients and literature radiotherapy review.

    abstract::A retrospective review is presented of 20 evaluable patients who underwent surgical resection or biopsy for limited stage thyroid carcinoma at two institutions between 1963 and 1983. The majority had external radiotherapy to the whole neck and upper mediastinum and the total dose given varied from 3,800 to 6,000 rads....

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930300205

    authors: Ampil FL

    更新日期:1985-10-01 00:00:00

  • Ablative therapies in adrenal tumors: primary and metastatic.

    abstract::A large number of adrenal tumors are now identified either incidentally or associated with a metastatic workup for cancer. While the vast majority of these lesions are benign, those that prove to be primary or secondary cancers are traditionally treated with surgical resection. A wide variety of alternative, less inva...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章,评审

    doi:10.1002/jso.23191

    authors: Pua BB,Solomon SB

    更新日期:2012-10-01 00:00:00

  • Fine-needle aspiration cytology of abdominal masses.

    abstract::An investigation of the role of blind fine-needle aspiration cytology (FNAC) in the assessment of palpable abdominal masses was carried out on 196 patients: 124 hepatic, 30 retroperitoneal, and 42 other masses. All of the smears were stained either by Papanicolaou stain or by hematoxylin and eosin stain. The results o...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930440105

    authors: Khanna AK,Misra MK,Khanna A,Misra VK,Khanna S

    更新日期:1990-05-01 00:00:00

  • Serological evaluation of human brain tumors using a microradioisotopic staphylococcal protein A assay.

    abstract::A microradioisotopic staphylococcal protein A assay was applied to the serological evaluation of preoperative sera from brain tumor patients. The assay was performed in Terasaki plates, and a stainless steel punch and multiholed die facilitated sample prearation. Using allogeneic astrocytoma target cells, 15/19 of the...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930140306

    authors: Cohen AM,Wood WC

    更新日期:1980-01-01 00:00:00

  • Neutrophil to lymphocyte ratio predicts pattern of recurrence in patients undergoing liver resection for colorectal liver metastasis and thus the overall survival.

    abstract:OBJECTIVE:We investigate the neutrophil to lymphocyte ratio (NLR) as a potential prognostic factor for patients undergoing curative liver resection for colorectal liver metastasis (CRLM). METHODS:We identified patients who underwent liver resection, via our prospectively accumulated surgical database at the Royal Mars...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.23845

    authors: Giakoustidis A,Neofytou K,Khan AZ,Mudan S

    更新日期:2015-03-15 00:00:00

  • The mortality rate from lung metastases in animals inhaling nitrogen dioxide (NO2).

    abstract::A study was carried out to determine the interrelationship between the inhalation of nitrogen dioxide (0.4 +/- 0.50 ppm), lung metastases development from circulating cancer cells, and death rate from such metastases. C57 BL/6J mice were used in these experiments. Animals were divided into control and NO2-exposed grou...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930280115

    authors: Richters A,Richters V,Alley WP

    更新日期:1985-01-01 00:00:00

  • Prognostic significance of the age factor in the thyroid cancer: statistical analysis.

    abstract:BACKGROUND AND OBJECTIVES:To determine whether thyroid carcinoma in elderly patients presents any peculiar characteristics, whether the greater biological aggressiveness of the neoplasm modifies the surgical treatment selected, and whether age greater than 70 years represents an independent prognostic factor. METHODS:...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.20140

    authors: Falvo L,Catania A,Sorrenti S,D'Andrea V,Berni A,De Stefano M,De Antoni E

    更新日期:2004-12-15 00:00:00

  • Validation of clinical prognostic scores for patients treated with curative-intent for recurrent colorectal liver metastases.

    abstract:BACKGROUND:Scoring systems were developed to stratify patients with colorectal liver metastases considered for liver resection into different risk groups. Such scores have never been evaluated in recurrent liver metastases. The aim of this study was to evaluate whether these scores are applicable to patients with recur...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.24959

    authors: Dupré A,Rehman A,Jones RP,Parker A,Diaz-Nieto R,Fenwick SW,Poston GJ,Malik HZ

    更新日期:2018-05-01 00:00:00

  • Postbiliary drainage rates of cholangitis are impacted by procedural technique for patients with supra-ampullary cholangiocarcinoma: A SEER-Medicare analysis.

    abstract:BACKGROUND:The optimal approach to biliary drainage for patients with supra-ampullary cholangiocarcinoma remains undetermined. Violation of sphincter of Oddi results in bacterial colonization of bile ducts and may increase postdrainage infectious complications. We sought to determine if rates of cholangitis are affecte...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.25485

    authors: Kariya CM,Wach MM,Ruff SM,Ayabe RI,Lo WM,Torres MB,Petrick JL,McNeel TS,Davis JL,McGlynn KA,Hernandez JM

    更新日期:2019-08-01 00:00:00

  • Use of subatmospheric pressure to prevent doxorubicin extravasation ulcers in a swine model.

    abstract:UNLABELLED:Application of subatmospheric pressure to sites injected with doxorubicin prevented ulcer formation in treated sites (0 ulcers/16 sites) compared to control wounds (10 ulcers/16 sites) in a pig model. BACKGROUND AND OBJECTIVES:Extravasation of doxorubicin hydrochloride (Adriamycin) frequently causes chronic...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/(sici)1096-9098(199909)72:1<14::aid-jso4>3

    authors: Morykwas MJ,Kennedy A,Argenta JP,Argenta LC

    更新日期:1999-09-01 00:00:00

  • Metastatic gastric cancer (MGC) patients: Can we improve survival by metastasectomy? A systematic review and meta-analysis.

    abstract:BACKGROUND:Prognosis with current management strategies continues to be dismal in metastatic gastric cancer (MGC) patients. We aimed to evaluate the role of metastasectomy in improving survival. METHODS:A comprehensive search of MEDLINE, EMBASE, SCOPUS, and Cochrane central databases (1965 to present) was performed. A...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/jso.23945

    authors: Gadde R,Tamariz L,Hanna M,Avisar E,Livingstone A,Franceschi D,Yakoub D

    更新日期:2015-07-01 00:00:00

  • Mitochondrial DNA alterations in thyroid cancer.

    abstract:BACKGROUND:Alterations in mitochondrial DNA have been identified in a number of solid tumor types, including gastric, head and neck, breast, colorectal, lung, and bladder carcinomas. Recently, a homopolymeric C stretch (D310) located within the noncoding D-loop of the mitochondrial genome was identified and described a...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.10202

    authors: Tong BC,Ha PK,Dhir K,Xing M,Westra WH,Sidransky D,Califano JA

    更新日期:2003-03-01 00:00:00

  • Rapid genetic counseling and testing in newly diagnosed breast cancer: Patients' and health professionals' attitudes, experiences, and evaluation of effects on treatment decision making.

    abstract:BACKGROUND:Rapid genetic counseling and testing (RGCT) in newly diagnosed high-risk breast cancer (BC) patients may influence surgical treatment decisions. To successfully integrate RGCT in practice, knowledge of professionals', and patients' attitudes toward RGCT is essential. METHODS:Between 2008 and 2010, we perfor...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.24763

    authors: Wevers MR,Aaronson NK,Bleiker EMA,Hahn DEE,Brouwer T,van Dalen T,Theunissen EB,van Ooijen B,de Roos MA,Borgstein PJ,Vrouenraets BC,Vriens E,Bouma WH,Rijna H,Vente JP,Kuenen MA,van der Sanden-Melis J,Witkamp AJ,Rutgers

    更新日期:2017-12-01 00:00:00

  • Antibiotic prophylaxis for prevention of wound infections after soft tissue sarcoma resection: A retrospective cohort study.

    abstract:BACKGROUND AND OBJECTIVES:The use of antibiotic prophylaxis for soft tissue sarcoma resection varies widely while little evidence on this topic exists. The aim of this study was to determine the impact of antibiotic prophylaxis on the occurrence of wound infections. METHODS:A single institutional retrospective cohort ...

    journal_title:Journal of surgical oncology

    pub_type: 临床试验,杂志文章

    doi:10.1002/jso.26188

    authors: Dadras M,Koepp P,Wagner JM,Wallner C,Sogorski A,Lehnhardt M,Harati K,Behr B

    更新日期:2020-12-01 00:00:00

  • The surgeon and chemotherapy: twenty five years personal experience.

    abstract::The realm of cancer chemotherapy is complex and often conflicting. The massive use of cytotoxic agents during the past 25 years has now reached a point where major decisions have to be made. The respective roles of regional techniques, systemic therapy for metastatic disease and adjuvant cytotoxic chemotherapy, all ne...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930300411

    authors: Burn I

    更新日期:1985-12-01 00:00:00

  • Prognostic impact of MMP-2 and MMP-9 expression in pathologic stage IA non-small cell lung cancer.

    abstract:BACKGROUND:The purpose of the present study was to assess the value of matrix metalloproteinase (MMP)-2 and MMP-9 expression and other potential prognostic factors in predicting the clinical outcome of patients after definitive surgery for pathologic stage IA non-small cell lung cancer (NSCLC). METHODS:One hundred and...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.22001

    authors: Shao W,Wang W,Xiong XG,Cao C,Yan TD,Chen G,Chen H,Yin W,Liu J,Gu Y,Mo M,He J

    更新日期:2011-12-01 00:00:00

  • Patient reasoning in palliative surgical oncology.

    abstract:BACKGROUND:The purpose of this study was to determine the patient reasoning behind treatment choice after palliative surgical consultation. METHODS:Patients undergoing palliative surgical consultation were prospectively enrolled in this observational cohort study (11/2009-5/2011) and administered an open-ended questio...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.23215

    authors: Collins LK,Goodwin JA,Spencer HJ,Guevara C,Ferrell B,McSweeney J,Badgwell BD

    更新日期:2013-03-01 00:00:00

  • Glutathione and phospholipid depletion of liver tumors after arterial ischemia.

    abstract::Breakdown of membrane phospholipids is a causative event leading to irreversible cell injury after ischemia and reperfusion insults, which might be one mechanism leading to liver tumor cell death after repeated arterial ischemia as well. After 2 hr of hepatic dearterialization followed by 30 min of reperfusion tumor p...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/(SICI)1096-9098(199604)61:4<284::AID-JSO11

    authors: Wang LQ,Persson BG,Xu N,Seidegård J,Jeppsson B,Bengmark S

    更新日期:1996-04-01 00:00:00

  • Neural cell adhesion molecule and perineural invasion in gallbladder cancer.

    abstract::To clarify the role of neural cell adhesion molecule (NCAM) in perineural invasion, NCAM expression was studied by immunohistochemical staining in 26 cases with gallbladder cancer. In gallbladder cancer, the incidence of perineural invasion and that of positive NCAM expression was 42% and 31%, respectively, which are ...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930580205

    authors: Seki H,Koyama K,Tanaka J,Sato Y,Umezawa A

    更新日期:1995-02-01 00:00:00

  • Verrucous carcinoma of the foot.

    abstract::A 50-year-old man presented with verrucous carcinoma on the sole of the foot. This unusual tumor, also called an epithelioma cuniculatum plantare, was successfully treated employing wide surgical excision. ...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930140407

    authors: Schwartz RA,Burgess GH

    更新日期:1980-01-01 00:00:00

  • The promoting effect of adiponectin in hepatocellular carcinoma.

    abstract:BACKGROUND AND OBJECTIVES:Adipokines may explain the newly established association of obesity with hepatocellular carcinoma (HCC). This study investigated if adiponectin levels in HCC patients differed from healthy controls and their potential effect in the development of HCC. METHODS:Radioimmunoassay was used to dete...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.23059

    authors: Chen MJ,Yeh YT,Lee KT,Tsai CJ,Lee HH,Wang SN

    更新日期:2012-08-01 00:00:00

  • Extra-adrenal paraganglioma and pulmonary chondroma: a case report and review of the literature.

    abstract::This report describes the findings of an extra-adrenal paraganglioma and chondroma of the lung in an elderly man. Tissue analysis of the paraganglioma showed a high level of catecholamines, as well as the presence of somatostatin and small amounts of other peptide hormones. Immunoperoxidase staining demonstrated the d...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930350205

    authors: Keyhani-Rofagha S,O'Dorisio TM,Lucas JG,Fontana MB,Tuttle SE

    更新日期:1987-06-01 00:00:00