Abstract:
BACKGROUND:Somatostatin analog functional imaging with gallium-68 (Ga-68) dotatate positron emission tomography/computed tomography (PET/CT) has demonstrated superiority in lesion detection in patients with neuroendocrine tumors (NETs). The clinical impact of this imaging modality on US surgical and medical oncology practices has not been established. METHODS:Consecutive patients with NET at our institution who received an initial Ga-68 dotatate PET/CT between July 2017 and September 2018 were included. Ga-68 dotatate PET/CT was compared with prior imaging. RESULTS:Among 101 eligible patients, 51 of 50 were female/male, site of origin was gastroenteropancreatic (75%), unknown primary (13%), lung (8%), thymus (2%), and other (2%). All NETs were histologically well/moderately differentiated. Ga-68 dotatate imaging findings altered management in 36 (35.6%) patients: documentation of progression led to the initiation of systemic therapy in 14 patients, obviated the need for biopsy in four patients, and altered surgical plans in 7 of 14 (50%) patients referred for surgery. In 11 patients, decisions regarding peptide receptor radionucleotide therapy and somatostatin analogs were altered. CONCLUSIONS:In this series, Ga-68 dotatate PET/CT altered diagnosis and management in one-third of patients and changed operative plans in half of the patients who were referred for surgical evaluation. These results support the routine use of this imaging in the care of patients with early-stage and advanced NETs.
journal_name
J Surg Oncoljournal_title
Journal of surgical oncologyauthors
Crown A,Rocha FG,Raghu P,Lin B,Funk G,Alseidi A,Hubka M,Rosales J,Lee M,Kennecke Hdoi
10.1002/jso.25812subject
Has Abstractpub_date
2020-03-01 00:00:00pages
480-485issue
3eissn
0022-4790issn
1096-9098journal_volume
121pub_type
杂志文章abstract:BACKGROUND:Recurrent pleomorphic adenoma (PA) of the parotid gland is a challenging surgical issue with controversy regarding management and long term outcome. METHODS:All patients who were operated for recurrent PA of the parotid gland between the years 1991 and 2013 were reviewed. Patient demographics, clinicopathol...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.24392
更新日期:2016-11-01 00:00:00
abstract::Tumor-associated antigen(s) from a specimen of human malignant melanoma and from spent culture medium of a melanoma cell line were extracted and purified. The incidence of antibody activity to these antigens, in sera from cancer patients with neoplasms of various histologic types, was higher (65--83%) than normal dono...
journal_title:Journal of surgical oncology
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doi:10.1002/jso.2930130112
更新日期:1980-01-01 00:00:00
abstract:BACKGROUND:Sentinel node biopsies (SNBs) have been clinically applied in melanoma and breast cancer for limited lymphadenectomy. However, the use of SNB remains controversial in gastric cancer due to unsatisfactory sensitivity and variability. This meta-analysis was performed to determine the sensitivity of SNB in gast...
journal_title:Journal of surgical oncology
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更新日期:2011-11-01 00:00:00
abstract::Sentinel lymph node (sN) biopsy has gained special attention among surgical and medical oncologists as it represents an accepted technique for detecting occult nodal disease in regional lymph nodes of patients with melanoma and breast cancer. The histopathologic examination of the sN may well predict regional lymph no...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.20031
更新日期:2004-03-01 00:00:00
abstract:BACKGROUND:This study aimed to compare voiding and male sexual dysfunction between open and laparoscopic rectal cancer surgery. METHODS:Ninety-seven patients (62 male and 35 female) who underwent open (n = 41) or laparoscopic (n = 56) surgery for rectal cancer were prospectively enrolled. Urine flowmetry, the internat...
journal_title:Journal of surgical oncology
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doi:10.1002/jso.23435
更新日期:2013-12-01 00:00:00
abstract::A case of symptomatic granular cell tumor of the esophagus is described. Another 32 cases collected from the English literature are analyzed. The reported cases have occurred mostly in women of less than 50 years of age presenting with dysphagia. Excision of the lesion is curative. ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930330409
更新日期:1986-12-01 00:00:00
abstract:BACKGROUND:Heme oxygenase-1 (HO-1) correlates with aggressive tumor behavior and chemotherapy resistance in pancreatic cancer (PC). We evaluated the prognostic value of the basal transcription controlling germ line GTn repeat polymorphism (GTn) in the promoter region of the HO-1 gene in PC. PATIENTS AND METHODS:We det...
journal_title:Journal of surgical oncology
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doi:10.1002/jso.21926
更新日期:2011-09-01 00:00:00
abstract::Cecal carcinoma has been associated with a poorer prognosis than other colon carcinomas because of the presumed longstanding obscure symptoms. In a combined study of three Dutch hospitals, a total of 166 patients with cecal carcinoma were evaluated after right hemicolectomy. Special emphasis was placed on clinical sym...
journal_title:Journal of surgical oncology
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doi:10.1002/jso.2930440309
更新日期:1990-07-01 00:00:00
abstract::Up to 50% of patients with colorectal cancer will develop metastatic disease in the liver. While surgical extirpation remains the best option for long-term survival, several complementary modalities such as laparoscopy, radiofrequency ablation, and microwave coagulation have gained wide acceptance as primary and adjun...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.21720
更新日期:2010-12-15 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Uncertainty exists about the value of cancer therapy in patients aged 90 years and older. Because of the relative paucity of these patients, as well as the possibility of selection bias in any one institution, the use of a large, total population-based cancer registry was employed. METHODS:Th...
journal_title:Journal of surgical oncology
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更新日期:2002-11-01 00:00:00
abstract:BACKGROUND:Identification of functional lymphatic vessels and localization of lymphatic vessels are important for lymphaticovenular anastomosis (LVA). Indocyanine green (ICG) lymphography is useful for localization of superficial lymphatic vessels where dermal backflow is not observed, but not for lymphatic vessels in ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.24812
更新日期:2018-02-01 00:00:00
abstract:BACKGROUND:Studies for patients with pelvic chondrosarcomas are limited. This study determines the outcome of patients with pelvic chondrosarcomas, and whether there is any association with tumors' grade, type, stage, margins and pelvic location. MATERIALS AND METHODS:We retrospectively studied 215 patients with pelvi...
journal_title:Journal of surgical oncology
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doi:10.1002/jso.23351
更新日期:2013-07-01 00:00:00
abstract::Adenocarcinomas of the trachea are rare but important because the only reported treatment in the past (radiation) has resulted in uniformly poor results. The authors recently had the opportunity to treat a young woman with a mucin-producing adenocarcinoma of the trachea. A sleeve resection of the involved trachea with...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930280108
更新日期:1985-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:There is paucity of studies on the predictors of bladder cancer (BC) management costs. We aimed to determine predictors of costs associated with radical cystectomy (RC) for BC. METHODS:We conducted a retrospective analysis in a cohort of 2,759 patients who underwent RC for BC between 2000 and...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.24132
更新日期:2016-02-01 00:00:00
abstract::A primary retroperitoneal dermoid cyst (benign cystic teratoma) is described in a 64-year-old male, who died postoperatively of a leaking grafted abdominal aortic aneurysm. The asymptomatic tumor, measuring 12 cm in greatest diameter, showed an extensive sclerosing lipogranulomatous reaction in its wall and wide-sprea...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930140102
更新日期:1980-01-01 00:00:00
abstract:BACKGROUND:The aim of this study was to analyze the potential utilization of external jugular vein (EJV) cutdown approach for totally implantable venous access device (TIVAD) placement. METHODS:This is a prospective, non-randomized, observational, uni-institutional study. All patients (n = 451) were first subjected to...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.21341
更新日期:2009-09-01 00:00:00
abstract:OBJECTIVE:To determine whether serum prealbumin levels are associated with long-term survival after hepatectomy in patients with primary hepatocellular carcinoma(HCC). METHODS:A consecutive sample of 526 patients with HCC who underwent potentially curative hepatectomy from August 2007 to August 2010 was retrospectivel...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.25378
更新日期:2019-05-01 00:00:00
abstract::Eight patients with sciatic nerve and sacral plexus nerve sheath tumors, seen at Louisiana State University Medical Center in Shreveport, are presented. These cases illustrate the broad spectrum of pathology and modes of presentation of patients with nerve sheath tumors in this region. Patients can be divided into 4 g...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930390103
更新日期:1988-09-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Despite advances in early detection of colon cancer, a minority of patients still require urgent surgery. Whether such urgent conditions result in poor outcome remains a topic of debate. METHODS:Using a prospectively maintained database, patients suffering exclusively from colon cancer and re...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.25469
更新日期:2019-06-01 00:00:00
abstract::At present, limb-sparing surgery is the most appropriate and acceptable treatment available for sarcomas of the extremities, although the right balance between conservative therapy and maximum efficacy has yet to be found. A better knowledge of prognostic factors may help in planning the appropriate strategy for each ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/(SICI)1096-9098(199609)63:1<3::AID-JSO2>3.
更新日期:1996-09-01 00:00:00
abstract:BACKGROUND:This retrospective study was conducted to compare the treatment and quality of life (QOL) results between radical surgery and definitive chemoradiotherapy (CRT) for stage II-III carcinoma of the esophagus. METHODS:Between 2000 and 2009, 128 consecutive patients were selected for this study in which 72 were ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.21361
更新日期:2009-11-01 00:00:00
abstract::Analysis of functional status of 197 breast cancer patients three years after curative radical mastectomy indicated a cumulative probability of disability of 25%, whereas the probability of death regardless of prior disability was 40.5%. Analysis of functional status by patient characteristics indicated that nonwhites...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
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更新日期:1979-01-01 00:00:00
abstract:INTRODUCTION:Alpha-fetoprotein (AFP) has a valuable role in postoperative surveillance for hepatocellular carcinoma (HCC) recurrence. The utility of pretreatment or baseline AFP remains controversial. The present study hypothesized that elevated baseline AFP levels are associated with worse overall survival in HCC pati...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
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更新日期:2017-12-01 00:00:00
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journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.25021
更新日期:2018-06-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:To evaluate the impact of plasminogen activator (PA) system genes, including urokinase plasminogen activator (uPA), uPA receptor (uPAR), and plasminogen activator inhibitor-1 (PAI-1) gene polymorphisms in patients with the cervical neoplasia. METHODS:In total, 336 blood samples were collected...
journal_title:Journal of surgical oncology
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doi:10.1002/jso.23072
更新日期:2012-08-01 00:00:00
abstract::In settings when it is biologically plausible that some patients are cured after definitive treatment, cure models present an alternative to conventional survival analysis. Cure models can inform on the group of patients cured, by estimating the probability of cure, and identifying factors that influence it; while sim...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.23411
更新日期:2013-11-01 00:00:00
abstract::Whole breast reconstruction using autologous tissue is the gold standard in many regions of the world. Reasons include breast replacement with native skin and fat, ability to shape and mold the tissue into a breast, no foreign materials are necessary, and it lasts forever when successful. There are now many options fo...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
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更新日期:2016-06-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:There have been few reports on the objective assessment of quality of life (QOL) in patients with gastric cancer following palliative operations. The benefit of a palliative operation for survival and QOL of patients with gastric cancer is not clear. METHODS:Survival and hospital-free surviva...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/(sici)1096-9098(199809)69:1<41::aid-jso8>3
更新日期:1998-09-01 00:00:00
abstract:OBJECTIVES:To identify the prognostic implications of human papillomavirus (HPV)-related cell cycle marker profiles in patients who have received a transoral lateral oropharyngectomy (TLO) as a primary treatment for tonsillar squamous cell carcinoma (TSCC). PATIENTS AND METHODS:Immunohistochemical profiles of HPV-rela...
journal_title:Journal of surgical oncology
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更新日期:2014-09-01 00:00:00
abstract::Correlations between levels of tissue polypeptide antigen (TPA) in serum and histologic stage or progression of cancer were studied in 94 patients with gastric cancer. Levels of TPA in serum from patients with cancerous invasion into the vein of the stomach wall (v-invasion) were elevated in parallel to the progressio...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930410214
更新日期:1989-06-01 00:00:00