Abstract:
:UDP-galactose:N-acetylglucosamine galactosyltransferase (GT) is a membrane-bound enzyme active in the biosynthesis of the carbohydrate moiety of glycoproteins and glycolipids. A soluble form of GT, present in human serum, has recently been found to be elevated in the presence of various neoplasms. In this study, GT levels were measured in randomized serum samples obtained from normal controls (group I, n = 49), patients with benign breast disease (group II, n = 46), disease controls (group III, n = 50), patients with primary breast carcinoma (group IV, n = 53), and untreated metastatic breast cancer (group V, n = 23). Although substantial serum GT elevations were observed in individual control patients with active inflammatory or metabolic diseases, the mean GT levels were significantly higher in the groups with breast carcinoma (P < 0.001, 0.001, 0.02; P < 0.001, 0.001, 0.001 for groups IV and V vs groups, 1, II, and III, respectively). Furthermore, when serum GT levels were correlated with the properative clinical stage of breast cancer, significant elevations were found in 14.3% (3/21) of stage I, 66.7% (8/12) of stage II, 78.6% (11/14) of stage III, and 96.5% (28/29) of stage IV patients. These data indicate that serum GT levels are elevated in the presence of breast carcinoma and that the enzyme elevations correlate positively with the clinical stage of disease. Serum GT may be potentially useful in the detection of recurrent breast carcinoma and as a marker of tumor response to therapy for advanced disease.
journal_name
J Surg Oncoljournal_title
Journal of surgical oncologyauthors
Paone JF,Waalkes TP,Baker RR,Shaper JHdoi
10.1002/jso.2930150110subject
Has Abstractpub_date
1980-01-01 00:00:00pages
59-66issue
1eissn
0022-4790issn
1096-9098journal_volume
15pub_type
杂志文章abstract:INTRODUCTION:Local recurrence and peritoneal dissemination is common after intentionally curative resection of colorectal carcinoma. It is not yet clear which mechanisms stimulate post-operative intra-abdominal tumor development. Enhanced adhesion or growth of tumor cells and/or post-operative immuno suppression may in...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.20273
更新日期:2005-11-01 00:00:00
abstract::Maximum diameter, tumour volume, and inflammatory response of host tissue in 282 surgical specimens with primary carcinoma of the bronchus were measured. Cell type, pT- and pN-stage, maximum diameter and volume of the primaries, and inflammatory response of host tissue were analyzed in respect to survival of the patie...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930360203
更新日期:1987-10-01 00:00:00
abstract::Surgery is a mainstay of primary breast cancer therapy. Alterations in surgical technique have reduced normal tissue injury, yet pain and functional compromise continue to occur following treatment. A tenuous evidence base bolstered by considerable expert opinion suggests that early intervention with conventional reha...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.20782
更新日期:2007-04-01 00:00:00
abstract::The aim was to evaluate sentinel node detection capacity by means of a magnetic probe in 11 patients with oral squamous cell carcinoma at stages T1-T2 received submucosal injections of a superparamagnetic iron oxide contrast agent (SPIO). A magnetic probe was used for sentinel node biopsy. The use of SPIO and magnetic...
journal_title:Journal of surgical oncology
pub_type:
doi:10.1002/jso.25810
更新日期:2019-12-15 00:00:00
abstract:BACKGROUND/OBJECTIVES:To report on the clinical presentation and outcome for 234 patients with extra-abdominal desmoids tumors. METHODS:Since 1977, the authors have treated 234 patients with extra-abdominal desmoid tumors. The patients had an average age of 36.7 and 61% were female. The tumors arose adjacent to muscle...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.21433
更新日期:2010-10-01 00:00:00
abstract::The efficacy of killing small cell lung cancer (SCLC) cells at the G1, S, and G2-M phase of the cell-cycle by a new 111In-bleomycin complex (111In-BLMC) was investigated. SCLC cells (N417, H526, H209) were synchronized by double thymidine block and assessed by DNA content with flow cytometry, and the period for the ma...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930400203
更新日期:1989-02-01 00:00:00
abstract::Twenty-two inflammatory, benign, or malignant parotid lesions were studied by means of the specific red cell adherence test (SRCA), a modification of the Coombs' mixed cell agglutination reaction. In 22 normal parotid tissues the acinar structures were devoid of red cell agglutination, but it was present in ductal epi...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930240306
更新日期:1983-11-01 00:00:00
abstract::Twenty-six patients with esophageal carcinoma at stage pT4 underwent esophagectomy with lymph node dissection leaving part of the tumor in adjacent organs. Several plastic catheters were fixed to the tumor bed and led to the outside of the thorax for postoperative brachytherapy. Using these catheters, the patients und...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/(SICI)1096-9098(199607)62:3<214::AID-JSO12
更新日期:1996-07-01 00:00:00
abstract::Mucin-producing tumors of the pancreas (MPT) are characterized by the production of much mucin and a benign course after surgical treatment. We examined 16 cases of MPT and 20 cases of "common" pancreatic duct cell carcinomas (DCC) in regard to K-ras and p53 mutations. The mutations were detected by constant denaturan...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930550205
更新日期:1994-02-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Stage II colon cancer is primarily a surgical disease. Only a still not well-defined subset of patients may benefit from postoperative adjuvant chemotherapy. The relationship between adjuvant chemotherapy and survival after relapse is furthermore still not definitely explored in this group of ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.25798
更新日期:2019-12-11 00:00:00
abstract:BACKGROUND:The role of surgical resection in the treatment of patients with metastatic/recurrent gastrointestinal stromal tumors (GIST) is unclear. The aim of this study was to identify preoperative factors associated with oncologic outcomes for recurrent/metastatic GIST after tyrosine kinase inhibitor (TKI) therapy. ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.24988
更新日期:2018-04-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Primary retroperitoneal tumors constitute a rather uncommon disease with an incidence of 2 in 100,000. Local recurrence after surgical resection is reported between 60% and 90% at 10 yr. The aim of this study was to present the problem of satellite tumors around the main tumor mass and their p...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/(sici)1096-9098(199805)68:1<30::aid-jso7>3
更新日期:1998-05-01 00:00:00
abstract::A malignant mesenchymoma consisting of nerve sheath sarcoma and liposarcoma occurred in the right median nerve of a 29-year-old man who did not have stigmata of von Recklinghausen neurofibromatosis. It produced pain at the affected part, referred pain to the palm, and weakness of muscles supplied by branches of this n...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930250214
更新日期:1984-02-01 00:00:00
abstract::This article describes the Danish National Indicator Project that aims to document and improve the quality of care at national level. Specific clinical indicators, standards, and prognostic factors have been developed for eight diseases (e.g. lung cancer). It has been implemented in all clinical departments in Denmark...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.21192
更新日期:2009-06-15 00:00:00
abstract::Selective sentinel lymph node dissection (SLND) plays an important role in the staging of the regional nodal basins for head and neck (H&N) melanoma. Preoperative lymphoscintigraphy is mandatory to identify the regional nodal basin(s) accurately for a newly diagnosed H&N primary melanoma of at least 1mm or greater. A ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.21964
更新日期:2011-09-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:To compare 3-year clinical outcomes of radiofrequency ablation (RFA) targeting 5- or 10-mm margins for small hepatocellular carcinomas (HCCs) in cirrhotic patients. METHODS:In total, 96 cirrhotic patients with a small solitary HCC (diameter ≤3 cm) were included in this prospective trial (ChiC...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,随机对照试验
doi:10.1002/jso.24607
更新日期:2017-06-01 00:00:00
abstract::Thirty-eight cases of advanced upper gastrointestinal cancer were assessed for their immune status prior to any form of therapy. Cell-mediated immunity, as tested by absolute lymphocyte count, T-cell count and delayed cutaneous hypersensitivity reactions to purified protein derivative and phytohemagglutinin showed sev...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930290113
更新日期:1985-05-01 00:00:00
abstract::Little information is available regarding acute upper gastrointestinal bleeding as a presenting sign of gastric carcinoma. Of 427 patients with gastric cancer, 36 (8.4%) underwent early endoscopy due to hematemesis. The hemorrhage was self-limited in 16 patients (44.4%), most of whom underwent elective surgery. Twenty...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930360212
更新日期:1987-10-01 00:00:00
abstract:UNLABELLED:Thirty-three patients with primary gastrointestinal lymphoma (GIL) followed at Ankara University Medical School have been evaluated. The most frequent locations of the disease are the small intestine (48.4%) and the stomach (39.3%). The intermediate and high grade lymphomas constitute 84.8% of the cases. The...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930510414
更新日期:1992-12-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:The objectives of this study were to investigate the role of growth factors and matrix metalloproteinases in the brain metastasis. METHODS:Tumors from 40 patients with brain metastasis (30 lung cancer, 10 breast cancer) were studied to investigate the expression-patterns of EGFR, MT1-MMP, MMP...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.21296
更新日期:2009-07-01 00:00:00
abstract:BACKGROUND:Familial soft tissue sarcomas are extremely rare. There is little information available on the clinical features and molecular findings of the hereditary occurrence of mesenchymal tumor. PATIENTS AND METHODS:A woman and her younger brother had malignant fibrous histiocytoma (pleomorphic type) and liposarcom...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.20720
更新日期:2007-03-15 00:00:00
abstract:BACKGROUND AND OBJECTIVES:We present the long-term functional results of a new technique for bladder substitution after cystectomy for bladder cancer in women. METHODS:Between 1991 and 1995, 10 women underwent radical cystectomy for bladder cancer with a new technique. We created a detubularized rectosigmoid neobladde...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/1096-9098(200005)74:1<49::aid-jso12>3.0.co
更新日期:2000-05-01 00:00:00
abstract:BACKGROUND:Increased activity of Src has been found in several human cancers, and often is associated with poor clinical outcome. The present study aimed to determine whether Src activity is increased in gastrointestinal stromal tumors (GIST), and whether it correlates with established tumor or patient characteristics ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.23544
更新日期:2014-05-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:Destructive metastatic lesions about the acetabulum result in pain and functional limitations. We assessed whether periacetabular reconstruction (PAR) improves quality of life by examining outcome measures of pain, function, and mobility. METHODS:Thirty-seven patients with a mean follow-up of 23....
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.21440
更新日期:2010-02-01 00:00:00
abstract:BACKGROUND:Unresectable tumors of the pancreatic head are encountered in up to 20% of patients taken for resection. The objective of this study was to evaluate the complications and outcome associated with palliative surgical procedures to help guide management decisions in these patients. METHODS:Patients with pancre...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.23560
更新日期:2014-06-01 00:00:00
abstract::The serum copper/zinc ratio was measured in 44 patients bearing primary large bowel malignancies. Measurements were repeated following removal of the primary tumour and again at the time of development of clinical evidence of cancer recurrence in order to evaluate the clinical value of the ratio to accurately reflect ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930210407
更新日期:1982-12-01 00:00:00
abstract:BACKGROUND:Subtotal stomach preserving pancreaticoduodenectomy (SSPPD) is compared retrospectively with pylorus preserving pancreaticoduodenectomy (PPPD). METHODS:During 2002-2005, 21 patients (13 female, 8 male) underwent SSPPD. The mean age was 64.3 (range 33-80). PPPD was performed for 12 patients after 1999. Days ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.20608
更新日期:2007-02-01 00:00:00
abstract::A retrospective review is presented of 20 evaluable patients who underwent surgical resection or biopsy for limited stage thyroid carcinoma at two institutions between 1963 and 1983. The majority had external radiotherapy to the whole neck and upper mediastinum and the total dose given varied from 3,800 to 6,000 rads....
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930300205
更新日期:1985-10-01 00:00:00
abstract::Six hundred sixty-eight patients with tumours of the larynx were treated by radiotherapy. The patients had stage T1 N0 M0 to T4 N3 M0 disease. Patients with T1 N0 M0 disease (273) had an excellent long-term survival (90%) as did those with T2 N0 M0 disease (142), whose 5-year survival was 70%. Patients with more advan...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930350402
更新日期:1987-08-01 00:00:00
abstract:BACKGROUND:Immediate breast reconstruction has many advantages but is associated with higher complication rates than delayed reconstruction. Complications can delay the delivery of adjuvant cancer treatments. This study aimed to develop and validate a risk stratification model for the prediction of perioperative compli...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.25714
更新日期:2019-12-01 00:00:00