Abstract：
INTRODUCTION:Isolated limb infusion (ILI) is a minimally invasive alternative to isolated limb perfusion (ILP) for delivering high-dose regional chemotherapy to treat locally advanced limb melanoma. The current study aimed to evaluate the applicability of ILI in four Australian tertiary referral centers outside of its originating institution, the Sydney Melanoma Unit (SMU; currently known as the Melanoma Institute Australia). METHODS:Data of 131 patients, treated between 1992 and 2008 were collectively analyzed. The ILI procedures were based on the Sydney Melanoma Unit protocol using melphalan. Response was determined using the WHO criteria and toxicity was assessed using the Wieberdink scale. RESULTS:The median patient age was 74 years (range 28-100). Fifty-six percent were female. Overall response (OR) rate to ILI was 63% (CR 27%; PR 36%). Wieberdink toxicity grade III or higher was seen in 13%. No toxicity-related amputations occurred. Median follow-up was 24 months; median survival was 58 months. In patients with a complete response (CR), median survival was 101 months; in patients with a partial response (PR) this was 41 months (P = 0.026). On univariate analysis a younger age, lower-limb procedures and a lower Breslow thickness of the primary melanoma were associated with a favorable response. On multivariate analysis Breslow thickness and lower-limb ILI remained significant predictors for response. CONCLUSION:In this, to date, largest multi-center study of ILI for melanoma the results are comparable to other reports and demonstrate that ILI can be widely implemented and safely applied across tertiary referral centers.
journal_name
J Surg Oncoljournal_title
Journal of surgical oncologyauthors
Coventry BJ,Kroon HM,Giles MH,Henderson M,Speakman D,Wall M,Barbour A,Serpell J,Paddle P,Coventry AG,Sullivan T,Smithers BMdoi
10.1002/jso.23590subject
Has Abstractpub_date
2014-06-01 00:00:00pages
780-5issue
8eissn
0022-4790issn
1096-9098journal_volume
109pub_type
杂志文章,多中心研究abstract：BACKGROUND AND OBJECTIVES:Long noncoding RNAs (lncRNAs) play key roles in carcinoma metastasis. We aimed to investigate lncRNA LINC01133 in oral squamous cell carcinoma (OSCC) metastasis. METHODS:The RNA levels of LINC01133 and growth and differentiation factor 15 (GDF15) in tissue samples from OSCC patients, and OSCC...
journal_title：Journal of surgical oncology
pub_type： 杂志文章
doi：10.1002/jso.25278
更新日期：2018-12-01 00:00:00
abstract：OBJECTIVES:To develop and validate a nomogram to estimate the pretest probability of malignancy in Chinese patients with solid solitary pulmonary nodule (SPN). MATERIALS AND METHODS:A primary cohort of 1798 patients with pathologically confirmed solid SPNs after surgery was retrospectively studied at five institutions...
journal_title：Journal of surgical oncology
pub_type： 杂志文章,多中心研究
doi：10.1002/jso.24704
更新日期：2017-11-01 00:00:00
abstract：:An unusual case of Merkel cell carcinoma of the lower lip with metastasis to the submental nodes is presented. Clinical similarities and the histopathologic and prognostic differences between this tumor and basal or squamous cell carcinomas of the head and neck area are discussed and the current thoughts for treatment...
journal_title：Journal of surgical oncology
pub_type： 杂志文章
doi：10.1002/jso.2930370212
更新日期：1988-02-01 00:00:00
abstract：BACKGROUNDS AND OBJECTIVES:The aim of this study was to describe the epidemiology and treatment of skin adnexal carcinoma (SAC) in the Netherlands and to identify prognostic factors for survival in patients with SAC. METHODS:We used population-based nationwide data from the Netherlands Cancer Registry with cases diagn...
journal_title：Journal of surgical oncology
pub_type： 杂志文章
doi：10.1002/jso.23331
更新日期：2013-06-01 00:00:00
abstract：:This paper presents an apparent case of danazol-induced primary hepatocellular carcinoma in a 49-year-old patient, following two years of continuous therapy with this inhibitor of pituitary gonadotrophin. Discontinuation of the drug failed to cause regression of the tumour. ...
journal_title：Journal of surgical oncology
pub_type： 杂志文章
doi：10.1002/jso.2930280209
更新日期：1985-02-01 00:00:00
abstract：:Liver metastasis represents a common systemic complication of colorectal cancers (CRCs). Partial liver resection has been demonstrated to result in long-term survival in certain well-selected patients with otherwise well-controlled systemic disease. Neoadjuvant therapy has been demonstrated to result in improved resec...
journal_title：Journal of surgical oncology
pub_type： 杂志文章,评审
doi：10.1002/jso.21691
更新日期：2010-12-15 00:00:00
abstract：:Patients with advanced glottic cancer, in whom there is extensive subglottic disease and/or low cervical lymph node metastasis, have a high incidence of recurrence in and about the tracheal stoma. Stoma recurrences can be prevented by immediate postoperative megavoltage radiotherapy when the stoma is included in the i...
journal_title：Journal of surgical oncology
pub_type： 杂志文章
doi：10.1002/jso.2930070303
更新日期：1975-01-01 00:00:00
abstract：BACKGROUND:The purpose of this study was to determine the patient reasoning behind treatment choice after palliative surgical consultation. METHODS:Patients undergoing palliative surgical consultation were prospectively enrolled in this observational cohort study (11/2009-5/2011) and administered an open-ended questio...
journal_title：Journal of surgical oncology
pub_type： 杂志文章
doi：10.1002/jso.23215
更新日期：2013-03-01 00:00:00
abstract：BACKGROUND:Local recurrence (LR) of sacral chordoma is a difficult problem and the mortality risk associated with LR remains poorly described. The purpose of this study was to evaluate the risk of mortality in patients with LR and determine if patient age is associated with mortality. METHODS:A total of 218 patients (...
journal_title：Journal of surgical oncology
pub_type： 杂志文章
doi：10.1002/jso.25774
更新日期：2019-11-22 00:00:00
abstract：:The ability to redefine risk factors and to predict prognosis in patients with malignant melanoma at the time they manifest nodal metastasis can be a benefit to the patient emotionally and to the physician therapeutically. A retrospective review of 1,273 patients with stage II malignant melanoma was performed at our i...
journal_title：Journal of surgical oncology
pub_type： 杂志文章
doi：10.1002/jso.2930390302
更新日期：1988-11-01 00:00:00
abstract：:The circumferential resection of the trachea with end-to-end anastomosis is a well-established clinical procedure. Still, some problems remain to be solved, such as the choice of optimal suture material. Dogs are primarily used for experimental work in this field, but are difficult to obtain. This operation was perfor...
journal_title：Journal of surgical oncology
pub_type： 杂志文章
doi：10.1002/jso.2930370114
更新日期：1988-01-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:In highly selected patients with peritoneal carcinomatosis, cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC) can be an aggressive but worthwhile treatment regimen. Resection of the rectosigmoid is frequently performed with CRS. The aim of the study wa...
journal_title：Journal of surgical oncology
pub_type： 杂志文章
doi：10.1002/jso.25189
更新日期：2018-09-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:Re-excision surgery is undertaken to obtain clear margins after breast-conserving surgery (BCS) for localized breast cancer. This study examines patient and tumor characteristics related to re-excision surgery in the universal-access Military Health System (MHS). METHODS:Retrospective analysi...
journal_title：Journal of surgical oncology
pub_type： 杂志文章
doi：10.1002/jso.25788
更新日期：2019-11-29 00:00:00
abstract：:The relationship of acute appendicitis occurring previous to cancer in colon and rectum was studied in the consecutive records of 561 patients, of 40 years of age and older, operated upon with an appendectomy because of acute appendicitis. Sixteen (2.9%) of these patients were readmitted within three years because of ...
journal_title：Journal of surgical oncology
pub_type： 杂志文章
doi：10.1002/jso.2930200105
更新日期：1982-05-01 00:00:00
abstract：BACKGROUND:Few studies have focused on distribution of lymph node metastasis. The aim of this study is to evaluate the prognostic significance of the location of involved lymph nodes in patients with advanced mid or low rectal cancer. METHODS:We defined proximal lymph node involvement (PLNp) as superior rectal and inf...
journal_title：Journal of surgical oncology
pub_type： 杂志文章
doi：10.1002/jso.21966
更新日期：2011-10-01 00:00:00
abstract：BACKGROUND:Mutation of the KRAS oncogene (mKRAS) in colorectal cancer has been associated with aggressive tumor biology, resistance to epidermal growth factor inhibitors, and decreased overall survival (OS). The aim of the current study was to analyze the association of mKRAS with pathologic complete response (pCR) and...
journal_title：Journal of surgical oncology
pub_type： 杂志文章
doi：10.1002/jso.26244
更新日期：2021-01-01 00:00:00
abstract：:A unique association between meningioma and breast cancer has recently been observed. A review of the literature reveals 33 such cases. Certain similarities exist between these two tumors. They each occur more frequently in women in the fifth and sixth decade, and pregnancy accelerates the symptoms of both entities. F...
journal_title：Journal of surgical oncology
pub_type： 杂志文章
doi：10.1002/jso.2930310309
更新日期：1986-03-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:Uncertainty exists about the value of cancer therapy in patients aged 90 years and older. Because of the relative paucity of these patients, as well as the possibility of selection bias in any one institution, the use of a large, total population-based cancer registry was employed. METHODS:Th...
journal_title：Journal of surgical oncology
pub_type： 杂志文章
doi：10.1002/jso.10160
更新日期：2002-11-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:Remifentanil infusion is used as an intraoperative anesthetic for thyroidectomy, but has been associated with acute opioid tolerance and hyperalgesia. A national shortage of remifentanil provided an opportunity to study postoperative pain in patients undergoing thyroidectomy. METHODS:Retrospe...
journal_title：Journal of surgical oncology
pub_type： 杂志文章
doi：10.1002/jso.25746
更新日期：2019-12-01 00:00:00
abstract：:In settings when it is biologically plausible that some patients are cured after definitive treatment, cure models present an alternative to conventional survival analysis. Cure models can inform on the group of patients cured, by estimating the probability of cure, and identifying factors that influence it; while sim...
journal_title：Journal of surgical oncology
pub_type： 杂志文章,评审
doi：10.1002/jso.23411
更新日期：2013-11-01 00:00:00
abstract：:Wilms' tumor, renal cell carcinoma, and neuroblastoma in animals were transplanted from donors to recipients with strong histocompatibility differences. No strong evidence of the privileged site theory was found in this study and no obvious evidence of an immunosuppressive effect of testosterone was found. The most im...
journal_title：Journal of surgical oncology
pub_type： 杂志文章
doi：10.1002/jso.2930140111
更新日期：1980-01-01 00:00:00
abstract：BACKGROUND:The aim of this study is to investigate clinical significance of miR-155 expression in breast cancer. METHODS:TaqMan real-time RT-PCR was performed to detect miR-155 expression in breast cancer tissues. The correlation of miR-155 expression with clinicopathological factors and prognosis of breast cancer pat...
journal_title：Journal of surgical oncology
pub_type： 杂志文章
doi：10.1002/jso.22153
更新日期：2012-09-01 00:00:00
abstract：:A case of leiomyosarcoma of a Meckel's diverticulum, presenting as an acute appendicitis, is reported. The literature is reviewed with particular emphasis on current trends in the diagnosis and management of leiomyosarcomas of the small intestine. ...
journal_title：Journal of surgical oncology
pub_type： 杂志文章
doi：10.1002/jso.2930320207
更新日期：1986-06-01 00:00:00
abstract：BACKGROUND:For tumours of the adrenal gland different surgical retroperitoneal approaches have been established, including the lateral and the dorsal approach. It is still unclear if the lateral or the dorsal approach should be preferred. PATIENTS AND METHODS:A retrospective comparison between 21 patients who underwen...
journal_title：Journal of surgical oncology
pub_type： 信件
doi：10.1002/jso.20793
更新日期：2008-01-01 00:00:00
abstract：:This is a retrospective review of 476 patients who had mastectomy for carcinoma of the breast during 1971-1980. There is a positive correlation of size of the primary tumor and the incidence of axillary nodal metastasis. Infiltrating ductal and lobular carcinoma had a significantly higher incidence of nodal metastasis...
journal_title：Journal of surgical oncology
pub_type： 杂志文章
doi：10.1002/jso.2930230105
更新日期：1983-05-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:To identify breast-specific factors and the role of tumor, treatment, and patient-related items in influencing patient opinion on cosmesis and satisfaction after breast-conserving therapy (BCT). METHODS:Data from the randomized COBALT study was used. At 3, 12, and 36 months, 128 patients with...
journal_title：Journal of surgical oncology
pub_type： 杂志文章,随机对照试验
doi：10.1002/jso.25012
更新日期：2018-04-01 00:00:00
abstract：:Dramatic improvements in morbidity and mortality rates following liver resections have been reported in the past decade. Consequently, the indications for hepatectomy are becoming more liberal. Many techniques of liver resection with or without vascular clamping have been reported with excellent clinical results. Tota...
journal_title：Journal of surgical oncology
pub_type： 杂志文章,评审
doi：10.1002/(sici)1096-9098(199909)72:1<50::aid-jso14>
更新日期：1999-09-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:The effect of esophagectomy with three-field lymph node dissection for submucosal carcinoma of the thoracic esophagus remains controversial. The aim of this study was to evaluate the effect of esophagectomy with three-field lymph node dissection for submucosal carcinoma of the thoracic esophag...
journal_title：Journal of surgical oncology
pub_type： 杂志文章
doi：10.1002/1096-9098(200009)75:1<37::aid-jso7>3.0.co;
更新日期：2000-09-01 00:00:00
abstract：AIM:To evaluate the efficacy of stereotactic body radiation therapy (SBRT) in small hepatocellular carcinoma (HCC) patients. METHODS:From March 2009 to April 2015, we treated 132 small HCC patients with SBRT. Eligibility criteria included longest tumor diameter ≤5.0 cm; Child-Turcotte-Pugh (CTP) Class A or B; unfeasib...
journal_title：Journal of surgical oncology
pub_type： 杂志文章
doi：10.1002/jso.24128
更新日期：2016-02-01 00:00:00
abstract：UNLABELLED:Application of subatmospheric pressure to sites injected with doxorubicin prevented ulcer formation in treated sites (0 ulcers/16 sites) compared to control wounds (10 ulcers/16 sites) in a pig model. BACKGROUND AND OBJECTIVES:Extravasation of doxorubicin hydrochloride (Adriamycin) frequently causes chronic...
journal_title：Journal of surgical oncology
pub_type： 杂志文章
doi：10.1002/(sici)1096-9098(199909)72:1<14::aid-jso4>3
更新日期：1999-09-01 00:00:00
