Abstract:
INTRODUCTION:The ACS-NSQIP surgical risk calculator is an open-access on-line tool that estimates the risk of adverse post-operative outcomes for a wide range of surgical procedures. Wide surgical resection of soft tissue sarcoma (STS) often requires complex reconstructive procedures that can be associated with relatively high rates of complications. This study evaluates the ability of this calculator to identify patients with STS at risk for post-operative complications following flap reconstruction. METHODS:Clinical details of 265 patients who underwent flap reconstruction following STS resection were entered into the online calculator. The predicted rates of complications were compared to the observed rates. The calculator model was validated using measures of prediction and discrimination. RESULTS:The mean predicted rate of any complication was 15.35 ± 5.6% which differed significantly from the observed rate of 32.5% (P = 0.009). The c-statistic was relatively low at 0.626 indicating poor discrimination between patients who are at risk of complications and those who are not. The Brier's score of 0.242 was significantly different from 0 (P < 0.001) indicating poor correlation between the predicted and actual probability of complications. CONCLUSION:The ACS-NSQIP universal risk calculator did not maintain its predictive value in patients undergoing flap reconstruction following STS resection. J. Surg. Oncol. 2016;114:570-575. © 2016 Wiley Periodicals, Inc.
journal_name
J Surg Oncoljournal_title
Journal of surgical oncologyauthors
Slump J,Ferguson PC,Wunder JS,Griffin A,Hoekstra HJ,Bagher S,Zhong T,Hofer SO,O'Neill ACdoi
10.1002/jso.24357subject
Has Abstractpub_date
2016-10-01 00:00:00pages
570-575issue
5eissn
0022-4790issn
1096-9098journal_volume
114pub_type
杂志文章abstract:BACKGROUND:The choice of performing surgery when tumors encroach onto joints remains a challenging and controversial issue. Pre-operative assessment by magnetic resonance imaging (MRI) is of critical importance in dictating surgical management and subsequent functional outcome. METHODS:We examined archival samples fro...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.20268
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abstract:BACKGROUND:Detection of tumor cells in lymph nodes (LNs) removed during the treatment of pulmonary tumor by radical surgery is limited by the possibilities of standard histopathological methods. The goal of this study was to obtain more accurate pTNM status by a more sensitive detection of micrometastases in LNs. METH...
journal_title:Journal of surgical oncology
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abstract:BACKGROUND AND OBJECTIVES:Stage II colon cancer is primarily a surgical disease. Only a still not well-defined subset of patients may benefit from postoperative adjuvant chemotherapy. The relationship between adjuvant chemotherapy and survival after relapse is furthermore still not definitely explored in this group of ...
journal_title:Journal of surgical oncology
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更新日期:2019-12-11 00:00:00
abstract:BACKGROUND:Cytoreductive surgery (CRS) and hyperthermic intra-peritoneal chemotherapy (HIPEC) treatment of colorectal peritoneal metastases (PM) is an established treatment alternative. The study aim was, first, to investigate the outcome of high-volume disease defined by the peritoneal cancer index (PCI) 20; second, t...
journal_title:Journal of surgical oncology
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doi:10.1002/jso.23610
更新日期:2014-08-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:The aim of this study was to evaluate the expression and prognostic roles of human ether à go-go related gene (hERG1) potassium channels in resected esophageal squamous cell carcinoma. METHODS:Expression of hERG1 protein and mRNA was detected by immunohistochemistry and reverse transcription ...
journal_title:Journal of surgical oncology
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abstract:BACKGROUND:Malignant hip lesions can be managed operatively by intramedullary (IM) nail fixation and hemiarthroplasty. METHODS:A retrospective review was performed on 86 patients who underwent hemiarthroplasty (n = 22) or IM nail fixation (n = 64) for prophylactic treatment of impending pathologic fracture due to mali...
journal_title:Journal of surgical oncology
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abstract:BACKGROUND AND OBJECTIVES:The poorer outcome amongst younger breast cancer patients continues to be an issue of debate. In order to clarify the prognostic value of patient age, we retrospectively analyzed the data of 1098 breast cancer patients. METHODS:Patients were divided into two groups based on the age 35 (Group ...
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abstract::In our previous study on liposome-mediated transfection of the human interferon-beta (HuIFN-beta) gene into subcutaneously implanted human gliomas in nude mice, we found that HuIFN-beta was produced and secreted by the tumor cells and that the growth of solid tumors was completely inhibited. The present study investig...
journal_title:Journal of surgical oncology
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abstract::The Noble rat prostatic adenocarcinoma, Nb-Pr-A.I.-II, an androgen-insensitive tumor, is the subject of this experiment. Dose responses were carried out with treatment of these tumors with three doses of adriamycin and two doses of methotrexate. Adriamycin treatment resulted in decreased tumor volume and decreased num...
journal_title:Journal of surgical oncology
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journal_title:Journal of surgical oncology
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journal_title:Journal of surgical oncology
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更新日期:2017-11-01 00:00:00
abstract:BACKGROUND:The purpose of this study was to determine whether LAPTM4B over-expression is associated with the prognosis and chemotherapy resistance in patients with stages III and IV epithelial ovarian carcinoma, i.e., patients with peritoneal metastasis or lymph node metastasis of epithelial ovarian carcinoma. METHODS...
journal_title:Journal of surgical oncology
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abstract:BACKGROUND:The benefit derived from lymph node dissection (LND) in patients with pancreatic neuroendocrine tumors (pNETs) based on clinicopathological characteristics remains unclear. METHODS:Patients undergoing surgery for pNET between 1997 and 2016 were identified using a multi-institutional dataset. The therapeutic...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,多中心研究
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更新日期:2019-12-01 00:00:00
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journal_title:Journal of surgical oncology
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更新日期:2012-12-01 00:00:00
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journal_title:Journal of surgical oncology
pub_type: 杂志文章
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更新日期:1991-12-01 00:00:00
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journal_title:Journal of surgical oncology
pub_type: 杂志文章
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journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
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更新日期:2018-01-01 00:00:00
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journal_title:Journal of surgical oncology
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journal_title:Journal of surgical oncology
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