Abstract:
BACKGROUND AND OBJECTIVES:Adipokines may explain the newly established association of obesity with hepatocellular carcinoma (HCC). This study investigated if adiponectin levels in HCC patients differed from healthy controls and their potential effect in the development of HCC. METHODS:Radioimmunoassay was used to determine serum adiponectin levels of 65 HCC patients and 165 healthy controls. The expressions of adiponectin protein in the tumor and adjacent non-tumor parts were examined by the immunoblotting method. Cell proliferation assays were used to assess the bioeffects of adiponectin in two human liver cancer cell lines. RESULTS:Serum adiponectin levels were significantly higher in the HCC patients than the controls. Significant correlations of serum adiponectin levels with serum triglyceride levels and insulin resistance were found in the controls, but not in the HCC patients. In contrast, serum adiponectin levels significantly correlated with serum albumin and alkaline phosphatase levels in the HCC patients, but this trend was not observed in the controls. The expression pattern of adiponectin protein between the paired tumor and adjacent non-tumor tissues significantly correlated with tumor size. In vitro, adiponectin increased cell proliferation in a dose-dependent manner. CONCLUSIONS:Increased adiponectin expressions were found in HCC and this increase might contribute to tumor growth.
journal_name
J Surg Oncoljournal_title
Journal of surgical oncologyauthors
Chen MJ,Yeh YT,Lee KT,Tsai CJ,Lee HH,Wang SNdoi
10.1002/jso.23059subject
Has Abstractpub_date
2012-08-01 00:00:00pages
181-7issue
2eissn
0022-4790issn
1096-9098journal_volume
106pub_type
杂志文章abstract::Breast cancers from 53 patients were explanted in culture, and 39 with two-year or more follow-up and documentable tissue forms of cancer in culture (histoculture) are the subject of this report. Clinicopathologic findings have been correlated with dynamic aspects of the cancers in short-term histocultures, including ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930130103
更新日期:1980-01-01 00:00:00
abstract:BACKGROUND:Esophageal anastomotic leak is associated with high morbidity and mortality and potentially lethal if not recognized promptly and treated aggressively. While many studies have attempted to delineate the surgical techniques associated with lower rates of anastomotic leak, few have attempted to determine its l...
journal_title:Journal of surgical oncology
pub_type: 临床试验,杂志文章
doi:10.1002/jso.23902
更新日期:2015-06-01 00:00:00
abstract::Surgery is a mainstay of primary breast cancer therapy. Alterations in surgical technique have reduced normal tissue injury, yet pain and functional compromise continue to occur following treatment. A tenuous evidence base bolstered by considerable expert opinion suggests that early intervention with conventional reha...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.20782
更新日期:2007-04-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Argyrophilic nucleolar organizer regions (AgNORs) have been recently identified as a marker of proliferative index in various tumors. These were evaluated in 46 patients with primary breast carcinoma and were correlated with clinical prognostic parameters of breast cancer. Ten patients with be...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/(sici)1096-9098(199707)65:3<201::aid-jso10
更新日期:1997-07-01 00:00:00
abstract:BACKGROUND:Somatostatin analog functional imaging with gallium-68 (Ga-68) dotatate positron emission tomography/computed tomography (PET/CT) has demonstrated superiority in lesion detection in patients with neuroendocrine tumors (NETs). The clinical impact of this imaging modality on US surgical and medical oncology pr...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.25812
更新日期:2020-03-01 00:00:00
abstract:OBJECTIVE:Three-dimensional (3D) printing has become widely available, and a few cases of its use in clinical practice have been described. The aim of this study was to explore facilities for the semi-automated delineation of breast cancer tumors and to assess the feasibility of 3D printing of breast cancer tumors. ME...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.24510
更新日期:2017-03-01 00:00:00
abstract:BACKGROUND:Hepatic arterial infusion chemotherapy (HAIC) has been recognized as one of the effective treatments for patients with hepatic metastatic tumor. However it is difficult to perform HAIC in the long term without complications. This report describes the laparotomic approach using the side holed catheter, which ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.20283
更新日期:2005-08-01 00:00:00
abstract:PURPOSE:The aims of the study were to estimate the frequency of epiphora and to identify factors associated with epiphora after orbital-sparing maxillectomy via modified Weber-Ferguson incision with lower blepharoplasty (OSOSM-MWFILB). METHODS:We performed a retrospective cohort study enrolling a sample derived from t...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.26408
更新日期:2021-02-01 00:00:00
abstract::Leiomyoma of the rectum and anal canal is an unusual clinical entity. Generally, it does not produce any clinical signs and in most cases it is discovered incidentally in the course of routine rectal examination. The clinical presentation, diagnosis, and surgical treatment are described in two presented cases of anal ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930330210
更新日期:1986-10-01 00:00:00
abstract:BACKGROUND:The purpose of the present study was to assess the value of matrix metalloproteinase (MMP)-2 and MMP-9 expression and other potential prognostic factors in predicting the clinical outcome of patients after definitive surgery for pathologic stage IA non-small cell lung cancer (NSCLC). METHODS:One hundred and...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.22001
更新日期:2011-12-01 00:00:00
abstract::Tumors attached or adjacent to critical structures can often not be completely resected or resected with adequate surgical margins. Sites involving major blood vessels, the paravertebral spaces, or critical abdominal structures often present technical difficulties for standard brachytherapy procedures using I-125 or I...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930420112
更新日期:1989-09-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Recent studies have disclosed the presence of somatic mutations in the epidermal growth factor receptor (EGFR) gene in non-small cell lung cancers (NSCLC), and susceptibility to the EGFR tyrosine kinase inhibitor (gefitinib) was determined by the presence of mutations in the kinase domain of t...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.20426
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:F-18 fluorodeoxyglucose-positron emission tomography (FDG-PET) has been used for diagnosis and staging of malignant diseases. However, the prognostic significance of FDG uptake on PET had not been sufficiently evaluated in patients with biliary carcinoma. METHODS:We performed a retrospective ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.21356
更新日期:2009-11-01 00:00:00
abstract::Three patients with unresectable malignant retroperitoneal tumors that invaded and perforated the distal duodenum presented with sepsis unresponsive to antibiotics. A technique of proximal side-to-side duodenojejunostomy with stapled occlusion of the distal duodenum resulted in successful diversion and immediate resol...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930260410
更新日期:1984-08-01 00:00:00
abstract::The cases of 42 patients with malignant ascites treated with a peritoneal venous shunt over a 5-year period are reviewed to establish the incidence of surgical and postsurgical complications. Although the yield of malignant cells found in the peripheral blood was increased after shunting, no new hematogenous metastase...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930330109
更新日期:1986-09-01 00:00:00
abstract::The clinicopathologic features of a case of malignant Brenner tumor with bilateral ovarian involvement are described. The tumor was apparently confined within the ovaries at initial laparotomy. However, multiple skeletal metastases developed 4 months later and the patient died of the disease 6 months after diagnosis. ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930260312
更新日期:1984-07-01 00:00:00
abstract::Perineural invasion is associated with tumor spreading and an unfavorable prognosis in a variety of cancers. Recently, neural cell adhesion molecule (NCAM) has been reported to be affinitive to neural tissues, which suggests some relationship between NCAM and perineural invasion. This study was designed to elucidate t...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930530205
更新日期:1993-06-01 00:00:00
abstract::The aim of this study was to investigate the compound 4-nitro-1-cyclohexyl-3-ethoxy-2-oxo-3-pyrroline (NOPYE) and some related compounds for skin sensitization in guinea pigs, as the first step in a search for more effective skin sensitizers for immunotherapy of cutaneous tumors. In guinea pigs, NOPYE and NOPYE-L-alan...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930130209
更新日期:1980-01-01 00:00:00
abstract::Responsiveness of experimental chemotherapy on human cancer xenografts in nude mice was directly compared with clinical response to the same chemotherapy in their donor patients. These xenografts were 1 line of rectal cancer (H-26), two lines of gastric cancer (H-08 and H-22), and 1 line of breast cancer (H-62). Exper...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930150304
更新日期:1980-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:We assessed the optimal extent of lymph node dissection and the effect of splenectomy in patients with proximal gastric cancer. METHOD:Recurrence and survival rates were compared between 881 patients with proximal gastric cancer who underwent modified radical lymphadenectomy and 3,098 patient...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.21137
更新日期:2008-12-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:The genetic alterations involved in extrahepatic bile duct (EHBD) cancer are poorly understood. Our aim was to identify aberrations of the K-ras, p53, and APC genes in EHBD cancer. METHODS:We investigated aberrations of these genes in 52 EHBD cancers using polymerase chain reaction (PCR) sing...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/(sici)1096-9098(200003)73:3<158::aid-jso9>
更新日期:2000-03-01 00:00:00
abstract::Patients undergoing neoadjuvant therapy for esophageal cancer are at a high risk for malnutrition due to the effects of chemoradiation, dysphagia, and malignancy induced cachexia. Preparation for esophagectomy requires careful assessment of nutritional risk and adequate supplementation as indicated. Supplementation vi...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.21289
更新日期:2009-07-01 00:00:00
abstract::Invasive fungal infections have emerged as a significant problem in patients with cancer with the development of better systemic therapies for malignancy and more effective antibacterial agents. The currently available world published medical literature was reviewed on invasive fungal infections in cancer patients wit...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.20115
更新日期:2004-10-01 00:00:00
abstract::Recently we resected and reconstructed the sternum in two female patients with thyroid carcinoma metastatic to the sternum. Histological diagnosis of the metastatic lesion was follicular carcinoma in the first case and papillary carcinoma in the second case. Reconstruction of the sternum was accomplished by using an a...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930600413
更新日期:1995-12-01 00:00:00
abstract:BACKGROUND:Use of hospice services among patients with pancreatic cancer following pancreatic resection remains unknown. METHODS:Patients with pancreatic cancer who underwent resection were identified in the Medicare Standard Analytic Files. Outcomes included overall hospice use, early hospice enrollment (≥4 weeks bef...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.25623
更新日期:2019-09-01 00:00:00
abstract::A poorly differentiated transitional cell carcinoma in C3H/He mice results from the oral ingestion of the urinary tract carcinogen FANFT. This model, designated MBT2, is readily transplantable into syngeneic animals and has proven to be very useful in the development of chemotherapy. Prior to the use of this model for...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930240113
更新日期:1983-09-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Accurately assessing breast volume (BV) relative to the volume of breast tissue to be removed could help objectively determine the optimal surgical candidates for breast conserving surgery. The objective of this study was to determine the optimal mammography-based method of BV estimation. MET...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.25076
更新日期:2018-06-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Soft tissue sarcomas of the head and neck (STSHN) comprise a rare group of malignancies. Our objective is to determine the utility of soft tissue sarcoma staging systems within the head and neck, and to validate an individualized soft tissue sarcoma nomogram within head and neck primary sites....
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.23868
更新日期:2015-05-01 00:00:00
abstract:INTRODUCTION:The Siewert classification has been used to plan treatment for tumours of the gastro-oesophageal junction since its proposal in the 1980s. The purpose of this study was to assess its continued relevance by evaluating whether there were differences in the biology and clinical characteristics of adenocarcino...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.23484
更新日期:2014-03-01 00:00:00
abstract:BACKGROUND:The most effective treatment for patients with esophageal small cell carcinoma has not yet been established because of the overall extremely poor prognosis regardless of the mode of treatment. The role of esophagectomy has been controversial in the management of patients with this disease. METHODS:The clini...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/(sici)1096-9098(199702)64:2<130::aid-jso8>
更新日期:1997-02-01 00:00:00