Correlation between serum prealbumin and prognosis of patients with hepatocellular carcinoma after hepatectomy.

Abstract:

OBJECTIVE:To determine whether serum prealbumin levels are associated with long-term survival after hepatectomy in patients with primary hepatocellular carcinoma(HCC). METHODS:A consecutive sample of 526 patients with HCC who underwent potentially curative hepatectomy from August 2007 to August 2010 was retrospectively analyzed. Patients were classified as having normal or reduced serum prealbumin based on cut-off values of 200 or 182 mg/L. RESULTS:Multivariate analysis identified the preoperative level of serum prealbumin as an independent prognostic factor of long-term survival (P < 0.05): Survival was significantly better for those with normal levels than for those with reduced levels, based on either cut-off value. Similar results were observed in subgroup analyses based on the degree of cirrhosis, level of ɑ-fetoprotein and Barcelona Clinic Liver Cancer stage. CONCLUSIONS:Preoperative level of serum prealbumin may be useful for predicting long-term survival in patients with HCC after hepatectomy.

journal_name

J Surg Oncol

authors

Jia RR,Zhong JH,Huo RR,Su QB,Xiang X,Zhao FL,Qin ZB,Chen JH,Liao YY,Ma L,Xiang BD,Zhang CY,Li LQ

doi

10.1002/jso.25378

subject

Has Abstract

pub_date

2019-05-01 00:00:00

pages

794-800

issue

6

eissn

0022-4790

issn

1096-9098

journal_volume

119

pub_type

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